The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit
Identifieur interne : 002F04 ( Pmc/Curation ); précédent : 002F03; suivant : 002F05The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit
Auteurs : Sung-Am Cho [Corée du Sud] ; Sang-Hun Park [Corée du Sud] ; Jin-Hyun Cho [Corée du Sud]Source :
- The Journal of Advanced Prosthodontics [ 2005-7806 ] ; 2014.
Abstract
The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.
A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.
While no statistically significant difference was observed between the two groups (
We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.
Url:
DOI: 10.4047/jap.2014.6.6.505
PubMed: 25551011
PubMed Central: 4279050
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<author><name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff>
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<author><name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name>
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<author><name sortKey="Cho, Jin Hyun" sort="Cho, Jin Hyun" uniqKey="Cho J" first="Jin-Hyun" last="Cho">Jin-Hyun Cho</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit</title>
<author><name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name>
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<wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea>
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<author><name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name>
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<author><name sortKey="Cho, Jin Hyun" sort="Cho, Jin Hyun" uniqKey="Cho J" first="Jin-Hyun" last="Cho">Jin-Hyun Cho</name>
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<series><title level="j">The Journal of Advanced Prosthodontics</title>
<idno type="ISSN">2005-7806</idno>
<idno type="eISSN">2005-7814</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title>
<p>The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.</p>
</sec>
<sec><title>MATERIALS AND METHODS</title>
<p>A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.</p>
</sec>
<sec><title>RESULTS</title>
<p>While no statistically significant difference was observed between the two groups (<italic>P</italic>
=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-toimplant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant.</p>
</sec>
<sec><title>CONCLUSION</title>
<p>We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id>
<journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id>
<journal-id journal-id-type="publisher-id">JAP</journal-id>
<journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title>
</journal-title-group>
<issn pub-type="ppub">2005-7806</issn>
<issn pub-type="epub">2005-7814</issn>
<publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25551011</article-id>
<article-id pub-id-type="pmc">4279050</article-id>
<article-id pub-id-type="doi">10.4047/jap.2014.6.6.505</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Cho</surname>
<given-names>Sung-Am</given-names>
</name>
<xref ref-type="aff" rid="A1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Sang-Hun</given-names>
</name>
<xref ref-type="aff" rid="A1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Cho</surname>
<given-names>Jin-Hyun</given-names>
</name>
<xref ref-type="aff" rid="A1"></xref>
</contrib>
</contrib-group>
<aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</aff>
<author-notes><corresp>Corresponding author: Jin-Hyun Cho. Department of Prosthodontics, School of Dentistry, Kyoungpook National University, #2175 Dalgubeoldae-ro, Jung-gu, Daegu 700-705, Republic of Korea. Tel. 82 53 600 7675: <email>prosth95@knu.ac.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>17</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>6</volume>
<issue>6</issue>
<fpage>505</fpage>
<lpage>511</lpage>
<history><date date-type="received"><day>26</day>
<month>3</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>16</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>05</day>
<month>8</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 The Korean Academy of Prosthodontics</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>PURPOSE</title>
<p>The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.</p>
</sec>
<sec><title>MATERIALS AND METHODS</title>
<p>A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.</p>
</sec>
<sec><title>RESULTS</title>
<p>While no statistically significant difference was observed between the two groups (<italic>P</italic>
=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-toimplant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant.</p>
</sec>
<sec><title>CONCLUSION</title>
<p>We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.</p>
</sec>
</abstract>
<kwd-group><kwd>Oxytocin</kwd>
<kwd>Removal torque test</kwd>
<kwd>Histomorphometric parameter</kwd>
<kwd>Dental implant</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="KR">Kyungpook National University Hospital</funding-source>
</award-group>
</funding-group>
</article-meta>
</front>
<floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label>
<caption><p>Intramuscular injections (oxytocin or saline) were given 2 times/2 days/week and animals were sacrificed at 31 days after surgery.</p>
</caption>
<graphic xlink:href="jap-6-505-g001"></graphic>
</fig>
<fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label>
<caption><p>An MGT-12 digital torque gauge (Mark-10 Corp, New York, NY, USA) was used to measure the removal torque with a connector specifically made to connect the torque gauge and the fixture.</p>
</caption>
<graphic xlink:href="jap-6-505-g002"></graphic>
</fig>
<fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label>
<caption><p>The inter-thread bone density was defined as the area of bone inside the 4 most-central threads (×100%). The percentage of peri-implant bone area was defined as the area of bone that had formed after implant insertion/rectangular area (×100%) (1 mm × 1.2 mm rectangle; 2 rectangles per implant). The bone-to-implant contact (BIC) was determined by linear measurement of direct bone contact with the implant surface.</p>
</caption>
<graphic xlink:href="jap-6-505-g003"></graphic>
</fig>
<fig id="F4" orientation="portrait" position="float"><label>Fig. 4</label>
<caption><p>Mean values of the removal torque force for the control and experimental groups. No statistically significant difference was observed between the two groups (<italic>P</italic>
=.787), although the control group showed higher values.</p>
</caption>
<graphic xlink:href="jap-6-505-g004"></graphic>
</fig>
<fig id="F5" orientation="portrait" position="float"><label>Fig. 5</label>
<caption><p>Oxytocin concentrations (pg/mL) were calculated from the standard curve. The mean value for the experimental group was 936.81 pg/mL and that of the control group was 705.89 pg/mL; the values were not significantly different.</p>
</caption>
<graphic xlink:href="jap-6-505-g005"></graphic>
</fig>
<fig id="F6" orientation="portrait" position="float"><label>Fig. 6</label>
<caption><p>Representative images at 31 days after dental implantation in an oxytocin (OT)-treated and a control sample with new bone formation between all threads. The histomorphometric cross-sectional view of an implant in an OT-treated sample (A) corresponding to the peri-implant bone area in which it was observed shows a similar percentage of bone tissue in contact with the implant when compared with similar sections in a control sample (B).</p>
</caption>
<graphic xlink:href="jap-6-505-g006"></graphic>
</fig>
<table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Summary of the measured removal torque values</p>
</caption>
<graphic xlink:href="jap-6-505-i001"></graphic>
</table-wrap>
<table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label>
<caption><p>Summary of the measured serum oxytocin concentration values</p>
</caption>
<graphic xlink:href="jap-6-505-i002"></graphic>
<table-wrap-foot><fn><p>The oxytocin concentrations (pg/mL) were calculated from the standard curve.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label>
<caption><p>Values of the histomorphometric parameters of osseointegration at 31 days (4 weeks + 3 days) after implantation. Although the values were higher in the experimental group, no significant differences were observed between the two groups</p>
</caption>
<graphic xlink:href="jap-6-505-i003"></graphic>
</table-wrap>
</floats-group>
</pmc>
</record>
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