In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus
Identifieur interne : 000D42 ( Main/Merge ); précédent : 000D41; suivant : 000D43In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus
Auteurs : Lan Li ; Xiaoming Yu ; Haoming Zhang ; Haiwei Cheng ; Liting Hou ; Qisheng Zheng ; Jibo HouSource :
- Virus Genes [ 0920-8569 ] ; 2019.
Abstract
Griffithsin is a lectin with potent antiviral activity against enveloped viruses. The objective of this study was to assess Griffithsin’s inhibitory effect on porcine epidemic diarrhea virus (PEDV). The results showed that Griffithsin reduced PEDV infection of Vero cells by approximately 82.8%. Moreover, using time-of-addition assays and RT-qPCR, we found that delayed addition of Griffithsin had a weaker inhibitory effect on PEDV than earlier treatment. The mechanism of Griffithsin’s action against PEDV involved both preventing viral attachment to host cells and disrupting cell-to-cell transmission; its dual mode of action distinguished Griffithsin from most other antiviral drugs. In conclusion, Griffithsin was identified as a potent PEDV inhibitor and may represent a candidate drug for preventing PEDV infection.
Url:
DOI: 10.1007/s11262-019-01633-7
PubMed: 30637608
PubMed Central: 7089098
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PMC:7089098Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="Par1">Griffithsin is a lectin with potent antiviral activity against enveloped viruses. The objective of this study was to assess Griffithsin’s inhibitory effect on porcine epidemic diarrhea virus (PEDV). The results showed that Griffithsin reduced PEDV infection of Vero cells by approximately 82.8%. Moreover, using time-of-addition assays and RT-qPCR, we found that delayed addition of Griffithsin had a weaker inhibitory effect on PEDV than earlier treatment. The mechanism of Griffithsin’s action against PEDV involved both preventing viral attachment to host cells and disrupting cell-to-cell transmission; its dual mode of action distinguished Griffithsin from most other antiviral drugs. In conclusion, Griffithsin was identified as a potent PEDV inhibitor and may represent a candidate drug for preventing PEDV infection.</p>
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