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Association of salivary lysozyme and C‐reactive protein with metabolic syndrome

Identifieur interne : 005475 ( Main/Merge ); précédent : 005474; suivant : 005476

Association of salivary lysozyme and C‐reactive protein with metabolic syndrome

Auteurs : Markku Qvarnstrom [Finlande] ; Sok-Ja Janket [États-Unis] ; Judith A. Jones [États-Unis] ; Kamal Jethwani [États-Unis] ; Pekka Nuutinen [Finlande] ; Raul I. Garcia [États-Unis] ; Alison E. Baird [États-Unis] ; Thomas E. Van Dyke [États-Unis] ; Jukka H. Meurman [Finlande]

Source :

RBID : ISTEX:8A7210433F60A476214F71CDA8E3DE04AAB30CDB

Descripteurs français

English descriptors

Abstract

Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.

Url:
DOI: 10.1111/j.1600-051X.2010.01605.x

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Links to Exploration step

ISTEX:8A7210433F60A476214F71CDA8E3DE04AAB30CDB

Le document en format XML

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<title level="j" type="main">Journal of Clinical Periodontology</title>
<title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title>
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<term>American heart association</term>
<term>Artery disease</term>
<term>Atherosclerosis</term>
<term>Body mass index</term>
<term>Boston university henry</term>
<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular risk factors</term>
<term>Cholesterol levels</term>
<term>Clin periodontol</term>
<term>Cohort</term>
<term>Common soil</term>
<term>Coronary artery disease</term>
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<term>Dental research</term>
<term>Diabetes</term>
<term>Diabetes care</term>
<term>Diabetic patients</term>
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<term>Lysozyme</term>
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<term>Mets</term>
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<term>Vascular disease</term>
<term>Vascular events</term>
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<term>American heart association</term>
<term>Artery disease</term>
<term>Atherosclerosis</term>
<term>Body mass index</term>
<term>Boston university henry</term>
<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular risk factors</term>
<term>Cholesterol levels</term>
<term>Clin periodontol</term>
<term>Cohort</term>
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<term>Coronary artery disease</term>
<term>Current smokers</term>
<term>Current study</term>
<term>Dental medicine</term>
<term>Dental research</term>
<term>Diabetes</term>
<term>Diabetes care</term>
<term>Diabetic patients</term>
<term>Drug administration</term>
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<term>Edentulous persons</term>
<term>Endothelial dysfunction</term>
<term>European heart journal</term>
<term>Fourth quartile</term>
<term>Funding sources</term>
<term>Goldman school</term>
<term>Heart disease</term>
<term>Helsinki university</term>
<term>High prevalence</term>
<term>Highest quartile</term>
<term>Hypertension</term>
<term>Internal medicine</term>
<term>Janket</term>
<term>John wiley sons</term>
<term>Jupiter cohort</term>
<term>Jupiter trial</term>
<term>Kuopio</term>
<term>Kuopio university hospital</term>
<term>Linear trend</term>
<term>Lipoprotein cholesterol</term>
<term>Lysozyme</term>
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<term>Mets status</term>
<term>Meurman</term>
<term>National heart</term>
<term>Ncep criteria</term>
<term>Nuutinen</term>
<term>Odds ratio</term>
<term>Oral health</term>
<term>Oral infection</term>
<term>Oral medicine</term>
<term>Oral pathology</term>
<term>Oral radiology</term>
<term>Oral surgery</term>
<term>Possible effects</term>
<term>Predictor</term>
<term>Present study</term>
<term>Prevalent hypertension</term>
<term>Previous observation</term>
<term>Previous studies</term>
<term>Prospective study</term>
<term>Proteolytic enzyme</term>
<term>Quartile</term>
<term>Qvarnstrom</term>
<term>Ridker</term>
<term>Risk factor</term>
<term>Risk increase</term>
<term>Salivary</term>
<term>Salivary lysozyme</term>
<term>Sigma chemical</term>
<term>Statin administration</term>
<term>Study design</term>
<term>Subgroup</term>
<term>Syndrome</term>
<term>Total cholesterol</term>
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<term>Vascular disease</term>
<term>Vascular events</term>
</keywords>
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<front>
<div type="abstract">Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.</div>
</front>
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<author>
<name sortKey="Qvarnstrom, Markku" sort="Qvarnstrom, Markku" uniqKey="Qvarnstrom M" first="Markku" last="Qvarnstrom">Markku Qvarnstrom</name>
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<nlm:aff id="A1"> Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff>
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<author>
<name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
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<nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
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<name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
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<nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author>
<name sortKey="Jethwani, Kamal" sort="Jethwani, Kamal" uniqKey="Jethwani K" first="Kamal" last="Jethwani">Kamal Jethwani</name>
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<nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA</wicri:regionArea>
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<region type="state">Massachusetts</region>
</placeName>
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<nlm:aff id="A3"> Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
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<wicri:regionArea> Massachusetts General Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
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<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name>
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<nlm:aff id="A4"> Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Cardiothoracic Surgery, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name>
<affiliation wicri:level="2">
<nlm:aff id="A5"> Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
<affiliation wicri:level="2">
<nlm:aff id="A6"> Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
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<nlm:aff id="A7"> Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
<affiliation wicri:level="4">
<nlm:aff id="A8"> Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea> Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName>
<settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
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<title level="j">Journal of clinical periodontology</title>
<idno type="ISSN">0303-6979</idno>
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<imprint>
<date when="2010">2010</date>
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<div type="abstract" xml:lang="en">
<sec id="S1">
<title>Introduction</title>
<p id="P1">Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leukocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.</p>
</sec>
<sec sec-type="methods" id="S2">
<title>Methods</title>
<p id="P2">Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and CRP levels. The analyses were stratified by CAD status to control for the possible effects of CAD.</p>
</sec>
<sec id="S3">
<title>Results</title>
<p id="P3">MetS was found in 122 persons. The adjusted Odds Ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20 - 3.12, p-value = 0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64 - 4.15,
<italic>p</italic>
=0.31), while in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09 - 3.52), p= 0.02]. In both subgroups, CRP was not significantly associated with metS.</p>
</sec>
<sec id="S4">
<title>Conclusion</title>
<p id="P4">Salivary lysozyme was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</p>
</sec>
</div>
</front>
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