TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance
Identifieur interne : 003F95 ( Main/Exploration ); précédent : 003F94; suivant : 003F96TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance
Auteurs : Matthew R. Lynch [États-Unis] ; Mei T. Tran [États-Unis] ; Kenneth M. Ralto [États-Unis] ; Zsuzsanna K. Zsengeller [États-Unis] ; Vinod Raman [États-Unis] ; Swati S. Bhasin [États-Unis] ; Nuo Sun [États-Unis] ; Xiuying Chen [États-Unis] ; Daniel Brown [États-Unis] ; Ilsa I. Rovira [États-Unis] ; Kensei Taguchi [États-Unis] ; Craig R. Brooks [États-Unis] ; Isaac E. Stillman [États-Unis] ; Manoj K. Bhasin [États-Unis] ; Toren Finkel [États-Unis] ; Samir M. Parikh [États-Unis]Source :
- JCI Insight [ 2379-3708 ] ; ????.
Abstract
Because injured mitochondria can accelerate cell death through the elaboration of oxidative free radicals and other mediators, it is striking that proliferator γ coactivator 1-α (PGC1α), a stimulator of increased mitochondrial abundance, protects stressed renal cells instead of potentiating injury. Here, we report that PGC1α’s induction of lysosomes via transcription factor EB (TFEB) may be pivotal for kidney protection. CRISPR and stable gene transfer showed that PGC1α-KO tubular cells were sensitized to the genotoxic stressor cisplatin, whereas Tg cells were protected. The biosensor mitochondrial-targeted Keima (mtKeima) unexpectedly revealed that cisplatin blunts mitophagy both in cells and mice. PGC1α and its downstream mediator NAD+ counteracted this effect. PGC1α did not consistently affect known autophagy pathways modulated by cisplatin. Instead RNA sequencing identified coordinated regulation of lysosomal biogenesis via TFEB. This effector pathway was sufficiently important that inhibition of TFEB or lysosomes unveiled a striking harmful effect of excess PGC1α in cells and conditional mice. These results uncover an unexpected effect of cisplatin on mitophagy and PGC1α’s reliance on lysosomes for kidney protection. Finally, the data illuminate TFEB as a potentially novel target for renal tubular stress resistance.
Url:
DOI: 10.1172/jci.insight.126749
PubMed: 30870143
PubMed Central: 6538327
Affiliations:
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Le document en format XML
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<affiliation wicri:level="4"><nlm:aff id="A6">Aging Institute of UPMC and the University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Aging Institute of UPMC and the University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Parikh, Samir M" sort="Parikh, Samir M" uniqKey="Parikh S" first="Samir M." last="Parikh">Samir M. Parikh</name>
<affiliation><nlm:aff id="A1">Division of Nephrology,</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">JCI Insight</title>
<idno type="eISSN">2379-3708</idno>
<imprint><date when="????">????</date>
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<front><div type="abstract" xml:lang="en"><p>Because injured mitochondria can accelerate cell death through the elaboration of oxidative free radicals and other mediators, it is striking that proliferator γ coactivator 1-α (PGC1α), a stimulator of increased mitochondrial abundance, protects stressed renal cells instead of potentiating injury. Here, we report that PGC1α’s induction of lysosomes via transcription factor EB (TFEB) may be pivotal for kidney protection. CRISPR and stable gene transfer showed that PGC1α-KO tubular cells were sensitized to the genotoxic stressor cisplatin, whereas Tg cells were protected. The biosensor mitochondrial-targeted Keima (mtKeima) unexpectedly revealed that cisplatin blunts mitophagy both in cells and mice. PGC1α and its downstream mediator NAD<sup>+</sup>
counteracted this effect. PGC1α did not consistently affect known autophagy pathways modulated by cisplatin. Instead RNA sequencing identified coordinated regulation of lysosomal biogenesis via TFEB. This effector pathway was sufficiently important that inhibition of TFEB or lysosomes unveiled a striking harmful effect of excess PGC1α in cells and conditional mice. These results uncover an unexpected effect of cisplatin on mitophagy and PGC1α’s reliance on lysosomes for kidney protection. Finally, the data illuminate TFEB as a potentially novel target for renal tubular stress resistance.</p>
</div>
</front>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Massachusetts</li>
<li>Pennsylvanie</li>
<li>Tennessee</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
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<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Lynch, Matthew R" sort="Lynch, Matthew R" uniqKey="Lynch M" first="Matthew R." last="Lynch">Matthew R. Lynch</name>
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<name sortKey="Bhasin, Swati S" sort="Bhasin, Swati S" uniqKey="Bhasin S" first="Swati S." last="Bhasin">Swati S. Bhasin</name>
<name sortKey="Brooks, Craig R" sort="Brooks, Craig R" uniqKey="Brooks C" first="Craig R." last="Brooks">Craig R. Brooks</name>
<name sortKey="Brown, Daniel" sort="Brown, Daniel" uniqKey="Brown D" first="Daniel" last="Brown">Daniel Brown</name>
<name sortKey="Chen, Xiuying" sort="Chen, Xiuying" uniqKey="Chen X" first="Xiuying" last="Chen">Xiuying Chen</name>
<name sortKey="Finkel, Toren" sort="Finkel, Toren" uniqKey="Finkel T" first="Toren" last="Finkel">Toren Finkel</name>
<name sortKey="Finkel, Toren" sort="Finkel, Toren" uniqKey="Finkel T" first="Toren" last="Finkel">Toren Finkel</name>
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</country>
</tree>
</affiliations>
</record>
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