Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats
Identifieur interne : 000419 ( Pmc/Checkpoint ); précédent : 000418; suivant : 000420Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats
Auteurs : Melissa A. Wren-Dail ; Robert T. Dauchy ; David E. Blask ; Steven M. Hill ; Tara G. Ooms [États-Unis] ; Lynell M. Dupepe [États-Unis] ; Rudolf P. Bohm [États-Unis]Source :
- Comparative Medicine [ 1532-0820 ] ; 2017.
Abstract
Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO2 anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO2 (70% CO2, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague–Dawley rats (Crl:SD;
Url:
PubMed: 28381314
PubMed Central: 5402733
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO<sub>2</sub>
anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO<sub>2</sub>
(70% CO<sub>2</sub>
, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague–Dawley rats (Crl:SD; <italic>n</italic>
= 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod. After 1 wk of acclimation, a series of 6 low-volume blood draws were collected by cardiocentesis under anesthesia using isoflurane (10 min or less) compared with CO<sub>2</sub>
(1 min or less) at a single circadian time point every 4 d (0400, 0800, 1200, 1600, 2000, or 2400) over 3 wk to assess arterial blood glucose, lactic acid, and potassium and plasma melatonin, leptin, insulin, total fatty acids, and corticosterone concentrations. Results revealed that plasma levels (mean ± SEM) of melatonin were low (11 ± 1 pg/mL) during the light phase in both groups but were significantly lower during the dark phase in the isoflurane group (48 ± 6 pg/mL) compared with the CO<sub>2</sub>
group (162 ± 18 pg/mL). In addition, prominent circadian rhythms of arterial plasma levels of corticosterone, glucose, total fatty acids, lactic acid, and potassium were altered in the isoflurane group compared with the CO<sub>2</sub>
group. These findings demonstrate that the normal circadian rhythms of endocrine physiology and metabolism observed during brief CO<sub>2</sub>
anesthesia in rats are markedly disrupted by isoflurane anesthesia.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Comp Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Comp. Med</journal-id>
<journal-id journal-id-type="publisher-id">cm</journal-id>
<journal-title-group><journal-title>Comparative Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1532-0820</issn>
<publisher><publisher-name>American Association for Laboratory Animal Science</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28381314</article-id>
<article-id pub-id-type="pmc">5402733</article-id>
<article-id pub-id-type="publisher-id">2017000138</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Rat Models</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of Isoflurane Anesthesia on Circadian Metabolism and Physiology in Rats</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wren-Dail</surname>
<given-names>Melissa A</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dauchy</surname>
<given-names>Robert T</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blask</surname>
<given-names>David E</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hill</surname>
<given-names>Steven M</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ooms</surname>
<given-names>Tara G</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dupepe</surname>
<given-names>Lynell M</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bohm</surname>
<given-names>Rudolf P</given-names>
<suffix>Jr</suffix>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<aff id="aff1">Departments of<label>1</label>
Structural and Cellular Biology and</aff>
<aff id="aff2"><label>2</label>
Comparative Medicine, Tulane University School of Medicine, New Orleans, Louisiana</aff>
<aff id="aff3"><label>3</label>
Section of Laboratory Animal Medicine, IIT Research Institute, Chicago, Illinois; and</aff>
<aff id="aff4"><label>4</label>
Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author: Email: <email>mwren@tulane.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>4</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><month>4</month>
<year>2017</year>
</pub-date>
<volume>67</volume>
<issue>2</issue>
<fpage>138</fpage>
<lpage>146</lpage>
<history><date date-type="received"><day>17</day>
<month>5</month>
<year>2016</year>
</date>
<date date-type="rev-recd"><day>01</day>
<month>7</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>13</day>
<month>11</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© American Association for Laboratory Animal Science</copyright-statement>
<copyright-year>2017</copyright-year>
</permissions>
<abstract><p>Isoflurane anesthesia alters the blood levels of several neuroendocrine hormones associated with normal metabolism and physiology and increases stress, but the effect of brief CO<sub>2</sub>
anesthesia on these parameters is unknown. In this study, we examined the effects of isoflurane (4%) compared with brief CO<sub>2</sub>
(70% CO<sub>2</sub>
, 30% air) anesthesia on circadian rhythms of plasma measures of physiology and metabolism. Adult male Sprague–Dawley rats (Crl:SD; <italic>n</italic>
= 6 per group) were maintained on a 12:12-h light:dark (300 lx; lights on, 0600) photoperiod. After 1 wk of acclimation, a series of 6 low-volume blood draws were collected by cardiocentesis under anesthesia using isoflurane (10 min or less) compared with CO<sub>2</sub>
(1 min or less) at a single circadian time point every 4 d (0400, 0800, 1200, 1600, 2000, or 2400) over 3 wk to assess arterial blood glucose, lactic acid, and potassium and plasma melatonin, leptin, insulin, total fatty acids, and corticosterone concentrations. Results revealed that plasma levels (mean ± SEM) of melatonin were low (11 ± 1 pg/mL) during the light phase in both groups but were significantly lower during the dark phase in the isoflurane group (48 ± 6 pg/mL) compared with the CO<sub>2</sub>
group (162 ± 18 pg/mL). In addition, prominent circadian rhythms of arterial plasma levels of corticosterone, glucose, total fatty acids, lactic acid, and potassium were altered in the isoflurane group compared with the CO<sub>2</sub>
group. These findings demonstrate that the normal circadian rhythms of endocrine physiology and metabolism observed during brief CO<sub>2</sub>
anesthesia in rats are markedly disrupted by isoflurane anesthesia.</p>
</abstract>
<kwd-group><title>Abbreviation</title>
<kwd>TFA, total fatty acids</kwd>
</kwd-group>
<counts><page-count count="9"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Louisiane</li>
</region>
</list>
<tree><noCountry><name sortKey="Blask, David E" sort="Blask, David E" uniqKey="Blask D" first="David E" last="Blask">David E. Blask</name>
<name sortKey="Dauchy, Robert T" sort="Dauchy, Robert T" uniqKey="Dauchy R" first="Robert T" last="Dauchy">Robert T. Dauchy</name>
<name sortKey="Hill, Steven M" sort="Hill, Steven M" uniqKey="Hill S" first="Steven M" last="Hill">Steven M. Hill</name>
<name sortKey="Wren Dail, Melissa A" sort="Wren Dail, Melissa A" uniqKey="Wren Dail M" first="Melissa A" last="Wren-Dail">Melissa A. Wren-Dail</name>
</noCountry>
<country name="États-Unis"><region name="Illinois"><name sortKey="Ooms, Tara G" sort="Ooms, Tara G" uniqKey="Ooms T" first="Tara G" last="Ooms">Tara G. Ooms</name>
</region>
<name sortKey="Bohm, Rudolf P" sort="Bohm, Rudolf P" uniqKey="Bohm R" first="Rudolf P" last="Bohm">Rudolf P. Bohm</name>
<name sortKey="Dupepe, Lynell M" sort="Dupepe, Lynell M" uniqKey="Dupepe L" first="Lynell M" last="Dupepe">Lynell M. Dupepe</name>
</country>
</tree>
</affiliations>
</record>
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