Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Identifieur interne : 005312 ( Ncbi/Merge ); précédent : 005311; suivant : 005313Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model
Auteurs : Lucas A. Kinard ; Rebecca L. Dahlin ; Johnny Lam ; Steven Lu ; Esther J. Lee ; F. Kurtis Kasper ; Antonios G. MikosSource :
- Acta biomaterialia [ 1742-7061 ] ; 2014.
Abstract
There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated
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DOI: 10.1016/j.actbio.2014.07.011
PubMed: 25046637
PubMed Central: 4186894
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Dahlin</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lam, Johnny" sort="Lam, Johnny" uniqKey="Lam J" first="Johnny" last="Lam">Johnny Lam</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Steven" sort="Lu, Steven" uniqKey="Lu S" first="Steven" last="Lu">Steven Lu</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Esther J" sort="Lee, Esther J" uniqKey="Lee E" first="Esther J." last="Lee">Esther J. Lee</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Kasper, F Kurtis" sort="Kasper, F Kurtis" uniqKey="Kasper F" first="F. Kurtis" last="Kasper">F. Kurtis Kasper</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Mikos, Antonios G" sort="Mikos, Antonios G" uniqKey="Mikos A" first="Antonios G." last="Mikos">Antonios G. Mikos</name><affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff><wicri:noCountry code="subfield">Department of Chemical and Biomolecular Engineering</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25046637</idno><idno type="pmc">4186894</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186894</idno><idno type="RBID">PMC:4186894</idno><idno type="doi">10.1016/j.actbio.2014.07.011</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002642</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002642</idno><idno type="wicri:Area/Pmc/Curation">002642</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002642</idno><idno type="wicri:Area/Pmc/Checkpoint">001194</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001194</idno><idno type="wicri:Area/Ncbi/Merge">005312</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model</title><author><name sortKey="Kinard, Lucas A" sort="Kinard, Lucas A" uniqKey="Kinard L" first="Lucas A." last="Kinard">Lucas A. Kinard</name><affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff><wicri:noCountry code="subfield">Department of Chemical and Biomolecular Engineering</wicri:noCountry></affiliation></author><author><name sortKey="Dahlin, Rebecca L" sort="Dahlin, Rebecca L" uniqKey="Dahlin R" first="Rebecca L." last="Dahlin">Rebecca L. Dahlin</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lam, Johnny" sort="Lam, Johnny" uniqKey="Lam J" first="Johnny" last="Lam">Johnny Lam</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lu, Steven" sort="Lu, Steven" uniqKey="Lu S" first="Steven" last="Lu">Steven Lu</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Esther J" sort="Lee, Esther J" uniqKey="Lee E" first="Esther J." last="Lee">Esther J. Lee</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Kasper, F Kurtis" sort="Kasper, F Kurtis" uniqKey="Kasper F" first="F. Kurtis" last="Kasper">F. Kurtis Kasper</name><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author><author><name sortKey="Mikos, Antonios G" sort="Mikos, Antonios G" uniqKey="Mikos A" first="Antonios G." last="Mikos">Antonios G. Mikos</name><affiliation><nlm:aff id="A1">Rice University, Department of Chemical and Biomolecular Engineering</nlm:aff><wicri:noCountry code="subfield">Department of Chemical and Biomolecular Engineering</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Rice University, Department of Bioengineering</nlm:aff><wicri:noCountry code="subfield">Department of Bioengineering</wicri:noCountry></affiliation></author></analytic><series><title level="j">Acta biomaterialia</title><idno type="ISSN">1742-7061</idno><idno type="eISSN">1878-7568</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated <italic>in vivo</italic> compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation exceeding 1:1 constructs and empty implants by 3-fold and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlated directly to DBM dose.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101233144</journal-id><journal-id journal-id-type="pubmed-jr-id">32834</journal-id><journal-id journal-id-type="nlm-ta">Acta Biomater</journal-id><journal-id journal-id-type="iso-abbrev">Acta Biomater</journal-id><journal-title-group><journal-title>Acta biomaterialia</journal-title></journal-title-group><issn pub-type="ppub">1742-7061</issn><issn pub-type="epub">1878-7568</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25046637</article-id><article-id pub-id-type="pmc">4186894</article-id><article-id pub-id-type="doi">10.1016/j.actbio.2014.07.011</article-id><article-id pub-id-type="manuscript">NIHMS615140</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Synthetic biodegradable hydrogel delivery of demineralized bone matrix for bone augmentation in a rat model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kinard</surname><given-names>Lucas A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Dahlin</surname><given-names>Rebecca L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lam</surname><given-names>Johnny</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Esther J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kasper</surname><given-names>F. Kurtis</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mikos</surname><given-names>Antonios G.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Rice University, Department of Chemical and Biomolecular Engineering</aff><aff id="A2"><label>2</label>Rice University, Department of Bioengineering</aff><author-notes><corresp id="FN1"><label>*</label>To whom correspondence should be addressed: Antonios G. Mikos, Ph.D., Rice University, Department of Bioengineering, MS-142, P.O. Box 1892, Houston, TX 77251-1892, Tel: (713) 348-5355, <email>mikos@rice.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>18</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2015</year></pub-date><volume>10</volume><issue>11</issue><fpage>4574</fpage><lpage>4582</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.actbio.2014.07.011</pmc-comment>
<permissions><copyright-statement>© 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P2">There exists a strong clinical need for a more capable and robust method to achieve bone augmentation, and a system with fine-tuned delivery of demineralized bone matrix (DBM) has potential to meet that need. As such, the objective of the present study was to investigate a synthetic biodegradable hydrogel for the delivery of DBM for bone augmentation in a rat model. Oligo(poly(ethylene glycol) fumarate) (OPF) constructs were designed and fabricated by varying the content of rat-derived DBM particles (either 1:3, 1:1, or 3:1 DBM:OPF weight ratio on a dry basis) and using two DBM particle size ranges (50–150 or 150–250 μm). The physical properties of the constructs and the bioactivity of the DBM were evaluated. Select formulations (1:1 and 3:1 with 50–150 μm DBM) were evaluated <italic>in vivo</italic> compared to an empty control to investigate the effect of DBM dose and construct properties on bone augmentation. Overall, 3:1 constructs with higher DBM content achieved the greatest volume of bone augmentation exceeding 1:1 constructs and empty implants by 3-fold and 5-fold, respectively. As such, we have established that a synthetic, biodegradable hydrogel can function as a carrier for DBM, and that the volume of bone augmentation achieved by the constructs correlated directly to DBM dose.</p></abstract><kwd-group><kwd>oligo(poly(ethylene glycol) fumarate)</kwd><kwd>demineralized bone matrix</kwd><kwd>bone augmentation</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Dahlin, Rebecca L" sort="Dahlin, Rebecca L" uniqKey="Dahlin R" first="Rebecca L." last="Dahlin">Rebecca L. Dahlin</name><name sortKey="Kasper, F Kurtis" sort="Kasper, F Kurtis" uniqKey="Kasper F" first="F. Kurtis" last="Kasper">F. Kurtis Kasper</name><name sortKey="Kinard, Lucas A" sort="Kinard, Lucas A" uniqKey="Kinard L" first="Lucas A." last="Kinard">Lucas A. Kinard</name><name sortKey="Lam, Johnny" sort="Lam, Johnny" uniqKey="Lam J" first="Johnny" last="Lam">Johnny Lam</name><name sortKey="Lee, Esther J" sort="Lee, Esther J" uniqKey="Lee E" first="Esther J." last="Lee">Esther J. Lee</name><name sortKey="Lu, Steven" sort="Lu, Steven" uniqKey="Lu S" first="Steven" last="Lu">Steven Lu</name><name sortKey="Mikos, Antonios G" sort="Mikos, Antonios G" uniqKey="Mikos A" first="Antonios G." last="Mikos">Antonios G. Mikos</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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