ChloroquineV1, PubMed, Curation, bibRecord, 000077

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.

Identifieur interne : 000077 ( PubMed/Curation ); précédent : 000076; suivant : 000078

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.

Source :

Journal of experimental & clinical cancer research : CR [ 1756-9966 ] ; 2018.

RBID : pubmed:30373678

Descripteurs français

KwdFr :
- Animaux, Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (traitement médicamenteux), Cellules A549, Concentration en ions d'hydrogène, Humains, Hydroxychloroquine (administration et posologie), Hydroxychloroquine (pharmacologie), Lignée cellulaire tumorale, Lymphocytes T CD8+ (), Lymphocytes T CD8+ (métabolisme), Lysosomes (), Macrophages (), Macrophages (anatomopathologie), Microenvironnement tumoral (), Prolifération cellulaire (), Régulation de l'expression des gènes tumoraux (), Souris, Survie cellulaire (), Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (traitement médicamenteux).
MESH :
- administration et posologie : Hydroxychloroquine.
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Macrophages, Tumeurs du poumon.
- métabolisme : Lymphocytes T CD8+.
- pharmacologie : Hydroxychloroquine.
- traitement médicamenteux : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- Animaux, Cellules A549, Concentration en ions d'hydrogène, Humains, Lignée cellulaire tumorale, Lymphocytes T CD8+, Lysosomes, Macrophages, Microenvironnement tumoral, Prolifération cellulaire, Régulation de l'expression des gènes tumoraux, Souris, Survie cellulaire, Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe.

English descriptors

KwdEn :
- A549 Cells, ATP Binding Cassette Transporter, Subfamily B (metabolism), Animals, CD8-Positive T-Lymphocytes (drug effects), CD8-Positive T-Lymphocytes (metabolism), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Tumor, Cell Proliferation (drug effects), Cell Survival (drug effects), Drug Synergism, Gene Expression Regulation, Neoplastic (drug effects), Humans, Hydrogen-Ion Concentration, Hydroxychloroquine (administration & dosage), Hydroxychloroquine (pharmacology), Lung Neoplasms (drug therapy), Lung Neoplasms (pathology), Lysosomes (chemistry), Lysosomes (drug effects), Macrophages (drug effects), Macrophages (pathology), Mice, Tumor Microenvironment (drug effects), Xenograft Model Antitumor Assays.
MESH :
- chemical , administration & dosage : Hydroxychloroquine.
- chemical , metabolism : ATP Binding Cassette Transporter, Subfamily B.
- chemistry : Lysosomes.
- drug effects : CD8-Positive T-Lymphocytes, Cell Proliferation, Cell Survival, Gene Expression Regulation, Neoplastic, Lysosomes, Macrophages, Tumor Microenvironment.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- metabolism : CD8-Positive T-Lymphocytes.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Macrophages.
- chemical , pharmacology : Hydroxychloroquine.
- A549 Cells, Animals, Cell Line, Tumor, Drug Synergism, Humans, Hydrogen-Ion Concentration, Mice, Xenograft Model Antitumor Assays.

Abstract

Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.

DOI: 10.1186/s13046-018-0938-5
PubMed: 30373678

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<author><name sortKey="Li, Pindong" sort="Li, Pindong" uniqKey="Li P" first="Pindong" last="Li">Pindong Li</name>
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<author><name sortKey="Yu, Yuandong" sort="Yu, Yuandong" uniqKey="Yu Y" first="Yuandong" last="Yu">Yuandong Yu</name>
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<author><name sortKey="Tai, Yun Yan" sort="Tai, Yun Yan" uniqKey="Tai Y" first="Yun Yan" last="Tai">Yun Yan Tai</name>
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<author><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name>
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<author><name sortKey="Jiang, Yingpin" sort="Jiang, Yingpin" uniqKey="Jiang Y" first="Yingpin" last="Jiang">Yingpin Jiang</name>
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<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
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<author><name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name>
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<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
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<author><name sortKey="Yu, Xiongjie" sort="Yu, Xiongjie" uniqKey="Yu X" first="Xiongjie" last="Yu">Xiongjie Yu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.</title>
<author><name sortKey="Li, Yong" sort="Li, Yong" uniqKey="Li Y" first="Yong" last="Li">Yong Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
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<author><name sortKey="Cao, Fengjun" sort="Cao, Fengjun" uniqKey="Cao F" first="Fengjun" last="Cao">Fengjun Cao</name>
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<country xml:lang="fr">République populaire de Chine</country>
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</affiliation>
</author>
<author><name sortKey="Li, Mingxing" sort="Li, Mingxing" uniqKey="Li M" first="Mingxing" last="Li">Mingxing Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Pindong" sort="Li, Pindong" uniqKey="Li P" first="Pindong" last="Li">Pindong Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yu, Yuandong" sort="Yu, Yuandong" uniqKey="Yu Y" first="Yuandong" last="Yu">Yuandong Yu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xiang, Longchao" sort="Xiang, Longchao" uniqKey="Xiang L" first="Longchao" last="Xiang">Longchao Xiang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lei, Jinhua" sort="Lei, Jinhua" uniqKey="Lei J" first="Jinhua" last="Lei">Jinhua Lei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tai, Yun Yan" sort="Tai, Yun Yan" uniqKey="Tai Y" first="Yun Yan" last="Tai">Yun Yan Tai</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Bingbing" sort="Yang, Bingbing" uniqKey="Yang B" first="Bingbing" last="Yang">Bingbing Yang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jiang, Yingpin" sort="Jiang, Yingpin" uniqKey="Jiang Y" first="Yingpin" last="Jiang">Yingpin Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Xiufang" sort="Zhang, Xiufang" uniqKey="Zhang X" first="Xiufang" last="Zhang">Xiufang Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duo, Long" sort="Duo, Long" uniqKey="Duo L" first="Long" last="Duo">Long Duo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yu, Xiongjie" sort="Yu, Xiongjie" uniqKey="Yu X" first="Xiongjie" last="Yu">Xiongjie Yu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China. yuxiongjie2002@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei</wicri:regionArea>
</affiliation>
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<series><title level="j">Journal of experimental & clinical cancer research : CR</title>
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<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term>
<term>ATP Binding Cassette Transporter, Subfamily B (metabolism)</term>
<term>Animals</term>
<term>CD8-Positive T-Lymphocytes (drug effects)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>Carcinoma, Non-Small-Cell Lung (drug therapy)</term>
<term>Carcinoma, Non-Small-Cell Lung (pathology)</term>
<term>Cell Line, Tumor</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cell Survival (drug effects)</term>
<term>Drug Synergism</term>
<term>Gene Expression Regulation, Neoplastic (drug effects)</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Hydroxychloroquine (administration & dosage)</term>
<term>Hydroxychloroquine (pharmacology)</term>
<term>Lung Neoplasms (drug therapy)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Lysosomes (chemistry)</term>
<term>Lysosomes (drug effects)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (pathology)</term>
<term>Mice</term>
<term>Tumor Microenvironment (drug effects)</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term>
<term>Carcinome pulmonaire non à petites cellules (traitement médicamenteux)</term>
<term>Cellules A549</term>
<term>Concentration en ions d'hydrogène</term>
<term>Humains</term>
<term>Hydroxychloroquine (administration et posologie)</term>
<term>Hydroxychloroquine (pharmacologie)</term>
<term>Lignée cellulaire tumorale</term>
<term>Lymphocytes T CD8+ ()</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
<term>Lysosomes ()</term>
<term>Macrophages ()</term>
<term>Macrophages (anatomopathologie)</term>
<term>Microenvironnement tumoral ()</term>
<term>Prolifération cellulaire ()</term>
<term>Régulation de l'expression des gènes tumoraux ()</term>
<term>Souris</term>
<term>Survie cellulaire ()</term>
<term>Synergie des médicaments</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ATP Binding Cassette Transporter, Subfamily B</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term>
<term>Macrophages</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lysosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Cell Proliferation</term>
<term>Cell Survival</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Lysosomes</term>
<term>Macrophages</term>
<term>Tumor Microenvironment</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term>
<term>Lung Neoplasms</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term>
<term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Drug Synergism</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Mice</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules A549</term>
<term>Concentration en ions d'hydrogène</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Lymphocytes T CD8+</term>
<term>Lysosomes</term>
<term>Macrophages</term>
<term>Microenvironnement tumoral</term>
<term>Prolifération cellulaire</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Synergie des médicaments</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
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<front><div type="abstract" xml:lang="en">Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30373678</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-9966</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>37</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Oct</Month>
<Day>29</Day>
</PubDate>
</JournalIssue>
<Title>Journal of experimental & clinical cancer research : CR</Title>
<ISOAbbreviation>J. Exp. Clin. Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.</ArticleTitle>
<Pagination><MedlinePgn>259</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13046-018-0938-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy in lung cancer treatment.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The effects of combined treatment on non-small cell lung cancer (NSCLC) were investigated using cell viability assays and animal models. The influence of HCQ on lysosomal pH was evaluated by lysosomal sensors and confocal microscopy. The effects of HCQ on the tumour immune microenvironment were analysed by flow cytometry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">HCQ elevates the lysosomal pH of cancer cells to inactivate P-gp while increasing drug release from the lysosome into the nucleus. Furthermore, single HCQ therapy inhibits lung cancer by inducing macrophage-modulated anti-tumour CD8<sup>+</sup>
 T cell immunity. Moreover, HCQ could promote the transition of M2 tumour-associated macrophages (TAMs) into M1-like macrophages, leading to CD8<sup>+</sup>
 T cell infiltration into the tumour microenvironment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">HCQ exerts anti-NSCLC cells effects by reversing the drug sequestration in lysosomes and enhancing the CD8<sup>+</sup>
 T cell immune response. These findings suggest that HCQ could act as a promising chemo-sensitizer and immune regulator for lung cancer chemotherapy in the clinic.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Fengjun</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Mingxing</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Pindong</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Yuandong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiang</LastName>
<ForeName>Longchao</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lei</LastName>
<ForeName>Jinhua</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tai</LastName>
<ForeName>Yun Yan</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Jianyong</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Bingbing</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Teaching practice base of Oncology, Shiyan Renmin Hospital, Jinzhou Medical University, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Yingpin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiufang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Teaching practice base of Oncology, Shiyan Renmin Hospital, Jinzhou Medical University, Shiyan, 442000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Duo</LastName>
<ForeName>Long</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Xiongjie</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang middle Rd, Shiyan, 442000, Hubei, China. yuxiongjie2002@163.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Cancer Research, Renmin Hospital, Hubei University of Medicine, Shiyan, 442000, China. yuxiongjie2002@163.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>81702767</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>81502697</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2017CFB246</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2016CFB374</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2018CFC874</GrantID>
<Agency>Hubei Provincial Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>WJ2017Q035</GrantID>
<Agency>Hubei Province Health and Family Planning Scientific Research Project</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>02.03.2013-80</GrantID>
<Agency>Union Hospital Key Laboratory Foundation of Biological Target Therapy</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>YWJKJJHKYJJ-B17241-Q1</GrantID>
<Agency>Beijing medical and health foundation</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>03328</GrantID>
<Agency>the Scientific Research Foundation for Doctors of Shiyan Renmin Hospital</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Exp Clin Cancer Res</MedlineTA>
<NlmUniqueID>8308647</NlmUniqueID>
<ISSNLinking>0392-9078</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018435">ATP Binding Cassette Transporter, Subfamily B</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018435" MajorTopicYN="N">ATP Binding Cassette Transporter, Subfamily B</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002289" MajorTopicYN="N">Carcinoma, Non-Small-Cell Lung</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008247" MajorTopicYN="N">Lysosomes</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059016" MajorTopicYN="N">Tumor Microenvironment</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023041" MajorTopicYN="N">Xenograft Model Antitumor Assays</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acidification</Keyword>
<Keyword MajorTopicYN="N">Chemotherapy resistance</Keyword>
<Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword>
<Keyword MajorTopicYN="N">Lung cancer</Keyword>
<Keyword MajorTopicYN="N">Lysosome</Keyword>
<Keyword MajorTopicYN="N">Macrophage remodelling</Keyword>
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Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages.

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