Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Identifieur interne : 000666 ( Pmc/Checkpoint ); précédent : 000665; suivant : 000667Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs
Auteurs : José S. Moya [Espagne] ; Arturo Martínez [Espagne] ; Roberto L Pez-Píriz [Espagne] ; Francisco Guitián [Espagne] ; Luis A. Díaz [Espagne] ; Leticia Esteban-Tejeda [Espagne] ; Belén Cabal [Espagne] ; Federico Sket [Espagne] ; Elisa Fernández-García [Espagne] ; Antoni P. Tomsia [États-Unis] ; Ram N Torrecillas [Espagne]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P2O5 glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.
Url:
DOI: 10.1038/srep31478
PubMed: 27515388
PubMed Central: 4981854
Affiliations:
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Moya</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute of Materials Science of Madrid (ICMM-CSIC)</institution>, Cantoblanco, 28049, Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martinez, Arturo" sort="Martinez, Arturo" uniqKey="Martinez A" first="Arturo" last="Martínez">Arturo Martínez</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Galician Institute of Ceramics, University of Santiago de Compostela</institution>, Avda Maestro Mateo, 15782 Santiago de Compostela,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Pez Piriz, Roberto" sort="L Pez Piriz, Roberto" uniqKey="L Pez Piriz R" first="Roberto" last="L Pez-Píriz">Roberto L Pez-Píriz</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guitian, Francisco" sort="Guitian, Francisco" uniqKey="Guitian F" first="Francisco" last="Guitián">Francisco Guitián</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Galician Institute of Ceramics, University of Santiago de Compostela</institution>, Avda Maestro Mateo, 15782 Santiago de Compostela,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diaz, Luis A" sort="Diaz, Luis A" uniqKey="Diaz L" first="Luis A." last="Díaz">Luis A. 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Moya</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute of Materials Science of Madrid (ICMM-CSIC)</institution>, Cantoblanco, 28049, Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Martinez, Arturo" sort="Martinez, Arturo" uniqKey="Martinez A" first="Arturo" last="Martínez">Arturo Martínez</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Galician Institute of Ceramics, University of Santiago de Compostela</institution>, Avda Maestro Mateo, 15782 Santiago de Compostela,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Pez Piriz, Roberto" sort="L Pez Piriz, Roberto" uniqKey="L Pez Piriz R" first="Roberto" last="L Pez-Píriz">Roberto L Pez-Píriz</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guitian, Francisco" sort="Guitian, Francisco" uniqKey="Guitian F" first="Francisco" last="Guitián">Francisco Guitián</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Galician Institute of Ceramics, University of Santiago de Compostela</institution>, Avda Maestro Mateo, 15782 Santiago de Compostela,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Diaz, Luis A" sort="Diaz, Luis A" uniqKey="Diaz L" first="Luis A." last="Díaz">Luis A. Díaz</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Esteban Tejeda, Leticia" sort="Esteban Tejeda, Leticia" uniqKey="Esteban Tejeda L" first="Leticia" last="Esteban-Tejeda">Leticia Esteban-Tejeda</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Institute of Materials Science of Madrid (ICMM-CSIC)</institution>, Cantoblanco, 28049, Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cabal, Belen" sort="Cabal, Belen" uniqKey="Cabal B" first="Belén" last="Cabal">Belén Cabal</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sket, Federico" sort="Sket, Federico" uniqKey="Sket F" first="Federico" last="Sket">Federico Sket</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>IMDEA Materials Institute</institution>, C/ Eric Kandel 2, Getafe, 28906, Madrid,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fernandez Garcia, Elisa" sort="Fernandez Garcia, Elisa" uniqKey="Fernandez Garcia E" first="Elisa" last="Fernández-García">Elisa Fernández-García</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tomsia, Antoni P" sort="Tomsia, Antoni P" uniqKey="Tomsia A" first="Antoni P." last="Tomsia">Antoni P. Tomsia</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Materials Sciences Division, Lawrence Berkeley National Laboratory</institution>, Berkeley, CA 94720,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Torrecillas, Ram N" sort="Torrecillas, Ram N" uniqKey="Torrecillas R" first="Ram N" last="Torrecillas">Ram N Torrecillas</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P<sub>2</sub>O<sub>5</sub> glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Darouiche, R O" uniqKey="Darouiche R">R. O. Darouiche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurtz, S" uniqKey="Kurtz S">S. Kurtz</name></author><author><name sortKey="Ong, K" uniqKey="Ong K">K. Ong</name></author><author><name sortKey="Lau, E" uniqKey="Lau E">E. Lau</name></author><author><name sortKey="Mowat, F" uniqKey="Mowat F">F. Mowat</name></author><author><name sortKey="Halpern, M" uniqKey="Halpern M">M. Halpern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyndon, J A" uniqKey="Lyndon J">J. A. Lyndon</name></author><author><name sortKey="Boyd, B J" uniqKey="Boyd B">B. J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27515388</article-id><article-id pub-id-type="pmc">4981854</article-id><article-id pub-id-type="pii">srep31478</article-id><article-id pub-id-type="doi">10.1038/srep31478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Moya</surname><given-names>José S.</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Martínez</surname><given-names>Arturo</given-names></name><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>López-Píriz</surname><given-names>Roberto</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guitián</surname><given-names>Francisco</given-names></name><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Díaz</surname><given-names>Luis A.</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Esteban-Tejeda</surname><given-names>Leticia</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cabal</surname><given-names>Belén</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sket</surname><given-names>Federico</given-names></name><xref ref-type="aff" rid="a4">4</xref></contrib><contrib contrib-type="author"><name><surname>Fernández-García</surname><given-names>Elisa</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tomsia</surname><given-names>Antoni P.</given-names></name><xref ref-type="aff" rid="a5">5</xref></contrib><contrib contrib-type="author"><name><surname>Torrecillas</surname><given-names>Ramón</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref></contrib><aff id="a1"><label>1</label><institution>Nanomaterials and Nanotechnology Research Center (CINN), CSIC - University of Oviedo (UO)</institution>, Avda de la Vega 4-6, El Entrego 33940, San Martín del Rey Aurelio,<country>Spain</country></aff><aff id="a2"><label>2</label><institution>Institute of Materials Science of Madrid (ICMM-CSIC)</institution>, Cantoblanco, 28049, Madrid,<country>Spain</country></aff><aff id="a3"><label>3</label><institution>Galician Institute of Ceramics, University of Santiago de Compostela</institution>, Avda Maestro Mateo, 15782 Santiago de Compostela,<country>Spain</country></aff><aff id="a4"><label>4</label><institution>IMDEA Materials Institute</institution>, C/ Eric Kandel 2, Getafe, 28906, Madrid,<country>Spain</country></aff><aff id="a5"><label>5</label><institution>Materials Sciences Division, Lawrence Berkeley National Laboratory</institution>, Berkeley, CA 94720,<country>USA</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>r.torrecillas@cinn.es</email></corresp></author-notes><pub-date pub-type="epub"><day>12</day><month>08</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>6</volume><elocation-id>31478</elocation-id><history><date date-type="received"><day>29</day><month>05</month><year>2015</year></date><date date-type="accepted"><day>20</day><month>07</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016, Macmillan Publishers Limited</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Macmillan Publishers Limited</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Bacterial and fungal infections remain a major clinical challenge. Implant infections very often require complicated revision procedures that are troublesome to patients and costly to the healthcare system. Innovative approaches to tackle infections are urgently needed. We investigated the histological response of novel free P<sub>2</sub>O<sub>5</sub> glass-ceramic rods implanted in the jaws of beagle dogs. Due to the particular percolated morphology of this glass-ceramic, the dissolution of the rods in the animal body environment and the immature bone formation during the fourth months of implantation maintained the integrity of the glass-ceramic rod. No clinical signs of inflammation took place in any of the beagle dogs during the four months of implantation. This new glass-ceramic biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing candidate for bone tissue engineering.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><p>X-ray computed tomography (XCT) images of the cross section of the implanted rod (<bold>a</bold>). Volume reconstruction of all the pores in the sample (colours indicates different pores) (<bold>b</bold>). The seven biggest pores in the sample with the rest of the pores in semitransparent for dimension comparison (<bold>c</bold>). Only the seven biggest pores in the sample (<bold>d</bold>). In Figure (<bold>b</bold>–<bold>d</bold>) the material was set to transparent.</p></caption><graphic xlink:href="srep31478-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Permeability of a fluorescently labelled BSA throughout the porous glass-ceramic rod.</title><p>A testing diagram (<bold>a</bold>) and images of the rod surface (<bold>b</bold>) and of the cross-section (<bold>c</bold>) after the test are shown. Green-fluorescence images were obtained from the rod surface (<bold>b1</bold>) and in cross section (<bold>c1</bold>) after incubation with FITC-albumin for 48 h; control rods (<bold>b2</bold>,<bold>c2</bold>) were immersed in PBS with the same test conditions. The appearance of the rods at each state is also included in (<bold>a</bold>–<bold>c</bold>).</p></caption><graphic xlink:href="srep31478-f2"></graphic></fig><fig id="f3"><label>Figure 3</label><caption><p>Histological image of the glass-ceramic rod (<bold>a</bold>). Optical micrographs showing interconnected microporosity allowing the migration of plasma fluid through capilar effect (<bold>a1</bold>) and details of the new bone-implant interface (<bold>b1,c1</bold>).</p></caption><graphic xlink:href="srep31478-f3"></graphic></fig><fig id="f4"><label>Figure 4</label><caption><p>Histological images of the glass-ceramic rod showing bone osseointegration (<bold>a</bold>). Optical micrographs: Apical area of the implant (<bold>b</bold>), detail of the buccal plate of the alveolar bone on the surface of the implant (<bold>c</bold>), detail of the bone-implant interface (<bold>d</bold>) and detail of the interface where one can appreciate the appearance/growth of a bridge of mineralized bone tissue on the implant surface. Pores filled with calcium and organic compounds are observable within the crust (arrows) (<bold>e</bold>). Abbreviations: -N- core material, -B- new bone, -BM- bone marrow, -IC- implant, -BP- buccal plate of the alveolar bone, -VS- vascular areas of the neo-formed bone, -CL- cemental bone remodeling line, -C- partially dissolved surface layer of the rod, -P- periosteum, -IB- immature bone, -L- osteocytarieslacunaes, -MB- immature mineralized bone.</p></caption><graphic xlink:href="srep31478-f4"></graphic></fig><fig id="f5"><label>Figure 5</label><caption><title>Field-emission scanning electron micrograph (FE-SEM) of the implanted rod and energy-dispersive X-ray spectroscopy (EDS) microanalysis of the selected spots, corresponding to numbers 1, 2, 3, 4.</title></caption><graphic xlink:href="srep31478-f5"></graphic></fig><fig id="f6"><label>Figure 6</label><caption><p>Backscattered field emission scanning electron microscopy (FESEM) image (<bold>a</bold>) showing a general view of the implant in contact with the bone at two magnifications (<bold>a1</bold>,<bold>a2</bold>). Energy-dispersive X-ray spectroscopy (EDS) maps of Si, Ca, and P (<bold>a2a–a2c</bold>).</p></caption><graphic xlink:href="srep31478-f6"></graphic></fig><fig id="f7"><label>Figure 7</label><caption><title>Image of a glass-ceramic rod, free of P<sub>2</sub>O<sub>5</sub> implanted by impaction into the jaw of a beagle dog (photo taken by Roberto López-Píriz during the surgery).</title></caption><graphic xlink:href="srep31478-f7"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Moya, Jose S" sort="Moya, Jose S" uniqKey="Moya J" first="José S." last="Moya">José S. Moya</name></noRegion><name sortKey="Cabal, Belen" sort="Cabal, Belen" uniqKey="Cabal B" first="Belén" last="Cabal">Belén Cabal</name><name sortKey="Diaz, Luis A" sort="Diaz, Luis A" uniqKey="Diaz L" first="Luis A." last="Díaz">Luis A. Díaz</name><name sortKey="Esteban Tejeda, Leticia" sort="Esteban Tejeda, Leticia" uniqKey="Esteban Tejeda L" first="Leticia" last="Esteban-Tejeda">Leticia Esteban-Tejeda</name><name sortKey="Fernandez Garcia, Elisa" sort="Fernandez Garcia, Elisa" uniqKey="Fernandez Garcia E" first="Elisa" last="Fernández-García">Elisa Fernández-García</name><name sortKey="Guitian, Francisco" sort="Guitian, Francisco" uniqKey="Guitian F" first="Francisco" last="Guitián">Francisco Guitián</name><name sortKey="L Pez Piriz, Roberto" sort="L Pez Piriz, Roberto" uniqKey="L Pez Piriz R" first="Roberto" last="L Pez-Píriz">Roberto L Pez-Píriz</name><name sortKey="Martinez, Arturo" sort="Martinez, Arturo" uniqKey="Martinez A" first="Arturo" last="Martínez">Arturo Martínez</name><name sortKey="Moya, Jose S" sort="Moya, Jose S" uniqKey="Moya J" first="José S." last="Moya">José S. Moya</name><name sortKey="Sket, Federico" sort="Sket, Federico" uniqKey="Sket F" first="Federico" last="Sket">Federico Sket</name><name sortKey="Torrecillas, Ram N" sort="Torrecillas, Ram N" uniqKey="Torrecillas R" first="Ram N" last="Torrecillas">Ram N Torrecillas</name></country><country name="États-Unis"><noRegion><name sortKey="Tomsia, Antoni P" sort="Tomsia, Antoni P" uniqKey="Tomsia A" first="Antoni P." last="Tomsia">Antoni P. Tomsia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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