A current review of COVID-19 for the cardiovascular specialist.
Identifieur interne : 001497 ( Main/Corpus ); précédent : 001496; suivant : 001498A current review of COVID-19 for the cardiovascular specialist.
Auteurs : Joshua P. Lang ; Xiaowen Wang ; Filipe A. Moura ; Hasan K. Siddiqi ; David A. Morrow ; Erin A. BohulaSource :
- American heart journal [ 1097-6744 ] ; 2020.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (therapeutic use), Alanine (analogs & derivatives), Alanine (therapeutic use), Antimalarials (therapeutic use), Antiviral Agents (therapeutic use), Betacoronavirus (immunology), Betacoronavirus (pathogenicity), Biomarkers (blood), COVID-19 (MeSH), Cardiovascular Diseases (complications), Chloroquine (therapeutic use), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Humans (MeSH), Hydroxychloroquine (therapeutic use), Hypoxia (complications), Pandemics (MeSH), Plasma (immunology), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy), Receptor, Angiotensin, Type 2 (metabolism), Risk Factors (MeSH), SARS-CoV-2 (MeSH), Takotsubo Cardiomyopathy (etiology), Virus Internalization (MeSH).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , blood : Biomarkers.
- chemical , metabolism : Receptor, Angiotensin, Type 2.
- chemical , therapeutic use : Adenosine Monophosphate, Alanine, Antimalarials, Antiviral Agents, Chloroquine, Hydroxychloroquine.
- complications : Cardiovascular Diseases, Coronavirus Infections, Hypoxia, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- etiology : Takotsubo Cardiomyopathy.
- immunology : Betacoronavirus, Plasma.
- pathogenicity : Betacoronavirus.
- COVID-19, Humans, Pandemics, Risk Factors, SARS-CoV-2, Virus Internalization.
Abstract
Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system. Cardiovascular risk factors and chronic cardiovascular conditions are prevalent among patients affected by COVID-19 and associated with adverse outcomes. However, whether pre-existing cardiovascular disease is an independent determinant of higher mortality risk with COVID-19 remains uncertain. Acute cardiac injury, manifest by increased blood levels of cardiac troponin, electrocardiographic abnormalities, or myocardial dysfunction, occurs in up to ~60% of hospitalized patients with severe COVID-19. Potential contributors to acute cardiac injury in the setting of COVID-19 include (1) acute changes in myocardial demand and supply due to tachycardia, hypotension, and hypoxemia resulting in type 2 myocardial infarction; (2) acute coronary syndrome due to acute atherothrombosis in a virally induced thrombotic and inflammatory milieu; (3) microvascular dysfunction due to diffuse microthrombi or vascular injury; (4) stress-related cardiomyopathy (Takotsubo syndrome); (5) nonischemic myocardial injury due to a hyperinflammatory cytokine storm; or (6) direct viral cardiomyocyte toxicity and myocarditis. Diffuse thrombosis is emerging as an important contributor to adverse outcomes in patients with COVID-19. Practitioners should be vigilant for cardiovascular complications of COVID-19. Monitoring may include serial cardiac troponin and natriuretic peptides, along with fibrinogen, D-dimer, and inflammatory biomarkers. Management decisions should rely on the clinical assessment for the probability of ongoing myocardial ischemia, as well as alternative nonischemic causes of injury, integrating the level of suspicion for COVID-19.
DOI: 10.1016/j.ahj.2020.04.025
PubMed: 32497913
PubMed Central: PMC7252118
Links to Exploration step
pubmed:32497913Le document en format XML
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<front><div type="abstract" xml:lang="en">Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system. Cardiovascular risk factors and chronic cardiovascular conditions are prevalent among patients affected by COVID-19 and associated with adverse outcomes. However, whether pre-existing cardiovascular disease is an independent determinant of higher mortality risk with COVID-19 remains uncertain. Acute cardiac injury, manifest by increased blood levels of cardiac troponin, electrocardiographic abnormalities, or myocardial dysfunction, occurs in up to ~60% of hospitalized patients with severe COVID-19. Potential contributors to acute cardiac injury in the setting of COVID-19 include (1) acute changes in myocardial demand and supply due to tachycardia, hypotension, and hypoxemia resulting in type 2 myocardial infarction; (2) acute coronary syndrome due to acute atherothrombosis in a virally induced thrombotic and inflammatory milieu; (3) microvascular dysfunction due to diffuse microthrombi or vascular injury; (4) stress-related cardiomyopathy (Takotsubo syndrome); (5) nonischemic myocardial injury due to a hyperinflammatory cytokine storm; or (6) direct viral cardiomyocyte toxicity and myocarditis. Diffuse thrombosis is emerging as an important contributor to adverse outcomes in patients with COVID-19. Practitioners should be vigilant for cardiovascular complications of COVID-19. Monitoring may include serial cardiac troponin and natriuretic peptides, along with fibrinogen, D-dimer, and inflammatory biomarkers. Management decisions should rely on the clinical assessment for the probability of ongoing myocardial ischemia, as well as alternative nonischemic causes of injury, integrating the level of suspicion for COVID-19.</div>
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<Abstract><AbstractText>Although coronavirus disease 2019 (COVID-19) predominantly disrupts the respiratory system, there is accumulating experience that the disease, particularly in its more severe manifestations, also affects the cardiovascular system. Cardiovascular risk factors and chronic cardiovascular conditions are prevalent among patients affected by COVID-19 and associated with adverse outcomes. However, whether pre-existing cardiovascular disease is an independent determinant of higher mortality risk with COVID-19 remains uncertain. Acute cardiac injury, manifest by increased blood levels of cardiac troponin, electrocardiographic abnormalities, or myocardial dysfunction, occurs in up to ~60% of hospitalized patients with severe COVID-19. Potential contributors to acute cardiac injury in the setting of COVID-19 include (1) acute changes in myocardial demand and supply due to tachycardia, hypotension, and hypoxemia resulting in type 2 myocardial infarction; (2) acute coronary syndrome due to acute atherothrombosis in a virally induced thrombotic and inflammatory milieu; (3) microvascular dysfunction due to diffuse microthrombi or vascular injury; (4) stress-related cardiomyopathy (Takotsubo syndrome); (5) nonischemic myocardial injury due to a hyperinflammatory cytokine storm; or (6) direct viral cardiomyocyte toxicity and myocarditis. Diffuse thrombosis is emerging as an important contributor to adverse outcomes in patients with COVID-19. Practitioners should be vigilant for cardiovascular complications of COVID-19. Monitoring may include serial cardiac troponin and natriuretic peptides, along with fibrinogen, D-dimer, and inflammatory biomarkers. Management decisions should rely on the clinical assessment for the probability of ongoing myocardial ischemia, as well as alternative nonischemic causes of injury, integrating the level of suspicion for COVID-19.</AbstractText>
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<ReferenceList><Reference><Citation>Clin Infect Dis. 2011 Feb 15;52(4):447-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2020 May;46(5):846-848</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32125452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Drug Discov. 2020 Mar;19(3):149-150</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32127666</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Heart J. 2020 May 14;41(19):1861-1862</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32267502</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2004 Jan 17;363(9404):203-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14738793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thromb Res. 2020 Jul;191:145-147</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32291094</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2020 Jan 21;141(3):161-171</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31587565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Jul 1;5(7):819-824</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32219357</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Kidney Dis. 2020 Jul;76(1):4-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32276031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mod Pathol. 2005 Jan;18(1):1-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15272286</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2014 May 06;5:3594</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24800825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1996 Mar 1;183(3):949-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8642298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2015 Sep 15;61(6):969-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25991468</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Heart J. 2020 Mar 16;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32176300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2020 May;46(5):854-887</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32222812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Microbiol Infect Dis. 2005 Jan;24(1):44-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15616839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2018 Jan 25;378(4):345-353</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29365305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Jul 1;5(7):811-818</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32219356</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ASAIO J. 2020 May;66(5):472-474</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32243267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 2;395(10234):1417-1418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32325026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Shock. 2015 Jan;43(1):3-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25186837</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1986-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Nephrol Hypertens. 2011 Jan;20(1):62-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21099686</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):347-352</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32214086</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncologist. 2018 Aug;23(8):943-947</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29622697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Intern Med. 2006 Dec 11-25;166(22):2446-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17159009</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2478-2480</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 28;323(16):1612-1614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32191259</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2020 Jun 9;141(23):1930-1936</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32243205</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1839-1841</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32215647</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood Adv. 2018 Nov 27;2(22):3257-3291</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30482765</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 28;323(16):1582-1589</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32219428</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorax. 2004 Mar;59(3):252-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14985565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 May 1;368(6490):489-493</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32179701</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Mar 5;382(10):929-936</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32004427</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2008 Apr;133(1):13-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17374415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2020 May 12;75(18):2352-2371</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32201335</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>mBio. 2018 Mar 6;9(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29511076</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6771-6776</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32054787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2019 Dec 12;381(24):2293-2303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31774950</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2020 Apr 10;295(15):4773-4779</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32094225</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2016 Jan 7;374(1):33-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26735992</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Heart J. 2011 Feb;32(4):404-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21169615</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Jul 1;5(7):802-810</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32211816</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2016 Jun 1;1(3):274-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27438105</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2012 Oct;84(10):1680-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22930518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Mar;55(3):105923</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32070753</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 21;323(15):1488-1494</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32125362</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheumatol. 2017 Jun;69(6):1154-1164</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28245350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Heart Fail. 2020 May;22(5):911-915</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32275347</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2020 May 19;141(20):1648-1655</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32200663</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Cardiol. 2013 Sep 10;167(6):2397-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23474244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Apr 28;323(16):1610-1612</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32129805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32311448</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>mBio. 2013 Aug 06;4(4):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23919993</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Card Fail. 2020 May;26(5):370</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32439095</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Catheter Cardiovasc Interv. 2020 Sep 1;96(3):586-597</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32212409</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Intern Med. 2020 Jul 1;180(7):934-943</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32167524</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JACC Basic Transl Sci. 2020 Apr 10;5(5):518-536</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32292848</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Apr 16;382(16):1564-1567</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32182409</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2007 Oct 4;357(14):1450-1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17914053</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Thromb Haemost. 2020 May;18(5):1233-1234</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32291954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Apr 23;382(17):e38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32268022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Heart Lung Transplant. 2020 May;39(5):405-407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32362390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infection. 2020 Oct;48(5):773-777</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32277408</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Coll Cardiol. 2020 Jul 7;76(1):72-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32305402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1843-1844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32159775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 11;382(24):2327-2336</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32275812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cardiol. 2020 May;17(5):259-260</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32139904</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Haematol. 2020 May;7(5):e362-e363</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32278361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2013 Dec;94(Pt 12):2679-2690</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24077366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Apr 23;382(17):1653-1659</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32227760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2020 May;158(6):1831-1833.e3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32142773</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
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