Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Identifieur interne : 003289 ( Main/Exploration ); précédent : 003288; suivant : 003290Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Auteurs : Arthur C. Sackeyfio [Ghana] ; Daniel K. Amankwaah [Ghana] ; Alhassan S. Yahaya [Ghana]Source :
- European Journal of Pharmacology [ 0014-2999 ] ; 1987.
English descriptors
- Teeft :
Abstract
Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.
Url:
DOI: 10.1016/0014-2999(87)90193-2
Affiliations:
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<term>Chloroquine</term>
<term>Contractile</term>
<term>Enhancement</term>
<term>Histamine</term>
<term>Indomethacin</term>
<term>Krebs</term>
<term>Krebs solution</term>
<term>Lipoxygenase</term>
<term>Maximal response</term>
<term>Mepacrine</term>
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<front><div type="abstract" xml:lang="en">Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</div>
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