Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome
Identifieur interne : 000948 ( Pmc/Curation ); précédent : 000947; suivant : 000949Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome
Auteurs : David L. Leverenz [États-Unis] ; E. William St. Clair [États-Unis]Source :
- F1000Research [ 2046-1402 ] ; 2019.
Abstract
Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.
Url:
DOI: 10.12688/f1000research.19842.1
PubMed: 31508200
PubMed Central: 6719673
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome</title><author><name sortKey="Leverenz, David L" sort="Leverenz, David L" uniqKey="Leverenz D" first="David L." last="Leverenz">David L. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea></affiliation></author><author><name sortKey="St Clair, E William" sort="St Clair, E William" uniqKey="St Clair E" first="E. William" last="St. Clair">E. William St. Clair</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31508200</idno><idno type="pmc">6719673</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719673</idno><idno type="RBID">PMC:6719673</idno><idno type="doi">10.12688/f1000research.19842.1</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000948</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000948</idno><idno type="wicri:Area/Pmc/Curation">000948</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000948</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome</title><author><name sortKey="Leverenz, David L" sort="Leverenz, David L" uniqKey="Leverenz D" first="David L." last="Leverenz">David L. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea></affiliation></author><author><name sortKey="St Clair, E William" sort="St Clair, E William" uniqKey="St Clair E" first="E. William" last="St. Clair">E. William St. Clair</name><affiliation wicri:level="1"><nlm:aff id="a1">Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110</wicri:regionArea></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sjogren, H" uniqKey="Sjogren H">H Sjögren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author><author><name sortKey="Puechal, X" uniqKey="Puechal X">X Puéchal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Ri" uniqKey="Fox R">RI Fox</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">F1000Res</journal-id><journal-id journal-id-type="iso-abbrev">F1000Res</journal-id><journal-id journal-id-type="pmc">F1000Research</journal-id><journal-title-group><journal-title>F1000Research</journal-title></journal-title-group><issn pub-type="epub">2046-1402</issn><publisher><publisher-name>F1000 Research Limited</publisher-name><publisher-loc>London, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31508200</article-id><article-id pub-id-type="pmc">6719673</article-id><article-id pub-id-type="doi">10.12688/f1000research.19842.1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group><subj-group><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome</article-title><fn-group content-type="pub-status"><fn><p>[version 1; peer review: 2 approved]</p></fn></fn-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Leverenz</surname><given-names>David L.</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Data Curation</role><role content-type="http://credit.casrai.org/">Visualization</role><role content-type="http://credit.casrai.org/">Writing – Original Draft Preparation</role><role content-type="http://credit.casrai.org/">Writing – Review & Editing</role><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2415-0690</contrib-id><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>St. Clair</surname><given-names>E. William</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Data Curation</role><role content-type="http://credit.casrai.org/">Project Administration</role><role content-type="http://credit.casrai.org/">Supervision</role><role content-type="http://credit.casrai.org/">Visualization</role><role content-type="http://credit.casrai.org/">Writing – Original Draft Preparation</role><role content-type="http://credit.casrai.org/">Writing – Review & Editing</role><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref></contrib><aff id="a1"><label>1</label>Department of Medicine, Division of Rheumatology and Immunology, School of Medicine, Duke University, 40 Duke Medicine Circle, Durham, NC, 27110, USA</aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email xlink:href="mailto:eugene.st.clair@duke.edu">eugene.st.clair@duke.edu</email></corresp><fn fn-type="COI-statement"><p><bold>Competing interests: </bold>DLL declares that he has no competing interests. EWS has been a consultant for and received a research grant from Bristol-Myers Squibb and has been a consultant for Viela Bio and Abbvie.</p></fn></author-notes><pub-date pub-type="epub"><day>29</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>8</volume><elocation-id>F1000 Faculty Rev-1532</elocation-id><history><date date-type="accepted"><day>22</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>Copyright: © 2019 Leverenz DL and St. Clair EW</copyright-statement><copyright-year>2019</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="f1000research-8-21770.pdf"></self-uri><abstract><p>Primary Sjögren’s syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and reduced quality of life. Many patients with primary Sjögren’s syndrome also have extraglandular systemic complications, some of which can be organ- or life-threatening. Over the last decade, numerous targeted immunomodulatory therapies for primary Sjögren’s syndrome have failed to show a benefit in clinical trials, and as yet no disease-modifying therapy has been approved for this disease. Herein, we provide an updated review of the clinical trial landscape for primary Sjögren’s syndrome and the numerous efforts to move the field forward, including the development of new classification criteria and outcome measures, the results of recent clinical trials in this field, the challenges faced in the search for effective therapies, and the expanding pipeline of novel therapies under development.</p></abstract><kwd-group kwd-group-type="author"><kwd>Sjögren's Syndrome</kwd><kwd>Sicca</kwd><kwd>Rheumatologic diseases</kwd></kwd-group><funding-group><funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement></funding-group></article-meta><notes><sec sec-type="editor-note"><title>Editorial Note on the Review Process</title><p><ext-link ext-link-type="uri" xlink:href="http://f1000research.com/browse/f1000-faculty-reviews">F1000 Faculty Reviews</ext-link> are commissioned from members of the prestigious
<ext-link ext-link-type="uri" xlink:href="http://f1000.com/prime/thefaculty">F1000 Faculty</ext-link> and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions (any comments will already have been addressed in the published version).</p><p>The referees who approved this article are: </p><list list-type="simple" list-content="reviewer-list"><list-item><p><named-content content-type="reviewer-name">Robert Fox</named-content>, Scripps Memorial Hospital and Research Foundation, La Jolla, CA, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p></fn></p></list-item><list-item><p><named-content content-type="reviewer-name">Alain Saraux</named-content>, Rheumatology Unit, Centre National de Référence des Maladies Auto-Immunes Rares (CERAINO), LBAI, U1227, Univ Brest, Inserm, CHU Brest, F-29200 Brest, France
<fn fn-type="COI-statement"><p>Competing interests: Dr. Saraux reports grants, personal fees or non-financial support from Abbvie, Bristol Myers Squibb, Lilly, MSD, Novartis, Pfizer, Roche-Chugai, UCB. </p></fn></p></list-item></list></sec></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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