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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</title>
<author><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name>
<affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26407668</idno>
<idno type="pmc">4808494</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808494</idno>
<idno type="RBID">PMC:4808494</idno>
<idno type="doi">10.1111/jcpe.12461</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002621</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002621</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</title>
<author><name sortKey="Andriankaja, Oelisoa M" sort="Andriankaja, Oelisoa M" uniqKey="Andriankaja O" first="Oelisoa M." last="Andriankaja">Oelisoa M. Andriankaja</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jimenez, James J" sort="Jimenez, James J" uniqKey="Jimenez J" first="James J." last="Jiménez">James J. Jiménez</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mu Oz Torres, Francisco J" sort="Mu Oz Torres, Francisco J" uniqKey="Mu Oz Torres F" first="Francisco J." last="Mu Oz-Torres">Francisco J. Mu Oz-Torres</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perez, Cynthia M" sort="Perez, Cynthia M" uniqKey="Perez C" first="Cynthia M." last="Pérez">Cynthia M. Pérez</name>
<affiliation><nlm:aff id="A2">Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vergara, Jose L" sort="Vergara, Jose L" uniqKey="Vergara J" first="José L." last="Vergara">José L. Vergara</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joshipura, Kaumudi" sort="Joshipura, Kaumudi" uniqKey="Joshipura K" first="Kaumudi" last="Joshipura">Kaumudi Joshipura</name>
<affiliation><nlm:aff id="A1">Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of clinical periodontology</title>
<idno type="ISSN">0303-6979</idno>
<idno type="eISSN">1600-051X</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.</p>
<sec id="S1"><title>Objective</title>
<p id="P2">To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P3">Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">Lipid-lowering agents may reduce both systemic and oral inflammatory responses.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4645</journal-id>
<journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id>
<journal-title-group><journal-title>Journal of clinical periodontology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0303-6979</issn>
<issn pub-type="epub">1600-051X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26407668</article-id>
<article-id pub-id-type="pmc">4808494</article-id>
<article-id pub-id-type="doi">10.1111/jcpe.12461</article-id>
<article-id pub-id-type="manuscript">NIHMS725781</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Lipid lowering agents use and systemic and oral inflammation in overweight or obese adult Puerto Ricans: the San Juan Overweight Adults Longitudinal Study (SOALS)</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Andriankaja</surname>
<given-names>Oelisoa M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jiménez</surname>
<given-names>James J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muñoz-Torres</surname>
<given-names>Francisco J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pérez</surname>
<given-names>Cynthia M.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vergara</surname>
<given-names>José L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Joshipura</surname>
<given-names>Kaumudi</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico</aff>
<aff id="A2"><label>2</label>
Department of Biostatistics and Epidemiology, Graduate School of Public Health, Medical Sciences Campus, University of Puerto Rico</aff>
<author-notes><corresp id="cor1"><bold><italic>Corresponding author:</italic>
</bold>
Oelisoa M. Andriankaja, DDS, MS, PhD, Center for Clinical Research and Health Promotion, University of Puerto Rico, School of Dental Medicine, Office A107, Box 365067, San Juan, PR 00936-5067, Tel: 787 758-2525 ext. 1182, Fax: 787-763-4868, <email>Oelisoa.andriankaja@upr.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>1</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>11</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>42</volume>
<issue>12</issue>
<fpage>1090</fpage>
<lpage>1096</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/jcpe.12461</pmc-comment>
<abstract><p id="P1">The effects of lipid-lowering agents (LLA) on reducing systemic and oral inflammation have not been evaluated.</p>
<sec id="S1"><title>Objective</title>
<p id="P2">To assess the association of LLA use with high-sensitivity C-reactive protein (hs-CRP) and oral inflammation.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P3">Cross-sectional analysis using baseline data from 1,300 overweight/obese participants aged 40–65 years, recruited for the ongoing San Juan Overweight Adults Longitudinal Study. Serum hs-CRP was measured by ELISA, gingival/periodontal inflammation was evaluated as bleeding upon probing (BOP), and LLA was self-reported. Separate logistic models were performed for systemic and oral inflammation.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">24% participants reported history of dyslipidemia, of which, 50.3% self-reported LLA use. Sixty percent of the participants had elevated hs-CRP (>3 mg/dL) and 50% had high BOP (defined as at or above the median: 21%). After adjusting for age, gender, smoking, HDL-C, physical activity, diabetes, blood pressure medications, and percent body fat composition, LLA users had significantly lower odds of elevated hs-CRP compared to LLA non-users (OR=0.58; 95% CI: 0.39–0.85). After adjusting for age, gender, smoking status, educational level, mean plaque index, and percent body fat, LLA users had significantly lower odds of high BOP compared to LLA non-users (OR= 0.62; 95% CI: 0.42–0.91).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">Lipid-lowering agents may reduce both systemic and oral inflammatory responses.</p>
</sec>
</abstract>
<kwd-group><title>Key terms</title>
<kwd>Lipid lowering agents</kwd>
<kwd>statins</kwd>
<kwd>periodontitis</kwd>
<kwd>systemic inflammation</kwd>
<kwd>hs-CRP</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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