The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit
Identifieur interne : 001166 ( Pmc/Checkpoint ); précédent : 001165; suivant : 001167The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit
Auteurs : Sung-Am Cho [Corée du Sud] ; Sang-Hun Park [Corée du Sud] ; Jin-Hyun Cho [Corée du Sud]Source :
- The Journal of Advanced Prosthodontics [ 2005-7806 ] ; 2014.
Abstract
The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.
A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.
While no statistically significant difference was observed between the two groups (
We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.
Url:
DOI: 10.4047/jap.2014.6.6.505
PubMed: 25551011
PubMed Central: 4279050
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit</title><author><name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Jin Hyun" sort="Cho, Jin Hyun" uniqKey="Cho J" first="Jin-Hyun" last="Cho">Jin-Hyun Cho</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25551011</idno><idno type="pmc">4279050</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279050</idno><idno type="RBID">PMC:4279050</idno><idno type="doi">10.4047/jap.2014.6.6.505</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002F04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F04</idno><idno type="wicri:Area/Pmc/Curation">002F04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F04</idno><idno type="wicri:Area/Pmc/Checkpoint">001166</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit</title><author><name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Jin Hyun" sort="Cho, Jin Hyun" uniqKey="Cho J" first="Jin-Hyun" last="Cho">Jin-Hyun Cho</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Advanced Prosthodontics</title><idno type="ISSN">2005-7806</idno><idno type="eISSN">2005-7814</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title><p>The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.</p></sec><sec><title>MATERIALS AND METHODS</title><p>A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.</p></sec><sec><title>RESULTS</title><p>While no statistically significant difference was observed between the two groups (<italic>P</italic>=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-toimplant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant.</p></sec><sec><title>CONCLUSION</title><p>We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id><journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id><journal-id journal-id-type="publisher-id">JAP</journal-id><journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title></journal-title-group><issn pub-type="ppub">2005-7806</issn><issn pub-type="epub">2005-7814</issn><publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25551011</article-id><article-id pub-id-type="pmc">4279050</article-id><article-id pub-id-type="doi">10.4047/jap.2014.6.6.505</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>The influence of systemically administered oxytocin on the implant-bone interface area: an experimental study in the rabbit</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Sung-Am</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Sang-Hun</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Cho</surname><given-names>Jin-Hyun</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib></contrib-group><aff id="A1">Department of Prosthodontics, School of Dentistry, Kyoungpook National University, Daegu, Republic of Korea.</aff><author-notes><corresp>Corresponding author: Jin-Hyun Cho. Department of Prosthodontics, School of Dentistry, Kyoungpook National University, #2175 Dalgubeoldae-ro, Jung-gu, Daegu 700-705, Republic of Korea. Tel. 82 53 600 7675: <email>prosth95@knu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2014</year></pub-date><volume>6</volume><issue>6</issue><fpage>505</fpage><lpage>511</lpage><history><date date-type="received"><day>26</day><month>3</month><year>2014</year></date><date date-type="rev-recd"><day>16</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>05</day><month>8</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Korean Academy of Prosthodontics</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>PURPOSE</title><p>The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test.</p></sec><sec><title>MATERIALS AND METHODS</title><p>A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; 200 µg/rabbit). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week.</p></sec><sec><title>RESULTS</title><p>While no statistically significant difference was observed between the two groups (<italic>P</italic>=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-toimplant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant.</p></sec><sec><title>CONCLUSION</title><p>We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.</p></sec></abstract><kwd-group><kwd>Oxytocin</kwd><kwd>Removal torque test</kwd><kwd>Histomorphometric parameter</kwd><kwd>Dental implant</kwd></kwd-group><funding-group><award-group><funding-source country="KR">Kyungpook National University Hospital</funding-source></award-group></funding-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><p>Intramuscular injections (oxytocin or saline) were given 2 times/2 days/week and animals were sacrificed at 31 days after surgery.</p></caption><graphic xlink:href="jap-6-505-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><p>An MGT-12 digital torque gauge (Mark-10 Corp, New York, NY, USA) was used to measure the removal torque with a connector specifically made to connect the torque gauge and the fixture.</p></caption><graphic xlink:href="jap-6-505-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><p>The inter-thread bone density was defined as the area of bone inside the 4 most-central threads (×100%). The percentage of peri-implant bone area was defined as the area of bone that had formed after implant insertion/rectangular area (×100%) (1 mm × 1.2 mm rectangle; 2 rectangles per implant). The bone-to-implant contact (BIC) was determined by linear measurement of direct bone contact with the implant surface.</p></caption><graphic xlink:href="jap-6-505-g003"></graphic></fig><fig id="F4" orientation="portrait" position="float"><label>Fig. 4</label><caption><p>Mean values of the removal torque force for the control and experimental groups. No statistically significant difference was observed between the two groups (<italic>P</italic>=.787), although the control group showed higher values.</p></caption><graphic xlink:href="jap-6-505-g004"></graphic></fig><fig id="F5" orientation="portrait" position="float"><label>Fig. 5</label><caption><p>Oxytocin concentrations (pg/mL) were calculated from the standard curve. The mean value for the experimental group was 936.81 pg/mL and that of the control group was 705.89 pg/mL; the values were not significantly different.</p></caption><graphic xlink:href="jap-6-505-g005"></graphic></fig><fig id="F6" orientation="portrait" position="float"><label>Fig. 6</label><caption><p>Representative images at 31 days after dental implantation in an oxytocin (OT)-treated and a control sample with new bone formation between all threads. The histomorphometric cross-sectional view of an implant in an OT-treated sample (A) corresponding to the peri-implant bone area in which it was observed shows a similar percentage of bone tissue in contact with the implant when compared with similar sections in a control sample (B).</p></caption><graphic xlink:href="jap-6-505-g006"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Summary of the measured removal torque values</p></caption><graphic xlink:href="jap-6-505-i001"></graphic></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Summary of the measured serum oxytocin concentration values</p></caption><graphic xlink:href="jap-6-505-i002"></graphic><table-wrap-foot><fn><p>The oxytocin concentrations (pg/mL) were calculated from the standard curve.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><p>Values of the histomorphometric parameters of osseointegration at 31 days (4 weeks + 3 days) after implantation. Although the values were higher in the experimental group, no significant differences were observed between the two groups</p></caption><graphic xlink:href="jap-6-505-i003"></graphic></table-wrap></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Cho, Sung Am" sort="Cho, Sung Am" uniqKey="Cho S" first="Sung-Am" last="Cho">Sung-Am Cho</name></noRegion><name sortKey="Cho, Jin Hyun" sort="Cho, Jin Hyun" uniqKey="Cho J" first="Jin-Hyun" last="Cho">Jin-Hyun Cho</name><name sortKey="Park, Sang Hun" sort="Park, Sang Hun" uniqKey="Park S" first="Sang-Hun" last="Park">Sang-Hun Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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