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The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit

Identifieur interne : 005749 ( Ncbi/Checkpoint ); précédent : 005748; suivant : 005750

The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit

Auteurs : Sung-Am Cho [Corée du Sud] ; Sang-Hun Park [Corée du Sud] ; Jin-Hyun Cho [Corée du Sud]

Source :

RBID : PMC:4279050

Abstract

PURPOSE

The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.

MATERIALS AND METHODS

A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.

RESULTS

While no statistically significant difference was observed between the two groups (P=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-toimplant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant.

CONCLUSION

We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.


Url:
DOI: 10.4047/jap.2014.6.6.505
PubMed: 25551011
PubMed Central: 4279050


Affiliations:


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PMC:4279050

Le document en format XML

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<title>MATERIALS AND METHODS</title>
<p>A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.</p>
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<title>RESULTS</title>
<p>While no statistically significant difference was observed between the two groups (
<italic>P</italic>
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<title>CONCLUSION</title>
<p>We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.</p>
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<name sortKey="Levy, F" uniqKey="Levy F">F Levy</name>
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<author>
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<name sortKey="I Eri, So" uniqKey="I Eri S">SO Işeri</name>
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<name sortKey="Gedik, N" uniqKey="Gedik N">N Gedik</name>
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<li>Corée du Sud</li>
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<name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name>
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<name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name>
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