Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Identifieur interne : 000757 ( Istex/Corpus ); précédent : 000756; suivant : 000758Interaction between chloroquine and indomethacin in airways smooth muscle in vivo
Auteurs : Arthur C. Sackeyfio ; Daniel K. Amankwaah ; Alhassan S. YahayaSource :
- European Journal of Pharmacology [ 0014-2999 ] ; 1987.
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- Teeft :
Abstract
Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.
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DOI: 10.1016/0014-2999(87)90193-2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title><author><name sortKey="Sackeyfio, Arthur C" sort="Sackeyfio, Arthur C" uniqKey="Sackeyfio A" first="Arthur C." last="Sackeyfio">Arthur C. Sackeyfio</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author><author><name sortKey="Amankwaah, Daniel K" sort="Amankwaah, Daniel K" uniqKey="Amankwaah D" first="Daniel K." last="Amankwaah">Daniel K. Amankwaah</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author><author><name sortKey="Yahaya, Alhassan S" sort="Yahaya, Alhassan S" uniqKey="Yahaya A" first="Alhassan S." last="Yahaya">Alhassan S. Yahaya</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BE85C510EE976D5C116C6ADE784D6482B00782AD</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1016/0014-2999(87)90193-2</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000757</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000757</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title><author><name sortKey="Sackeyfio, Arthur C" sort="Sackeyfio, Arthur C" uniqKey="Sackeyfio A" first="Arthur C." last="Sackeyfio">Arthur C. Sackeyfio</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author><author><name sortKey="Amankwaah, Daniel K" sort="Amankwaah, Daniel K" uniqKey="Amankwaah D" first="Daniel K." last="Amankwaah">Daniel K. Amankwaah</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author><author><name sortKey="Yahaya, Alhassan S" sort="Yahaya, Alhassan S" uniqKey="Yahaya A" first="Alhassan S." last="Yahaya">Alhassan S. Yahaya</name><affiliation><mods:affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Pharmacology</title><title level="j" type="abbrev">EJP</title><idno type="ISSN">0014-2999</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">137</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="135">135</biblScope><biblScope unit="page" to="138">138</biblScope></imprint><idno type="ISSN">0014-2999</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2999</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetylcholine</term><term>Airway</term><term>Arachidonic</term><term>Bronchospasm</term><term>Chloroquine</term><term>Contractile</term><term>Enhancement</term><term>Histamine</term><term>Indomethacin</term><term>Krebs</term><term>Krebs solution</term><term>Lipoxygenase</term><term>Maximal response</term><term>Mepacrine</term><term>Pharmacol</term><term>Phospholipase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>indomethacin</json:string><json:string>chloroquine</json:string><json:string>histamine</json:string><json:string>bronchospasm</json:string><json:string>phospholipase</json:string><json:string>airway</json:string><json:string>enhancement</json:string><json:string>contractile</json:string><json:string>mepacrine</json:string><json:string>arachidonic</json:string><json:string>lipoxygenase</json:string><json:string>krebs</json:string><json:string>pharmacol</json:string><json:string>krebs solution</json:string><json:string>acetylcholine</json:string><json:string>maximal response</json:string></teeft></keywords><author><json:item><name>Arthur C. Sackeyfio</name><affiliations><json:string>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</json:string></affiliations></json:item><json:item><name>Daniel K. Amankwaah</name><affiliations><json:string>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</json:string></affiliations></json:item><json:item><name>Alhassan S. Yahaya</name><affiliations><json:string>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Chloroquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Indomethacin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Histamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Airways</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Phospholipase A2</value></json:item></subject><arkIstex>ark:/67375/6H6-XNGMVHTL-6</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</abstract><qualityIndicators><score>4.421</score><pdfWordCount>1509</pdfWordCount><pdfCharCount>9692</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>576 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>76</abstractWordCount><abstractCharCount>629</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title><pmid><json:string>3111868</json:string></pmid><pii><json:string>0014-2999(87)90193-2</json:string></pii><genre><json:string>brief-communication</json:string></genre><host><title>European Journal of Pharmacology</title><language><json:string>unknown</json:string></language><publicationDate>1987</publicationDate><issn><json:string>0014-2999</json:string></issn><pii><json:string>S0014-2999(00)X0650-4</json:string></pii><volume>137</volume><issue>1</issue><pages><first>135</first><last>138</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1987</json:string></date><geogName></geogName><orgName><json:string>Ghana Received</json:string><json:string>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Discussion</json:string><json:string>Thomas Ansah</json:string><json:string>J. Blucoo-Allotey</json:string></persName><placeName><json:string>Ghana</json:string><json:string>Kumasi</json:string><json:string>Guinea</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Orehek et al., 1975</json:string><json:string>compare similar observations for mepacrine by Anderson, 1982</json:string><json:string>Authi and Traynor, 1979</json:string><json:string>Blackwell et al., 1978</json:string><json:string>Adcock and Garland, 1980</json:string><json:string>Authi and Traymor, 1979</json:string><json:string>Mitchell (1984)</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-XNGMVHTL-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pharmacology & pharmacy</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - pharmacology & pharmacy</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Pharmacology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate><doi><json:string>10.1016/0014-2999(87)90193-2</json:string></doi><id>BE85C510EE976D5C116C6ADE784D6482B00782AD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1987</date></publicationStmt><notesStmt><note type="brief-communication" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Short communication</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title><author xml:id="author-0000"><persName><forename type="first">Arthur C.</forename><surname>Sackeyfio</surname></persName><affiliation>To whom all correspondence should be addressed: Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana.</affiliation><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Daniel K.</forename><surname>Amankwaah</surname></persName><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Alhassan S.</forename><surname>Yahaya</surname></persName><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation></author><idno type="istex">BE85C510EE976D5C116C6ADE784D6482B00782AD</idno><idno type="ark">ark:/67375/6H6-XNGMVHTL-6</idno><idno type="DOI">10.1016/0014-2999(87)90193-2</idno><idno type="PII">0014-2999(87)90193-2</idno></analytic><monogr><title level="j">European Journal of Pharmacology</title><title level="j" type="abbrev">EJP</title><idno type="pISSN">0014-2999</idno><idno type="PII">S0014-2999(00)X0650-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987"></date><biblScope unit="volume">137</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="135">135</biblScope><biblScope unit="page" to="138">138</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Chloroquine</term></item><item><term>Indomethacin</term></item><item><term>Histamine</term></item><item><term>Airways</term></item><item><term>Phospholipase A2</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1987">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco"><item-info><jid>EJP</jid><aid>87901932</aid><ce:pii>0014-2999(87)90193-2</ce:pii><ce:doi>10.1016/0014-2999(87)90193-2</ce:doi><ce:copyright type="unknown" year="1987"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</ce:title><ce:author-group><ce:author><ce:given-name>Arthur C.</ce:given-name><ce:surname>Sackeyfio</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Daniel K.</ce:given-name><ce:surname>Amankwaah</ce:surname></ce:author><ce:author><ce:given-name>Alhassan S.</ce:given-name><ce:surname>Yahaya</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom all correspondence should be addressed: Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="11" month="12" year="1986"></ce:date-received><ce:date-accepted day="24" month="3" year="1987"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A<ce:inf>2</ce:inf> inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A<ce:inf>2</ce:inf> inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Chloroquine</ce:text></ce:keyword><ce:keyword><ce:text>Indomethacin</ce:text></ce:keyword><ce:keyword><ce:text>Histamine</ce:text></ce:keyword><ce:keyword><ce:text>Airways</ce:text></ce:keyword><ce:keyword><ce:text>Phospholipase A<ce:inf>2</ce:inf></ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Interaction between chloroquine and indomethacin in airways smooth muscle in vivo</title></titleInfo><name type="personal"><namePart type="given">Arthur C.</namePart><namePart type="family">Sackeyfio</namePart><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation><description>To whom all correspondence should be addressed: Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel K.</namePart><namePart type="family">Amankwaah</namePart><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alhassan S.</namePart><namePart type="family">Yahaya</namePart><affiliation>Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1987</dateIssued><copyrightDate encoding="w3cdtf">1987</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The indomethacin-induced enhancement of airways smooth muscle contractility to histamine reported earlier in vitro has now been demonstrated in conscious guinea-pigs. Chloroquine, an anti-malarial drug with phospholipase A2 inhibitory activity, antagonized histamine and also reversed the indomethacin-induced enhancement. These observations indicate that histamine-induced bronchospasm in vivo is modulated by the arachidonate system and that chloroquine-type phospholipase A2 inhibitors may ameliorate such bronchospasm. These findings also explain the observed clinical benefits of chloroquine in chronic asthmatics.</abstract><note type="content">Section title: Short communication</note><subject><genre>Keywords</genre><topic>Chloroquine</topic><topic>Indomethacin</topic><topic>Histamine</topic><topic>Airways</topic><topic>Phospholipase A2</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>EJP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1987</dateIssued></originInfo><identifier type="ISSN">0014-2999</identifier><identifier type="PII">S0014-2999(00)X0650-4</identifier><part><date>1987</date><detail type="volume"><number>137</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>148</end></extent><extent unit="pages"><start>135</start><end>138</end></extent></part></relatedItem><identifier type="istex">BE85C510EE976D5C116C6ADE784D6482B00782AD</identifier><identifier type="ark">ark:/67375/6H6-XNGMVHTL-6</identifier><identifier type="DOI">10.1016/0014-2999(87)90193-2</identifier><identifier type="PII">0014-2999(87)90193-2</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XNGMVHTL-6/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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