Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Identifieur interne : 005312 ( Ncbi/Curation ); précédent : 005311; suivant : 005313Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Auteurs : Lucas A. Kinard ; Rebecca L. Dahlin ; Johnny Lam ; Steven Lu ; Esther J. Lee ; F. Kurtis Kasper ; Antonios G. MikosSource :
- Acta biomaterialia [ 1742-7061 ] ; 2014.
Abstract
There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated
Url:
DOI: 10.1016/j.actbio.2014.07.011
PubMed: 25046637
PubMed Central: 4186894
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Lucas A. Kinard<affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff>
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<wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry>
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<front><div type="abstract" xml:lang="en"><p id="P2">There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated <italic>in vivo</italic>
compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation exceeding 1:1 constructs and empty implants by 3-fold and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlated directly to DBM dose.</p>
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