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Association of salivary lysozyme and C-reactive protein with metabolic syndrome

Identifieur interne : 002089 ( Pmc/Corpus ); précédent : 002088; suivant : 002090

Association of salivary lysozyme and C-reactive protein with metabolic syndrome

Auteurs : Markku Qvarnstrom ; Sok-Ja Janket ; Judith A. Jones ; Kamal Jethwani ; Pekka Nuutinen ; Raul I. Garcia ; Alison E. Baird ; Thomas E. Van Dyke ; Jukka H. Meurman

Source :

Journal of clinical periodontology [ 0303-6979 ] ; 2010.

RBID : PMC:2923268

Abstract

Introduction

Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leukocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.

Methods

Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and CRP levels. The analyses were stratified by CAD status to control for the possible effects of CAD.

Results

MetS was found in 122 persons. The adjusted Odds Ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20 - 3.12, p-value = 0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64 - 4.15, p=0.31), while in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09 - 3.52), p= 0.02]. In both subgroups, CRP was not significantly associated with metS.

Conclusion

Salivary lysozyme was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923268

DOI: 10.1111/j.1600-051X.2010.01605.x
PubMed: 20666873
PubMed Central: 2923268

Links to Exploration step

PMC:2923268

Le document en format XML

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<author><name sortKey="Qvarnstrom, Markku" sort="Qvarnstrom, Markku" uniqKey="Qvarnstrom M" first="Markku" last="Qvarnstrom">Markku Qvarnstrom</name>
<affiliation><nlm:aff id="A1"> Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jethwani, Kamal" sort="Jethwani, Kamal" uniqKey="Jethwani K" first="Kamal" last="Jethwani">Kamal Jethwani</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
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<affiliation><nlm:aff id="A3"> Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name>
<affiliation><nlm:aff id="A4"> Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</nlm:aff>
</affiliation>
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<author><name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name>
<affiliation><nlm:aff id="A5"> Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
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<author><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
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</affiliation>
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<author><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
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</affiliation>
</author>
<author><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
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<author><name sortKey="Qvarnstrom, Markku" sort="Qvarnstrom, Markku" uniqKey="Qvarnstrom M" first="Markku" last="Qvarnstrom">Markku Qvarnstrom</name>
<affiliation><nlm:aff id="A1"> Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</nlm:aff>
</affiliation>
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<author><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jethwani, Kamal" sort="Jethwani, Kamal" uniqKey="Jethwani K" first="Kamal" last="Jethwani">Kamal Jethwani</name>
<affiliation><nlm:aff id="A2"> General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3"> Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Nuutinen, Pekka" sort="Nuutinen, Pekka" uniqKey="Nuutinen P" first="Pekka" last="Nuutinen">Pekka Nuutinen</name>
<affiliation><nlm:aff id="A4"> Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia, Raul I" sort="Garcia, Raul I" uniqKey="Garcia R" first="Raul I." last="Garcia">Raul I. Garcia</name>
<affiliation><nlm:aff id="A5"> Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
<affiliation><nlm:aff id="A6"> Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
<affiliation><nlm:aff id="A7"> Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
<affiliation><nlm:aff id="A8"> Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
</affiliation>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leukocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and CRP levels. The analyses were stratified by CAD status to control for the possible effects of CAD.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">MetS was found in 122 persons. The adjusted Odds Ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20 - 3.12, p-value = 0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64 - 4.15, <italic>p</italic>
=0.31), while in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09 - 3.52), p= 0.02]. In both subgroups, CRP was not significantly associated with metS.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Salivary lysozyme was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4645</journal-id>
<journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id>
<journal-title>Journal of clinical periodontology</journal-title>
<issn pub-type="ppub">0303-6979</issn>
<issn pub-type="epub">1600-051X</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20666873</article-id>
<article-id pub-id-type="pmc">2923268</article-id>
<article-id pub-id-type="doi">10.1111/j.1600-051X.2010.01605.x</article-id>
<article-id pub-id-type="manuscript">NIHMS223732</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Association of salivary lysozyme and C-reactive protein with metabolic syndrome</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Qvarnstrom</surname>
<given-names>Markku</given-names>
</name>
<degrees>DDS, MS</degrees>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Janket</surname>
<given-names>Sok-Ja</given-names>
</name>
<degrees>DMD, MPH</degrees>
<xref rid="FN1" ref-type="author-notes">*</xref>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Judith A.</given-names>
</name>
<degrees>DDS, DScD</degrees>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jethwani</surname>
<given-names>Kamal</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref rid="A2" ref-type="aff">2</xref>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nuutinen</surname>
<given-names>Pekka</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Garcia</surname>
<given-names>Raul I.</given-names>
</name>
<degrees>DMD, MMSc</degrees>
<xref rid="A5" ref-type="aff">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baird</surname>
<given-names>Alison E.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A6" ref-type="aff">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Van Dyke</surname>
<given-names>Thomas E.</given-names>
</name>
<degrees>DDS, PhD</degrees>
<xref rid="A7" ref-type="aff">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meurman</surname>
<given-names>Jukka H.</given-names>
</name>
<degrees>MD, PhD. DDS</degrees>
<xref rid="A8" ref-type="aff">8</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
 Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</aff>
<aff id="A2"><label>2</label>
 General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</aff>
<aff id="A3"><label>3</label>
 Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</aff>
<aff id="A4"><label>4</label>
 Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</aff>
<aff id="A5"><label>5</label>
 Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</aff>
<aff id="A6"><label>6</label>
 Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</aff>
<aff id="A7"><label>7</label>
 Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</aff>
<aff id="A8"><label>8</label>
 Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author: Sok-Ja Janket, DMD, MPH, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, <email>skjanket@bu.edu</email>
, Fax: (617) 414-1061, Tel: (617) 414-1060</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>3</day>
<month>8</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>7</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>9</month>
<year>2011</year>
</pub-date>
<volume>37</volume>
<issue>9</issue>
<fpage>805</fpage>
<lpage>811</lpage>
<abstract><sec id="S1"><title>Introduction</title>
<p id="P1">Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leukocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and CRP levels. The analyses were stratified by CAD status to control for the possible effects of CAD.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">MetS was found in 122 persons. The adjusted Odds Ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20 - 3.12, p-value = 0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64 - 4.15, <italic>p</italic>
=0.31), while in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09 - 3.52), p= 0.02]. In both subgroups, CRP was not significantly associated with metS.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Salivary lysozyme was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</p>
</sec>
</abstract>
<kwd-group><kwd>inflammation</kwd>
<kwd>metabolic syndrome</kwd>
<kwd>Salivary lysozyme</kwd>
<kwd>C-reactive protein</kwd>
<kwd>atherosclerosis</kwd>
</kwd-group>
<contract-num rid="DE1">R01 DE015566-01A1
				||DE</contract-num>
<contract-num rid="DE1">P50 DE016191-030003
				||DE</contract-num>
<contract-num rid="DE1">K24 DE018211-05
				||DE</contract-num>
<contract-num rid="DE1">K24 DE000419-10
				||DE</contract-num>
<contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research  : NIDCR</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

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Association of salivary lysozyme and C-reactive protein with metabolic syndrome

Association of salivary lysozyme and C-reactive protein with metabolic syndrome

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki