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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort</title>
<author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
<affiliation><nlm:aff id="A1">Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
<affiliation><nlm:aff id="A2">Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
<affiliation><nlm:aff id="A1">Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Elizabeth A" sort="Jackson, Elizabeth A" uniqKey="Jackson E" first="Elizabeth A." last="Jackson">Elizabeth A. Jackson</name>
<affiliation><nlm:aff id="A3">University of Michigan, Department of internal medicine, Ann Arbor, MI, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Surraka, Markku" sort="Surraka, Markku" uniqKey="Surraka M" first="Markku" last="Surraka">Markku Surraka</name>
<affiliation><nlm:aff id="A4">Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tao, Wen" sort="Tao, Wen" uniqKey="Tao W" first="Wen" last="Tao">Wen Tao</name>
<affiliation><nlm:aff id="A5">Department of Biostatistics, Boston University, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
<affiliation><nlm:aff id="A6">Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
<affiliation><nlm:aff id="A7">Forsyth Institute, Periodontology, Cambridge, MA, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24354534</idno>
<idno type="pmc">3934352</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934352</idno>
<idno type="RBID">PMC:3934352</idno>
<idno type="doi">10.1111/jcpe.12192</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002620</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002620</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort</title>
<author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
<affiliation><nlm:aff id="A1">Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
<affiliation><nlm:aff id="A2">Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
<affiliation><nlm:aff id="A1">Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Elizabeth A" sort="Jackson, Elizabeth A" uniqKey="Jackson E" first="Elizabeth A." last="Jackson">Elizabeth A. Jackson</name>
<affiliation><nlm:aff id="A3">University of Michigan, Department of internal medicine, Ann Arbor, MI, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Surraka, Markku" sort="Surraka, Markku" uniqKey="Surraka M" first="Markku" last="Surraka">Markku Surraka</name>
<affiliation><nlm:aff id="A4">Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tao, Wen" sort="Tao, Wen" uniqKey="Tao W" first="Wen" last="Tao">Wen Tao</name>
<affiliation><nlm:aff id="A5">Department of Biostatistics, Boston University, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
<affiliation><nlm:aff id="A6">Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
<affiliation><nlm:aff id="A7">Forsyth Institute, Periodontology, Cambridge, MA, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of clinical periodontology</title>
<idno type="ISSN">0303-6979</idno>
<idno type="eISSN">1600-051X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim(s)</title>
<p id="P1">To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31<sup>st</sup>
, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4645</journal-id>
<journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id>
<journal-title-group><journal-title>Journal of clinical periodontology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0303-6979</issn>
<issn pub-type="epub">1600-051X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24354534</article-id>
<article-id pub-id-type="pmc">3934352</article-id>
<article-id pub-id-type="doi">10.1111/jcpe.12192</article-id>
<article-id pub-id-type="manuscript">NIHMS541869</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Janket</surname>
<given-names>Sok-Ja</given-names>
</name>
<degrees>DMD, MPH</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baird</surname>
<given-names>Alison E.</given-names>
</name>
<degrees>MD, MPH, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Judith A.</given-names>
</name>
<degrees>DDS, DSc.D</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jackson</surname>
<given-names>Elizabeth A.</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Surraka</surname>
<given-names>Markku</given-names>
</name>
<degrees>DDS, MS</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tao</surname>
<given-names>Wen</given-names>
</name>
<degrees>MS, BS</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meurman</surname>
<given-names>Jukka H.</given-names>
</name>
<degrees>MD, DDS, PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Dyke</surname>
<given-names>Thomas E.</given-names>
</name>
<degrees>DDS, PhD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</aff>
<aff id="A2"><label>2</label>
Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY, USA</aff>
<aff id="A3"><label>3</label>
University of Michigan, Department of internal medicine, Ann Arbor, MI, USA</aff>
<aff id="A4"><label>4</label>
Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</aff>
<aff id="A5"><label>5</label>
Department of Biostatistics, Boston University, Boston, MA, USA</aff>
<aff id="A6"><label>6</label>
Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki, Finland</aff>
<aff id="A7"><label>7</label>
Forsyth Institute, Periodontology, Cambridge, MA, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author: Sok-Ja Janket, DMD, MPH, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-107C, Boston, MA 02118, <email>skjanket@bu.edu</email>
, Fax: (617) 414-1061, Tel: (617) 414-1060</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>2</month>
<year>2015</year>
</pub-date>
<volume>41</volume>
<issue>2</issue>
<fpage>131</fpage>
<lpage>140</lpage>
<pmc-comment>elocation-id from pubmed: 10.1111/jcpe.12192</pmc-comment>
<abstract><sec id="S1"><title>Aim(s)</title>
<p id="P1">To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31<sup>st</sup>
, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.</p>
</sec>
</abstract>
<kwd-group><kwd>CVD mortality</kwd>
<kwd>Number of teeth</kwd>
<kwd>C-reactive protein</kwd>
<kwd>fibrinogen</kwd>
<kwd>mediation analyses</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source>
<award-id>R01 AG045136 || AG</award-id>
</award-group>
<award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source>
<award-id>M01 RR002602 || RR</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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