Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice
Identifieur interne : 006166 ( Istex/Curation ); précédent : 006165; suivant : 006167Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice
Auteurs : Susan L. Hall [États-Unis] ; Shin-Tai Chen [États-Unis] ; Jon E. Wergedal [États-Unis] ; Daila S. Gridley [États-Unis] ; Subburaman Mohan [États-Unis] ; K. William Lau [États-Unis]Source :
- The Journal of Gene Medicine [ 1099-498X ] ; 2011-02.
Descripteurs français
- Wicri :
- topic : Mineur (ouvrier).
English descriptors
- KwdEn :
- Bone, Bone formation, Bone formation response, Bone growth, Bone loss, Bone marrow, Bone marrow cavity, Bone marrow cells, Bone mass, Bone miner, Bone resorption, Bone surface, Cells transduced, Control group, Cortical, Cortical thickness, Endocrinology, Endosteal, Endosteal bone formation, Endosteal bone mass, Endosteum, Engraftment, Facs analysis, Femur, Gene, Gene therapy, Gene transfer strategy, Growth factor, Growth hormone, Growth plate, Hematopoietic, High levels, Igfbps, John wiley sons, Loma, Loma linda, Loma linda university school, Marrow, Marrow cavity, Marrow transplantation, Medical center, Mesenchymal, Miner, Mouse, Mrna, Mrna levels, Murine, Musculoskeletal disease center, Ndings, Nonparametric test, Osmotic lysis, Osteoblast, Osteoclast, Osteoclast surface, Osteoclastic, Osteoclastic resorption, Osteogenic, Osteogenic gene, Overexpression, Periosteal, Peripheral blood, Peripheral blood cells, Pettis memorial, Pqct, Present study, Receptor, Recipient, Recipient mice, Recipient mouse, Representative sample, Resorption, Sca1, Secondary spongiosa, Serum levels, Trabecular, Trabecular bone formation, Trabecular bone volume, Trabecular number, Trabecular separation, Transduced, Transgene, Transgenic, Transgenic mice, Transgenic mouse strains, Transgenic overexpression, Transgenic strains, Transplantation, Upper right, Viable cells, Vivo, Vivo gene transfer strategy.
- Teeft :
- Bone, Bone formation, Bone formation response, Bone growth, Bone loss, Bone marrow, Bone marrow cavity, Bone marrow cells, Bone mass, Bone miner, Bone resorption, Bone surface, Cells transduced, Control group, Cortical, Cortical thickness, Endocrinology, Endosteal, Endosteal bone formation, Endosteal bone mass, Endosteum, Engraftment, Facs analysis, Femur, Gene, Gene therapy, Gene transfer strategy, Growth factor, Growth hormone, Growth plate, Hematopoietic, High levels, Igfbps, John wiley sons, Loma, Loma linda, Loma linda university school, Marrow, Marrow cavity, Marrow transplantation, Medical center, Mesenchymal, Miner, Mouse, Mrna, Mrna levels, Murine, Musculoskeletal disease center, Ndings, Nonparametric test, Osmotic lysis, Osteoblast, Osteoclast, Osteoclast surface, Osteoclastic, Osteoclastic resorption, Osteogenic, Osteogenic gene, Overexpression, Periosteal, Peripheral blood, Peripheral blood cells, Pettis memorial, Pqct, Present study, Receptor, Recipient, Recipient mice, Recipient mouse, Representative sample, Resorption, Sca1, Secondary spongiosa, Serum levels, Trabecular, Trabecular bone formation, Trabecular bone volume, Trabecular number, Trabecular separation, Transduced, Transgene, Transgenic, Transgenic mice, Transgenic mouse strains, Transgenic overexpression, Transgenic strains, Transplantation, Upper right, Viable cells, Vivo, Vivo gene transfer strategy.
Abstract
The present study assesses the effect of the stem cell antigen‐1 positive (Sca‐1+) cell‐based human growth hormone (hGH) ex vivo gene transfer strategy on endosteal bone mass in the mouse.
Url:
DOI: 10.1002/jgm.1542
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stem cell antigen‐1 positive cell‐based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice</title><author><name sortKey="Hall, Susan L" sort="Hall, Susan L" uniqKey="Hall S" first="Susan L." last="Hall">Susan L. Hall</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. 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Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gridley, Daila S" sort="Gridley, Daila S" uniqKey="Gridley D" first="Daila S." last="Gridley">Daila S. 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Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Lau, K William" sort="Lau, K William" uniqKey="Lau K" first="K. William" last="Lau">K. William Lau</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. 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Hall</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: susan.hall1@va.gov</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Correspondence address: Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Shin Ai" sort="Chen, Shin Ai" uniqKey="Chen S" first="Shin-Tai" last="Chen">Shin-Tai Chen</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Wergedal, Jon E" sort="Wergedal, Jon E" uniqKey="Wergedal J" first="Jon E." last="Wergedal">Jon E. Wergedal</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gridley, Daila S" sort="Gridley, Daila S" uniqKey="Gridley D" first="Daila S." last="Gridley">Daila S. Gridley</name><affiliation wicri:level="1"><mods:affiliation>Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Mohan, Subburaman" sort="Mohan, Subburaman" uniqKey="Mohan S" first="Subburaman" last="Mohan">Subburaman Mohan</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author><author><name sortKey="Lau, K William" sort="Lau, K William" uniqKey="Lau K" first="K. William" last="Lau">K. William Lau</name><affiliation wicri:level="1"><mods:affiliation>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Gene Medicine</title><title level="j" type="alt">JOURNAL OF GENE MEDICINE, THE</title><idno type="ISSN">1099-498X</idno><idno type="eISSN">1521-2254</idno><imprint><biblScope unit="vol">13</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="88">88</biblScope><biblScope unit="page-count">12</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-02">2011-02</date></imprint><idno type="ISSN">1099-498X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1099-498X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone</term><term>Bone formation</term><term>Bone formation response</term><term>Bone growth</term><term>Bone loss</term><term>Bone marrow</term><term>Bone marrow cavity</term><term>Bone marrow cells</term><term>Bone mass</term><term>Bone miner</term><term>Bone resorption</term><term>Bone surface</term><term>Cells transduced</term><term>Control group</term><term>Cortical</term><term>Cortical thickness</term><term>Endocrinology</term><term>Endosteal</term><term>Endosteal bone formation</term><term>Endosteal bone mass</term><term>Endosteum</term><term>Engraftment</term><term>Facs analysis</term><term>Femur</term><term>Gene</term><term>Gene therapy</term><term>Gene transfer strategy</term><term>Growth factor</term><term>Growth hormone</term><term>Growth plate</term><term>Hematopoietic</term><term>High levels</term><term>Igfbps</term><term>John wiley sons</term><term>Loma</term><term>Loma linda</term><term>Loma linda university school</term><term>Marrow</term><term>Marrow cavity</term><term>Marrow transplantation</term><term>Medical center</term><term>Mesenchymal</term><term>Miner</term><term>Mouse</term><term>Mrna</term><term>Mrna levels</term><term>Murine</term><term>Musculoskeletal disease center</term><term>Ndings</term><term>Nonparametric test</term><term>Osmotic lysis</term><term>Osteoblast</term><term>Osteoclast</term><term>Osteoclast surface</term><term>Osteoclastic</term><term>Osteoclastic resorption</term><term>Osteogenic</term><term>Osteogenic gene</term><term>Overexpression</term><term>Periosteal</term><term>Peripheral blood</term><term>Peripheral blood cells</term><term>Pettis memorial</term><term>Pqct</term><term>Present study</term><term>Receptor</term><term>Recipient</term><term>Recipient mice</term><term>Recipient mouse</term><term>Representative sample</term><term>Resorption</term><term>Sca1</term><term>Secondary spongiosa</term><term>Serum levels</term><term>Trabecular</term><term>Trabecular bone formation</term><term>Trabecular bone volume</term><term>Trabecular number</term><term>Trabecular separation</term><term>Transduced</term><term>Transgene</term><term>Transgenic</term><term>Transgenic mice</term><term>Transgenic mouse strains</term><term>Transgenic overexpression</term><term>Transgenic strains</term><term>Transplantation</term><term>Upper right</term><term>Viable cells</term><term>Vivo</term><term>Vivo gene transfer strategy</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bone</term><term>Bone formation</term><term>Bone formation response</term><term>Bone growth</term><term>Bone loss</term><term>Bone marrow</term><term>Bone marrow cavity</term><term>Bone marrow cells</term><term>Bone mass</term><term>Bone miner</term><term>Bone resorption</term><term>Bone surface</term><term>Cells transduced</term><term>Control group</term><term>Cortical</term><term>Cortical thickness</term><term>Endocrinology</term><term>Endosteal</term><term>Endosteal bone formation</term><term>Endosteal bone mass</term><term>Endosteum</term><term>Engraftment</term><term>Facs analysis</term><term>Femur</term><term>Gene</term><term>Gene therapy</term><term>Gene transfer strategy</term><term>Growth factor</term><term>Growth hormone</term><term>Growth plate</term><term>Hematopoietic</term><term>High levels</term><term>Igfbps</term><term>John wiley sons</term><term>Loma</term><term>Loma linda</term><term>Loma linda university school</term><term>Marrow</term><term>Marrow cavity</term><term>Marrow transplantation</term><term>Medical center</term><term>Mesenchymal</term><term>Miner</term><term>Mouse</term><term>Mrna</term><term>Mrna levels</term><term>Murine</term><term>Musculoskeletal disease center</term><term>Ndings</term><term>Nonparametric test</term><term>Osmotic lysis</term><term>Osteoblast</term><term>Osteoclast</term><term>Osteoclast surface</term><term>Osteoclastic</term><term>Osteoclastic resorption</term><term>Osteogenic</term><term>Osteogenic gene</term><term>Overexpression</term><term>Periosteal</term><term>Peripheral blood</term><term>Peripheral blood cells</term><term>Pettis memorial</term><term>Pqct</term><term>Present study</term><term>Receptor</term><term>Recipient</term><term>Recipient mice</term><term>Recipient mouse</term><term>Representative sample</term><term>Resorption</term><term>Sca1</term><term>Secondary spongiosa</term><term>Serum levels</term><term>Trabecular</term><term>Trabecular bone formation</term><term>Trabecular bone volume</term><term>Trabecular number</term><term>Trabecular separation</term><term>Transduced</term><term>Transgene</term><term>Transgenic</term><term>Transgenic mice</term><term>Transgenic mouse strains</term><term>Transgenic overexpression</term><term>Transgenic strains</term><term>Transplantation</term><term>Upper right</term><term>Viable cells</term><term>Vivo</term><term>Vivo gene transfer strategy</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mineur (ouvrier)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">The present study assesses the effect of the stem cell antigen‐1 positive (Sca‐1+) cell‐based human growth hormone (hGH) ex vivo gene transfer strategy on endosteal bone mass in the mouse.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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