ChloroquineV1, Main, Exploration, bibRecord, 002C26

Mefloquine distribution in postmortem cases

Identifieur interne : 002C26 ( Main/Exploration ); précédent : 002C25; suivant : 002C27

Mefloquine distribution in postmortem cases

Auteurs : Robert Jones [États-Unis] ; Gary Kunsman [États-Unis] ; Barry Levine [États-Unis] ; Michael Smith [États-Unis] ; Charles Stahl [États-Unis]

Source :

Forensic Science International [ 0379-0738 ] ; 1994.

RBID : ISTEX:0C4CC0149D784F9EBA40CDB941667225F090B843

English descriptors

Teeft :
- Active duty, Ammonium hydroxide, Chromatograph, Combat conditions, Film thickness, Forensic science, Hydroxide, Levine, Malaria, Malaria prophylaxis, Mass spectrum, Mefloquine, Mefloquine concentrations, Mefloquine elutes, Mefloquine overdoses, Military personnel, Phenyl methyl silicone, Postmortem, Postmortem cases, Postmortem data, Postmortem formation, Postmortem redistribution, Prophylaxis, Quantitation, Relative retention time, Silica capillary column, Sodium hydroxide, Sulfuric acid.

Abstract

Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.

Url:

https://api.istex.fr/ark:/67375/6H6-XQV2L8TT-G/fulltext.pdf

DOI: 10.1016/0379-0738(94)90376-X

Affiliations:

États-Unis

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</div>
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<name sortKey="Stahl, Charles" sort="Stahl, Charles" uniqKey="Stahl C" first="Charles" last="Stahl">Charles Stahl</name>
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Mefloquine distribution in postmortem cases

Mefloquine distribution in postmortem cases

Source :

English descriptors

Abstract

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