Association of salivary lysozyme and C‐reactive protein with metabolic syndrome
Identifieur interne : 004492 ( Istex/Corpus ); précédent : 004491; suivant : 004493Association of salivary lysozyme and C‐reactive protein with metabolic syndrome
Auteurs : Markku Qvarnstrom ; Sok-Ja Janket ; Judith A. Jones ; Kamal Jethwani ; Pekka Nuutinen ; Raul I. Garcia ; Alison E. Baird ; Thomas E. Van Dyke ; Jukka H. MeurmanSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2010-09.
English descriptors
- KwdEn :
- American heart association, Artery disease, Atherosclerosis, Body mass index, Boston university henry, Cardiovascular, Cardiovascular disease, Cardiovascular risk factors, Cholesterol levels, Clin periodontol, Cohort, Common soil, Coronary artery disease, Current smokers, Current study, Dental medicine, Dental research, Diabetes, Diabetes care, Diabetic patients, Drug administration, Dyke, Edentulous persons, Endothelial dysfunction, European heart journal, Fourth quartile, Funding sources, Goldman school, Heart disease, Helsinki university, High prevalence, Highest quartile, Hypertension, Internal medicine, Janket, John wiley sons, Jupiter cohort, Jupiter trial, Kuopio, Kuopio university hospital, Linear trend, Lipoprotein cholesterol, Lysozyme, Metabolic, Metabolic syndrome, Metabolic syndrome table, Mets, Mets status, Meurman, National heart, Ncep criteria, Nuutinen, Odds ratio, Oral health, Oral infection, Oral medicine, Oral pathology, Oral radiology, Oral surgery, Possible effects, Predictor, Present study, Prevalent hypertension, Previous observation, Previous studies, Prospective study, Proteolytic enzyme, Quartile, Qvarnstrom, Ridker, Risk factor, Risk increase, Salivary, Salivary lysozyme, Sigma chemical, Statin administration, Study design, Subgroup, Syndrome, Total cholesterol, Vascular biology, Vascular disease, Vascular events.
- Teeft :
- American heart association, Artery disease, Atherosclerosis, Body mass index, Boston university henry, Cardiovascular, Cardiovascular disease, Cardiovascular risk factors, Cholesterol levels, Clin periodontol, Cohort, Common soil, Coronary artery disease, Current smokers, Current study, Dental medicine, Dental research, Diabetes, Diabetes care, Diabetic patients, Drug administration, Dyke, Edentulous persons, Endothelial dysfunction, European heart journal, Fourth quartile, Funding sources, Goldman school, Heart disease, Helsinki university, High prevalence, Highest quartile, Hypertension, Internal medicine, Janket, John wiley sons, Jupiter cohort, Jupiter trial, Kuopio, Kuopio university hospital, Linear trend, Lipoprotein cholesterol, Lysozyme, Metabolic, Metabolic syndrome, Metabolic syndrome table, Mets, Mets status, Meurman, National heart, Ncep criteria, Nuutinen, Odds ratio, Oral health, Oral infection, Oral medicine, Oral pathology, Oral radiology, Oral surgery, Possible effects, Predictor, Present study, Prevalent hypertension, Previous observation, Previous studies, Prospective study, Proteolytic enzyme, Quartile, Qvarnstrom, Ridker, Risk factor, Risk increase, Salivary, Salivary lysozyme, Sigma chemical, Statin administration, Study design, Subgroup, Syndrome, Total cholesterol, Vascular biology, Vascular disease, Vascular events.
Abstract
Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.
Url:
DOI: 10.1111/j.1600-051X.2010.01605.x
Links to Exploration step
ISTEX:8A7210433F60A476214F71CDA8E3DE04AAB30CDBLe document en format XML
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Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. 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Goldman School of Dental Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Judith A. Jones</name><affiliations><json:string>General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Kamal Jethwani</name><affiliations><json:string>General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</json:string><json:string>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Pekka Nuutinen</name><affiliations><json:string>Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</json:string></affiliations></json:item><json:item><name>Raul I. Garcia</name><affiliations><json:string>Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Alison E. Baird</name><affiliations><json:string>Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</json:string></affiliations></json:item><json:item><name>Thomas E. Van Dyke</name><affiliations><json:string>Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</json:string></affiliations></json:item><json:item><name>Jukka H. Meurman</name><affiliations><json:string>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>atherosclerosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>C‐reactive protein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>inflammation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>metabolic syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>salivary lysozyme</value></json:item></subject><articleId><json:string>JCPE1605</json:string></articleId><arkIstex>ark:/67375/WNG-SR42QXK2-T</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. 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Goldman School of Dental Medicine, Boston, MA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Judith A.</forename><surname>Jones</surname></persName><affiliation>General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kamal</forename><surname>Jethwani</surname></persName><affiliation>General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA<address><country key="US"></country></address></affiliation><affiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Pekka</forename><surname>Nuutinen</surname></persName><affiliation>Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland<address><country key="FI"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Raul I.</forename><surname>Garcia</surname></persName><affiliation>Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Alison E.</forename><surname>Baird</surname></persName><affiliation>Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Thomas E.</forename><surname>Van Dyke</surname></persName><affiliation>Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Jukka H.</forename><surname>Meurman</surname></persName><affiliation>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland<address><country key="FI"></country></address></affiliation></author><idno type="istex">8A7210433F60A476214F71CDA8E3DE04AAB30CDB</idno><idno type="ark">ark:/67375/WNG-SR42QXK2-T</idno><idno type="DOI">10.1111/j.1600-051X.2010.01605.x</idno><idno type="unit">JCPE1605</idno><idno type="supplier">1605</idno><idno type="toTypesetVersion">file:JCPE.JCPE1605.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Clinical Periodontology</title><title level="j" type="alt">JOURNAL OF CLINICAL PERIODONTOLOGY</title><idno type="pISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><idno type="book-DOI">10.1111/(ISSN)1600-051X</idno><idno type="book-part-DOI">10.1111/cpe.2010.37.issue-9</idno><idno type="product">JCPE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">37</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="805">805</biblScope><biblScope unit="page" to="811">811</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>
<hi rend="italic">Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.</hi>
</p>
Abstract
<p><hi rend="bold">Introduction: </hi> Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro‐inflammatory state.</p><p><hi rend="bold">Methods: </hi> Utilizing cross‐sectional data from 250 coronary artery disease (CAD) and 250 non‐CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C‐reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD.</p><p><hi rend="bold">Results: </hi> MetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20–3.12, <hi rend="italic">p</hi>‐value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64–4.15, <hi rend="italic">p</hi>=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09–3.52), <hi rend="italic">p</hi>=0.02]. In both subgroups, CRP was not significantly associated with metS.</p><p><hi rend="bold">Conclusion: </hi> SLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">atherosclerosis</term><term xml:id="k2">C‐reactive protein</term><term xml:id="k3">inflammation</term><term xml:id="k4">metabolic syndrome</term><term xml:id="k5">salivary lysozyme</term></keywords><keywords rend="tocHeading1"><term>Periodontal Diseases</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/8A7210433F60A476214F71CDA8E3DE04AAB30CDB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-051X</doi><issn type="print">0303-6979</issn><issn type="electronic">1600-051X</issn><idGroup><id type="product" value="JCPE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CLINICAL PERIODONTOLOGY">Journal of Clinical Periodontology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09009"><doi origin="wiley">10.1111/cpe.2010.37.issue-9</doi><numberingGroup><numbering type="journalVolume" number="37">37</numbering><numbering type="journalIssue" number="9">9</numbering></numberingGroup><coverDate startDate="2010-09">September 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1600-051X.2010.01605.x</doi><idGroup><id type="unit" value="JCPE1605"></id><id type="supplier" value="1605"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Periodontal Diseases</title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText" date="2010-08-15"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-07-28"></event><event type="publishedOnlineFinalForm" date="2010-08-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="805">805</numbering><numbering type="pageLast" number="811">811</numbering></numberingGroup><correspondenceTo>Address:
<i>Sok‐Ja Janket</i>
<i>Boston University School of Dental Medicine</i>
<i>100 East Newton Street, Rm. G‐619</i>
<i>Boston, MA 02118</i>
<i>USA</i>
E‐mail: <email normalForm="skjanket@bu.edu">skjanket@bu.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JCPE.JCPE1605.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 10 June 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="6"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="39"></count><count type="wordTotal" number="6718"></count><count type="linksCrossRef" number="60"></count></countGroup><titleGroup><title type="main">Association of salivary lysozyme and C‐reactive protein with metabolic syndrome</title><title type="shortAuthors">Qvarnstrom et al.</title><title type="short">Salivary lysozyme and CRP in metabolic syndrome</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Markku</givenNames><familyName>Qvarnstrom</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Sok‐Ja</givenNames><familyName>Janket</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Judith A.</givenNames><familyName>Jones</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2 #a3"><personName><givenNames>Kamal</givenNames><familyName>Jethwani</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>Pekka</givenNames><familyName>Nuutinen</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a5"><personName><givenNames>Raul I.</givenNames><familyName>Garcia</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a6"><personName><givenNames>Alison E.</givenNames><familyName>Baird</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a7"><personName><givenNames>Thomas E.</givenNames><familyName>Van Dyke</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a8"><personName><givenNames>Jukka H.</givenNames><familyName>Meurman</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FI"><unparsedAffiliation>Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>General Dentistry, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FI"><unparsedAffiliation>Cardiothoracic Surgery, Kuopio University Hospital, Kuopio, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="US"><unparsedAffiliation>Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="US"><unparsedAffiliation>Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="US"><unparsedAffiliation>Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a8" countryCode="FI"><unparsedAffiliation>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">atherosclerosis</keyword><keyword xml:id="k2">C‐reactive protein</keyword><keyword xml:id="k3">inflammation</keyword><keyword xml:id="k4">metabolic syndrome</keyword><keyword xml:id="k5">salivary lysozyme</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="sec-sum-1"><p> <i>Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.</i> </p></section><section xml:id="abs1-1"><title type="main">Abstract</title><p><b>Introduction: </b> Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro‐inflammatory state.</p><p><b>Methods: </b> Utilizing cross‐sectional data from 250 coronary artery disease (CAD) and 250 non‐CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C‐reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD.</p><p><b>Results: </b> MetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20–3.12, <i>p</i>‐value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64–4.15, <i>p</i>=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09–3.52), <i>p</i>=0.02]. In both subgroups, CRP was not significantly associated with metS.</p><p><b>Conclusion: </b> SLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1" numbered="no"><p><b>Conflict of interest and source of funding statement</b>
<i>Declaration of competing interests</i>: Nothing to declare.
<i>Funding sources</i>:
The funding sources listed below had no influence in our results.
1. This study is supported by a grant from the American Heart Association # 0635351N to Dr. Sok‐Ja Janket.
2. Dr. Meurman is supported by Grant TYH 3245 from the Helsinki University Central Hospital, Helsinki, Finland and a grant from the Finnish Medical Society.
3. Dr. Jones is supported by NIH K24 DE018211 award from National Institute of Health.
4. Dr. Van Dyke is supported by NIH Grant DE DE16191 and USPHS Grant DE15566.
5. Dr. Garcia is supported by NIH Grant K24 DE000419 and R01 DE019833.</p></note><note xml:id="fn2" numbered="no"><p>Abstract of this study has been presented at The 3rd International Metabolic Syndrome Congress in Nice, France in April 2009.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Association of salivary lysozyme and C‐reactive protein with metabolic syndrome</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Salivary lysozyme and CRP in metabolic syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Association of salivary lysozyme and C‐reactive protein with metabolic syndrome</title></titleInfo><name type="personal"><namePart type="given">Markku</namePart><namePart type="family">Qvarnstrom</namePart><affiliation>Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sok‐Ja</namePart><namePart type="family">Janket</namePart><affiliation>General Dentistry, Boston University Henry M. 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Goldman School of Dental Medicine, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alison E.</namePart><namePart type="family">Baird</namePart><affiliation>Cerebrovascular Disease and Stroke Div., SUNY Downstate Medical Center, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas E.</namePart><namePart type="family">Van Dyke</namePart><affiliation>Periodontology and Oral Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jukka H.</namePart><namePart type="family">Meurman</namePart><affiliation>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-09</dateIssued><edition>Accepted for publication 10 June 2010</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">6</extent><extent unit="formulas">0</extent><extent unit="references">39</extent><extent unit="linksCrossRef">60</extent><extent unit="words">6718</extent></physicalDescription><abstract>Qvarnstrom M, Janket S‐J, Jones JA, Jethwani K, Nuutinen P, Garcia RI, Baird AE, Van Dyke TE and Meurman JH. Association of salivary lysozyme and C‐reactive protein with metabolic syndrome. J Clin Periodontol 2010; 37: 805–811. doi: 10.1111/j.1600‐051X.2010.01605.x.</abstract><abstract>Introduction: Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro‐inflammatory state. Methods: Utilizing cross‐sectional data from 250 coronary artery disease (CAD) and 250 non‐CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C‐reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD. Results: MetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20–3.12, p‐value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64–4.15, p=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09–3.52), p=0.02]. In both subgroups, CRP was not significantly associated with metS. Conclusion: SLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.</abstract><subject lang="en"><genre>keywords</genre><topic>atherosclerosis</topic><topic>C‐reactive protein</topic><topic>inflammation</topic><topic>metabolic syndrome</topic><topic>salivary lysozyme</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Clinical Periodontology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0303-6979</identifier><identifier type="eISSN">1600-051X</identifier><identifier type="DOI">10.1111/(ISSN)1600-051X</identifier><identifier type="PublisherID">JCPE</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>805</start><end>811</end><total>7</total></extent></part></relatedItem><identifier type="istex">8A7210433F60A476214F71CDA8E3DE04AAB30CDB</identifier><identifier type="ark">ark:/67375/WNG-SR42QXK2-T</identifier><identifier type="DOI">10.1111/j.1600-051X.2010.01605.x</identifier><identifier type="ArticleID">JCPE1605</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/8A7210433F60A476214F71CDA8E3DE04AAB30CDB/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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