ChloroquineV1, PascalFrancis, Corpus, bibRecord, 000032

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Identifieur interne : 000032 ( PascalFrancis/Corpus ); précédent : 000031; suivant : 000033

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Auteurs : Masakazu Kono ; Koichiro Tatsumi ; Alberto M. Imai ; Kengo Saito ; Takayuki Kuriyama ; Hiroshi Shirasawa

Source :

Antiviral research [ 0166-3542 ] ; 2008.

RBID : Pascal:08-0128813

Descripteurs français

Pascal (Inist)
- Homme, Coronavirus, Infection, Cellule épithéliale, Poumon, Chloroquine, p38 Mitogen activated protein kinase, Mitogen-activated protein kinase, Mécanisme action, Réplication, Antipaludique, Antiparasitaire, Antirhumatismal, Lignée L132.

English descriptors

KwdEn :
- Antimalarial, Antirheumatic agent, Chloroquine, Coronavirus, Epithelial cell, Human, Infection, Lung, Mechanism of action, Mitogen-activated protein kinase, Parasiticide, Replication, p38 Mitogen activated protein kinase.

Abstract

The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 KONO (Masakazu)`
A11	`02`	`1`		`@1 TATSUMI (Koichiro)`
A11	`03`	`1`		`@1 IMAI (Alberto M.)`
A11	`04`	`1`		`@1 SAITO (Kengo)`
A11	`05`	`1`		`@1 KURIYAMA (Takayuki)`
A11	`06`	`1`		`@1 SHIRASAWA (Hiroshi)`
A14	`01`			`@1 Department of Molecular Virology, Chiba University School of Medicine @2 1-8-1 Inohana, Chiba 260-8670 @3 JPN @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Chest Medicine, Chiba University School of Medicine @2 1-8-1 Inohana, Chiba 260-8670 @3 JPN @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A20				`@1 150-152`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18839 @5 354000161878910090`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 1/2 p.`
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A60				`@1 P @3 CC`
A61				`@0 A`
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A66	`01`			`@0 NLD`
C01	`01`		`ENG`	@0 The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.
C02	`01`	`X`		`@0 002B02S05`
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C03	`03`	`X`	`SPA`	`@0 Infección @5 03`
C03	`04`	`X`	`FRE`	`@0 Cellule épithéliale @5 04`
C03	`04`	`X`	`ENG`	`@0 Epithelial cell @5 04`
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C03	`05`	`X`	`SPA`	`@0 Pulmón @5 05`
C03	`06`	`X`	`FRE`	`@0 Chloroquine @2 NK @2 FR @5 06`
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C03	`06`	`X`	`SPA`	`@0 Cloroquina @2 NK @2 FR @5 06`
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C07	`04`	`X`	`FRE`	`@0 Transferases @2 FE`
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C07	`05`	`X`	`FRE`	`@0 Enzyme @2 FE`
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Format Inist (serveur)

NO :	PASCAL 08-0128813 INIST
ET :	Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK
AU :	KONO (Masakazu); TATSUMI (Koichiro); IMAI (Alberto M.); SAITO (Kengo); KURIYAMA (Takayuki); SHIRASAWA (Hiroshi)
AF :	Department of Molecular Virology, Chiba University School of Medicine/1-8-1 Inohana, Chiba 260-8670/Japon (1 aut., 3 aut., 4 aut., 6 aut.); Department of Chest Medicine, Chiba University School of Medicine/1-8-1 Inohana, Chiba 260-8670/Japon (1 aut., 2 aut., 5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Antiviral research; ISSN 0166-3542; Coden ARSRDR; Pays-Bas; Da. 2008; Vol. 77; No. 2; Pp. 150-152; Bibl. 1/2 p.
LA :	Anglais
EA :	The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.
CC :	002B02S05
FD :	Homme; Coronavirus; Infection; Cellule épithéliale; Poumon; Chloroquine; p38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mécanisme action; Réplication; Antipaludique; Antiparasitaire; Antirhumatismal; Lignée L132
FG :	Coronaviridae; Nidovirales; Virus; Transferases; Enzyme
ED :	Human; Coronavirus; Infection; Epithelial cell; Lung; Chloroquine; p38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mechanism of action; Replication; Antimalarial; Parasiticide; Antirheumatic agent
EG :	Coronaviridae; Nidovirales; Virus; Transferases; Enzyme
SD :	Hombre; Coronavirus; Infección; Célula epitelial; Pulmón; Cloroquina; P38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mecanismo acción; Replicación; Antipalúdico; Antiparasitario; Antireumático
LO :	INIST-18839.354000161878910090
ID :	08-0128813

Links to Exploration step

Pascal:08-0128813

Le document en format XML

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<term>Human</term>
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<term>Lung</term>
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<front><div type="abstract" xml:lang="en">The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</div>
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<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antiviral research</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Homme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Human</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Infection</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Infection</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Infección</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Cellule épithéliale</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Epithelial cell</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Célula epitelial</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Poumon</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Lung</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Pulmón</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Chloroquine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Chloroquine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Cloroquina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>p38 Mitogen activated protein kinase</s0>
<s2>FE</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>p38 Mitogen activated protein kinase</s0>
<s2>FE</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>P38 Mitogen activated protein kinase</s0>
<s2>FE</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Mitogen-activated protein kinase</s0>
<s2>NK</s2>
<s2>FE</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Mitogen-activated protein kinase</s0>
<s2>NK</s2>
<s2>FE</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Mitogen-activated protein kinase</s0>
<s2>NK</s2>
<s2>FE</s2>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Mécanisme action</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Mechanism of action</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Mecanismo acción</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Réplication</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Replication</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Replicación</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Antipaludique</s0>
<s5>26</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Antimalarial</s0>
<s5>26</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Antipalúdico</s0>
<s5>26</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Antiparasitaire</s0>
<s5>27</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Parasiticide</s0>
<s5>27</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Antiparasitario</s0>
<s5>27</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Antirhumatismal</s0>
<s5>28</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Antirheumatic agent</s0>
<s5>28</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Antireumático</s0>
<s5>28</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Lignée L132</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Transferases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fN21><s1>077</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 08-0128813 INIST</NO>
<ET>Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK</ET>
<AU>KONO (Masakazu); TATSUMI (Koichiro); IMAI (Alberto M.); SAITO (Kengo); KURIYAMA (Takayuki); SHIRASAWA (Hiroshi)</AU>
<AF>Department of Molecular Virology, Chiba University School of Medicine/1-8-1 Inohana, Chiba 260-8670/Japon (1 aut., 3 aut., 4 aut., 6 aut.); Department of Chest Medicine, Chiba University School of Medicine/1-8-1 Inohana, Chiba 260-8670/Japon (1 aut., 2 aut., 5 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Antiviral research; ISSN 0166-3542; Coden ARSRDR; Pays-Bas; Da. 2008; Vol. 77; No. 2; Pp. 150-152; Bibl. 1/2 p.</SO>
<LA>Anglais</LA>
<EA>The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, LI 32 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</EA>
<CC>002B02S05</CC>
<FD>Homme; Coronavirus; Infection; Cellule épithéliale; Poumon; Chloroquine; p38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mécanisme action; Réplication; Antipaludique; Antiparasitaire; Antirhumatismal; Lignée L132</FD>
<FG>Coronaviridae; Nidovirales; Virus; Transferases; Enzyme</FG>
<ED>Human; Coronavirus; Infection; Epithelial cell; Lung; Chloroquine; p38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mechanism of action; Replication; Antimalarial; Parasiticide; Antirheumatic agent</ED>
<EG>Coronaviridae; Nidovirales; Virus; Transferases; Enzyme</EG>
<SD>Hombre; Coronavirus; Infección; Célula epitelial; Pulmón; Cloroquina; P38 Mitogen activated protein kinase; Mitogen-activated protein kinase; Mecanismo acción; Replicación; Antipalúdico; Antiparasitario; Antireumático</SD>
<LO>INIST-18839.354000161878910090</LO>
<ID>08-0128813</ID>
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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine : Involvement of p38 MAPK and ERK

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