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Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

Identifieur interne : 004503 ( Main/Exploration ); précédent : 004502; suivant : 004504

Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

Auteurs : Susan L. Hall [États-Unis] ; Shin-Tai Chen [États-Unis] ; Jon E. Wergedal [États-Unis] ; Daila S. Gridley [États-Unis] ; Subburaman Mohan [États-Unis] ; K. William Lau [États-Unis]

Source :

The Journal of Gene Medicine [ 1099-498X ] ; 2011-02.

RBID : ISTEX:C46A00C509094ACA3F0BACBAE45E1D78AB1475E4

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Wicri :
- topic : Mineur (ouvrier).

English descriptors

Abstract

The present study assesses the effect of the stem cell antigen‐1 positive (Sca‐1+) cell‐based human growth hormone (hGH) ex vivo gene transfer strategy on endosteal bone mass in the mouse.

Url:

https://api.istex.fr/document/C46A00C509094ACA3F0BACBAE45E1D78AB1475E4/fulltext/pdf

DOI: 10.1002/jgm.1542

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone</term>
<term>Bone formation</term>
<term>Bone formation response</term>
<term>Bone growth</term>
<term>Bone loss</term>
<term>Bone marrow</term>
<term>Bone marrow cavity</term>
<term>Bone marrow cells</term>
<term>Bone mass</term>
<term>Bone miner</term>
<term>Bone resorption</term>
<term>Bone surface</term>
<term>Cells transduced</term>
<term>Control group</term>
<term>Cortical</term>
<term>Cortical thickness</term>
<term>Endocrinology</term>
<term>Endosteal</term>
<term>Endosteal bone formation</term>
<term>Endosteal bone mass</term>
<term>Endosteum</term>
<term>Engraftment</term>
<term>Facs analysis</term>
<term>Femur</term>
<term>Gene</term>
<term>Gene therapy</term>
<term>Gene transfer strategy</term>
<term>Growth factor</term>
<term>Growth hormone</term>
<term>Growth plate</term>
<term>Hematopoietic</term>
<term>High levels</term>
<term>Igfbps</term>
<term>John wiley sons</term>
<term>Loma</term>
<term>Loma linda</term>
<term>Loma linda university school</term>
<term>Marrow</term>
<term>Marrow cavity</term>
<term>Marrow transplantation</term>
<term>Medical center</term>
<term>Mesenchymal</term>
<term>Miner</term>
<term>Mouse</term>
<term>Mrna</term>
<term>Mrna levels</term>
<term>Murine</term>
<term>Musculoskeletal disease center</term>
<term>Ndings</term>
<term>Nonparametric test</term>
<term>Osmotic lysis</term>
<term>Osteoblast</term>
<term>Osteoclast</term>
<term>Osteoclast surface</term>
<term>Osteoclastic</term>
<term>Osteoclastic resorption</term>
<term>Osteogenic</term>
<term>Osteogenic gene</term>
<term>Overexpression</term>
<term>Periosteal</term>
<term>Peripheral blood</term>
<term>Peripheral blood cells</term>
<term>Pettis memorial</term>
<term>Pqct</term>
<term>Present study</term>
<term>Receptor</term>
<term>Recipient</term>
<term>Recipient mice</term>
<term>Recipient mouse</term>
<term>Representative sample</term>
<term>Resorption</term>
<term>Sca1</term>
<term>Secondary spongiosa</term>
<term>Serum levels</term>
<term>Trabecular</term>
<term>Trabecular bone formation</term>
<term>Trabecular bone volume</term>
<term>Trabecular number</term>
<term>Trabecular separation</term>
<term>Transduced</term>
<term>Transgene</term>
<term>Transgenic</term>
<term>Transgenic mice</term>
<term>Transgenic mouse strains</term>
<term>Transgenic overexpression</term>
<term>Transgenic strains</term>
<term>Transplantation</term>
<term>Upper right</term>
<term>Viable cells</term>
<term>Vivo</term>
<term>Vivo gene transfer strategy</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Bone</term>
<term>Bone formation</term>
<term>Bone formation response</term>
<term>Bone growth</term>
<term>Bone loss</term>
<term>Bone marrow</term>
<term>Bone marrow cavity</term>
<term>Bone marrow cells</term>
<term>Bone mass</term>
<term>Bone miner</term>
<term>Bone resorption</term>
<term>Bone surface</term>
<term>Cells transduced</term>
<term>Control group</term>
<term>Cortical</term>
<term>Cortical thickness</term>
<term>Endocrinology</term>
<term>Endosteal</term>
<term>Endosteal bone formation</term>
<term>Endosteal bone mass</term>
<term>Endosteum</term>
<term>Engraftment</term>
<term>Facs analysis</term>
<term>Femur</term>
<term>Gene</term>
<term>Gene therapy</term>
<term>Gene transfer strategy</term>
<term>Growth factor</term>
<term>Growth hormone</term>
<term>Growth plate</term>
<term>Hematopoietic</term>
<term>High levels</term>
<term>Igfbps</term>
<term>John wiley sons</term>
<term>Loma</term>
<term>Loma linda</term>
<term>Loma linda university school</term>
<term>Marrow</term>
<term>Marrow cavity</term>
<term>Marrow transplantation</term>
<term>Medical center</term>
<term>Mesenchymal</term>
<term>Miner</term>
<term>Mouse</term>
<term>Mrna</term>
<term>Mrna levels</term>
<term>Murine</term>
<term>Musculoskeletal disease center</term>
<term>Ndings</term>
<term>Nonparametric test</term>
<term>Osmotic lysis</term>
<term>Osteoblast</term>
<term>Osteoclast</term>
<term>Osteoclast surface</term>
<term>Osteoclastic</term>
<term>Osteoclastic resorption</term>
<term>Osteogenic</term>
<term>Osteogenic gene</term>
<term>Overexpression</term>
<term>Periosteal</term>
<term>Peripheral blood</term>
<term>Peripheral blood cells</term>
<term>Pettis memorial</term>
<term>Pqct</term>
<term>Present study</term>
<term>Receptor</term>
<term>Recipient</term>
<term>Recipient mice</term>
<term>Recipient mouse</term>
<term>Representative sample</term>
<term>Resorption</term>
<term>Sca1</term>
<term>Secondary spongiosa</term>
<term>Serum levels</term>
<term>Trabecular</term>
<term>Trabecular bone formation</term>
<term>Trabecular bone volume</term>
<term>Trabecular number</term>
<term>Trabecular separation</term>
<term>Transduced</term>
<term>Transgene</term>
<term>Transgenic</term>
<term>Transgenic mice</term>
<term>Transgenic mouse strains</term>
<term>Transgenic overexpression</term>
<term>Transgenic strains</term>
<term>Transplantation</term>
<term>Upper right</term>
<term>Viable cells</term>
<term>Vivo</term>
<term>Vivo gene transfer strategy</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mineur (ouvrier)</term>
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<front><div type="abstract">The present study assesses the effect of the stem cell antigen‐1 positive (Sca‐1+) cell‐based human growth hormone (hGH) ex vivo gene transfer strategy on endosteal bone mass in the mouse.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Hall, Susan L" sort="Hall, Susan L" uniqKey="Hall S" first="Susan L." last="Hall">Susan L. Hall</name>
<name sortKey="Lau, K William" sort="Lau, K William" uniqKey="Lau K" first="K. William" last="Lau">K. William Lau</name>
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<name sortKey="Wergedal, Jon E" sort="Wergedal, Jon E" uniqKey="Wergedal J" first="Jon E." last="Wergedal">Jon E. Wergedal</name>
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Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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