Dramatic response of refractory sarcoidosis under ruxolitinib in a patient with associated JAK2-mutated polycythemia.
Identifieur interne : 000478 ( Ncbi/Merge ); précédent : 000477; suivant : 000479Dramatic response of refractory sarcoidosis under ruxolitinib in a patient with associated JAK2-mutated polycythemia.
Auteurs : Cécile Rotenberg [France] ; Valérie Besnard [France] ; Pierre-Yves Brillet [France] ; Stéphane Giraudier [France] ; Hilario Nunes [France] ; Dominique Valeyre [France]Source :
- The European respiratory journal [ 1399-3003 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biopsie, Femelle, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Hydroxychloroquine (usage thérapeutique), Kinase Janus-2 (génétique), Mutation, Polyglobulie primitive essentielle (génétique), Polyglobulie primitive essentielle (traitement médicamenteux), Pyrazoles (usage thérapeutique), Radiographie thoracique, Résultat thérapeutique, Sarcoïdose (génétique), Sarcoïdose (traitement médicamenteux), Tomodensitométrie, Transduction du signal.
- MESH :
- génétique : Kinase Janus-2, Polyglobulie primitive essentielle, Sarcoïdose.
- traitement médicamenteux : Polyglobulie primitive essentielle, Sarcoïdose.
- usage thérapeutique : Hormones corticosurrénaliennes, Hydroxychloroquine, Pyrazoles.
- Adulte d'âge moyen, Biopsie, Femelle, Humains, Mutation, Radiographie thoracique, Résultat thérapeutique, Tomodensitométrie, Transduction du signal.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Biopsy, Female, Humans, Hydroxychloroquine (therapeutic use), Janus Kinase 2 (genetics), Middle Aged, Mutation, Polycythemia Vera (drug therapy), Polycythemia Vera (genetics), Pyrazoles (therapeutic use), Radiography, Thoracic, Sarcoidosis (drug therapy), Sarcoidosis (genetics), Signal Transduction, Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical , genetics : Janus Kinase 2.
- chemical , therapeutic use : Adrenal Cortex Hormones, Hydroxychloroquine, Pyrazoles.
- drug therapy : Polycythemia Vera, Sarcoidosis.
- genetics : Polycythemia Vera, Sarcoidosis.
- Biopsy, Female, Humans, Middle Aged, Mutation, Radiography, Thoracic, Signal Transduction, Tomography, X-Ray Computed, Treatment Outcome.
DOI: 10.1183/13993003.01482-2018
PubMed: 30361243
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000078
- to stream PubMed, to step Curation: 000078
- to stream PubMed, to step Checkpoint: 000113
Links to Exploration step
pubmed:30361243Le document en format XML
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polycythemia.</title><author><name sortKey="Rotenberg, Cecile" sort="Rotenberg, Cecile" uniqKey="Rotenberg C" first="Cécile" last="Rotenberg">Cécile Rotenberg</name><affiliation wicri:level="3"><nlm:affiliation>Dept of Respiratory Diseases, APHP, Avicenne Hospital, Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dept of Respiratory Diseases, APHP, Avicenne Hospital, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Besnard, Valerie" sort="Besnard, Valerie" uniqKey="Besnard V" first="Valérie" last="Besnard">Valérie Besnard</name><affiliation wicri:level="4"><nlm:affiliation>EA 2363 "Hypoxia & the lung: fibrosing pneumonitis, ventilatory and circulatory modulations", UFR SMBH, Université Paris 13, Sorbonne Paris Cite, Bobigny, France.</nlm:affiliation><country 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thérapeutique)</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Kinase Janus-2 (génétique)</term><term>Mutation</term><term>Polyglobulie primitive essentielle (génétique)</term><term>Polyglobulie primitive essentielle (traitement médicamenteux)</term><term>Pyrazoles (usage thérapeutique)</term><term>Radiographie thoracique</term><term>Résultat thérapeutique</term><term>Sarcoïdose (génétique)</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Tomodensitométrie</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Janus Kinase 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Hydroxychloroquine</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Polycythemia Vera</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Polycythemia Vera</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Kinase Janus-2</term><term>Polyglobulie primitive essentielle</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyglobulie primitive essentielle</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term><term>Hydroxychloroquine</term><term>Pyrazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biopsy</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Mutation</term><term>Radiography, Thoracic</term><term>Signal Transduction</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Femelle</term><term>Humains</term><term>Mutation</term><term>Radiographie thoracique</term><term>Résultat thérapeutique</term><term>Tomodensitométrie</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30361243</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>29</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>29</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1399-3003</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>6</Issue><PubDate><Year>2018</Year><Month>12</Month></PubDate></JournalIssue><Title>The European respiratory journal</Title><ISOAbbreviation>Eur. Respir. J.</ISOAbbreviation></Journal><ArticleTitle>Dramatic response of refractory sarcoidosis under ruxolitinib in a patient with associated JAK2-mutated polycythemia.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">1801482</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1183/13993003.01482-2018</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rotenberg</LastName><ForeName>Cécile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Dept of Respiratory Diseases, APHP, Avicenne Hospital, Bobigny, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Besnard</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>EA 2363 "Hypoxia & the lung: fibrosing pneumonitis, ventilatory and circulatory modulations", UFR SMBH, Université Paris 13, Sorbonne Paris Cite, Bobigny, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brillet</LastName><ForeName>Pierre-Yves</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Dept of Radiology, APHP, Avicenne Hospital, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giraudier</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dept of Cellular Biology, INSERM U1131, APHP, Saint Louis Hospital, Paris-Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nunes</LastName><ForeName>Hilario</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Dept of Respiratory Diseases, APHP, Avicenne Hospital, Bobigny, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EA 2363 "Hypoxia & the lung: fibrosing pneumonitis, ventilatory and circulatory modulations", UFR SMBH, Université Paris 13, Sorbonne Paris Cite, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valeyre</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Dept of Respiratory Diseases, APHP, Avicenne Hospital, Bobigny, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EA 2363 "Hypoxia & the lung: fibrosing pneumonitis, ventilatory and circulatory modulations", UFR SMBH, Université Paris 13, Sorbonne Paris Cite, Bobigny, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016422">Letter</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Respir J</MedlineTA><NlmUniqueID>8803460</NlmUniqueID><ISSNLinking>0903-1936</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C540383">INCB018424</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011720">Pyrazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber><NameOfSubstance UI="C507924">JAK2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber><NameOfSubstance UI="D053614">Janus Kinase 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053614" MajorTopicYN="N">Janus Kinase 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011087" MajorTopicYN="N">Polycythemia Vera</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011720" MajorTopicYN="N">Pyrazoles</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013902" MajorTopicYN="N">Radiography, Thoracic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012507" MajorTopicYN="N">Sarcoidosis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>Conflict of interest: C. Rotenberg has nothing to disclose. Conflict of interest: V. Besnard has nothing to disclose. Conflict of interest: P-Y. Brillet has nothing to disclose. Conflict of interest: S. Giraudier reports grants from Novartis. Conflict of interest: H. Nunes reports grants and personal fees for consultancy and research from Roche/Genentech and Boehringer Ingelheim, other (for investigator in clinical trials) from Sanofi and Gilead, outside the submitted work. Conflict of interest: D. Valeyre reports personal fees (scientific advisory board membership) from Boehringer Ingelheim and Roche, personal fees for lecturing from AstraZeneca, and personal fees for travel and accommodation from Boehringer Ingelheim and Roche, outside the submitted work.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30361243</ArticleId><ArticleId IdType="pii">13993003.01482-2018</ArticleId><ArticleId IdType="doi">10.1183/13993003.01482-2018</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Paris</li></settlement><orgName><li>Université Paris 13</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Rotenberg, Cecile" sort="Rotenberg, Cecile" uniqKey="Rotenberg C" first="Cécile" last="Rotenberg">Cécile Rotenberg</name></region><name sortKey="Besnard, Valerie" sort="Besnard, Valerie" uniqKey="Besnard V" first="Valérie" last="Besnard">Valérie Besnard</name><name sortKey="Brillet, Pierre Yves" sort="Brillet, Pierre Yves" uniqKey="Brillet P" first="Pierre-Yves" last="Brillet">Pierre-Yves Brillet</name><name sortKey="Giraudier, Stephane" sort="Giraudier, Stephane" uniqKey="Giraudier S" first="Stéphane" last="Giraudier">Stéphane Giraudier</name><name sortKey="Nunes, Hilario" sort="Nunes, Hilario" uniqKey="Nunes H" first="Hilario" last="Nunes">Hilario Nunes</name><name sortKey="Valeyre, Dominique" sort="Valeyre, Dominique" uniqKey="Valeyre D" first="Dominique" last="Valeyre">Dominique Valeyre</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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