Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial
Identifieur interne : 000622 ( Istex/Corpus ); précédent : 000621; suivant : 000623Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial
Auteurs : Ö. Özçaka ; Ö. K. Ba O Lu ; N. Buduneli ; M. S. Ta Bakan ; F. Bacako Lu ; D. F. KinaneSource :
- Journal of Periodontal Research [ 0022-3484 ] ; 2012-10.
English descriptors
- KwdEn :
- Acinetobacter species, Acute physiology, Adverse events, Apache, Average length, Bacterial colonization, Baseline characteristics, Buccal mucosa, Chlorhexidine, Chlorhexidine gluconate, Chlorhexidine mouthrinses, Chronic health evaluation, Clin, Clin periodontol brecx, Clinical trials, Colonization, Common pathogen, Control group, Control groups, Crit, Crit care, Decontamination, Dental plaque, Dentate patients, Development rate, Development risk, Endotracheal tube, Gluconate, Head nurse, Heart surgery, Intensive care, Intensive care unit, Intensive care unit patients, Late onset, Logistic regression analysis, Mechanical ventilation, Ndings, Nosocomial, Nosocomial infections, Nosocomial pneumonia, Numerical evaluation, Odds ratio, Oral antiseptics, Oral care, Oral cavity, Oral colonization, Oral decontamination, Oral hygiene, Oral mucosa, Oral swabbing, Oropharyngeal colonization, Other hand, Outcome variables hospitalization, Pathogen, Periodontal, Periodontal status, Periodontol, Plaque, Plaque index, Pneumonia, Pneumonia development, Present study, Previous studies, Prps, Quantifying colonies, Randomized, Randomized trial, Respir crit care, Respiratory pathogens, Scannapieco, Standard deviation, Statistical analysis, Study groups, Study protocol, Swabbing, Tooth staining, Topical application, Ventilatorassociated pneumonia.
- Teeft :
- Acinetobacter species, Acute physiology, Adverse events, Apache, Average length, Bacterial colonization, Baseline characteristics, Buccal mucosa, Chlorhexidine, Chlorhexidine gluconate, Chlorhexidine mouthrinses, Chronic health evaluation, Clin, Clin periodontol brecx, Clinical trials, Colonization, Common pathogen, Control group, Control groups, Crit, Crit care, Decontamination, Dental plaque, Dentate patients, Development rate, Development risk, Endotracheal tube, Gluconate, Head nurse, Heart surgery, Intensive care, Intensive care unit, Intensive care unit patients, Late onset, Logistic regression analysis, Mechanical ventilation, Ndings, Nosocomial, Nosocomial infections, Nosocomial pneumonia, Numerical evaluation, Odds ratio, Oral antiseptics, Oral care, Oral cavity, Oral colonization, Oral decontamination, Oral hygiene, Oral mucosa, Oral swabbing, Oropharyngeal colonization, Other hand, Outcome variables hospitalization, Pathogen, Periodontal, Periodontal status, Periodontol, Plaque, Plaque index, Pneumonia, Pneumonia development, Present study, Previous studies, Prps, Quantifying colonies, Randomized, Randomized trial, Respir crit care, Respiratory pathogens, Scannapieco, Standard deviation, Statistical analysis, Study groups, Study protocol, Swabbing, Tooth staining, Topical application, Ventilatorassociated pneumonia.
Abstract
Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S
Url:
DOI: 10.1111/j.1600-0765.2012.01470.x
Links to Exploration step
ISTEX:0CF663C9C950C389807C13531EA7EAEBC0758BB6Le document en format XML
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Ba O Lu</name><affiliation><mods:affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</mods:affiliation></affiliation></author><author><name sortKey="Buduneli, N" sort="Buduneli, N" uniqKey="Buduneli N" first="N." last="Buduneli">N. Buduneli</name><affiliation><mods:affiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</mods:affiliation></affiliation></author><author><name sortKey="Ta Bakan, M S" sort="Ta Bakan, M S" uniqKey="Ta Bakan M" first="M. S." last="Ta Bakan">M. S. Ta Bakan</name><affiliation><mods:affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</mods:affiliation></affiliation></author><author><name sortKey="Bacako Lu, F" sort="Bacako Lu, F" uniqKey="Bacako Lu F" first="F." last="Bacako Lu">F. 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xml:lang="en"><term>Acinetobacter species</term><term>Acute physiology</term><term>Adverse events</term><term>Apache</term><term>Average length</term><term>Bacterial colonization</term><term>Baseline characteristics</term><term>Buccal mucosa</term><term>Chlorhexidine</term><term>Chlorhexidine gluconate</term><term>Chlorhexidine mouthrinses</term><term>Chronic health evaluation</term><term>Clin</term><term>Clin periodontol brecx</term><term>Clinical trials</term><term>Colonization</term><term>Common pathogen</term><term>Control group</term><term>Control groups</term><term>Crit</term><term>Crit care</term><term>Decontamination</term><term>Dental plaque</term><term>Dentate patients</term><term>Development rate</term><term>Development risk</term><term>Endotracheal tube</term><term>Gluconate</term><term>Head nurse</term><term>Heart surgery</term><term>Intensive care</term><term>Intensive care unit</term><term>Intensive care unit patients</term><term>Late onset</term><term>Logistic regression analysis</term><term>Mechanical ventilation</term><term>Ndings</term><term>Nosocomial</term><term>Nosocomial infections</term><term>Nosocomial pneumonia</term><term>Numerical evaluation</term><term>Odds ratio</term><term>Oral antiseptics</term><term>Oral care</term><term>Oral cavity</term><term>Oral colonization</term><term>Oral decontamination</term><term>Oral hygiene</term><term>Oral mucosa</term><term>Oral swabbing</term><term>Oropharyngeal colonization</term><term>Other hand</term><term>Outcome variables hospitalization</term><term>Pathogen</term><term>Periodontal</term><term>Periodontal status</term><term>Periodontol</term><term>Plaque</term><term>Plaque index</term><term>Pneumonia</term><term>Pneumonia development</term><term>Present study</term><term>Previous studies</term><term>Prps</term><term>Quantifying colonies</term><term>Randomized</term><term>Randomized trial</term><term>Respir crit care</term><term>Respiratory pathogens</term><term>Scannapieco</term><term>Standard deviation</term><term>Statistical analysis</term><term>Study groups</term><term>Study protocol</term><term>Swabbing</term><term>Tooth staining</term><term>Topical application</term><term>Ventilatorassociated pneumonia</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acinetobacter species</term><term>Acute physiology</term><term>Adverse events</term><term>Apache</term><term>Average length</term><term>Bacterial colonization</term><term>Baseline characteristics</term><term>Buccal mucosa</term><term>Chlorhexidine</term><term>Chlorhexidine gluconate</term><term>Chlorhexidine mouthrinses</term><term>Chronic health evaluation</term><term>Clin</term><term>Clin periodontol brecx</term><term>Clinical trials</term><term>Colonization</term><term>Common pathogen</term><term>Control group</term><term>Control groups</term><term>Crit</term><term>Crit care</term><term>Decontamination</term><term>Dental plaque</term><term>Dentate patients</term><term>Development rate</term><term>Development risk</term><term>Endotracheal tube</term><term>Gluconate</term><term>Head nurse</term><term>Heart surgery</term><term>Intensive care</term><term>Intensive care unit</term><term>Intensive care unit patients</term><term>Late onset</term><term>Logistic regression analysis</term><term>Mechanical ventilation</term><term>Ndings</term><term>Nosocomial</term><term>Nosocomial infections</term><term>Nosocomial pneumonia</term><term>Numerical evaluation</term><term>Odds ratio</term><term>Oral antiseptics</term><term>Oral care</term><term>Oral cavity</term><term>Oral colonization</term><term>Oral decontamination</term><term>Oral hygiene</term><term>Oral mucosa</term><term>Oral swabbing</term><term>Oropharyngeal colonization</term><term>Other hand</term><term>Outcome variables hospitalization</term><term>Pathogen</term><term>Periodontal</term><term>Periodontal status</term><term>Periodontol</term><term>Plaque</term><term>Plaque 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Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. 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Özçaka</name><affiliations><json:string>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</json:string><json:string>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA</json:string></affiliations></json:item><json:item><name>Ö. K. Başoğlu</name><affiliations><json:string>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</json:string></affiliations></json:item><json:item><name>N. Buduneli</name><affiliations><json:string>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</json:string></affiliations></json:item><json:item><name>M. S. Taşbakan</name><affiliations><json:string>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</json:string></affiliations></json:item><json:item><name>F. Bacakoğlu</name><affiliations><json:string>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</json:string></affiliations></json:item><json:item><name>D. F. Kinane</name><affiliations><json:string>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>chlorhexidine gluconate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dental care</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>intensive care units</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>periodontal disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ventilator‐associated pneumonia</value></json:item></subject><articleId><json:string>JRE1470</json:string></articleId><arkIstex>ark:/67375/WNG-D86ZB8G8-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S</abstract><qualityIndicators><score>7.492</score><pdfWordCount>5099</pdfWordCount><pdfCharCount>34934</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>41</abstractWordCount><abstractCharCount>264</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title><pmid><json:string>22376026</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Periodontal Research</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0765</json:string></doi><issn><json:string>0022-3484</json:string></issn><eissn><json:string>1600-0765</json:string></eissn><publisherId><json:string>JRE</json:string></publisherId><volume>47</volume><issue>5</issue><pages><first>584</first><last>592</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2012</json:string><json:string>between November 2007 and November 2009</json:string></date><geogName></geogName><orgName><json:string>Department of Chest Diseases, Respiratory ICU</json:string><json:string>Department of Chest Disease, School of Medicine, Ege</json:string><json:string>Turkish Thoracic Society</json:string><json:string>Ege University</json:string><json:string>Department of Periodontology, School of Dentistry, Ege</json:string><json:string>Department of Periodontology and Pathology</json:string><json:string>American Thoracic Society</json:string><json:string>Research Assistant</json:string><json:string>Department of Biostatistics and Medical Informatics</json:string><json:string>University of Pennsylvania</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>N. Buduneli</json:string><json:string>John Wiley</json:string><json:string>Ö. K. Basoglu</json:string><json:string>F. Bacakoglu</json:string><json:string>Ö. ÖzÅaka</json:string><json:string>Dr Timur</json:string><json:string>La Foret</json:string><json:string>Özgün ÖzÅaka</json:string><json:string>M. S. Tasbakan</json:string><json:string>D. F. Kinane</json:string></persName><placeName><json:string>Turkey</json:string><json:string>Helsinki</json:string><json:string>France</json:string><json:string>Izmir</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Houston et al.</json:string><json:string>Chan et al.</json:string><json:string>Scannapieco et al.</json:string><json:string>Tantipong et al.</json:string><json:string>Fourrier et al.</json:string><json:string>Ozcaka et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-D86ZB8G8-X</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string></scopus></categories><publicationDate>2012</publicationDate><copyrightDate>2012</copyrightDate><doi><json:string>10.1111/j.1600-0765.2012.01470.x</json:string></doi><id>0CF663C9C950C389807C13531EA7EAEBC0758BB6</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/0CF663C9C950C389807C13531EA7EAEBC0758BB6/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/0CF663C9C950C389807C13531EA7EAEBC0758BB6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0CF663C9C950C389807C13531EA7EAEBC0758BB6/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2012 John Wiley & Sons A/S</licence></availability><date type="published" when="2012-10"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title><title level="a" type="short">CHX decreases VAP in ICU</title><author xml:id="author-0000"><persName><forename type="first">Ö.</forename><surname>Özçaka</surname></persName><affiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</affiliation><affiliation>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ö. K.</forename><surname>Başoğlu</surname></persName><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation></author><author xml:id="author-0002"><persName><forename type="first">N.</forename><surname>Buduneli</surname></persName><affiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</affiliation></author><author xml:id="author-0003"><persName><forename type="first">M. S.</forename><surname>Taşbakan</surname></persName><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation></author><author xml:id="author-0004"><persName><forename type="first">F.</forename><surname>Bacakoğlu</surname></persName><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation></author><author xml:id="author-0005"><persName><forename type="first">D. F.</forename><surname>Kinane</surname></persName><affiliation>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA<address><country key="US"></country></address></affiliation></author><idno type="istex">0CF663C9C950C389807C13531EA7EAEBC0758BB6</idno><idno type="ark">ark:/67375/WNG-D86ZB8G8-X</idno><idno type="DOI">10.1111/j.1600-0765.2012.01470.x</idno><idno type="unit">JRE1470</idno><idno type="toTypesetVersion">file:JRE.JRE1470.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Periodontal Research</title><title level="j" type="alt">JOURNAL OF PERIODONTAL RESEARCH</title><idno type="pISSN">0022-3484</idno><idno type="eISSN">1600-0765</idno><idno type="book-DOI">10.1111/(ISSN)1600-0765</idno><idno type="book-part-DOI">10.1111/jre.2012.47.issue-5</idno><idno type="product">JRE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">47</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="584">584</biblScope><biblScope unit="page" to="592">592</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="italic">Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S</hi></p><p><hi rend="bold">Background and Objective: </hi> The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</p><p><hi rend="bold">Material and Methods: </hi> Sixty‐one dentate patients scheduled for invasive mechanical ventilation for at least 48 h were included in this randomized, double‐blind, controlled study. As these patients were variably incapacitated, oral care was provided by swabbing the oral mucosa four times/d with CHX in the CHX group (29 patients) and with saline in the control group (32 patients). Clinical periodontal measurements were recorded, and lower‐respiratory‐tract specimens were obtained for microbiological analysis on admission and when VAP was suspected. Pathogens were identified by quantifying colonies using standard culture techniques.</p><p><hi rend="bold">Results: </hi> Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; <hi rend="italic">p</hi> = 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). <hi rend="italic">Acinetobacter baumannii</hi> was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</p><p><hi rend="bold">Conclusion: </hi> The finding of the present study, that oral care with CHX swabbing reduces the risk of VAP development in mechanically ventilated patients, strongly supports its use in ICUs and indeed the importance of adequate oral hygiene in preventing medical complications.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">chlorhexidine gluconate</term><term xml:id="k2">dental care</term><term xml:id="k3">intensive care units</term><term xml:id="k4">periodontal disease</term><term xml:id="k5">ventilator‐associated pneumonia</term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/0CF663C9C950C389807C13531EA7EAEBC0758BB6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0765</doi><issn type="print">0022-3484</issn><issn type="electronic">1600-0765</issn><idGroup><id type="product" value="JRE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PERIODONTAL RESEARCH">Journal of Periodontal Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="10105"><doi origin="wiley">10.1111/jre.2012.47.issue-5</doi><numberingGroup><numbering type="journalVolume" number="47">47</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="2012-10">October 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1600-0765.2012.01470.x</doi><idGroup><id type="unit" value="JRE1470"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><copyright>© 2012 John Wiley & Sons A/S</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.6 mode:FullText" date="2012-08-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-02-29"></event><event type="firstOnline" date="2012-02-29"></event><event type="publishedOnlineFinalForm" date="2012-08-26"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="584">584</numbering><numbering type="pageLast" number="592">592</numbering></numberingGroup><correspondenceTo>Dr Özgün Özçaka, DDS, PhD, Department of Periodontology, School of Dentistry, Ege University, 35100 Bornova, İzmir, Türkiye
Tel: +90 232 388 11 05
Fax: +90 232 388 03 25
e‐mail: <email>ozgunozcaka@yahoo.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JRE.JRE1470.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication January 16, 2012</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="5"></count></countGroup><titleGroup><title type="main">Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title><title type="shortAuthors"><i>Özçaka</i> et al.</title><title type="short"><i>CHX decreases VAP in ICU</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Ö.</givenNames><familyName>Özçaka</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>Ö. K.</givenNames><familyName>Başoğlu</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>N.</givenNames><familyName>Buduneli</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>M. S.</givenNames><familyName>Taşbakan</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>F.</givenNames><familyName>Bacakoğlu</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>D. F.</givenNames><familyName>Kinane</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">chlorhexidine gluconate</keyword><keyword xml:id="k2">dental care</keyword><keyword xml:id="k3">intensive care units</keyword><keyword xml:id="k4">periodontal disease</keyword><keyword xml:id="k5">ventilator‐associated pneumonia</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><i>Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S</i></p><p><b>Background and Objective: </b> The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</p><p><b>Material and Methods: </b> Sixty‐one dentate patients scheduled for invasive mechanical ventilation for at least 48 h were included in this randomized, double‐blind, controlled study. As these patients were variably incapacitated, oral care was provided by swabbing the oral mucosa four times/d with CHX in the CHX group (29 patients) and with saline in the control group (32 patients). Clinical periodontal measurements were recorded, and lower‐respiratory‐tract specimens were obtained for microbiological analysis on admission and when VAP was suspected. Pathogens were identified by quantifying colonies using standard culture techniques.</p><p><b>Results: </b> Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; <i>p</i> = 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). <i>Acinetobacter baumannii</i> was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</p><p><b>Conclusion: </b> The finding of the present study, that oral care with CHX swabbing reduces the risk of VAP development in mechanically ventilated patients, strongly supports its use in ICUs and indeed the importance of adequate oral hygiene in preventing medical complications.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>CHX decreases VAP in ICU</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial</title></titleInfo><name type="personal"><namePart type="given">Ö.</namePart><namePart type="family">Özçaka</namePart><affiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</affiliation><affiliation>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ö. K.</namePart><namePart type="family">Başoğlu</namePart><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Buduneli</namePart><affiliation>Department of Periodontology, School of Dentistry, Ege University, İzmir, Türkiye</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. S.</namePart><namePart type="family">Taşbakan</namePart><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Bacakoğlu</namePart><affiliation>Department of Chest Disease, School of Medicine, Ege University, İzmir, Türkiye</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. F.</namePart><namePart type="family">Kinane</namePart><affiliation>Department of Periodontology and Pathology, School of Dental Medicine, University of Pennsylvania, PA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-10</dateIssued><edition>Accepted for publication January 16, 2012</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">5</extent></physicalDescription><abstract>Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S</abstract><abstract>Background and Objective: The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</abstract><abstract>Material and Methods: Sixty‐one dentate patients scheduled for invasive mechanical ventilation for at least 48 h were included in this randomized, double‐blind, controlled study. As these patients were variably incapacitated, oral care was provided by swabbing the oral mucosa four times/d with CHX in the CHX group (29 patients) and with saline in the control group (32 patients). Clinical periodontal measurements were recorded, and lower‐respiratory‐tract specimens were obtained for microbiological analysis on admission and when VAP was suspected. Pathogens were identified by quantifying colonies using standard culture techniques.</abstract><abstract>Results: Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; p = 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). Acinetobacter baumannii was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</abstract><abstract>Conclusion: The finding of the present study, that oral care with CHX swabbing reduces the risk of VAP development in mechanically ventilated patients, strongly supports its use in ICUs and indeed the importance of adequate oral hygiene in preventing medical complications.</abstract><subject lang="en"><genre>keywords</genre><topic>chlorhexidine gluconate</topic><topic>dental care</topic><topic>intensive care units</topic><topic>periodontal disease</topic><topic>ventilator‐associated pneumonia</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Periodontal Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-3484</identifier><identifier type="eISSN">1600-0765</identifier><identifier type="DOI">10.1111/(ISSN)1600-0765</identifier><identifier type="PublisherID">JRE</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>584</start><end>592</end><total>9</total></extent></part></relatedItem><identifier type="istex">0CF663C9C950C389807C13531EA7EAEBC0758BB6</identifier><identifier type="ark">ark:/67375/WNG-D86ZB8G8-X</identifier><identifier type="DOI">10.1111/j.1600-0765.2012.01470.x</identifier><identifier type="ArticleID">JRE1470</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2012 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/0CF663C9C950C389807C13531EA7EAEBC0758BB6/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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