Recent advances in antimalarial drug development
Identifieur interne : 001B09 ( Main/Exploration ); précédent : 001B08; suivant : 001B10Recent advances in antimalarial drug development
Auteurs : Suryanaryana Vangapandu [Inde, États-Unis] ; Meenakshi Jain [Inde] ; Kirandeep Kaur [Inde] ; Premanand Patil [Inde] ; Sanjay R. Patel [Inde] ; Rahul Jain [Inde]Source :
- Medicinal Research Reviews [ 0198-6325 ] ; 2007-01.
English descriptors
- Teeft :
- Aablaquine, Active compound, Adohcy, Alkyl, Amodiaquine, Analog, Antimalarial, Antimalarial activity, Antimalarial agents, Antimalarial drug development, Antimalarial drugs, Antiplasmodial, Antiplasmodial activity, Artemisinin, Berghei, Biochem, Biochem pharmacol, Bioorg, Bisquinolines, Blood cells, Bray, Calas, Cerebral malaria, Chalcones, Chelators, Chem, Chem lett, Chloroquine, Chloroquine resistance, Compound, Cynomolgi, Cytotoxic, Cytotoxicity, Derivative, Dihydrofolate, Dimer, Dutta, Endoperoxides, Erythrocyte, Ester, Falciparum, Falciparum malaria, Food vacuole, Genome, Grellier, Hematin, Hematin polymerization, Heme, Hemozoin, Inhibitor, Inhibitory activity, Iron chelators, Jain, Jomaa, Lett, Malaria, Malaria parasite, Malarial, Medicinal, Medicinal chemistry, Meshnick, Metabolically, Methb, Milhous, Moiety, Mutant, Mutation, Parasite, Parasitol, Parasitol today, Pathway, Pfmrk, Pharm, Pharmacol, Phospholipid, Plasmepsin, Plasmodium, Plasmodium falciparum, Posner, Primaquine, Proc, Proc natl acad, Prophylactic, Puri, Pyrimethamine, Quinine, Quinoline, Quinoline ring, Reductase, Relapse, Resistant strains, Rhesus, Rhesus monkeys, Schlitzer, Sergheraert, Singh, Structural classes, Substituents, Sulfonamide, Synthase, Tafenoquine, Toxicity, Vacuole, Vangapandu, Vennerstrom, Verapamil, Vivax, Vivo antimalarial activity, Wiesner, Yoelii.
Abstract
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to commonly used drugs such as chloroquine, and the lack of affordable new drugs are the limiting factors in the fight against malaria. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re‐examination of the existing antimalarial drugs that may be effective against resistant strains. This review provides an in‐depth look at the most significant progress made during the past 10 years in antimalarial drug development. © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 65–107, 2007
Url:
DOI: 10.1002/med.20062
Affiliations:
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Nagar, Punjab 160 062</wicri:regionArea><wicri:noRegion>Punjab 160 062</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R." last="Patel">Sanjay R. Patel</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062</wicri:regionArea><wicri:noRegion>Punjab 160 062</wicri:noRegion></affiliation></author><author><name sortKey="Jain, Rahul" sort="Jain, Rahul" uniqKey="Jain R" first="Rahul" last="Jain">Rahul Jain</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062</wicri:regionArea><wicri:noRegion>Punjab 160 062</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Inde</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Correspondence address: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062</wicri:regionArea><wicri:noRegion>Punjab 160 062</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Medicinal Research Reviews</title><title level="j" type="alt">MEDICINAL RESEARCH REVIEWS</title><idno type="ISSN">0198-6325</idno><idno type="eISSN">1098-1128</idno><imprint><biblScope unit="vol">27</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="65">65</biblScope><biblScope unit="page" to="107">107</biblScope><biblScope unit="page-count">43</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-01">2007-01</date></imprint><idno type="ISSN">0198-6325</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0198-6325</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aablaquine</term><term>Active compound</term><term>Adohcy</term><term>Alkyl</term><term>Amodiaquine</term><term>Analog</term><term>Antimalarial</term><term>Antimalarial activity</term><term>Antimalarial agents</term><term>Antimalarial drug development</term><term>Antimalarial drugs</term><term>Antiplasmodial</term><term>Antiplasmodial activity</term><term>Artemisinin</term><term>Berghei</term><term>Biochem</term><term>Biochem pharmacol</term><term>Bioorg</term><term>Bisquinolines</term><term>Blood cells</term><term>Bray</term><term>Calas</term><term>Cerebral malaria</term><term>Chalcones</term><term>Chelators</term><term>Chem</term><term>Chem lett</term><term>Chloroquine</term><term>Chloroquine resistance</term><term>Compound</term><term>Cynomolgi</term><term>Cytotoxic</term><term>Cytotoxicity</term><term>Derivative</term><term>Dihydrofolate</term><term>Dimer</term><term>Dutta</term><term>Endoperoxides</term><term>Erythrocyte</term><term>Ester</term><term>Falciparum</term><term>Falciparum malaria</term><term>Food vacuole</term><term>Genome</term><term>Grellier</term><term>Hematin</term><term>Hematin polymerization</term><term>Heme</term><term>Hemozoin</term><term>Inhibitor</term><term>Inhibitory activity</term><term>Iron chelators</term><term>Jain</term><term>Jomaa</term><term>Lett</term><term>Malaria</term><term>Malaria parasite</term><term>Malarial</term><term>Medicinal</term><term>Medicinal chemistry</term><term>Meshnick</term><term>Metabolically</term><term>Methb</term><term>Milhous</term><term>Moiety</term><term>Mutant</term><term>Mutation</term><term>Parasite</term><term>Parasitol</term><term>Parasitol today</term><term>Pathway</term><term>Pfmrk</term><term>Pharm</term><term>Pharmacol</term><term>Phospholipid</term><term>Plasmepsin</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Posner</term><term>Primaquine</term><term>Proc</term><term>Proc natl acad</term><term>Prophylactic</term><term>Puri</term><term>Pyrimethamine</term><term>Quinine</term><term>Quinoline</term><term>Quinoline ring</term><term>Reductase</term><term>Relapse</term><term>Resistant strains</term><term>Rhesus</term><term>Rhesus monkeys</term><term>Schlitzer</term><term>Sergheraert</term><term>Singh</term><term>Structural classes</term><term>Substituents</term><term>Sulfonamide</term><term>Synthase</term><term>Tafenoquine</term><term>Toxicity</term><term>Vacuole</term><term>Vangapandu</term><term>Vennerstrom</term><term>Verapamil</term><term>Vivax</term><term>Vivo antimalarial activity</term><term>Wiesner</term><term>Yoelii</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to commonly used drugs such as chloroquine, and the lack of affordable new drugs are the limiting factors in the fight against malaria. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re‐examination of the existing antimalarial drugs that may be effective against resistant strains. This review provides an in‐depth look at the most significant progress made during the past 10 years in antimalarial drug development. © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 65–107, 2007</div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Vangapandu, Suryanaryana" sort="Vangapandu, Suryanaryana" uniqKey="Vangapandu S" first="Suryanaryana" last="Vangapandu">Suryanaryana Vangapandu</name></noRegion><name sortKey="Jain, Meenakshi" sort="Jain, Meenakshi" uniqKey="Jain M" first="Meenakshi" last="Jain">Meenakshi Jain</name><name sortKey="Jain, Rahul" sort="Jain, Rahul" uniqKey="Jain R" first="Rahul" last="Jain">Rahul Jain</name><name sortKey="Jain, Rahul" sort="Jain, Rahul" uniqKey="Jain R" first="Rahul" last="Jain">Rahul Jain</name><name sortKey="Jain, Rahul" sort="Jain, Rahul" uniqKey="Jain R" first="Rahul" last="Jain">Rahul Jain</name><name sortKey="Kaur, Kirandeep" sort="Kaur, Kirandeep" uniqKey="Kaur K" first="Kirandeep" last="Kaur">Kirandeep Kaur</name><name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R." last="Patel">Sanjay R. Patel</name><name sortKey="Patil, Premanand" sort="Patil, Premanand" uniqKey="Patil P" first="Premanand" last="Patil">Premanand Patil</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Vangapandu, Suryanaryana" sort="Vangapandu, Suryanaryana" uniqKey="Vangapandu S" first="Suryanaryana" last="Vangapandu">Suryanaryana Vangapandu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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