ChloroquineV1, Main, Exploration, bibRecord, 003751

Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs

Identifieur interne : 003751 ( Main/Exploration ); précédent : 003750; suivant : 003752

Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs

Auteurs : Gernot Duncker [Allemagne] ; Fred Hartmann [Allemagne] ; Klaus Mohr [Allemagne]

Source :

Naunyn-Schmiedeberg's Archives of Pharmacology [ 0028-1298 ] ; 1982-12-01.

RBID : ISTEX:8DB224E66C7FA77BE4210D4D9DDB5DD84666066F

English descriptors

Abstract

Summary: The influence of three potent lipidosis-inducing agents, i.e. iprindole, triparanol and chloroquine, on the rat adrenal cortex was investigated by determination of the corticosterone excretion in the urine, the responsiveness to ACTH and by determination of the corticosterone content of the adrenals and of the corticosterone concentration in plasma. Administration of iprindole and triparanol left the function of the adrenal cortex unaffected, while under chloroquine treatment an activation with time was observed. Morphologically, similar degrees of lipidosis were found in all experiments. The results demonstrate that the functional capacity of the rat adrenal cortex is not directly correlated to lipidotic alterations.

Url:

https://api.istex.fr/ark:/67375/1BB-TLF7WXG1-9/fulltext.pdf

DOI: 10.1007/BF00498524

Affiliations:

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Le document en format XML

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<term>Chloroquine</term>
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<term>Iprindole</term>
<term>Triparanol</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Acth</term>
<term>Adrenal</term>
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<term>Adrenocortical cells</term>
<term>Adrenocortical function</term>
<term>Adrenocortical system</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Control rats</term>
<term>Corticosterone</term>
<term>Corticosterone concentration</term>
<term>Corticosterone content</term>
<term>Corticosterone excretion</term>
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<term>Cortisol</term>
<term>Excretion</term>
<term>Hartmann</term>
<term>Inclusion bodies</term>
<term>Iprindole</term>
<term>Lipidosis</term>
<term>Lipidotic alterations</term>
<term>Plasma corticosterone</term>
<term>Plasma corticosterone concentration</term>
<term>Triparanol</term>
<term>Urinary corticosterone excretion</term>
<term>Urine</term>
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<front><div type="abstract" xml:lang="en">Summary: The influence of three potent lipidosis-inducing agents, i.e. iprindole, triparanol and chloroquine, on the rat adrenal cortex was investigated by determination of the corticosterone excretion in the urine, the responsiveness to ACTH and by determination of the corticosterone content of the adrenals and of the corticosterone concentration in plasma. Administration of iprindole and triparanol left the function of the adrenal cortex unaffected, while under chloroquine treatment an activation with time was observed. Morphologically, similar degrees of lipidosis were found in all experiments. The results demonstrate that the functional capacity of the rat adrenal cortex is not directly correlated to lipidotic alterations.</div>
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Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs

Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri