Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial
Identifieur interne : 000622 ( Istex/Corpus ); précédent : 000621; suivant : 000623Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial
Auteurs : Ö. Özçaka ; Ö. K. Ba O Lu ; N. Buduneli ; M. S. Ta Bakan ; F. Bacako Lu ; D. F. KinaneSource :
- Journal of Periodontal Research [ 0022-3484 ] ; 2012-10.
English descriptors
- KwdEn :
- Acinetobacter species, Acute physiology, Adverse events, Apache, Average length, Bacterial colonization, Baseline characteristics, Buccal mucosa, Chlorhexidine, Chlorhexidine gluconate, Chlorhexidine mouthrinses, Chronic health evaluation, Clin, Clin periodontol brecx, Clinical trials, Colonization, Common pathogen, Control group, Control groups, Crit, Crit care, Decontamination, Dental plaque, Dentate patients, Development rate, Development risk, Endotracheal tube, Gluconate, Head nurse, Heart surgery, Intensive care, Intensive care unit, Intensive care unit patients, Late onset, Logistic regression analysis, Mechanical ventilation, Ndings, Nosocomial, Nosocomial infections, Nosocomial pneumonia, Numerical evaluation, Odds ratio, Oral antiseptics, Oral care, Oral cavity, Oral colonization, Oral decontamination, Oral hygiene, Oral mucosa, Oral swabbing, Oropharyngeal colonization, Other hand, Outcome variables hospitalization, Pathogen, Periodontal, Periodontal status, Periodontol, Plaque, Plaque index, Pneumonia, Pneumonia development, Present study, Previous studies, Prps, Quantifying colonies, Randomized, Randomized trial, Respir crit care, Respiratory pathogens, Scannapieco, Standard deviation, Statistical analysis, Study groups, Study protocol, Swabbing, Tooth staining, Topical application, Ventilatorassociated pneumonia.
- Teeft :
- Acinetobacter species, Acute physiology, Adverse events, Apache, Average length, Bacterial colonization, Baseline characteristics, Buccal mucosa, Chlorhexidine, Chlorhexidine gluconate, Chlorhexidine mouthrinses, Chronic health evaluation, Clin, Clin periodontol brecx, Clinical trials, Colonization, Common pathogen, Control group, Control groups, Crit, Crit care, Decontamination, Dental plaque, Dentate patients, Development rate, Development risk, Endotracheal tube, Gluconate, Head nurse, Heart surgery, Intensive care, Intensive care unit, Intensive care unit patients, Late onset, Logistic regression analysis, Mechanical ventilation, Ndings, Nosocomial, Nosocomial infections, Nosocomial pneumonia, Numerical evaluation, Odds ratio, Oral antiseptics, Oral care, Oral cavity, Oral colonization, Oral decontamination, Oral hygiene, Oral mucosa, Oral swabbing, Oropharyngeal colonization, Other hand, Outcome variables hospitalization, Pathogen, Periodontal, Periodontal status, Periodontol, Plaque, Plaque index, Pneumonia, Pneumonia development, Present study, Previous studies, Prps, Quantifying colonies, Randomized, Randomized trial, Respir crit care, Respiratory pathogens, Scannapieco, Standard deviation, Statistical analysis, Study groups, Study protocol, Swabbing, Tooth staining, Topical application, Ventilatorassociated pneumonia.
Abstract
Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S
Url:
DOI: 10.1111/j.1600-0765.2012.01470.x
Links to Exploration step
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<profileDesc><abstract xml:lang="en" style="main"><p><hi rend="italic">Özçaka Ö, Başoğlu ÖK, Buduneli N, Taşbakan MS, Bacakoğlu F, Kinane DF. Chlorhexidine decreases the risk of ventilator‐associated pneumonia in intensive care unit patients: a randomized clinical trial. J Periodont Res 2012; 47: 584–592. © 2012 John Wiley & Sons A/S</hi>
</p>
<p><hi rend="bold">Background and Objective: </hi>
The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</p>
<p><hi rend="bold">Material and Methods: </hi>
Sixty‐one dentate patients scheduled for invasive mechanical ventilation for at least 48 h were included in this randomized, double‐blind, controlled study. As these patients were variably incapacitated, oral care was provided by swabbing the oral mucosa four times/d with CHX in the CHX group (29 patients) and with saline in the control group (32 patients). Clinical periodontal measurements were recorded, and lower‐respiratory‐tract specimens were obtained for microbiological analysis on admission and when VAP was suspected. Pathogens were identified by quantifying colonies using standard culture techniques.</p>
<p><hi rend="bold">Results: </hi>
Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; <hi rend="italic">p</hi>
= 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). <hi rend="italic">Acinetobacter baumannii</hi>
was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</p>
<p><hi rend="bold">Conclusion: </hi>
The finding of the present study, that oral care with CHX swabbing reduces the risk of VAP development in mechanically ventilated patients, strongly supports its use in ICUs and indeed the importance of adequate oral hygiene in preventing medical complications.</p>
</abstract>
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<p><b>Background and Objective: </b>
The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</p>
<p><b>Material and Methods: </b>
Sixty‐one dentate patients scheduled for invasive mechanical ventilation for at least 48 h were included in this randomized, double‐blind, controlled study. As these patients were variably incapacitated, oral care was provided by swabbing the oral mucosa four times/d with CHX in the CHX group (29 patients) and with saline in the control group (32 patients). Clinical periodontal measurements were recorded, and lower‐respiratory‐tract specimens were obtained for microbiological analysis on admission and when VAP was suspected. Pathogens were identified by quantifying colonies using standard culture techniques.</p>
<p><b>Results: </b>
Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; <i>p</i>
= 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). <i>Acinetobacter baumannii</i>
was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</p>
<p><b>Conclusion: </b>
The finding of the present study, that oral care with CHX swabbing reduces the risk of VAP development in mechanically ventilated patients, strongly supports its use in ICUs and indeed the importance of adequate oral hygiene in preventing medical complications.</p>
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<abstract>Background and Objective: The aim was to evaluate whether oral swabbing with 0.2% chlorhexidine gluconate (CHX) decreases the risk of ventilator‐associated pneumonia (VAP) in intensive care unit (ICU) patients.</abstract>
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<abstract>Results: Ventilator‐associated pneumonia developed in 34/61 patients (55.7%) within 6.8 d. The VAP development rate was significantly higher in the control group than in the CHX group (68.8% vs. 41.4%, respectively; p = 0.03) with an odds ratio of 3.12 (95% confidence interval = 1.09–8.91). Acinetobacter baumannii was the most common pathogen (64.7%) of all species identified. There were no significant differences between the two groups in clinical periodontal measurements, VAP development time, pathogens detected or mortality rate.</abstract>
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