Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis
Identifieur interne : 000249 ( Ncbi/Merge ); précédent : 000248; suivant : 000250Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis
Auteurs : K. Nagashima [Allemagne] ; H. Wege [Allemagne] ; R. Meyermann [Allemagne] ; V. Ter Meulen [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1978.
Descripteurs français
- KwdFr :
- Animaux, Axones (ultrastructure), Chiasma optique (ultrastructure), Encéphale (ultrastructure), Encéphalomyélite (anatomopathologie), Facteurs temps, Infections à Coronaviridae (anatomopathologie), Maladies démyélinisantes (anatomopathologie), Microscopie électronique, Moelle spinale (ultrastructure), Neurones (ultrastructure), Plasmocytes (ultrastructure), Pont (ultrastructure), Rats.
- MESH :
- anatomopathologie : Encéphalomyélite, Infections à Coronaviridae, Maladies démyélinisantes.
- ultrastructure : Animaux, Axones, Chiasma optique, Encéphale, Facteurs temps, Microscopie électronique, Moelle spinale, Neurones, Plasmocytes, Pont, Rats.
English descriptors
- KwdEn :
- Animals, Axons (ultrastructure), Brain (ultrastructure), Coronaviridae Infections (pathology), Demyelinating Diseases (pathology), Encephalomyelitis (pathology), Microscopy, Electron, Neurons (ultrastructure), Optic Chiasm (ultrastructure), Plasma Cells (ultrastructure), Pons (ultrastructure), Rats, Spinal Cord (ultrastructure), Time Factors.
- MESH :
- pathology : Coronaviridae Infections, Demyelinating Diseases, Encephalomyelitis.
- ultrastructure : Axons, Brain, Neurons, Optic Chiasm, Plasma Cells, Pons, Spinal Cord.
- Animals, Microscopy, Electron, Rats, Time Factors.
Abstract
Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found.
Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.
Url:
DOI: 10.1007/BF00691641
PubMed: 212923
PubMed Central: 7086507
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PMC:7086507Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found.</p>
<p>Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</p>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis</title>
<author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K." last="Nagashima">K. Nagashima</name>
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<institution>University of Würzburg,</institution>
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Versbacher Landstr. 7, D-8700 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
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Versbacher Landstr. 7, D-8700 Würzburg, Germany</nlm:aff>
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<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name>
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<institution>Institute of Virology and Immunbiology,</institution>
<institution>University of Würzburg,</institution>
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Versbacher Landstr. 7, D-8700 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Versbacher Landstr. 7, D-8700 Würzburg</wicri:regionArea>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.8379.5</institution-id>
<institution-id institution-id-type="ISNI">0000000119588658</institution-id>
<institution>Institute of Virology and Immunbiology,</institution>
<institution>University of Würzburg,</institution>
</institution-wrap>
Versbacher Landstr. 7, D-8700 Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Versbacher Landstr. 7, D-8700 Würzburg</wicri:regionArea>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
<wicri:noRegion>D-8700 Würzburg</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Acta Neuropathologica</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><date when="1978">1978</date>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found.</p>
<p>Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bailey, O T" uniqKey="Bailey O">O. T. Bailey</name>
</author>
<author><name sortKey="Pappenheimer, A M" uniqKey="Pappenheimer A">A. M. Pappenheimer</name>
</author>
<author><name sortKey="Cheever, F S" uniqKey="Cheever F">F. S. Cheever</name>
</author>
<author><name sortKey="Daniels, J B" uniqKey="Daniels J">J. B. Daniels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blumcke, S" uniqKey="Blumcke S">S. Blümcke</name>
</author>
<author><name sortKey="Niedorf, H R" uniqKey="Niedorf H">H. R. Niedorf</name>
</author>
<author><name sortKey="Rode, J" uniqKey="Rode J">J. Rode</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bunge, R P" uniqKey="Bunge R">R. P. Bunge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Field, E J" uniqKey="Field E">E. J. Field</name>
</author>
<author><name sortKey="Raine, C S" uniqKey="Raine C">C. S. Raine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fujita, S" uniqKey="Fujita S">S. Fujita</name>
</author>
<author><name sortKey="Kitamura, T" uniqKey="Kitamura T">T. Kitamura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koestner, A" uniqKey="Koestner A">A. Koestner</name>
</author>
<author><name sortKey="Mccullough, B" uniqKey="Mccullough B">B. McCullough</name>
</author>
<author><name sortKey="Krakowka, G S" uniqKey="Krakowka G">G. S. Krakowka</name>
</author>
<author><name sortKey="Long, J F" uniqKey="Long J">J. F. Long</name>
</author>
<author><name sortKey="Olsen, R G" uniqKey="Olsen R">R. G. Olsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lampert, P W" uniqKey="Lampert P">P. W. Lampert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lampert, P W" uniqKey="Lampert P">P. W. Lampert</name>
</author>
<author><name sortKey="Sims, J K" uniqKey="Sims J">J. K. Sims</name>
</author>
<author><name sortKey="Kinazeff, A J" uniqKey="Kinazeff A">A. J. Kinazeff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, S" uniqKey="Mori S">S. Mori</name>
</author>
<author><name sortKey="Leblond, C P" uniqKey="Leblond C">C. P. Leblond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagashima, K" uniqKey="Nagashima K">K. Nagashima</name>
</author>
<author><name sortKey="Wege, H" uniqKey="Wege H">H. Wege</name>
</author>
<author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V. ter Meulen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raine, C S" uniqKey="Raine C">C. S. Raine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skoff, R P" uniqKey="Skoff R">R. P. Skoff</name>
</author>
<author><name sortKey="Price, D L" uniqKey="Price D">D. L. Price</name>
</author>
<author><name sortKey="Stocks, A" uniqKey="Stocks A">A. Stocks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skoff, R P" uniqKey="Skoff R">R. P. Skoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaughn, J E" uniqKey="Vaughn J">J. E. Vaughn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waksman, B H" uniqKey="Waksman B">B. H. Waksman</name>
</author>
<author><name sortKey="Adams, R D" uniqKey="Adams R">R. D. Adams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weiner, L P" uniqKey="Weiner L">L. P. Weiner</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Wisniewski, H" uniqKey="Wisniewski H">H. Wisniewski</name>
</author>
<author><name sortKey="Raine, C S" uniqKey="Raine C">C. S. Raine</name>
</author>
<author><name sortKey="Kay, W J" uniqKey="Kay W">W. J. Kay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wisniewski, H" uniqKey="Wisniewski H">H. Wisniewski</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.</title>
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<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name>
</author>
<author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R" last="Meyermann">R. Meyermann</name>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.</title>
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</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name>
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<author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R" last="Meyermann">R. Meyermann</name>
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</author>
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<series><title level="j">Acta neuropathologica</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Axons (ultrastructure)</term>
<term>Brain (ultrastructure)</term>
<term>Coronaviridae Infections (pathology)</term>
<term>Demyelinating Diseases (pathology)</term>
<term>Encephalomyelitis (pathology)</term>
<term>Microscopy, Electron</term>
<term>Neurons (ultrastructure)</term>
<term>Optic Chiasm (ultrastructure)</term>
<term>Plasma Cells (ultrastructure)</term>
<term>Pons (ultrastructure)</term>
<term>Rats</term>
<term>Spinal Cord (ultrastructure)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Axones (ultrastructure)</term>
<term>Chiasma optique (ultrastructure)</term>
<term>Encéphale (ultrastructure)</term>
<term>Encéphalomyélite (anatomopathologie)</term>
<term>Facteurs temps</term>
<term>Infections à Coronaviridae (anatomopathologie)</term>
<term>Maladies démyélinisantes (anatomopathologie)</term>
<term>Microscopie électronique</term>
<term>Moelle spinale (ultrastructure)</term>
<term>Neurones (ultrastructure)</term>
<term>Plasmocytes (ultrastructure)</term>
<term>Pont (ultrastructure)</term>
<term>Rats</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalomyélite</term>
<term>Infections à Coronaviridae</term>
<term>Maladies démyélinisantes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronaviridae Infections</term>
<term>Demyelinating Diseases</term>
<term>Encephalomyelitis</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Axons</term>
<term>Brain</term>
<term>Neurons</term>
<term>Optic Chiasm</term>
<term>Plasma Cells</term>
<term>Pons</term>
<term>Spinal Cord</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Microscopy, Electron</term>
<term>Rats</term>
<term>Time Factors</term>
</keywords>
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<term>Axones</term>
<term>Chiasma optique</term>
<term>Encéphale</term>
<term>Facteurs temps</term>
<term>Microscopie électronique</term>
<term>Moelle spinale</term>
<term>Neurones</term>
<term>Plasmocytes</term>
<term>Pont</term>
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<front><div type="abstract" xml:lang="en">Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectabll preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</div>
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