Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.
Identifieur interne : 000479 ( Ncbi/Merge ); précédent : 000478; suivant : 000480Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.
Auteurs : Yong Li [République populaire de Chine] ; Fengjun Cao [République populaire de Chine] ; Mingxing Li [République populaire de Chine] ; Pindong Li [République populaire de Chine] ; Yuandong Yu [République populaire de Chine] ; Longchao Xiang [République populaire de Chine] ; Tao Xu [République populaire de Chine] ; Jinhua Lei [République populaire de Chine] ; Yun Yan Tai [République populaire de Chine] ; Jianyong Zhu [République populaire de Chine] ; Bingbing Yang [République populaire de Chine] ; Yingpin Jiang [République populaire de Chine] ; Xiufang Zhang [République populaire de Chine] ; Long Duo [République populaire de Chine] ; Ping Chen [République populaire de Chine] ; Xiongjie Yu [République populaire de Chine]Source :
- Journal of experimental & clinical cancer research : CR [ 1756-9966 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (traitement médicamenteux), Cellules A549, Concentration en ions d'hydrogène, Humains, Hydroxychloroquine (administration et posologie), Hydroxychloroquine (pharmacologie), Lignée cellulaire tumorale, Lymphocytes T CD8+ (), Lymphocytes T CD8+ (métabolisme), Lysosomes (), Macrophages (), Macrophages (anatomopathologie), Microenvironnement tumoral (), Prolifération cellulaire (), Régulation de l'expression des gènes tumoraux (), Souris, Survie cellulaire (), Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- administration et posologie : Hydroxychloroquine.
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Macrophages, Tumeurs du poumon.
- métabolisme : Lymphocytes T CD8+.
- pharmacologie : Hydroxychloroquine.
- traitement médicamenteux : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- Animaux, Cellules A549, Concentration en ions d'hydrogène, Humains, Lignée cellulaire tumorale, Lymphocytes T CD8+, Lysosomes, Macrophages, Microenvironnement tumoral, Prolifération cellulaire, Régulation de l'expression des gènes tumoraux, Souris, Survie cellulaire, Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- A549 Cells, ATP Binding Cassette Transporter, Subfamily B (metabolism), Animals, CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (metabolism), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Tumor, Cell Proliferation (drug effects), Cell Survival (drug effects), Drug Synergism, Gene Expression Regulation, Neoplastic (drug effects), Humans, Hydrogen-Ion Concentration, Hydroxychloroquine (administration & dosage), Hydroxychloroquine (pharmacology), Lung Neoplasms (drug therapy), Lung Neoplasms (pathology), Lysosomes (chemistry), Lysosomes (drug effects), Macrophages (drug effects), Macrophages (pathology), Mice, Tumor Microenvironment (drug effects), Xenograft Model Antitumor Assays.
- MESH :
- chemical , administration & dosage : Hydroxychloroquine.
- chemical , metabolism : ATP Binding Cassette Transporter, Subfamily B.
- chemistry : Lysosomes.
- drug effects : CD8-Positive T-Lymphocytes, Cell Proliferation, Cell Survival, Gene Expression Regulation, Neoplastic, Lysosomes, Macrophages, Tumor Microenvironment.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- metabolism : CD8-Positive T-Lymphocytes.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Macrophages.
- chemical , pharmacology : Hydroxychloroquine.
- A549 Cells, Animals, Cell Line, Tumor, Drug Synergism, Humans, Hydrogen-Ion Concentration, Mice, Xenograft Model Antitumor Assays.
Abstract
Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.
DOI: 10.1186/s13046-018-0938-5
PubMed: 30373678
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pubmed:30373678Le document en format XML
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Li, Pindong" sort="Li, Pindong" uniqKey="Li P" first="Pindong" last="Li">Pindong Li</name>
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<author><name sortKey="Yu, Yuandong" sort="Yu, Yuandong" uniqKey="Yu Y" first="Yuandong" last="Yu">Yuandong Yu</name>
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<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
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<author><name sortKey="Xiang, Longchao" sort="Xiang, Longchao" uniqKey="Xiang L" first="Longchao" last="Xiang">Longchao Xiang</name>
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<author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name>
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<author><name sortKey="Lei, Jinhua" sort="Lei, Jinhua" uniqKey="Lei J" first="Jinhua" last="Lei">Jinhua Lei</name>
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<author><name sortKey="Tai, Yun Yan" sort="Tai, Yun Yan" uniqKey="Tai Y" first="Yun Yan" last="Tai">Yun Yan Tai</name>
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<author><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name>
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<author><name sortKey="Yang, Bingbing" sort="Yang, Bingbing" uniqKey="Yang B" first="Bingbing" last="Yang">Bingbing Yang</name>
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<author><name sortKey="Jiang, Yingpin" sort="Jiang, Yingpin" uniqKey="Jiang Y" first="Yingpin" last="Jiang">Yingpin Jiang</name>
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<author><name sortKey="Zhang, Xiufang" sort="Zhang, Xiufang" uniqKey="Zhang X" first="Xiufang" last="Zhang">Xiufang Zhang</name>
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<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
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<author><name sortKey="Duo, Long" sort="Duo, Long" uniqKey="Duo L" first="Long" last="Duo">Long Duo</name>
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<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
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<author><name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<series><title level="j">Journal of experimental & clinical cancer research : CR</title>
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<term>ATP Binding Cassette Transporter, Subfamily B (metabolism)</term>
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<term>CD8-Positive T-Lymphocytes (drug effects)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>Carcinoma, Non-Small-Cell Lung (drug therapy)</term>
<term>Carcinoma, Non-Small-Cell Lung (pathology)</term>
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<term>Cell Survival (drug effects)</term>
<term>Drug Synergism</term>
<term>Gene Expression Regulation, Neoplastic (drug effects)</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Hydroxychloroquine (administration & dosage)</term>
<term>Hydroxychloroquine (pharmacology)</term>
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<term>Lung Neoplasms (pathology)</term>
<term>Lysosomes (chemistry)</term>
<term>Lysosomes (drug effects)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (pathology)</term>
<term>Mice</term>
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<term>Xenograft Model Antitumor Assays</term>
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<term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term>
<term>Carcinome pulmonaire non à petites cellules (traitement médicamenteux)</term>
<term>Cellules A549</term>
<term>Concentration en ions d'hydrogène</term>
<term>Humains</term>
<term>Hydroxychloroquine (administration et posologie)</term>
<term>Hydroxychloroquine (pharmacologie)</term>
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<term>Lymphocytes T CD8+ ()</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
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<term>Souris</term>
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<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
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<term>Drug Synergism</term>
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<term>Mice</term>
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<term>Cellules A549</term>
<term>Concentration en ions d'hydrogène</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
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<term>Lysosomes</term>
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<term>Régulation de l'expression des gènes tumoraux</term>
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<front><div type="abstract" xml:lang="en">Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30373678</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-9966</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>37</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Oct</Month>
<Day>29</Day>
</PubDate>
</JournalIssue>
<Title>Journal of experimental & clinical cancer research : CR</Title>
<ISOAbbreviation>J. Exp. Clin. Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.</ArticleTitle>
<Pagination><MedlinePgn>259</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13046-018-0938-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The effects of combined treatment on non-small cell lung cancer (NSCLC) were investigated using cell viability assays and animal models. The influence of HCQ on lysosomal pH was evaluated by lysosomal sensors and confocal microscopy. The effects of HCQ on the tumour immune microenvironment were analysed by flow cytometry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">HCQ elevates the lysosomal pH of cancer cells to inactivate P-gp while increasing drug release from the lysosome into the nucleus. Furthermore, single HCQ therapy inhibits lung cancer by inducing macrophage-modulated anti-tumour CD8<sup>+</sup>
T cell immunity. Moreover, HCQ could promote the transition of M2 tumour-associated macrophages (TAMs) into M1-like macrophages, leading to CD8<sup>+</sup>
T cell infiltration into the tumour microenvironment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HCQ exerts anti-NSCLC cells effects by reversing the drug sequestration in lysosomes and enhancing the CD8<sup>+</sup>
T cell immune response. These findings suggest that HCQ could act as a promising chemo-sensitizer and immune regulator for lung cancer chemotherapy in the clinic.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Fengjun</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Mingxing</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Pindong</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Yuandong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiang</LastName>
<ForeName>Longchao</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lei</LastName>
<ForeName>Jinhua</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tai</LastName>
<ForeName>Yun Yan</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Jianyong</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Bingbing</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Teaching practice base of Oncology, Shiyan Renmin Hospital, Jinzhou Medical University, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Yingpin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiufang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Teaching practice base of Oncology, Shiyan Renmin Hospital, Jinzhou Medical University, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duo</LastName>
<ForeName>Long</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Xiongjie</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China. yuxiongjie2002@163.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Cancer Research, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, China. yuxiongjie2002@163.com.</Affiliation>
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</Author>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>81702767</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>81502697</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2017CFB246</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2016CFB374</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2018CFC874</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>WJ2017Q035</GrantID>
<Agency>Hubei Province Health and Family Planning Scientific Research Project</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>02.03.2013-80</GrantID>
<Agency>Union Hospital Key Laboratory Foundation of Biological Target Therapy</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>YWJKJJHKYJJ-B17241-Q1</GrantID>
<Agency>Beijing medical and health foundation</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>03328</GrantID>
<Agency>the Scientific Research Foundation for Doctors of Shiyan Renmin Hospital</Agency>
<Country></Country>
</Grant>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>29</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>England</Country>
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<NlmUniqueID>8308647</NlmUniqueID>
<ISSNLinking>0392-9078</ISSNLinking>
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<NameOfSubstance UI="D018435">ATP Binding Cassette Transporter, Subfamily B</NameOfSubstance>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Cao, Fengjun" sort="Cao, Fengjun" uniqKey="Cao F" first="Fengjun" last="Cao">Fengjun Cao</name>
<name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name>
<name sortKey="Duo, Long" sort="Duo, Long" uniqKey="Duo L" first="Long" last="Duo">Long Duo</name>
<name sortKey="Jiang, Yingpin" sort="Jiang, Yingpin" uniqKey="Jiang Y" first="Yingpin" last="Jiang">Yingpin Jiang</name>
<name sortKey="Lei, Jinhua" sort="Lei, Jinhua" uniqKey="Lei J" first="Jinhua" last="Lei">Jinhua Lei</name>
<name sortKey="Li, Mingxing" sort="Li, Mingxing" uniqKey="Li M" first="Mingxing" last="Li">Mingxing Li</name>
<name sortKey="Li, Pindong" sort="Li, Pindong" uniqKey="Li P" first="Pindong" last="Li">Pindong Li</name>
<name sortKey="Tai, Yun Yan" sort="Tai, Yun Yan" uniqKey="Tai Y" first="Yun Yan" last="Tai">Yun Yan Tai</name>
<name sortKey="Xiang, Longchao" sort="Xiang, Longchao" uniqKey="Xiang L" first="Longchao" last="Xiang">Longchao Xiang</name>
<name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name>
<name sortKey="Yang, Bingbing" sort="Yang, Bingbing" uniqKey="Yang B" first="Bingbing" last="Yang">Bingbing Yang</name>
<name sortKey="Yu, Xiongjie" sort="Yu, Xiongjie" uniqKey="Yu X" first="Xiongjie" last="Yu">Xiongjie Yu</name>
<name sortKey="Yu, Yuandong" sort="Yu, Yuandong" uniqKey="Yu Y" first="Yuandong" last="Yu">Yuandong Yu</name>
<name sortKey="Zhang, Xiufang" sort="Zhang, Xiufang" uniqKey="Zhang X" first="Xiufang" last="Zhang">Xiufang Zhang</name>
<name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name>
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