Targeting viral entry as a strategy for broad-spectrum antivirals
Identifieur interne : 000949 ( Pmc/Curation ); précédent : 000948; suivant : 000950Targeting viral entry as a strategy for broad-spectrum antivirals
Auteurs : Michela Mazzon [Royaume-Uni] ; Mark Marsh [Royaume-Uni]Source :
- F1000Research [ 2046-1402 ] ; 2019.
Abstract
The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.
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DOI: 10.12688/f1000research.19694.1
PubMed: 31559009
PubMed Central: 6743247
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting viral entry as a strategy for broad-spectrum antivirals</title><author><name sortKey="Mazzon, Michela" sort="Mazzon, Michela" uniqKey="Mazzon M" first="Michela" last="Mazzon">Michela Mazzon</name><affiliation wicri:level="1"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Marsh, Mark" sort="Marsh, Mark" uniqKey="Marsh M" first="Mark" last="Marsh">Mark Marsh</name><affiliation wicri:level="1"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31559009</idno><idno type="pmc">6743247</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743247</idno><idno type="RBID">PMC:6743247</idno><idno type="doi">10.12688/f1000research.19694.1</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000949</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000949</idno><idno type="wicri:Area/Pmc/Curation">000949</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000949</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting viral entry as a strategy for broad-spectrum antivirals</title><author><name sortKey="Mazzon, Michela" sort="Mazzon, Michela" uniqKey="Mazzon M" first="Michela" last="Mazzon">Michela Mazzon</name><affiliation wicri:level="1"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Marsh, Mark" sort="Marsh, Mark" uniqKey="Marsh M" first="Mark" last="Marsh">Mark Marsh</name><affiliation wicri:level="1"><nlm:aff id="a1">MRC Laboratory for Molecular Cell Biology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Laboratory for Molecular Cell Biology, University College London, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marsh, M" uniqKey="Marsh M">M Marsh</name></author><author><name sortKey="Helenius, A" uniqKey="Helenius A">A Helenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercer, J" uniqKey="Mercer J">J Mercer</name></author><author><name sortKey="Schelhaas, M" uniqKey="Schelhaas M">M Schelhaas</name></author><author><name sortKey="Helenius, A" uniqKey="Helenius A">A Helenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez San Martin, C" uniqKey="Sanchez San Martin C">C Sánchez-San Martín</name></author><author><name sortKey="Liu, Cy" uniqKey="Liu C">CY Liu</name></author><author><name sortKey="Kielian, M" uniqKey="Kielian M">M Kielian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercer, J" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">F1000Res</journal-id><journal-id journal-id-type="iso-abbrev">F1000Res</journal-id><journal-id journal-id-type="pmc">F1000Research</journal-id><journal-title-group><journal-title>F1000Research</journal-title></journal-title-group><issn pub-type="epub">2046-1402</issn><publisher><publisher-name>F1000 Research Limited</publisher-name><publisher-loc>London, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31559009</article-id><article-id pub-id-type="pmc">6743247</article-id><article-id pub-id-type="doi">10.12688/f1000research.19694.1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group><subj-group><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Targeting viral entry as a strategy for broad-spectrum antivirals</article-title><fn-group content-type="pub-status"><fn><p>[version 1; peer review: 3 approved]</p></fn></fn-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mazzon</surname><given-names>Michela</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Writing – Original Draft Preparation</role><role content-type="http://credit.casrai.org/">Writing – Review & Editing</role><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2462-9925</contrib-id><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Marsh</surname><given-names>Mark</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Funding Acquisition</role><role content-type="http://credit.casrai.org/">Supervision</role><role content-type="http://credit.casrai.org/">Writing – Original Draft Preparation</role><role content-type="http://credit.casrai.org/">Writing – Review & Editing</role><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0213-3259</contrib-id><xref ref-type="corresp" rid="c2">b</xref><xref ref-type="aff" rid="a1">1</xref></contrib><aff id="a1"><label>1</label>MRC Laboratory for Molecular Cell Biology, University College London, London, UK</aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email xlink:href="mailto:m.mazzon@ucl.ac.uk">m.mazzon@ucl.ac.uk</email></corresp><corresp id="c2"><label>b</label><email xlink:href="mailto:m.marsh@ucl.ac.uk">m.marsh@ucl.ac.uk</email></corresp><fn fn-type="COI-statement"><p>No competing interests were disclosed.</p></fn></author-notes><pub-date pub-type="epub"><day>12</day><month>9</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>8</volume><elocation-id>F1000 Faculty Rev-1628</elocation-id><history><date date-type="accepted"><day>30</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>Copyright: © 2019 Mazzon M and Marsh M</copyright-statement><copyright-year>2019</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="f1000research-8-21600.pdf"></self-uri><abstract><p>The process of entry into a host cell is a key step in the life cycle of most viruses. In recent years, there has been a significant increase in our understanding of the routes and mechanisms of entry for a number of these viruses. This has led to the development of novel broad-spectrum antiviral approaches that target host cell proteins and pathways, in addition to strategies focused on individual viruses or virus families. Here we consider a number of these approaches and their broad-spectrum potential.</p></abstract><kwd-group kwd-group-type="author"><kwd>Antiviral</kwd><kwd>Virus entry</kwd><kwd>Endocytosis</kwd><kwd>Virus fusion</kwd><kwd>Broad-spectrum</kwd><kwd>Host-targeted</kwd></kwd-group><funding-group><award-group id="fund-1"><funding-source>Medical Research Council</funding-source><award-id>MC_UU_12018/1</award-id></award-group><funding-statement>The authors are supported by Medical Research Council funding to the MRC-UCL LMCB University Unit (MC_UU_12018/1).</funding-statement><funding-statement><italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic></funding-statement></funding-group></article-meta><notes><sec sec-type="editor-note"><title>Editorial Note on the Review Process</title><p><ext-link ext-link-type="uri" xlink:href="http://f1000research.com/browse/f1000-faculty-reviews">F1000 Faculty Reviews</ext-link> are commissioned from members of the prestigious
<ext-link ext-link-type="uri" xlink:href="http://f1000.com/prime/thefaculty">F1000 Faculty</ext-link> and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions (any comments will already have been addressed in the published version).</p><p>The referees who approved this article are: </p><list list-type="simple" list-content="reviewer-list"><list-item><p><named-content content-type="reviewer-name">Priscilla L Yang</named-content>, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p></fn></p></list-item><list-item><p><named-content content-type="reviewer-name">Graham Simmons</named-content>, Department of Pathology and Laboratory Medicine, University of California, San Francisco , California, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p></fn></p></list-item><list-item><p><named-content content-type="reviewer-name">Jun Wang</named-content>, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tuscon, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p></fn></p></list-item></list></sec></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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