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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rescuing failed oral implants via Wnt activation</title><author><name sortKey="Yin, Xing" sort="Yin, Xing" uniqKey="Yin X" first="Xing" last="Yin">Xing Yin</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingtao" sort="Li, Jingtao" uniqKey="Li J" first="Jingtao" last="Li">Jingtao Li</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Tao" sort="Chen, Tao" uniqKey="Chen T" first="Tao" last="Chen">Tao Chen</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mouraret, Sylvain" sort="Mouraret, Sylvain" uniqKey="Mouraret S" first="Sylvain" last="Mouraret">Sylvain Mouraret</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Dhamdhere, Girija" sort="Dhamdhere, Girija" uniqKey="Dhamdhere G" first="Girija" last="Dhamdhere">Girija Dhamdhere</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Brunski, John B" sort="Brunski, John B" uniqKey="Brunski J" first="John B." last="Brunski">John B. Brunski</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Zou, Shujuan" sort="Zou, Shujuan" uniqKey="Zou S" first="Shujuan" last="Zou">Shujuan Zou</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Helms, Jill A" sort="Helms, Jill A" uniqKey="Helms J" first="Jill A." last="Helms">Jill A. Helms</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26718012</idno><idno type="pmc">4973628</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973628</idno><idno type="RBID">PMC:4973628</idno><idno type="doi">10.1111/jcpe.12503</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002622</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002622</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rescuing failed oral implants via Wnt activation</title><author><name sortKey="Yin, Xing" sort="Yin, Xing" uniqKey="Yin X" first="Xing" last="Yin">Xing Yin</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingtao" sort="Li, Jingtao" uniqKey="Li J" first="Jingtao" last="Li">Jingtao Li</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Tao" sort="Chen, Tao" uniqKey="Chen T" first="Tao" last="Chen">Tao Chen</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Mouraret, Sylvain" sort="Mouraret, Sylvain" uniqKey="Mouraret S" first="Sylvain" last="Mouraret">Sylvain Mouraret</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Dhamdhere, Girija" sort="Dhamdhere, Girija" uniqKey="Dhamdhere G" first="Girija" last="Dhamdhere">Girija Dhamdhere</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Brunski, John B" sort="Brunski, John B" uniqKey="Brunski J" first="John B." last="Brunski">John B. Brunski</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Zou, Shujuan" sort="Zou, Shujuan" uniqKey="Zou S" first="Shujuan" last="Zou">Shujuan Zou</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Helms, Jill A" sort="Helms, Jill A" uniqKey="Helms J" first="Jill A." last="Helms">Jill A. Helms</name><affiliation><nlm:aff id="A2">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim</title><p id="P1">Implant osseointegration is not always guaranteed and once fibrous encapsulation occurs clinicians have few options other than implant removal. Our goal was to test whether a WNT protein therapeutic could rescue such failed implants.</p></sec><sec id="S2"><title>Material and Methods</title><p id="P2">Titanium implants were placed in over-sized murine oral osteotomies. A lack of primary stability was verified by mechanical testing. Interfacial strains were estimated by finite element modelling and histology coupled with histomorphometry confirmed the lack of peri-implant bone. After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated. Quantitative assays were employed to analyse the effects of L-WNT3A treatment.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implants in gap-type interfaces exhibited high interfacial strains and no primary stability. After verification of implant failure, L-WNT3A or L-PBS injections were initiated. L-WNT3A induced a rapid, significant increase in Wnt responsiveness in the peri-implant environment, cell proliferation and osteogenic protein expression. The amount of peri-implant bone and bone in contact with the implant were significantly higher in L-WNT3A cases.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These data demonstrate L-WNT3A can induce peri-implant bone formation even in cases where fibrous encapsulation predominates.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id><journal-id journal-id-type="pubmed-jr-id">4645</journal-id><journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id><journal-title-group><journal-title>Journal of clinical periodontology</journal-title></journal-title-group><issn pub-type="ppub">0303-6979</issn><issn pub-type="epub">1600-051X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26718012</article-id><article-id pub-id-type="pmc">4973628</article-id><article-id pub-id-type="doi">10.1111/jcpe.12503</article-id><article-id pub-id-type="manuscript">NIHMS799744</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Rescuing failed oral implants via Wnt activation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Xing</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingtao</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mouraret</surname><given-names>Sylvain</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dhamdhere</surname><given-names>Girija</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Brunski</surname><given-names>John B.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Shujuan</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Helms</surname><given-names>Jill A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</aff><aff id="A2"><label>2</label>Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA</aff><author-notes><corresp id="FN1">Address: Jill A. Helms, Division of Plastic and Reconstructive, Surgery, Department of Surgery, Stanford School of Medicine, Room GK207, 257 Campus Dr. Stanford, CA 94305, USA, <email>jhelms@stanford.edu</email></corresp><fn id="FN2" fn-type="equal"><label>†</label><p>Authors contributing equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>7</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>8</month><year>2016</year></pub-date><volume>43</volume><issue>2</issue><fpage>180</fpage><lpage>192</lpage><pmc-comment>elocation-id from pubmed: 10.1111/jcpe.12503</pmc-comment>
<abstract><sec id="S1"><title>Aim</title><p id="P1">Implant osseointegration is not always guaranteed and once fibrous encapsulation occurs clinicians have few options other than implant removal. Our goal was to test whether a WNT protein therapeutic could rescue such failed implants.</p></sec><sec id="S2"><title>Material and Methods</title><p id="P2">Titanium implants were placed in over-sized murine oral osteotomies. A lack of primary stability was verified by mechanical testing. Interfacial strains were estimated by finite element modelling and histology coupled with histomorphometry confirmed the lack of peri-implant bone. After fibrous encapsulation was established peri-implant injections of a liposomal formulation of WNT3A protein (L-WNT3A) or liposomal PBS (L-PBS) were then initiated. Quantitative assays were employed to analyse the effects of L-WNT3A treatment.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implants in gap-type interfaces exhibited high interfacial strains and no primary stability. After verification of implant failure, L-WNT3A or L-PBS injections were initiated. L-WNT3A induced a rapid, significant increase in Wnt responsiveness in the peri-implant environment, cell proliferation and osteogenic protein expression. The amount of peri-implant bone and bone in contact with the implant were significantly higher in L-WNT3A cases.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These data demonstrate L-WNT3A can induce peri-implant bone formation even in cases where fibrous encapsulation predominates.</p></sec></abstract><kwd-group><kwd>biomechanics</kwd><kwd>fibrosis</kwd><kwd>finite element analysis</kwd><kwd>osseointegration</kwd><kwd>osteogenesis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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