A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine.
Identifieur interne : 001498 ( Main/Corpus ); précédent : 001497; suivant : 001499A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine.
Auteurs : E. Maillart ; S. Leemans ; H. Van Noten ; T. Vandergraesen ; B. Mahadeb ; M T Salaouatchi ; D. De Bels ; P. ClevenberghSource :
- Infectious diseases (London, England) [ 2374-4243 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Azithromycin (therapeutic use), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Blood Transfusion (MeSH), COVID-19 (MeSH), Continuous Renal Replacement Therapy (MeSH), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Drug Therapy, Combination (MeSH), Enzyme Inhibitors (adverse effects), Enzyme Inhibitors (therapeutic use), Glucosephosphate Dehydrogenase Deficiency (complications), Haptoglobins (analysis), Hemolysis (MeSH), Humans (MeSH), Hydroxychloroquine (adverse effects), Hydroxychloroquine (therapeutic use), Hypoxia (chemically induced), Hypoxia (complications), Male (MeSH), Nasopharynx (virology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy), Respiratory Distress Syndrome (complications), SARS Virus (genetics), SARS Virus (isolation & purification), SARS-CoV-2 (MeSH).
- MESH :
- chemical , adverse effects : Enzyme Inhibitors, Hydroxychloroquine.
- chemical , analysis : Haptoglobins.
- chemical , therapeutic use : Azithromycin, Enzyme Inhibitors, Hydroxychloroquine.
- chemically induced : Hypoxia.
- complications : Coronavirus Infections, Glucosephosphate Dehydrogenase Deficiency, Hypoxia, Pneumonia, Viral, Respiratory Distress Syndrome.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, SARS Virus.
- isolation & purification : Betacoronavirus, SARS Virus.
- virology : Nasopharynx.
- Aged, Blood Transfusion, COVID-19, Continuous Renal Replacement Therapy, Drug Therapy, Combination, Hemolysis, Humans, Male, Pandemics, SARS-CoV-2.
Abstract
While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. Use of hydroxychloroquine has been popularised on mass media and put forward as a valid treatment option without strong evidence of efficacy. Hydroxychloroquine (HCQ) has its own side effects, some of which are very serious like acute haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Side effects may be worse than the disease itself. Belgian national treatment guidelines recommend the use of HCQ in mild to severe COVID-19 disease. As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. Results of sound clinical trials are eagerly awaited. We report a case of acute haemolysis leading to admission in intensive care unit and renal failure in a patient with uncovered G6PD deficiency.
DOI: 10.1080/23744235.2020.1774644
PubMed: 32496938
PubMed Central: PMC7284136
Links to Exploration step
pubmed:32496938Le document en format XML
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<term>Betacoronavirus (isolation & purification)</term>
<term>Blood Transfusion (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Continuous Renal Replacement Therapy (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (drug therapy)</term>
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<term>Enzyme Inhibitors (adverse effects)</term>
<term>Enzyme Inhibitors (therapeutic use)</term>
<term>Glucosephosphate Dehydrogenase Deficiency (complications)</term>
<term>Haptoglobins (analysis)</term>
<term>Hemolysis (MeSH)</term>
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<term>Hydroxychloroquine (adverse effects)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Hypoxia (chemically induced)</term>
<term>Hypoxia (complications)</term>
<term>Male (MeSH)</term>
<term>Nasopharynx (virology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Respiratory Distress Syndrome (complications)</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (isolation & purification)</term>
<term>SARS-CoV-2 (MeSH)</term>
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<term>COVID-19</term>
<term>Continuous Renal Replacement Therapy</term>
<term>Drug Therapy, Combination</term>
<term>Hemolysis</term>
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<front><div type="abstract" xml:lang="en">While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. Use of hydroxychloroquine has been popularised on mass media and put forward as a valid treatment option without strong evidence of efficacy. Hydroxychloroquine (HCQ) has its own side effects, some of which are very serious like acute haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Side effects may be worse than the disease itself. Belgian national treatment guidelines recommend the use of HCQ in mild to severe COVID-19 disease. As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. Results of sound clinical trials are eagerly awaited. We report a case of acute haemolysis leading to admission in intensive care unit and renal failure in a patient with uncovered G6PD deficiency.</div>
</front>
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<Abstract><AbstractText>While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. Use of hydroxychloroquine has been popularised on mass media and put forward as a valid treatment option without strong evidence of efficacy. Hydroxychloroquine (HCQ) has its own side effects, some of which are very serious like acute haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Side effects may be worse than the disease itself. Belgian national treatment guidelines recommend the use of HCQ in mild to severe COVID-19 disease. As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. Results of sound clinical trials are eagerly awaited. We report a case of acute haemolysis leading to admission in intensive care unit and renal failure in a patient with uncovered G6PD deficiency.</AbstractText>
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