Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.
Identifieur interne : 000E15 ( PubMed/Curation ); précédent : 000E14; suivant : 000E16Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.
Auteurs : K. Nagashima ; H. Wege ; R. Meyermann ; V. Ter MeulenSource :
- Acta neuropathologica [ 0001-6322 ] ; 1978.
Descripteurs français
- KwdFr :
- Animaux, Axones (ultrastructure), Chiasma optique (ultrastructure), Encéphale (ultrastructure), Encéphalomyélite (anatomopathologie), Facteurs temps, Infections à Coronaviridae (anatomopathologie), Maladies démyélinisantes (anatomopathologie), Microscopie électronique, Moelle spinale (ultrastructure), Neurones (ultrastructure), Plasmocytes (ultrastructure), Pont (ultrastructure), Rats.
- MESH :
- anatomopathologie : Encéphalomyélite, Infections à Coronaviridae, Maladies démyélinisantes.
- ultrastructure : Animaux, Axones, Chiasma optique, Encéphale, Facteurs temps, Microscopie électronique, Moelle spinale, Neurones, Plasmocytes, Pont, Rats.
English descriptors
- KwdEn :
- Animals, Axons (ultrastructure), Brain (ultrastructure), Coronaviridae Infections (pathology), Demyelinating Diseases (pathology), Encephalomyelitis (pathology), Microscopy, Electron, Neurons (ultrastructure), Optic Chiasm (ultrastructure), Plasma Cells (ultrastructure), Pons (ultrastructure), Rats, Spinal Cord (ultrastructure), Time Factors.
- MESH :
- pathology : Coronaviridae Infections, Demyelinating Diseases, Encephalomyelitis.
- ultrastructure : Axons, Brain, Neurons, Optic Chiasm, Plasma Cells, Pons, Spinal Cord.
- Animals, Microscopy, Electron, Rats, Time Factors.
Abstract
Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectabll preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.
DOI: 10.1007/bf00691641
PubMed: 212923
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Ter Meulen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1978">1978</date><idno type="RBID">pubmed:212923</idno><idno type="pmid">212923</idno><idno type="doi">10.1007/bf00691641</idno><idno type="wicri:Area/PubMed/Corpus">000E15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E15</idno><idno type="wicri:Area/PubMed/Curation">000E15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.</title><author><name sortKey="Nagashima, K" sort="Nagashima, K" uniqKey="Nagashima K" first="K" last="Nagashima">K. Nagashima</name></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H" last="Wege">H. Wege</name></author><author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R" last="Meyermann">R. Meyermann</name></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V" last="Ter Meulen">V. Ter Meulen</name></author></analytic><series><title level="j">Acta neuropathologica</title><idno type="ISSN">0001-6322</idno><imprint><date when="1978" type="published">1978</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Axons (ultrastructure)</term><term>Brain (ultrastructure)</term><term>Coronaviridae Infections (pathology)</term><term>Demyelinating Diseases (pathology)</term><term>Encephalomyelitis (pathology)</term><term>Microscopy, Electron</term><term>Neurons (ultrastructure)</term><term>Optic Chiasm (ultrastructure)</term><term>Plasma Cells (ultrastructure)</term><term>Pons (ultrastructure)</term><term>Rats</term><term>Spinal Cord (ultrastructure)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Axones (ultrastructure)</term><term>Chiasma optique (ultrastructure)</term><term>Encéphale (ultrastructure)</term><term>Encéphalomyélite (anatomopathologie)</term><term>Facteurs temps</term><term>Infections à Coronaviridae (anatomopathologie)</term><term>Maladies démyélinisantes (anatomopathologie)</term><term>Microscopie électronique</term><term>Moelle spinale (ultrastructure)</term><term>Neurones (ultrastructure)</term><term>Plasmocytes (ultrastructure)</term><term>Pont (ultrastructure)</term><term>Rats</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalomyélite</term><term>Infections à Coronaviridae</term><term>Maladies démyélinisantes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronaviridae Infections</term><term>Demyelinating Diseases</term><term>Encephalomyelitis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Axons</term><term>Brain</term><term>Neurons</term><term>Optic Chiasm</term><term>Plasma Cells</term><term>Pons</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Microscopy, Electron</term><term>Rats</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Animaux</term><term>Axones</term><term>Chiasma optique</term><term>Encéphale</term><term>Facteurs temps</term><term>Microscopie électronique</term><term>Moelle spinale</term><term>Neurones</term><term>Plasmocytes</term><term>Pont</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectabll preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">212923</PMID><DateCompleted><Year>1978</Year><Month>12</Month><Day>27</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-6322</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>1</Issue><PubDate><Year>1978</Year><Month>Oct</Month><Day>13</Day></PubDate></JournalIssue><Title>Acta neuropathologica</Title><ISOAbbreviation>Acta Neuropathol.</ISOAbbreviation></Journal><ArticleTitle>Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis.</ArticleTitle><Pagination><MedlinePgn>63-70</MedlinePgn></Pagination><Abstract><AbstractText>Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectabll preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nagashima</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Wege</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Meyermann</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>ter Meulen</LastName><ForeName>V</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Acta Neuropathol</MedlineTA><NlmUniqueID>0412041</NlmUniqueID><ISSNLinking>0001-6322</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName 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