Mefloquine distribution in postmortem cases
Identifieur interne : 000D43 ( Istex/Corpus ); précédent : 000D42; suivant : 000D44Mefloquine distribution in postmortem cases
Auteurs : Robert Jones ; Gary Kunsman ; Barry Levine ; Michael Smith ; Charles StahlSource :
- Forensic Science International [ 0379-0738 ] ; 1994.
English descriptors
- Teeft :
- Active duty, Ammonium hydroxide, Chromatograph, Combat conditions, Film thickness, Forensic science, Hydroxide, Levine, Malaria, Malaria prophylaxis, Mass spectrum, Mefloquine, Mefloquine concentrations, Mefloquine elutes, Mefloquine overdoses, Military personnel, Phenyl methyl silicone, Postmortem, Postmortem cases, Postmortem data, Postmortem formation, Postmortem redistribution, Prophylaxis, Quantitation, Relative retention time, Silica capillary column, Sodium hydroxide, Sulfuric acid.
Abstract
Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.
Url:
DOI: 10.1016/0379-0738(94)90376-X
Links to Exploration step
ISTEX:0C4CC0149D784F9EBA40CDB941667225F090B843Le document en format XML
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sortKey="Levine, Barry" sort="Levine, Barry" uniqKey="Levine B" first="Barry" last="Levine">Barry Levine</name><affiliation><mods:affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</mods:affiliation></affiliation></author><author><name sortKey="Smith, Michael" sort="Smith, Michael" uniqKey="Smith M" first="Michael" last="Smith">Michael Smith</name><affiliation><mods:affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</mods:affiliation></affiliation></author><author><name sortKey="Stahl, Charles" sort="Stahl, Charles" uniqKey="Stahl C" first="Charles" last="Stahl">Charles Stahl</name><affiliation><mods:affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Forensic Science 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personnel</term><term>Phenyl methyl silicone</term><term>Postmortem</term><term>Postmortem cases</term><term>Postmortem data</term><term>Postmortem formation</term><term>Postmortem redistribution</term><term>Prophylaxis</term><term>Quantitation</term><term>Relative retention time</term><term>Silica capillary column</term><term>Sodium hydroxide</term><term>Sulfuric acid</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>mefloquine</json:string><json:string>postmortem</json:string><json:string>levine</json:string><json:string>chromatograph</json:string><json:string>prophylaxis</json:string><json:string>quantitation</json:string><json:string>hydroxide</json:string><json:string>relative retention time</json:string><json:string>postmortem redistribution</json:string><json:string>silica capillary column</json:string><json:string>postmortem formation</json:string><json:string>postmortem cases</json:string><json:string>forensic science</json:string><json:string>phenyl methyl silicone</json:string><json:string>malaria prophylaxis</json:string><json:string>film thickness</json:string><json:string>mefloquine elutes</json:string><json:string>military personnel</json:string><json:string>postmortem data</json:string><json:string>mefloquine concentrations</json:string><json:string>active duty</json:string><json:string>mefloquine overdoses</json:string><json:string>sulfuric acid</json:string><json:string>combat conditions</json:string><json:string>sodium hydroxide</json:string><json:string>ammonium hydroxide</json:string><json:string>mass spectrum</json:string><json:string>malaria</json:string></teeft></keywords><author><json:item><name>Robert Jones</name><affiliations><json:string>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</json:string></affiliations></json:item><json:item><name>Gary Kunsman</name><affiliations><json:string>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</json:string></affiliations></json:item><json:item><name>Barry Levine</name><affiliations><json:string>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</json:string></affiliations></json:item><json:item><name>Michael Smith</name><affiliations><json:string>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</json:string></affiliations></json:item><json:item><name>Charles Stahl</name><affiliations><json:string>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Mefloquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Postmortem distribution</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antimalarial</value></json:item></subject><arkIstex>ark:/67375/6H6-XQV2L8TT-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (>25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</abstract><qualityIndicators><score>6.004</score><pdfWordCount>1352</pdfWordCount><pdfCharCount>9291</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>526 x 749 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>221</abstractWordCount><abstractCharCount>1514</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Mefloquine distribution in postmortem cases</title><pmid><json:string>7959478</json:string></pmid><pii><json:string>0379-0738(94)90376-X</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Forensic Science International</title><language><json:string>unknown</json:string></language><publicationDate>1994</publicationDate><issn><json:string>0379-0738</json:string></issn><pii><json:string>S0379-0738(00)X0280-0</json:string></pii><volume>68</volume><issue>1</issue><pages><first>29</first><last>32</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1994</json:string></date><geogName></geogName><orgName><json:string>Division of Forensic Toxicology</json:string><json:string>Elsevier Science Ireland Ltd</json:string><json:string>LaRoche, Inc.</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Gary Kunsman</json:string><json:string>B. 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Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Mefloquine</term></item><item><term>Postmortem distribution</term></item><item><term>Antimalarial</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-03-18">Modified</change><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XQV2L8TT-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>FSI</jid><aid>9490376X</aid><ce:pii>0379-0738(94)90376-X</ce:pii><ce:doi>10.1016/0379-0738(94)90376-X</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Mefloquine distribution in postmortem cases</ce:title><ce:author-group><ce:author><ce:given-name>Robert</ce:given-name><ce:surname>Jones</ce:surname></ce:author><ce:author><ce:given-name>Gary</ce:given-name><ce:surname>Kunsman</ce:surname></ce:author><ce:author><ce:given-name>Barry</ce:given-name><ce:surname>Levine</ce:surname></ce:author><ce:author><ce:given-name>Michael</ce:given-name><ce:surname>Smith</ce:surname></ce:author><ce:author><ce:given-name>Charles</ce:given-name><ce:surname>Stahl</ce:surname></ce:author><ce:affiliation><ce:textfn>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="30" month="12" year="1993"></ce:date-received><ce:date-revised day="18" month="3" year="1994"></ce:date-revised><ce:date-accepted day="27" month="4" year="1994"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Mefloquine</ce:text></ce:keyword><ce:keyword><ce:text>Postmortem distribution</ce:text></ce:keyword><ce:keyword><ce:text>Antimalarial</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Mefloquine distribution in postmortem cases</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Mefloquine distribution in postmortem cases</title></titleInfo><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Jones</namePart><affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gary</namePart><namePart type="family">Kunsman</namePart><affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barry</namePart><namePart type="family">Levine</namePart><affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Smith</namePart><affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles</namePart><namePart type="family">Stahl</namePart><affiliation>Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><dateModified encoding="w3cdtf">1994-03-18</dateModified><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Mefloquine is currently the drug-of-choice for malaria prophylaxis among military personnel. Four active duty military personnel receiving 250 mg mefloquine per week were killed in the line of duty under combat conditions. Samples of blood, bile, liver, kidney, muscle, brain, spleen and lung were submitted to the Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, for routine toxicologic analysis. Qualitative screening revealed only the presence of ethanol (<25 mg/dl, probably attributable to postmortem formation) and mefloquine. Quantitation of mefloquine was performed using an HP 5880 gas chromatograph equipped with a nitrogen/phosphorus detector. The column was an HP-5 cross-linked 5% phenyl methyl silicone fused silica capillary column (15 m × 0.25 mm i.d. × 0.25 μm film thickness). The temperature program began at 110°C, was held for 1 min and ramped at 20°C/min to 200°C, held for 1 min and then ramped at 10°C/min to 280°C and held for 10 min. Mefloquine elutes with a relative retention time similar to that of the tricyclic antidepresssants. No postmortem data concerning mefloquine concentrations or tissue distribution was available. Quantitated blood concentrations in the presented cases were greater than the expected therapeutic values indicating the possibility of postmortem redistribution of this drug. No mefloquine overdoses were identified in the literature making comparison to the postmortem therapeutic concentraitons impossible at this time.</abstract><subject><genre>Keywords</genre><topic>Mefloquine</topic><topic>Postmortem distribution</topic><topic>Antimalarial</topic></subject><relatedItem type="host"><titleInfo><title>Forensic Science International</title></titleInfo><titleInfo type="abbreviated"><title>FSI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0379-0738</identifier><identifier type="PII">S0379-0738(00)X0280-0</identifier><part><date>1994</date><detail type="volume"><number>68</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>73</end></extent><extent unit="pages"><start>29</start><end>32</end></extent></part></relatedItem><identifier type="istex">0C4CC0149D784F9EBA40CDB941667225F090B843</identifier><identifier type="ark">ark:/67375/6H6-XQV2L8TT-G</identifier><identifier type="DOI">10.1016/0379-0738(94)90376-X</identifier><identifier type="PII">0379-0738(94)90376-X</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-XQV2L8TT-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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