Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Identifieur interne : 000791 ( Main/Exploration ); précédent : 000790; suivant : 000792Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Auteurs : José S. Moya [Espagne] ; Arturo Martínez [Espagne] ; Roberto L Pez-Píriz [Espagne] ; Francisco Guitián [Espagne] ; Luis A. Díaz [Espagne] ; Leticia Esteban-Tejeda [Espagne] ; Belén Cabal [Espagne] ; Federico Sket [Espagne] ; Elisa Fernández-García [Espagne] ; Antoni P. Tomsia [États-Unis] ; Ram N Torrecillas [Espagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.
Url:
DOI: 10.1038/srep31478
PubMed: 27515388
PubMed Central: 4981854
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P<sub>2</sub>
O<sub>5</sub>
glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.</p>
</div>
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<li>États-Unis</li>
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<name sortKey="Esteban Tejeda, Leticia" sort="Esteban Tejeda, Leticia" uniqKey="Esteban Tejeda L" first="Leticia" last="Esteban-Tejeda">Leticia Esteban-Tejeda</name>
<name sortKey="Fernandez Garcia, Elisa" sort="Fernandez Garcia, Elisa" uniqKey="Fernandez Garcia E" first="Elisa" last="Fernández-García">Elisa Fernández-García</name>
<name sortKey="Guitian, Francisco" sort="Guitian, Francisco" uniqKey="Guitian F" first="Francisco" last="Guitián">Francisco Guitián</name>
<name sortKey="L Pez Piriz, Roberto" sort="L Pez Piriz, Roberto" uniqKey="L Pez Piriz R" first="Roberto" last="L Pez-Píriz">Roberto L Pez-Píriz</name>
<name sortKey="Martinez, Arturo" sort="Martinez, Arturo" uniqKey="Martinez A" first="Arturo" last="Martínez">Arturo Martínez</name>
<name sortKey="Moya, Jose S" sort="Moya, Jose S" uniqKey="Moya J" first="José S." last="Moya">José S. Moya</name>
<name sortKey="Sket, Federico" sort="Sket, Federico" uniqKey="Sket F" first="Federico" last="Sket">Federico Sket</name>
<name sortKey="Torrecillas, Ram N" sort="Torrecillas, Ram N" uniqKey="Torrecillas R" first="Ram N" last="Torrecillas">Ram N Torrecillas</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Tomsia, Antoni P" sort="Tomsia, Antoni P" uniqKey="Tomsia A" first="Antoni P." last="Tomsia">Antoni P. Tomsia</name>
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