SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.
Identifieur interne : 000213 ( Main/Corpus ); précédent : 000212; suivant : 000214SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.
Auteurs : Pengfei Wang ; Lihong Liu ; Manoj S. Nair ; Michael T. Yin ; Yang Luo ; Qian Wang ; Ting Yuan ; Kanako Mori ; Axel Guzman Solis ; Masahiro Yamashita ; Ankur Garg ; Lawrence J. Purpura ; Justin C. Laracy ; Jian Yu ; Leemor Joshua-Tor ; Joseph Sodroski ; Yaoxing Huang ; David D. HoSource :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Antibodies, Neutralizing (blood), Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Antigens, Viral (immunology), Betacoronavirus (immunology), Coronavirus Infections (immunology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Neutralization Tests (MeSH), Nucleocapsid (immunology), Pandemics (MeSH), Pneumonia, Viral (immunology), Severity of Illness Index (MeSH), Spike Glycoprotein, Coronavirus (immunology), Viral Envelope Proteins (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins.
- immunology : Betacoronavirus, Coronavirus Infections, Nucleocapsid, Pneumonia, Viral.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neutralization Tests, Pandemics, Severity of Illness Index.
Abstract
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
DOI: 10.1080/22221751.2020.1823890
PubMed: 32930052
Links to Exploration step
pubmed:32930052Le document en format XML
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<author><name sortKey="Nair, Manoj S" sort="Nair, Manoj S" uniqKey="Nair M" first="Manoj S" last="Nair">Manoj S. Nair</name>
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<author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
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<author><name sortKey="Yuan, Ting" sort="Yuan, Ting" uniqKey="Yuan T" first="Ting" last="Yuan">Ting Yuan</name>
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<author><name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name>
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<author><name sortKey="Garg, Ankur" sort="Garg, Ankur" uniqKey="Garg A" first="Ankur" last="Garg">Ankur Garg</name>
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<author><name sortKey="Purpura, Lawrence J" sort="Purpura, Lawrence J" uniqKey="Purpura L" first="Lawrence J" last="Purpura">Lawrence J. Purpura</name>
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<author><name sortKey="Laracy, Justin C" sort="Laracy, Justin C" uniqKey="Laracy J" first="Justin C" last="Laracy">Justin C. Laracy</name>
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</affiliation>
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<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
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<author><name sortKey="Joshua Tor, Leemor" sort="Joshua Tor, Leemor" uniqKey="Joshua Tor L" first="Leemor" last="Joshua-Tor">Leemor Joshua-Tor</name>
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</affiliation>
</author>
<author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name>
<affiliation><nlm:affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huang, Yaoxing" sort="Huang, Yaoxing" uniqKey="Huang Y" first="Yaoxing" last="Huang">Yaoxing Huang</name>
<affiliation><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ho, David D" sort="Ho, David D" uniqKey="Ho D" first="David D" last="Ho">David D. Ho</name>
<affiliation><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.</title>
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</affiliation>
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<author><name sortKey="Liu, Lihong" sort="Liu, Lihong" uniqKey="Liu L" first="Lihong" last="Liu">Lihong Liu</name>
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<author><name sortKey="Nair, Manoj S" sort="Nair, Manoj S" uniqKey="Nair M" first="Manoj S" last="Nair">Manoj S. Nair</name>
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<author><name sortKey="Yin, Michael T" sort="Yin, Michael T" uniqKey="Yin M" first="Michael T" last="Yin">Michael T. Yin</name>
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</affiliation>
</author>
<author><name sortKey="Luo, Yang" sort="Luo, Yang" uniqKey="Luo Y" first="Yang" last="Luo">Yang Luo</name>
<affiliation><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
<affiliation><nlm:affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yuan, Ting" sort="Yuan, Ting" uniqKey="Yuan T" first="Ting" last="Yuan">Ting Yuan</name>
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</affiliation>
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<author><name sortKey="Mori, Kanako" sort="Mori, Kanako" uniqKey="Mori K" first="Kanako" last="Mori">Kanako Mori</name>
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</affiliation>
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<author><name sortKey="Solis, Axel Guzman" sort="Solis, Axel Guzman" uniqKey="Solis A" first="Axel Guzman" last="Solis">Axel Guzman Solis</name>
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</affiliation>
</author>
<author><name sortKey="Yamashita, Masahiro" sort="Yamashita, Masahiro" uniqKey="Yamashita M" first="Masahiro" last="Yamashita">Masahiro Yamashita</name>
<affiliation><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garg, Ankur" sort="Garg, Ankur" uniqKey="Garg A" first="Ankur" last="Garg">Ankur Garg</name>
<affiliation><nlm:affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Purpura, Lawrence J" sort="Purpura, Lawrence J" uniqKey="Purpura L" first="Lawrence J" last="Purpura">Lawrence J. Purpura</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laracy, Justin C" sort="Laracy, Justin C" uniqKey="Laracy J" first="Justin C" last="Laracy">Justin C. Laracy</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
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</affiliation>
</author>
<author><name sortKey="Joshua Tor, Leemor" sort="Joshua Tor, Leemor" uniqKey="Joshua Tor L" first="Leemor" last="Joshua-Tor">Leemor Joshua-Tor</name>
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</affiliation>
</author>
<author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name>
<affiliation><nlm:affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huang, Yaoxing" sort="Huang, Yaoxing" uniqKey="Huang Y" first="Yaoxing" last="Huang">Yaoxing Huang</name>
<affiliation><nlm:affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ho, David D" sort="Ho, David D" uniqKey="Ho D" first="David D" last="Ho">David D. Ho</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Antibodies, Neutralizing (immunology)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antigens, Viral (immunology)</term>
<term>Betacoronavirus (immunology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Neutralization Tests (MeSH)</term>
<term>Nucleocapsid (immunology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
<term>Viral Envelope Proteins (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term>
<term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Nucleocapsid</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Severity of Illness Index</term>
</keywords>
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<front><div type="abstract" xml:lang="en">We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
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<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
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<ArticleTitle>SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.</ArticleTitle>
<Pagination><MedlinePgn>2091-2093</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1823890</ELocationID>
<Abstract><AbstractText>We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Pengfei</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-2454-7652</Identifier>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Lihong</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nair</LastName>
<ForeName>Manoj S</ForeName>
<Initials>MS</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-5994-3957</Identifier>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Michael T</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qian</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yuan</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mori</LastName>
<ForeName>Kanako</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solis</LastName>
<ForeName>Axel Guzman</ForeName>
<Initials>AG</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamashita</LastName>
<ForeName>Masahiro</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garg</LastName>
<ForeName>Ankur</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Purpura</LastName>
<ForeName>Lawrence J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laracy</LastName>
<ForeName>Justin C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Joshua-Tor</LastName>
<ForeName>Leemor</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sodroski</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yaoxing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ho</LastName>
<ForeName>David D</ForeName>
<Initials>DD</Initials>
<AffiliationInfo><Affiliation>Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType>
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<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019251" MajorTopicYN="N">Nucleocapsid</DescriptorName>
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<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
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</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">antibody</Keyword>
<Keyword MajorTopicYN="N">neutralization</Keyword>
<Keyword MajorTopicYN="N">non-severe</Keyword>
<Keyword MajorTopicYN="N">severe</Keyword>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>15</Day>
<Hour>8</Hour>
<Minute>43</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32930052</ArticleId>
<ArticleId IdType="doi">10.1080/22221751.2020.1823890</ArticleId>
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