ChloroquineV1, PascalFrancis, Checkpoint, bibRecord, 000032

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Identifieur interne : 000032 ( PascalFrancis/Checkpoint ); précédent : 000031; suivant : 000033

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Auteurs : Masakazu Kono [Japon] ; Koichiro Tatsumi [Japon] ; Alberto M. Imai [Japon] ; Kengo Saito [Japon] ; Takayuki Kuriyama [Japon] ; Hiroshi Shirasawa [Japon]

Source :

Antiviral research [ 0166-3542 ] ; 2008.

RBID : Pascal:08-0128813

Descripteurs français

Pascal (Inist)
- Homme, Coronavirus, Infection, Cellule épithéliale, Poumon, Chloroquine, p38 Mitogen activated protein kinase, Mitogen-activated protein kinase, Mécanisme action, Réplication, Antipaludique, Antiparasitaire, Antirhumatismal, Lignée L132.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antimalarial, Antirheumatic agent, Chloroquine, Coronavirus, Epithelial cell, Human, Infection, Lung, Mechanism of action, Mitogen-activated protein kinase, Parasiticide, Replication, p38 Mitogen activated protein kinase.

Abstract

The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.

Affiliations:

Japon

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Pascal:08-0128813

Le document en format XML

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<front><div type="abstract" xml:lang="en">The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</div>
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<s5>27</s5>
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<fC03 i1="13" i2="X" l="FRE"><s0>Antirhumatismal</s0>
<s5>28</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Antirheumatic agent</s0>
<s5>28</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Antireumático</s0>
<s5>28</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Lignée L132</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fN21><s1>077</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Kono, Masakazu" sort="Kono, Masakazu" uniqKey="Kono M" first="Masakazu" last="Kono">Masakazu Kono</name>
</noRegion>
<name sortKey="Imai, Alberto M" sort="Imai, Alberto M" uniqKey="Imai A" first="Alberto M." last="Imai">Alberto M. Imai</name>
<name sortKey="Kono, Masakazu" sort="Kono, Masakazu" uniqKey="Kono M" first="Masakazu" last="Kono">Masakazu Kono</name>
<name sortKey="Kuriyama, Takayuki" sort="Kuriyama, Takayuki" uniqKey="Kuriyama T" first="Takayuki" last="Kuriyama">Takayuki Kuriyama</name>
<name sortKey="Saito, Kengo" sort="Saito, Kengo" uniqKey="Saito K" first="Kengo" last="Saito">Kengo Saito</name>
<name sortKey="Shirasawa, Hiroshi" sort="Shirasawa, Hiroshi" uniqKey="Shirasawa H" first="Hiroshi" last="Shirasawa">Hiroshi Shirasawa</name>
<name sortKey="Tatsumi, Koichiro" sort="Tatsumi, Koichiro" uniqKey="Tatsumi K" first="Koichiro" last="Tatsumi">Koichiro Tatsumi</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK
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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

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