Biological Roles and Mechanisms of Circular RNA in Human Cancers
Identifieur interne : 000A82 ( Pmc/Curation ); précédent : 000A81; suivant : 000A83Biological Roles and Mechanisms of Circular RNA in Human Cancers
Auteurs : Qing Tang [République populaire de Chine] ; Swei Sunny Hann [République populaire de Chine]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2020.
Abstract
Circular RNA (circRNA) is an intriguing class of RNA with covalently closed-loop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.
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DOI: 10.2147/OTT.S233672
PubMed: NONE
PubMed Central: 7069569
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<author><name sortKey="Tang, Qing" sort="Tang, Qing" uniqKey="Tang Q" first="Qing" last="Tang">Qing Tang</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine</institution>
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,<country>People’s Republic of China</country>
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<author><name sortKey="Hann, Swei Sunny" sort="Hann, Swei Sunny" uniqKey="Hann S" first="Swei Sunny" last="Hann">Swei Sunny Hann</name>
<affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine</institution>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Biological Roles and Mechanisms of Circular RNA in Human Cancers</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Circular RNA (circRNA) is an intriguing class of RNA with covalently closed-loop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Onco Targets Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Onco Targets Ther</journal-id>
<journal-id journal-id-type="publisher-id">OTT</journal-id>
<journal-id journal-id-type="pmc">ott</journal-id>
<journal-title-group><journal-title>OncoTargets and therapy</journal-title>
</journal-title-group>
<issn pub-type="epub">1178-6930</issn>
<publisher><publisher-name>Dove</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">7069569</article-id>
<article-id pub-id-type="publisher-id">233672</article-id>
<article-id pub-id-type="doi">10.2147/OTT.S233672</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Biological Roles and Mechanisms of Circular RNA in Human Cancers</article-title>
<alt-title alt-title-type="running-authors">Tang and Hann</alt-title>
<alt-title alt-title-type="running-title">Tang and Hann</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tang</surname>
<given-names>Qing</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-2030-5285</contrib-id>
<name><surname>Hann</surname>
<given-names>Swei Sunny</given-names>
</name>
<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<aff id="AFF0001"><label>1</label>
<institution>Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine</institution>
,<addr-line>Guangzhou</addr-line>
<addr-line>510120</addr-line>
,<addr-line>Guangdong Province</addr-line>
,<country>People’s Republic of China</country>
</aff>
</contrib-group>
<author-notes><corresp id="AN0001">Correspondence: Swei Sunny Hann <institution>Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine</institution>
, <addr-line>No. 111, Dade Road</addr-line>
, <addr-line>Guangzhou</addr-line>
<addr-line>510120</addr-line>
, <addr-line>Guangdong Province</addr-line>
, <country>People’s Republic of China</country>
<phone>Tel +86 20-39318472</phone>
Email hann2012@outlook.com</corresp>
</author-notes>
<pub-date pub-type="epub"><day>09</day>
<month>3</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><year>2020</year>
</pub-date>
<volume>13</volume>
<fpage>2067</fpage>
<lpage>2092</lpage>
<history><date date-type="received"><day>07</day>
<month>10</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>20</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 Tang and Hann.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>Tang and Hann.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
).</license-p>
</license>
</permissions>
<abstract><title>Abstract</title>
<p>Circular RNA (circRNA) is an intriguing class of RNA with covalently closed-loop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>circRNA</kwd>
<kwd>cancer</kwd>
<kwd>miRNA sponge</kwd>
<kwd>protein scaffolding</kwd>
<kwd>gene splicing and transcription</kwd>
<kwd>biomarker</kwd>
<kwd>therapeutic target</kwd>
</kwd-group>
<counts><fig-count count="2"></fig-count>
<table-count count="2"></table-count>
<ref-count count="263"></ref-count>
<page-count count="26"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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