SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility.
Identifieur interne : 000246 ( Main/Exploration ); précédent : 000245; suivant : 000247SARS-CoV-2 sample-to-answer nucleic acid testing in a tertiary care emergency department: evaluation and utility.
Auteurs : Pia Jokela [Finlande] ; Anu E. J Skel Inen [Finlande] ; Hanna Jarva [Finlande] ; Tanja Holma [Finlande] ; Maarit J. Ahava [Finlande] ; Laura Mannonen [Finlande] ; Maija Lappalainen [Finlande] ; Satu Kurkela [Finlande] ; Raisa Loginov [Finlande]Source :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Finlande (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Jeune adulte (MeSH), Mâle (MeSH), Nourrisson (MeSH), Nouveau-né (MeSH), Pandémies (MeSH), Partie nasale du pharynx (virologie), Pneumopathie virale (diagnostic), Sensibilité et spécificité (MeSH), Service hospitalier d'urgences (statistiques et données numériques), Soins de santé tertiaires (statistiques et données numériques), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Techniques d'amplification d'acides nucléiques (MeSH), Techniques de diagnostic moléculaire (MeSH), Techniques de laboratoire clinique (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Service hospitalier d'urgences, Soins de santé tertiaires.
- virologie : Partie nasale du pharynx.
- Adolescent, Adulte, Adulte d'âge moyen, Betacoronavirus, Enfant, Enfant d'âge préscolaire, Femelle, Finlande, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Pandémies, Sensibilité et spécificité, Sujet âgé, Sujet âgé de 80 ans ou plus, Techniques d'amplification d'acides nucléiques, Techniques de diagnostic moléculaire, Techniques de laboratoire clinique.
- Wicri :
- geographic : Finlande.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Child (MeSH), Child, Preschool (MeSH), Clinical Laboratory Techniques (MeSH), Coronavirus Infections (diagnosis), Emergency Service, Hospital (statistics & numerical data), Female (MeSH), Finland (MeSH), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Male (MeSH), Middle Aged (MeSH), Molecular Diagnostic Techniques (MeSH), Nasopharynx (virology), Nucleic Acid Amplification Techniques (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Sensitivity and Specificity (MeSH), Tertiary Healthcare (statistics & numerical data), Young Adult (MeSH).
- MESH :
- geographic : Finland.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Emergency Service, Hospital, Tertiary Healthcare.
- virology : Nasopharynx.
- Adolescent, Adult, Aged, Aged, 80 and over, Betacoronavirus, Child, Child, Preschool, Clinical Laboratory Techniques, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Molecular Diagnostic Techniques, Nucleic Acid Amplification Techniques, Pandemics, Sensitivity and Specificity, Young Adult.
Abstract
BACKGROUND
Rapid sample-to-answer tests for detection of SARS-CoV-2 are emerging and data on their relative performance is urgently needed.
OBJECTIVES
We evaluated the analytical performance of two rapid nucleic acid tests, Cepheid Xpert® Xpress SARS-CoV-2 and Mobidiag Novodiag® Covid-19, in comparison to a combination reference of three large-scale PCR tests. Moreover, utility of the Novodiag® test in tertiary care emergency departments was assessed.
RESULTS
In the preliminary evaluation, analysis of 90 respiratory samples resulted in 100% specificity and sensitivity for Xpert®, whereas analysis of 107 samples resulted in 93.4% sensitivity and 100% specificity for Novodiag®. Rapid SARS-CoV-2 testing with Novodiag® was made available for four tertiary care emergency departments in Helsinki, Finland between 18 and 31 May, coinciding with a rapidly declining epidemic phase. Altogether 361 respiratory specimens, together with relevant clinical data, were analyzed with Novodiag® and reference tests: 355/361 of the specimens were negative with both methods, and 1/361 was positive in Novodiag® and negative by the reference method. Of the 5 remaining specimens, two were negative with Novodiag®, but positive with the reference method with late Ct values. On average, a test result using Novodiag® was available nearly 8 hours earlier than that obtained with the large-scale PCR tests.
CONCLUSIONS
While the performance of novel sample-to-answer PCR tests need to be carefully evaluated, they may provide timely and reliable results in detection of SARS-CoV-2 and thus facilitate patient management including effective cohorting.
DOI: 10.1016/j.jcv.2020.104614
PubMed: 32889495
PubMed Central: PMC7451096
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Clinical Laboratory Techniques (MeSH)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Emergency Service, Hospital (statistics & numerical data)</term>
<term>Female (MeSH)</term>
<term>Finland (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Infant, Newborn (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Molecular Diagnostic Techniques (MeSH)</term>
<term>Nasopharynx (virology)</term>
<term>Nucleic Acid Amplification Techniques (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Sensitivity and Specificity (MeSH)</term>
<term>Tertiary Healthcare (statistics & numerical data)</term>
<term>Young Adult (MeSH)</term>
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<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Finlande (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Sensibilité et spécificité (MeSH)</term>
<term>Service hospitalier d'urgences (statistiques et données numériques)</term>
<term>Soins de santé tertiaires (statistiques et données numériques)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Techniques d'amplification d'acides nucléiques (MeSH)</term>
<term>Techniques de diagnostic moléculaire (MeSH)</term>
<term>Techniques de laboratoire clinique (MeSH)</term>
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<term>Adult</term>
<term>Aged</term>
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<term>Betacoronavirus</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Clinical Laboratory Techniques</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Molecular Diagnostic Techniques</term>
<term>Nucleic Acid Amplification Techniques</term>
<term>Pandemics</term>
<term>Sensitivity and Specificity</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Finlande</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Techniques d'amplification d'acides nucléiques</term>
<term>Techniques de diagnostic moléculaire</term>
<term>Techniques de laboratoire clinique</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Rapid sample-to-answer tests for detection of SARS-CoV-2 are emerging and data on their relative performance is urgently needed.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>We evaluated the analytical performance of two rapid nucleic acid tests, Cepheid Xpert® Xpress SARS-CoV-2 and Mobidiag Novodiag® Covid-19, in comparison to a combination reference of three large-scale PCR tests. Moreover, utility of the Novodiag® test in tertiary care emergency departments was assessed.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>In the preliminary evaluation, analysis of 90 respiratory samples resulted in 100% specificity and sensitivity for Xpert®, whereas analysis of 107 samples resulted in 93.4% sensitivity and 100% specificity for Novodiag®. Rapid SARS-CoV-2 testing with Novodiag® was made available for four tertiary care emergency departments in Helsinki, Finland between 18 and 31 May, coinciding with a rapidly declining epidemic phase. Altogether 361 respiratory specimens, together with relevant clinical data, were analyzed with Novodiag® and reference tests: 355/361 of the specimens were negative with both methods, and 1/361 was positive in Novodiag® and negative by the reference method. Of the 5 remaining specimens, two were negative with Novodiag®, but positive with the reference method with late Ct values. On average, a test result using Novodiag® was available nearly 8 hours earlier than that obtained with the large-scale PCR tests.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>While the performance of novel sample-to-answer PCR tests need to be carefully evaluated, they may provide timely and reliable results in detection of SARS-CoV-2 and thus facilitate patient management including effective cohorting.</p>
</div>
</front>
</TEI>
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<Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2020.104614</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Rapid sample-to-answer tests for detection of SARS-CoV-2 are emerging and data on their relative performance is urgently needed.</AbstractText>
<AbstractText Label="OBJECTIVES">We evaluated the analytical performance of two rapid nucleic acid tests, Cepheid Xpert® Xpress SARS-CoV-2 and Mobidiag Novodiag® Covid-19, in comparison to a combination reference of three large-scale PCR tests. Moreover, utility of the Novodiag® test in tertiary care emergency departments was assessed.</AbstractText>
<AbstractText Label="RESULTS">In the preliminary evaluation, analysis of 90 respiratory samples resulted in 100% specificity and sensitivity for Xpert®, whereas analysis of 107 samples resulted in 93.4% sensitivity and 100% specificity for Novodiag®. Rapid SARS-CoV-2 testing with Novodiag® was made available for four tertiary care emergency departments in Helsinki, Finland between 18 and 31 May, coinciding with a rapidly declining epidemic phase. Altogether 361 respiratory specimens, together with relevant clinical data, were analyzed with Novodiag® and reference tests: 355/361 of the specimens were negative with both methods, and 1/361 was positive in Novodiag® and negative by the reference method. Of the 5 remaining specimens, two were negative with Novodiag®, but positive with the reference method with late Ct values. On average, a test result using Novodiag® was available nearly 8 hours earlier than that obtained with the large-scale PCR tests.</AbstractText>
<AbstractText Label="CONCLUSIONS">While the performance of novel sample-to-answer PCR tests need to be carefully evaluated, they may provide timely and reliable results in detection of SARS-CoV-2 and thus facilitate patient management including effective cohorting.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jokela</LastName>
<ForeName>Pia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jääskeläinen</LastName>
<ForeName>Anu E</ForeName>
<Initials>AE</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland. Electronic address: anu.e.jaaskelainen@hus.fi.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jarva</LastName>
<ForeName>Hanna</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland; Translational Immunology Research Program and Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holma</LastName>
<ForeName>Tanja</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ahava</LastName>
<ForeName>Maarit J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mannonen</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lappalainen</LastName>
<ForeName>Maija</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurkela</LastName>
<ForeName>Satu</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loginov</LastName>
<ForeName>Raisa</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>HUS Diagnostic Center, HUSLAB, Clinical Microbiology, University of Helsinki and Helsinki University Hospital, Finland.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Clin Virol</MedlineTA>
<NlmUniqueID>9815671</NlmUniqueID>
<ISSNLinking>1386-6532</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004636" MajorTopicYN="N">Emergency Service, Hospital</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005387" MajorTopicYN="N" Type="Geographic">Finland</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025202" MajorTopicYN="Y">Molecular Diagnostic Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021141" MajorTopicYN="Y">Nucleic Acid Amplification Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063128" MajorTopicYN="N">Tertiary Healthcare</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">PCR</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">sample-to-answer</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>07</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>5</Day>
<Hour>12</Hour>
<Minute>30</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32889495</ArticleId>
<ArticleId IdType="pii">S1386-6532(20)30356-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcv.2020.104614</ArticleId>
<ArticleId IdType="pmc">PMC7451096</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Finlande</li>
</country>
</list>
<tree><country name="Finlande"><noRegion><name sortKey="Jokela, Pia" sort="Jokela, Pia" uniqKey="Jokela P" first="Pia" last="Jokela">Pia Jokela</name>
</noRegion>
<name sortKey="Ahava, Maarit J" sort="Ahava, Maarit J" uniqKey="Ahava M" first="Maarit J" last="Ahava">Maarit J. Ahava</name>
<name sortKey="Holma, Tanja" sort="Holma, Tanja" uniqKey="Holma T" first="Tanja" last="Holma">Tanja Holma</name>
<name sortKey="J Skel Inen, Anu E" sort="J Skel Inen, Anu E" uniqKey="J Skel Inen A" first="Anu E" last="J Skel Inen">Anu E. J Skel Inen</name>
<name sortKey="Jarva, Hanna" sort="Jarva, Hanna" uniqKey="Jarva H" first="Hanna" last="Jarva">Hanna Jarva</name>
<name sortKey="Kurkela, Satu" sort="Kurkela, Satu" uniqKey="Kurkela S" first="Satu" last="Kurkela">Satu Kurkela</name>
<name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name>
<name sortKey="Loginov, Raisa" sort="Loginov, Raisa" uniqKey="Loginov R" first="Raisa" last="Loginov">Raisa Loginov</name>
<name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name>
</country>
</tree>
</affiliations>
</record>
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