Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Identifieur interne : 001691 ( Main/Merge ); précédent : 001690; suivant : 001692Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Auteurs : Lucas A. Kinard ; Rebecca L. Dahlin ; Johnny Lam ; Steven Lu ; Esther J. Lee ; F. Kurtis Kasper ; Antonios G. MikosSource :
- Acta biomaterialia [ 1742-7061 ] ; 2014.
Abstract
There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated
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DOI: 10.1016/j.actbio.2014.07.011
PubMed: 25046637
PubMed Central: 4186894
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Dahlin</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lam, Johnny" sort="Lam, Johnny" uniqKey="Lam J" first="Johnny" last="Lam">Johnny Lam</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Steven" sort="Lu, Steven" uniqKey="Lu S" first="Steven" last="Lu">Steven Lu</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Esther J" sort="Lee, Esther J" uniqKey="Lee E" first="Esther J." last="Lee">Esther J. Lee</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Kasper, F Kurtis" sort="Kasper, F Kurtis" uniqKey="Kasper F" first="F. Kurtis" last="Kasper">F. Kurtis Kasper</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Mikos, Antonios G" sort="Mikos, Antonios G" uniqKey="Mikos A" first="Antonios G." last="Mikos">Antonios G. 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Kinard</name><affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff><wicri:noCountry code="subfield">Department of Chemical and Biomolecular Engineering</wicri:noCountry></affiliation></author><author><name sortKey="Dahlin, Rebecca L" sort="Dahlin, Rebecca L" uniqKey="Dahlin R" first="Rebecca L." last="Dahlin">Rebecca L. Dahlin</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lam, Johnny" sort="Lam, Johnny" uniqKey="Lam J" first="Johnny" last="Lam">Johnny Lam</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Steven" sort="Lu, Steven" uniqKey="Lu S" first="Steven" last="Lu">Steven Lu</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Esther J" sort="Lee, Esther J" uniqKey="Lee E" first="Esther J." last="Lee">Esther J. Lee</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Kasper, F Kurtis" sort="Kasper, F Kurtis" uniqKey="Kasper F" first="F. Kurtis" last="Kasper">F. Kurtis Kasper</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Mikos, Antonios G" sort="Mikos, Antonios G" uniqKey="Mikos A" first="Antonios G." last="Mikos">Antonios G. Mikos</name><affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff><wicri:noCountry code="subfield">Department of Chemical and Biomolecular Engineering</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author></analytic><series><title level="j">Acta biomaterialia</title><idno type="ISSN">1742-7061</idno><idno type="eISSN">1878-7568</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated <italic>in vivo</italic> compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation exceeding 1:1 constructs and empty implants by 3-fold and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlated directly to DBM dose.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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