CovidSeniorV1, Main, Exploration, bibRecord, 000247

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

Identifieur interne : 000247 ( Main/Exploration ); précédent : 000246; suivant : 000248

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

Auteurs : Pengfei Wang [États-Unis] ; Lihong Liu [États-Unis] ; Manoj S. Nair [États-Unis] ; Michael T. Yin [États-Unis] ; Yang Luo [États-Unis] ; Qian Wang [États-Unis] ; Ting Yuan [États-Unis] ; Kanako Mori [États-Unis] ; Axel Guzman Solis [États-Unis] ; Masahiro Yamashita [États-Unis] ; Ankur Garg [États-Unis] ; Lawrence J. Purpura [États-Unis] ; Justin C. Laracy [États-Unis] ; Jian Yu [États-Unis] ; Leemor Joshua-Tor [États-Unis] ; Joseph Sodroski [États-Unis] ; Yaoxing Huang [États-Unis] ; David D. Ho [États-Unis]

Source :

Emerging microbes & infections [ 2222-1751 ] ; 2020.

RBID : pubmed:32930052

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Antigens, Viral (immunology), Betacoronavirus (immunology), Coronavirus Infections (immunology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Neutralization Tests (MeSH), Nucleocapsid (immunology), Pandemics (MeSH), Pneumonia, Viral (immunology), Severity of Illness Index (MeSH), Spike Glycoprotein, Coronavirus (immunology), Viral Envelope Proteins (immunology).
MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins.
- immunology : Betacoronavirus, Coronavirus Infections, Nucleocapsid, Pneumonia, Viral.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neutralization Tests, Pandemics, Severity of Illness Index.

Abstract

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

DOI: 10.1080/22221751.2020.1823890
PubMed: 32930052

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000213
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Le document en format XML

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<author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
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<author><name sortKey="Solis, Axel Guzman" sort="Solis, Axel Guzman" uniqKey="Solis A" first="Axel Guzman" last="Solis">Axel Guzman Solis</name>
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<author><name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name>
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<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
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<author><name sortKey="Joshua Tor, Leemor" sort="Joshua Tor, Leemor" uniqKey="Joshua Tor L" first="Leemor" last="Joshua-Tor">Leemor Joshua-Tor</name>
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<author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name>
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<author><name sortKey="Huang, Yaoxing" sort="Huang, Yaoxing" uniqKey="Huang Y" first="Yaoxing" last="Huang">Yaoxing Huang</name>
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<author><name sortKey="Ho, David D" sort="Ho, David D" uniqKey="Ho D" first="David D" last="Ho">David D. Ho</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.</title>
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<author><name sortKey="Nair, Manoj S" sort="Nair, Manoj S" uniqKey="Nair M" first="Manoj S" last="Nair">Manoj S. Nair</name>
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<author><name sortKey="Yin, Michael T" sort="Yin, Michael T" uniqKey="Yin M" first="Michael T" last="Yin">Michael T. Yin</name>
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<author><name sortKey="Luo, Yang" sort="Luo, Yang" uniqKey="Luo Y" first="Yang" last="Luo">Yang Luo</name>
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<author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA</wicri:regionArea>
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<author><name sortKey="Yuan, Ting" sort="Yuan, Ting" uniqKey="Yuan T" first="Ting" last="Yuan">Ting Yuan</name>
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<author><name sortKey="Mori, Kanako" sort="Mori, Kanako" uniqKey="Mori K" first="Kanako" last="Mori">Kanako Mori</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Solis, Axel Guzman" sort="Solis, Axel Guzman" uniqKey="Solis A" first="Axel Guzman" last="Solis">Axel Guzman Solis</name>
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<placeName><region type="state">État de New York</region>
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<author><name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
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<author><name sortKey="Garg, Ankur" sort="Garg, Ankur" uniqKey="Garg A" first="Ankur" last="Garg">Ankur Garg</name>
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<wicri:regionArea>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Purpura, Lawrence J" sort="Purpura, Lawrence J" uniqKey="Purpura L" first="Lawrence J" last="Purpura">Lawrence J. Purpura</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
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<author><name sortKey="Laracy, Justin C" sort="Laracy, Justin C" uniqKey="Laracy J" first="Justin C" last="Laracy">Justin C. Laracy</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
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<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<affiliation wicri:level="2"><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Joshua Tor, Leemor" sort="Joshua Tor, Leemor" uniqKey="Joshua Tor L" first="Leemor" last="Joshua-Tor">Leemor Joshua-Tor</name>
<affiliation wicri:level="2"><nlm:affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Yaoxing" sort="Huang, Yaoxing" uniqKey="Huang Y" first="Yaoxing" last="Huang">Yaoxing Huang</name>
<affiliation wicri:level="2"><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ho, David D" sort="Ho, David D" uniqKey="Ho D" first="David D" last="Ho">David D. Ho</name>
<affiliation wicri:level="2"><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Emerging microbes & infections</title>
<idno type="eISSN">2222-1751</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antigens, Viral (immunology)</term>
<term>Betacoronavirus (immunology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Neutralization Tests (MeSH)</term>
<term>Nucleocapsid (immunology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Viral Envelope Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps neutralisants (immunologie)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Betacoronavirus (immunologie)</term>
<term>Femelle (MeSH)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Mâle (MeSH)</term>
<term>Nucléocapside (immunologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Tests de neutralisation (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
<term>Antigènes viraux</term>
<term>Betacoronavirus</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Infections à coronavirus</term>
<term>Nucléocapside</term>
<term>Pneumopathie virale</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Nucleocapsid</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps neutralisants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.</ArticleTitle>
<Pagination><MedlinePgn>2091-2093</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1823890</ELocationID>
<Abstract><AbstractText>We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Pengfei</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-2454-7652</Identifier>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Lihong</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nair</LastName>
<ForeName>Manoj S</ForeName>
<Initials>MS</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-5994-3957</Identifier>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Michael T</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qian</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yuan</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mori</LastName>
<ForeName>Kanako</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solis</LastName>
<ForeName>Axel Guzman</ForeName>
<Initials>AG</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamashita</LastName>
<ForeName>Masahiro</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garg</LastName>
<ForeName>Ankur</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Purpura</LastName>
<ForeName>Lawrence J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laracy</LastName>
<ForeName>Justin C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Joshua-Tor</LastName>
<ForeName>Leemor</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sodroski</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yaoxing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ho</LastName>
<ForeName>David D</ForeName>
<Initials>DD</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
</MedlineJournalInfo>
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</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019251" MajorTopicYN="N">Nucleocapsid</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
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</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">antibody</Keyword>
<Keyword MajorTopicYN="N">neutralization</Keyword>
<Keyword MajorTopicYN="N">non-severe</Keyword>
<Keyword MajorTopicYN="N">severe</Keyword>
</KeywordList>
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<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
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<Month>9</Month>
<Day>15</Day>
<Hour>8</Hour>
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</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>État de New York</li>
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</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Wang, Pengfei" sort="Wang, Pengfei" uniqKey="Wang P" first="Pengfei" last="Wang">Pengfei Wang</name>
</region>
<name sortKey="Garg, Ankur" sort="Garg, Ankur" uniqKey="Garg A" first="Ankur" last="Garg">Ankur Garg</name>
<name sortKey="Ho, David D" sort="Ho, David D" uniqKey="Ho D" first="David D" last="Ho">David D. Ho</name>
<name sortKey="Huang, Yaoxing" sort="Huang, Yaoxing" uniqKey="Huang Y" first="Yaoxing" last="Huang">Yaoxing Huang</name>
<name sortKey="Joshua Tor, Leemor" sort="Joshua Tor, Leemor" uniqKey="Joshua Tor L" first="Leemor" last="Joshua-Tor">Leemor Joshua-Tor</name>
<name sortKey="Laracy, Justin C" sort="Laracy, Justin C" uniqKey="Laracy J" first="Justin C" last="Laracy">Justin C. Laracy</name>
<name sortKey="Liu, Lihong" sort="Liu, Lihong" uniqKey="Liu L" first="Lihong" last="Liu">Lihong Liu</name>
<name sortKey="Luo, Yang" sort="Luo, Yang" uniqKey="Luo Y" first="Yang" last="Luo">Yang Luo</name>
<name sortKey="Mori, Kanako" sort="Mori, Kanako" uniqKey="Mori K" first="Kanako" last="Mori">Kanako Mori</name>
<name sortKey="Nair, Manoj S" sort="Nair, Manoj S" uniqKey="Nair M" first="Manoj S" last="Nair">Manoj S. Nair</name>
<name sortKey="Purpura, Lawrence J" sort="Purpura, Lawrence J" uniqKey="Purpura L" first="Lawrence J" last="Purpura">Lawrence J. Purpura</name>
<name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name>
<name sortKey="Solis, Axel Guzman" sort="Solis, Axel Guzman" uniqKey="Solis A" first="Axel Guzman" last="Solis">Axel Guzman Solis</name>
<name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
<name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name>
<name sortKey="Yin, Michael T" sort="Yin, Michael T" uniqKey="Yin M" first="Michael T" last="Yin">Michael T. Yin</name>
<name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<name sortKey="Yuan, Ting" sort="Yuan, Ting" uniqKey="Yuan T" first="Ting" last="Yuan">Ting Yuan</name>
</country>
</tree>
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SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

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