Host-Microbiome Cross-talk in Oral Mucositis
Identifieur interne : 000790 ( Main/Exploration ); précédent : 000789; suivant : 000791Host-Microbiome Cross-talk in Oral Mucositis
Auteurs : R. M. Vasconcelos [États-Unis, Brésil] ; N. Sanfilippo [États-Unis] ; B. J. Paster [États-Unis] ; A. R. Kerr [États-Unis] ; Y. Li [États-Unis] ; L. Ramalho [Brésil] ; E. L. Queiroz [États-Unis] ; B. Smith [États-Unis] ; S. T. Sonis [États-Unis] ; P. M. Corby [États-Unis]Source :
- Journal of Dental Research [ 0022-0345 ] ; 2016.
Abstract
Oral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen–related treatment, resulting in the formation of ulcers, which are susceptible to increased colonization of microorganisms. Novel discoveries in OM have focused on understanding the host-microbial interactions, because current pathways have shown that major virulence factors from microorganisms have the potential to contribute to the development of OM and may even prolong the existence of already established ulcerations, affecting tissue healing. Additional comprehensive and disciplined clinical investigation is needed to carefully characterize the relationship between the clinical trajectory of OM, the local levels of inflammatory changes (both clinical and molecular), and the ebb and flow of the oral microbiota. Answering such questions will increase our knowledge of the mechanisms engaged by the oral immune system in response to mucositis, facilitating their translation into novel therapeutic approaches. In doing so, directed clinical strategies can be developed that specifically target those times and tissues that are most susceptible to intervention.
Url:
DOI: 10.1177/0022034516641890
PubMed: 27053118
PubMed Central: 4914867
Affiliations:
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Smith</name><affiliation wicri:level="2"><nlm:aff id="aff1-0022034516641890">School of Medicine, New York University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4-0022034516641890">New York University Perlmutter Cancer Center, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Perlmutter Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sonis, S T" sort="Sonis, S T" uniqKey="Sonis S" first="S. T." last="Sonis">S. T. Sonis</name><affiliation wicri:level="2"><nlm:aff id="aff7-0022034516641890">Biomodels, LLC, Watertown, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomodels, LLC, Watertown, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8-0022034516641890">Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Corby, P M" sort="Corby, P M" uniqKey="Corby P" first="P. M." last="Corby">P. M. Corby</name><affiliation wicri:level="2"><nlm:aff id="aff1-0022034516641890">School of Medicine, New York University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2-0022034516641890">College of Dentistry, New York University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Dentistry, New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Dental Research</title><idno type="ISSN">0022-0345</idno><idno type="eISSN">1544-0591</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oral mucositis (OM) is among the most common, painful, and debilitating toxicities of cancer regimen–related treatment, resulting in the formation of ulcers, which are susceptible to increased colonization of microorganisms. Novel discoveries in OM have focused on understanding the host-microbial interactions, because current pathways have shown that major virulence factors from microorganisms have the potential to contribute to the development of OM and may even prolong the existence of already established ulcerations, affecting tissue healing. Additional comprehensive and disciplined clinical investigation is needed to carefully characterize the relationship between the clinical trajectory of OM, the local levels of inflammatory changes (both clinical and molecular), and the ebb and flow of the oral microbiota. Answering such questions will increase our knowledge of the mechanisms engaged by the oral immune system in response to mucositis, facilitating their translation into novel therapeutic approaches. In doing so, directed clinical strategies can be developed that specifically target those times and tissues that are most susceptible to intervention.</p></div></front></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Bahia</li><li>Massachusetts</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Vasconcelos, R M" sort="Vasconcelos, R M" uniqKey="Vasconcelos R" first="R. M." last="Vasconcelos">R. M. Vasconcelos</name></region><name sortKey="Corby, P M" sort="Corby, P M" uniqKey="Corby P" first="P. M." last="Corby">P. M. Corby</name><name sortKey="Corby, P M" sort="Corby, P M" uniqKey="Corby P" first="P. M." last="Corby">P. M. Corby</name><name sortKey="Kerr, A R" sort="Kerr, A R" uniqKey="Kerr A" first="A. R." last="Kerr">A. R. Kerr</name><name sortKey="Li, Y" sort="Li, Y" uniqKey="Li Y" first="Y." last="Li">Y. Li</name><name sortKey="Paster, B J" sort="Paster, B J" uniqKey="Paster B" first="B. J." last="Paster">B. J. Paster</name><name sortKey="Paster, B J" sort="Paster, B J" uniqKey="Paster B" first="B. J." last="Paster">B. J. Paster</name><name sortKey="Queiroz, E L" sort="Queiroz, E L" uniqKey="Queiroz E" first="E. L." last="Queiroz">E. L. Queiroz</name><name sortKey="Sanfilippo, N" sort="Sanfilippo, N" uniqKey="Sanfilippo N" first="N." last="Sanfilippo">N. Sanfilippo</name><name sortKey="Sanfilippo, N" sort="Sanfilippo, N" uniqKey="Sanfilippo N" first="N." last="Sanfilippo">N. Sanfilippo</name><name sortKey="Smith, B" sort="Smith, B" uniqKey="Smith B" first="B." last="Smith">B. Smith</name><name sortKey="Smith, B" sort="Smith, B" uniqKey="Smith B" first="B." last="Smith">B. Smith</name><name sortKey="Sonis, S T" sort="Sonis, S T" uniqKey="Sonis S" first="S. T." last="Sonis">S. T. Sonis</name><name sortKey="Sonis, S T" sort="Sonis, S T" uniqKey="Sonis S" first="S. T." last="Sonis">S. T. Sonis</name><name sortKey="Vasconcelos, R M" sort="Vasconcelos, R M" uniqKey="Vasconcelos R" first="R. M." last="Vasconcelos">R. M. Vasconcelos</name></country><country name="Brésil"><region name="Bahia"><name sortKey="Vasconcelos, R M" sort="Vasconcelos, R M" uniqKey="Vasconcelos R" first="R. M." last="Vasconcelos">R. M. Vasconcelos</name></region><name sortKey="Ramalho, L" sort="Ramalho, L" uniqKey="Ramalho L" first="L." last="Ramalho">L. Ramalho</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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