Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Identifieur interne : 000F87 ( Ncbi/Curation ); précédent : 000F86; suivant : 000F88Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Auteurs : Cheng Qin [République populaire de Chine] ; Gang Yang [République populaire de Chine] ; Jinshou Yang [République populaire de Chine] ; Bo Ren [République populaire de Chine] ; Huanyu Wang [République populaire de Chine] ; Guangyu Chen [République populaire de Chine] ; Fangyu Zhao [République populaire de Chine] ; Lei You [République populaire de Chine] ; Weibin Wang [République populaire de Chine] ; Yupei Zhao [République populaire de Chine]Source :
- Molecular Cancer [ 1476-4598 ] ; 2020.
Abstract
Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer.
Url:
DOI: 10.1186/s12943-020-01169-7
PubMed: 32122374
PubMed Central: 7053123
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<front><div type="abstract" xml:lang="en"><p id="Par1">Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer.</p>
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