Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
Identifieur interne : 001410 ( Istex/Checkpoint ); précédent : 001409; suivant : 001411Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
Auteurs : A. J. Moritz [Autriche, États-Unis] ; C. Kunz [Autriche, États-Unis] ; H. Hofman [Autriche, États-Unis] ; E. Liehl [Autriche, États-Unis] ; P. Reeve [Autriche, États-Unis, Royaume-Uni] ; H. F. Maassab [Autriche, États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1980.
Abstract
A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.
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DOI: 10.1093/infdis/142.6.857
Affiliations:
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<wicri:cityArea>Please address requests for reprints to Dr. P. Reeve at his present address: National Institute for Biological Standards and Control, London NW3</wicri:cityArea>
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<front><div type="abstract">A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</div>
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