Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs
Identifieur interne : 003751 ( Main/Curation ); précédent : 003750; suivant : 003752Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs
Auteurs : Gernot Duncker [Allemagne] ; Fred Hartmann [Allemagne] ; Klaus Mohr [Allemagne]Source :
- Naunyn-Schmiedeberg's Archives of Pharmacology [ 0028-1298 ] ; 1982-12-01.
English descriptors
- KwdEn :
- Teeft :
- Acth, Adrenal, Adrenal cortex, Adrenocortical, Adrenocortical cells, Adrenocortical function, Adrenocortical system, Chloroquine, Chlorphentermine, Control rats, Corticosterone, Corticosterone concentration, Corticosterone content, Corticosterone excretion, Corticosterone synthesis, Cortisol, Excretion, Hartmann, Inclusion bodies, Iprindole, Lipidosis, Lipidotic alterations, Plasma corticosterone, Plasma corticosterone concentration, Triparanol, Urinary corticosterone excretion, Urine, Zona, Zona fasciculata.
Abstract
Summary: The influence of three potent lipidosis-inducing agents, i.e. iprindole, triparanol and chloroquine, on the rat adrenal cortex was investigated by determination of the corticosterone excretion in the urine, the responsiveness to ACTH and by determination of the corticosterone content of the adrenals and of the corticosterone concentration in plasma. Administration of iprindole and triparanol left the function of the adrenal cortex unaffected, while under chloroquine treatment an activation with time was observed. Morphologically, similar degrees of lipidosis were found in all experiments. The results demonstrate that the functional capacity of the rat adrenal cortex is not directly correlated to lipidotic alterations.
Url:
DOI: 10.1007/BF00498524
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000484
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000484
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002510
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003830
Links to Exploration step
ISTEX:8DB224E66C7FA77BE4210D4D9DDB5DD84666066FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs</title>
<author><name sortKey="Duncker, Gernot" sort="Duncker, Gernot" uniqKey="Duncker G" first="Gernot" last="Duncker">Gernot Duncker</name>
</author>
<author><name sortKey="Hartmann, Fred" sort="Hartmann, Fred" uniqKey="Hartmann F" first="Fred" last="Hartmann">Fred Hartmann</name>
</author>
<author><name sortKey="Mohr, Klaus" sort="Mohr, Klaus" uniqKey="Mohr K" first="Klaus" last="Mohr">Klaus Mohr</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8DB224E66C7FA77BE4210D4D9DDB5DD84666066F</idno>
<date when="1982" year="1982">1982</date>
<idno type="doi">10.1007/BF00498524</idno>
<idno type="url">https://api.istex.fr/ark:/67375/1BB-TLF7WXG1-9/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000484</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000484</idno>
<idno type="wicri:Area/Istex/Curation">000484</idno>
<idno type="wicri:Area/Istex/Checkpoint">002510</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002510</idno>
<idno type="wicri:doubleKey">0028-1298:1982:Duncker G:adrenocortical:function:of</idno>
<idno type="wicri:Area/Main/Merge">003830</idno>
<idno type="wicri:Area/Main/Curation">003751</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs</title>
<author><name sortKey="Duncker, Gernot" sort="Duncker, Gernot" uniqKey="Duncker G" first="Gernot" last="Duncker">Gernot Duncker</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung Pharmakologie, Universität Kiel, Hospitalstrasse 4-6, D-2300, Kiel 1</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Fred" sort="Hartmann, Fred" uniqKey="Hartmann F" first="Fred" last="Hartmann">Fred Hartmann</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung Allgemeine innere Medizin, Universität Kiel, Hospitalstrasse 4-6, D-2300, Kiel 1</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mohr, Klaus" sort="Mohr, Klaus" uniqKey="Mohr K" first="Klaus" last="Mohr">Klaus Mohr</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung Pharmakologie, Universität Kiel, Hospitalstrasse 4-6, D-2300, Kiel 1</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Naunyn-Schmiedeberg's Archives of Pharmacology</title>
<title level="j" type="abbrev">Naunyn-Schmiedeberg's Arch. Pharmacol.</title>
<idno type="ISSN">0028-1298</idno>
<idno type="eISSN">1432-1912</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1982-12-01">1982-12-01</date>
<biblScope unit="volume">321</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="341">341</biblScope>
<biblScope unit="page" to="346">346</biblScope>
</imprint>
<idno type="ISSN">0028-1298</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0028-1298</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocortical function</term>
<term>Chloroquine</term>
<term>Drug-induced lipidosis</term>
<term>Iprindole</term>
<term>Triparanol</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acth</term>
<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenocortical</term>
<term>Adrenocortical cells</term>
<term>Adrenocortical function</term>
<term>Adrenocortical system</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Control rats</term>
<term>Corticosterone</term>
<term>Corticosterone concentration</term>
<term>Corticosterone content</term>
<term>Corticosterone excretion</term>
<term>Corticosterone synthesis</term>
<term>Cortisol</term>
<term>Excretion</term>
<term>Hartmann</term>
<term>Inclusion bodies</term>
<term>Iprindole</term>
<term>Lipidosis</term>
<term>Lipidotic alterations</term>
<term>Plasma corticosterone</term>
<term>Plasma corticosterone concentration</term>
<term>Triparanol</term>
<term>Urinary corticosterone excretion</term>
<term>Urine</term>
<term>Zona</term>
<term>Zona fasciculata</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Summary: The influence of three potent lipidosis-inducing agents, i.e. iprindole, triparanol and chloroquine, on the rat adrenal cortex was investigated by determination of the corticosterone excretion in the urine, the responsiveness to ACTH and by determination of the corticosterone content of the adrenals and of the corticosterone concentration in plasma. Administration of iprindole and triparanol left the function of the adrenal cortex unaffected, while under chloroquine treatment an activation with time was observed. Morphologically, similar degrees of lipidosis were found in all experiments. The results demonstrate that the functional capacity of the rat adrenal cortex is not directly correlated to lipidotic alterations.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003751 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003751 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:8DB224E66C7FA77BE4210D4D9DDB5DD84666066F |texte= Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs }}
This area was generated with Dilib version V0.6.33. |