Recent advances in antimalarial drug development
Identifieur interne : 000577 ( Istex/Corpus ); précédent : 000576; suivant : 000578Recent advances in antimalarial drug development
Auteurs : Suryanaryana Vangapandu ; Meenakshi Jain ; Kirandeep Kaur ; Premanand Patil ; Sanjay R. Patel ; Rahul JainSource :
- Medicinal Research Reviews [ 0198-6325 ] ; 2007-01.
English descriptors
- Teeft :
- Aablaquine, Active compound, Adohcy, Alkyl, Amodiaquine, Analog, Antimalarial, Antimalarial activity, Antimalarial agents, Antimalarial drug development, Antimalarial drugs, Antiplasmodial, Antiplasmodial activity, Artemisinin, Berghei, Biochem, Biochem pharmacol, Bioorg, Bisquinolines, Blood cells, Bray, Calas, Cerebral malaria, Chalcones, Chelators, Chem, Chem lett, Chloroquine, Chloroquine resistance, Compound, Cynomolgi, Cytotoxic, Cytotoxicity, Derivative, Dihydrofolate, Dimer, Dutta, Endoperoxides, Erythrocyte, Ester, Falciparum, Falciparum malaria, Food vacuole, Genome, Grellier, Hematin, Hematin polymerization, Heme, Hemozoin, Inhibitor, Inhibitory activity, Iron chelators, Jain, Jomaa, Lett, Malaria, Malaria parasite, Malarial, Medicinal, Medicinal chemistry, Meshnick, Metabolically, Methb, Milhous, Moiety, Mutant, Mutation, Parasite, Parasitol, Parasitol today, Pathway, Pfmrk, Pharm, Pharmacol, Phospholipid, Plasmepsin, Plasmodium, Plasmodium falciparum, Posner, Primaquine, Proc, Proc natl acad, Prophylactic, Puri, Pyrimethamine, Quinine, Quinoline, Quinoline ring, Reductase, Relapse, Resistant strains, Rhesus, Rhesus monkeys, Schlitzer, Sergheraert, Singh, Structural classes, Substituents, Sulfonamide, Synthase, Tafenoquine, Toxicity, Vacuole, Vangapandu, Vennerstrom, Verapamil, Vivax, Vivo antimalarial activity, Wiesner, Yoelii.
Abstract
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to commonly used drugs such as chloroquine, and the lack of affordable new drugs are the limiting factors in the fight against malaria. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re‐examination of the existing antimalarial drugs that may be effective against resistant strains. This review provides an in‐depth look at the most significant progress made during the past 10 years in antimalarial drug development. © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 65–107, 2007
Url:
DOI: 10.1002/med.20062
Links to Exploration step
ISTEX:6EB6B8455CDE3E9CE47A857C57BCF11CE5906A5CLe document en format XML
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Nagar, Punjab 160 062, India</mods:affiliation></affiliation></author><author><name sortKey="Jain, Rahul" sort="Jain, Rahul" uniqKey="Jain R" first="Rahul" last="Jain">Rahul Jain</name><affiliation><mods:affiliation>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: rahuljain@niper.ac.in</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. 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Nagar, Punjab 160 062, India</json:string><json:string>Current Address: Emory University School of Medicine, Atlanta, GA 30322, USA.</json:string></affiliations></json:item><json:item><name>Meenakshi Jain</name><affiliations><json:string>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</json:string></affiliations></json:item><json:item><name>Kirandeep Kaur</name><affiliations><json:string>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</json:string></affiliations></json:item><json:item><name>Premanand Patil</name><affiliations><json:string>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</json:string></affiliations></json:item><json:item><name>Sanjay R. Patel</name><affiliations><json:string>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</json:string></affiliations></json:item><json:item><name>Rahul Jain</name><affiliations><json:string>Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India</json:string><json:string>E-mail: rahuljain@niper.ac.in</json:string><json:string>Correspondence address: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>malaria</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drug resistance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>artemisinins</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>4‐aminoquinolines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chloroquine resistance reversal agents</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>8‐aminoquinolines</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quaternary ammonium salts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>new structural classes of antimalarial agents</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>iron chelators</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>target‐based antimalarial agents</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chalcones</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>natural product‐based antimalarial agents</value></json:item></subject><articleId><json:string>MED20062</json:string></articleId><arkIstex>ark:/67375/WNG-JQ6TG66S-J</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. 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Nagar, Punjab 160 062, India</affiliation><affiliation>E-mail: rahuljain@niper.ac.in</affiliation><affiliation>Correspondence address: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-01</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">24</extent><extent unit="tables">0</extent><extent unit="references">224</extent><extent unit="words">4639</extent></physicalDescription><abstract lang="en">Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence, and drug resistance, is the most serious and widespread parasitic disease encountered by mankind. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to commonly used drugs such as chloroquine, and the lack of affordable new drugs are the limiting factors in the fight against malaria. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re‐examination of the existing antimalarial drugs that may be effective against resistant strains. This review provides an in‐depth look at the most significant progress made during the past 10 years in antimalarial drug development. © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 65–107, 2007</abstract><subject lang="en"><genre>keywords</genre><topic>malaria</topic><topic>drug resistance</topic><topic>artemisinins</topic><topic>4‐aminoquinolines</topic><topic>chloroquine resistance reversal agents</topic><topic>8‐aminoquinolines</topic><topic>quaternary ammonium salts</topic><topic>new structural classes of antimalarial agents</topic><topic>iron chelators</topic><topic>target‐based antimalarial agents</topic><topic>chalcones</topic><topic>natural product‐based antimalarial agents</topic></subject><relatedItem type="host"><titleInfo><title>Medicinal Research Reviews</title></titleInfo><titleInfo type="abbreviated"><title>Med. Res. Rev.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0198-6325</identifier><identifier type="eISSN">1098-1128</identifier><identifier type="DOI">10.1002/(ISSN)1098-1128</identifier><identifier type="PublisherID">MED</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>65</start><end>107</end><total>43</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Medicinal need, scientific opportunity and the drive for antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ridley RG. Medicinal need, scientific opportunity and the drive for antimalarial drugs. Nature 2002; 415: 686–693.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>415</number></detail><extent unit="pages"><start>686</start><end>693</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>415</number></detail><extent unit="pages"><start>686</start><end>693</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Survey of malaria treatment and deaths</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Mishra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Satpathy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mohanty</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mishra SK, Satpathy SK, Mohanty S. Survey of malaria treatment and deaths. Bull WHO 1999; 77: 1020.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>1020</start></extent></part><relatedItem type="host"><titleInfo><title>Bull WHO</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>1020</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>National Institute of Allergy and Infectious Diseases (NIAID) global health research plan for HIV/AIDS, malaria and tuberculosis</title></titleInfo><name type="corporate"><namePart>Anonymous</namePart></name><genre>journal-article</genre><note type="citation/reference">Anonymous. National Institute of Allergy and Infectious Diseases (NIAID) global health research plan for HIV/AIDS, malaria and tuberculosis. World Health Organ 2001; 18–29.</note><part><date>2001</date><extent unit="pages"><start>18</start><end>29</end></extent></part><relatedItem type="host"><titleInfo><title>World Health Organ</title></titleInfo><part><date>2001</date><extent unit="pages"><start>18</start><end>29</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Malaria: New ideas, old problems, new technologies</title></titleInfo><name type="personal"><namePart type="given">GA</namePart><namePart type="family">Butcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RE</namePart><namePart type="family">Sinden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Curtis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Butcher GA, Sinden RE, Curtis C. Malaria: New ideas, old problems, new technologies. Parasitol Today 2000; 16: 43–44.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>43</start><end>44</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>43</start><end>44</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Malaria research and reference reagent resource center</title></titleInfo><name type="personal"><namePart type="given">JH</namePart><namePart type="family">Adams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Fairfield</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adams JH, Wu Y, Fairfield A. Malaria research and reference reagent resource center. Parasitol Today 2000; 16: 89.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>89</start></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>89</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Molecular approaches to epidemology and clinical aspects of malaria</title></titleInfo><name type="personal"><namePart type="given">GV</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HP</namePart><namePart type="family">Beck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Molyneux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Marsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brown GV, Beck HP, Molyneux M, Marsh K. Molecular approaches to epidemology and clinical aspects of malaria. Parasitol Today 2000; 16: 448–451.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>448</start><end>451</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>448</start><end>451</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Pathogenesis of malaria</title></titleInfo><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Clark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Schofield</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clark IA, Schofield L. Pathogenesis of malaria. Parasitol Today 2000; 16: 451–454.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>451</start><end>454</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>451</start><end>454</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Heme metabolism of Plasmodium is a major antimalarial target</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Padmanabhan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PN</namePart><namePart type="family">Rangarajan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Padmanabhan G, Rangarajan PN. Heme metabolism of Plasmodium is a major antimalarial target. Biochem Biophys Res Commun 2000; 268: 665–668.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>268</number></detail><extent unit="pages"><start>665</start><end>668</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Biophys Res Commun</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>268</number></detail><extent unit="pages"><start>665</start><end>668</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Chloroquine as intercelator: A hypothesis revived</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meshnick SR. Chloroquine as intercelator: A hypothesis revived. Parasitol Today 1990; 6: 77–79.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>77</start><end>79</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>77</start><end>79</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Lysosomes, pH and the anti‐malarial action of chloroquine</title></titleInfo><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Homewood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Warhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Peters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Baggaley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Homewood CA, Warhurst DC, Peters W, Baggaley VC. Lysosomes, pH and the anti‐malarial action of chloroquine. Nature 1972; 235: 50–52.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>50</start><end>52</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>50</start><end>52</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Chloroquine inhibits heme‐dependent protein synthesis in P. falciparum</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Surolia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Padmanabhan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Surolia N, Padmanabhan G. Chloroquine inhibits heme‐dependent protein synthesis in P. falciparum. Proc Natl Acad Sci USA 1991; 88: 4786–4790.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>4786</start><end>4790</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>4786</start><end>4790</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites</title></titleInfo><name type="personal"><namePart type="given">AFG</namePart><namePart type="family">Slater</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Cerami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Slater AFG, Cerami A. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites. Nature 1992; 355: 167–169.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>167</start><end>169</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>167</start><end>169</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>McChesney EW,Fitch CW.Antimalarial Drugs II. In: Handbook of experimental pharmacology 68.Berlin: Springer‐Verlag;1984. pp3–39.</title></titleInfo><note type="citation/reference">McChesney EW, Fitch CW. Antimalarial Drugs II. In: Handbook of experimental pharmacology 68. Berlin: Springer‐Verlag; 1984. pp 3–39.</note><name type="personal"><namePart type="given">EW</namePart><namePart type="family">McChesney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Fitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Springer‐Verlag</publisher><place><placeTerm type="text">Berlin</placeTerm></place></originInfo><part><date>1984</date><extent unit="pages"><start>3</start><end>39</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>The role of heme in the activity of chloroquine and related antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Egan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HM</namePart><namePart type="family">Marques</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Egan TJ, Marques HM. The role of heme in the activity of chloroquine and related antimalarial drugs. Coord Chem Rev 1999; 190: 493–517.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>493</start><end>517</end></extent></part><relatedItem type="host"><titleInfo><title>Coord Chem Rev</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>493</start><end>517</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>The mechanism of action of quinolines and related antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Egan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Ross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Adams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Egan TJ, Ross DC, Adams PA. The mechanism of action of quinolines and related antimalarial drugs. S Afr J Sci 1996; 92: 11–14.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>11</start><end>14</end></extent></part><relatedItem type="host"><titleInfo><title>S Afr J Sci</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>11</start><end>14</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Metal effects on metalloporphyrins and on their pi‐pi charge transfer complexes with aromatic acceptors: Urohemin complexes</title></titleInfo><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Shellnutt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shellnutt JA. Metal effects on metalloporphyrins and on their pi‐pi charge transfer complexes with aromatic acceptors: Urohemin complexes. Inorg Chem 1983; 22: 2535–2544.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>2535</start><end>2544</end></extent></part><relatedItem type="host"><titleInfo><title>Inorg Chem</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>2535</start><end>2544</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is dependent on NHE activity of Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Janneh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Raynes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Mungthin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Ginsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bray PG, Janneh O, Raynes KJ, Mungthin M, Ginsburg H, Ward SA. Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is dependent on NHE activity of Plasmodium falciparum. J Cell Biol 1999; 145: 363–376.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>363</start><end>376</end></extent></part><relatedItem type="host"><titleInfo><title>J Cell Biol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>363</start><end>376</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Haemozion: Identification and quantification</title></titleInfo><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sullivan AD, Meshnick SR. Haemozion: Identification and quantification. Parasitol Today 1996; 12: 161–163.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>161</start><end>163</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>161</start><end>163</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>The mode of action of antimalarial endoperoxides</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meshnick SR. The mode of action of antimalarial endoperoxides. Trans R Soc Trop Med Hyg 1994; 88: 31–39.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>31</start><end>39</end></extent></part><relatedItem type="host"><titleInfo><title>Trans R Soc Trop Med Hyg</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>31</start><end>39</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Possible modes of action of the artemisinin‐type compounds</title></titleInfo><name type="personal"><namePart type="given">LP</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KR</namePart><namePart type="family">Haynes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Meunier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yuthavong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Olliaro LP, Haynes KR, Meunier B, Yuthavong Y. Possible modes of action of the artemisinin‐type compounds. Trends Parasitol 2001; 17: 122–126.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>122</start><end>126</end></extent></part><relatedItem type="host"><titleInfo><title>Trends Parasitol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>122</start><end>126</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Haem‐mediated decomposition of artemisinin and its derivatives: Pharmacological and toxicological considerations</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Edwards G. Haem‐mediated decomposition of artemisinin and its derivatives: Pharmacological and toxicological considerations. J Pharm Pharmacol 1997; 49: 49–53.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>49</start><end>53</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharm Pharmacol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>49</start><end>53</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Prog Clin Biol Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Meshnick SR, Tsang TW, Lin FB, Pan HZ, Chang CN, Kuypers F, Chni D, Lubin B. Prog Clin Biol Res 1989; 313: 95–104.</note><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TW</namePart><namePart type="family">Tsang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FB</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HZ</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CN</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Kuypers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Chni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Lubin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>313</number></detail><extent unit="pages"><start>95</start><end>104</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Hemoglobin degradation in the malaria parasite P. falciparum: An ordered process in a unique organelle</title></titleInfo><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AFG</namePart><namePart type="family">Slater</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Cerami</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GB</namePart><namePart type="family">Henderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Goldberg DE, Slater AFG, Cerami A, Henderson GB. Hemoglobin degradation in the malaria parasite P. falciparum: An ordered process in a unique organelle. Proc Natl Acad Sci USA 1990; 87: 2931–2935.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>2931</start><end>2935</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>2931</start><end>2935</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Iron‐dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YZ</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Lima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Kuypers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamchonwongpaisan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yuthavong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meshnick SR, Yang YZ, Lima V, Kuypers F, Kamchonwongpaisan S, Yuthavong Y. Iron‐dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). Antimicrob Agents Chemother 1993; 37: 1108–1114.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>1108</start><end>1114</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>1108</start><end>1114</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Enhancement of hemin‐induced membrane damage by artemisinin</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SMH</namePart><namePart type="family">Sadrzadeh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wei N, Sadrzadeh SMH. Enhancement of hemin‐induced membrane damage by artemisinin. Biochem Pharmacol 1994; 48: 737–741.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>737</start><end>741</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>737</start><end>741</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>A regiospecifically oxygen‐18 labeled 1,2,4 trioxane: A simple chemical model to probe the mechanisms for antimalarial activity of artemisinin (qinghaosu)</title></titleInfo><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Oh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Posner GH, Oh CH. A regiospecifically oxygen‐18 labeled 1,2,4 trioxane: A simple chemical model to probe the mechanisms for antimalarial activity of artemisinin (qinghaosu). J Am Chem Soc 1992; 114: 8328–8329.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>8328</start><end>8329</end></extent></part><relatedItem type="host"><titleInfo><title>J Am Chem Soc</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>8328</start><end>8329</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Further evidence supporting the importance of and the restrictions on a carbon‐centered radical for high antimalarial activity of 1,2,4‐trioxanes like artemisinin</title></titleInfo><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Posner GH. Further evidence supporting the importance of and the restrictions on a carbon‐centered radical for high antimalarial activity of 1,2,4‐trioxanes like artemisinin. J Med Chem 1995; 38: 607–612.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>607</start><end>612</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>607</start><end>612</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>The behavior of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)</title></titleInfo><name type="personal"><namePart type="given">RK</namePart><namePart type="family">Haynes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Vonwiller</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">(a) Haynes RK, Vonwiller SC. The behavior of qinghaosu (artemisinin) in the presence of heme iron(II) and (III). Tetrahedron Lett 1996; 37: 253–256.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>253</start><end>256</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron Lett</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>253</start><end>256</end></extent></part></relatedItem><titleInfo><title>Artemisinins targets the Serca of P. facliparum</title></titleInfo><name type="personal"><namePart type="given">U</namePart><namePart type="family">Eckstein‐Ludwig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RJ</namePart><namePart type="family">Webb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IDA</namePart><namePart type="family">van Goethem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">East</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AG</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AG</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kimura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">(b) Eckstein‐Ludwig U, Webb RJ, van Goethem IDA, East JM, Lee AG, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S. Artemisinins targets the Serca of P. facliparum. Nature 2003; 424: 957–961.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>424</number></detail><extent unit="pages"><start>957</start><end>961</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>424</number></detail><extent unit="pages"><start>957</start><end>961</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Interaction of artemisinin with malarial hemozoin</title></titleInfo><name type="personal"><namePart type="given">YL</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YZ</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hong YL, Yang YZ, Meshnick SR. Interaction of artemisinin with malarial hemozoin. Mol Biochem Parasitol 1994; 63: 121–128.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>121</start><end>128</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Biochem Parasitol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>121</start><end>128</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>Synergistic antimalarial activity of pyrimethamine and sulfadoxine against P. falciparum in vitro</title></titleInfo><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Chulay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WM</namePart><namePart type="family">Watkins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DG</namePart><namePart type="family">Sixsmith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chulay JD, Watkins WM, Sixsmith DG. Synergistic antimalarial activity of pyrimethamine and sulfadoxine against P. falciparum in vitro. Am J Trop Med Hyg 1984; 33: 325–330.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>325</start><end>330</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>325</start><end>330</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>A bifunctional thymidylate synthetase‐dihydrofolate reductase in protozoa</title></titleInfo><name type="personal"><namePart type="given">CE</namePart><namePart type="family">Garrett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Coderre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TD</namePart><namePart type="family">Meek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EP</namePart><namePart type="family">Garvey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Beverly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DV</namePart><namePart type="family">Santi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Garrett CE, Coderre JA, Meek TD, Garvey EP, Beverly SM, Santi DV. A bifunctional thymidylate synthetase‐dihydrofolate reductase in protozoa. Mol Biochem Parasitol 1984; 11: 257–265.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>257</start><end>265</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Biochem Parasitol</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>257</start><end>265</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Origin of reactive oxygen species in erythrocytes infected with P. falciparum</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Atamna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Ginsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Atamna H, Ginsburg H. Origin of reactive oxygen species in erythrocytes infected with P. falciparum. Mol Biochem Parasitol 1993; 61: 231–242.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>231</start><end>242</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Biochem Parasitol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>61</number></detail><extent unit="pages"><start>231</start><end>242</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides</title></titleInfo><name type="personal"><namePart type="given">O</namePart><namePart type="family">Augusto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CLV</namePart><namePart type="family">Weingrill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Schreier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Amemiya</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Augusto O, Weingrill CLV, Schreier S, Amemiya H. Hydroxyl radical formation as a result of the interaction between primaquine and reduced pyridine nucleotides. Arch Biochem Biophys 1986; 244: 147–155.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>147</start><end>155</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Biochem Biophys</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>244</number></detail><extent unit="pages"><start>147</start><end>155</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Studies on the mechanisms of oxidation in the erythrocyte by metabolites of primaquine</title></titleInfo><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Fletcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PF</namePart><namePart type="family">Barton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Kelly</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fletcher KA, Barton PF, Kelly JA. Studies on the mechanisms of oxidation in the erythrocyte by metabolites of primaquine. Biochem Pharmacol 1988; 37: 2683–2690.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>2683</start><end>2690</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>2683</start><end>2690</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>A mechanism for primaquine mediated oxidation of NADPH in red blood cells</title></titleInfo><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Thornalley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Stern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JV</namePart><namePart type="family">Bannister</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thornalley PJ, Stern A, Bannister JV. A mechanism for primaquine mediated oxidation of NADPH in red blood cells. Biochem Pharmacol 1983; 32: 3571–3575.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>3571</start><end>3575</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>3571</start><end>3575</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Oxidants, oxidant drugs, and malaria</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Eaton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vennerstrom JL, Eaton JW. Oxidants, oxidant drugs, and malaria. J Med Chem 1988; 31: 1269–1277.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1269</start><end>1277</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>1269</start><end>1277</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin‐producing and glutathione‐depleting activity in human erythrocytes</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Allahyari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Strother</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IM</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Verbiscar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Allahyari R, Strother A, Fraser IM, Verbiscar AJ. Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin‐producing and glutathione‐depleting activity in human erythrocytes. J Med Chem 1984; 27: 407–410.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>407</start><end>410</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>407</start><end>410</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vasquez‐Vivar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Augusto</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vasquez‐Vivar J, Augusto O. Hydroxylated metabolites of the antimalarial drug primaquine. Oxidation and redox cycling. J Biol Chem 1992; 267: 6848–6854.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>267</number></detail><extent unit="pages"><start>6848</start><end>6854</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>267</number></detail><extent unit="pages"><start>6848</start><end>6854</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Primaquine blocks transport by inhibiting the formation of functional transport vesicles</title></titleInfo><name type="personal"><namePart type="given">RR</namePart><namePart type="family">Hiebsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Raub</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BW</namePart><namePart type="family">Wattenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hiebsch RR, Raub TJ, Wattenberg BW. Primaquine blocks transport by inhibiting the formation of functional transport vesicles. J Biol Chem 1991; 30: 20323–20328.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>20323</start><end>20328</end></extent></part><relatedItem type="host"><titleInfo><title>J Biol Chem</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>20323</start><end>20328</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Primaquine, an inhibitor of vesicular transport, blocks the calcium‐release‐activated current in rat megakaryocytes</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Somasundaram</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Norman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Mahaut‐Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Somasundaram B, Norman JC, Mahaut‐Smith MP. Primaquine, an inhibitor of vesicular transport, blocks the calcium‐release‐activated current in rat megakaryocytes. Biochem J 1995; 309: 725–729.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>309</number></detail><extent unit="pages"><start>725</start><end>729</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem J</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>309</number></detail><extent unit="pages"><start>725</start><end>729</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase</title></titleInfo><name type="personal"><namePart type="given">IW</namePart><namePart type="family">Ittarat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Asawamahasadka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ittarat IW, Asawamahasadka W, Meshnick SR. The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp Parasitol 1994; 79: 50–56.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>50</start><end>56</end></extent></part><relatedItem type="host"><titleInfo><title>Exp Parasitol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>50</start><end>56</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>An assessment of drug‐hematin binding as a mechanism for inhibition of hematin polymerization by quinoline antimalarials</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Vippagunta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Matile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Jacquet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstorm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dorn A, Vippagunta SR, Matile H, Jacquet C, Vennerstorm JL, Ridley RG. An assessment of drug‐hematin binding as a mechanism for inhibition of hematin polymerization by quinoline antimalarials. Biochem Pharmacol 1998; 55: 727–736.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>727</start><end>736</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>727</start><end>736</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>A comparison and analysis of several ways to promote hematin (heme) polymerization and an assessment of its initiation in vitro</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Vippagunta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Matile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Bubendorf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dorn A, Vippagunta SR, Matile H, Bubendorf A, Vennerstrom JL, Ridley RG. A comparison and analysis of several ways to promote hematin (heme) polymerization and an assessment of its initiation in vitro. Biochem Pharmacol 1998; 55: 737–747.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>737</start><end>747</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>737</start><end>747</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Assignments of dissociation constants of primaquine by 13C NMR spectroscopy</title></titleInfo><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Hufford</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">McChesney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Baker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hufford CD, McChesney JD, Baker JK. Assignments of dissociation constants of primaquine by 13C NMR spectroscopy. J Heterocycl Chem 1983; 20: 273–275.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>273</start><end>275</end></extent></part><relatedItem type="host"><titleInfo><title>J Heterocycl Chem</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>273</start><end>275</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Resurgent malaria at the millennium</title></titleInfo><name type="personal"><namePart type="given">BJ</namePart><namePart type="family">Kevin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kevin BJ. Resurgent malaria at the millennium. Drugs 2000; 59: 719–743.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>719</start><end>743</end></extent></part><relatedItem type="host"><titleInfo><title>Drugs</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>719</start><end>743</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Drug resistance in malaria</title></titleInfo><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">White NJ. Drug resistance in malaria. Br Med Bull 1998; 54: 703–715.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>703</start><end>715</end></extent></part><relatedItem type="host"><titleInfo><title>Br Med Bull</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>703</start><end>715</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>Cerebral malaria</title></titleInfo><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Warrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Warrell DA. Cerebral malaria. Scweiz Med Wschr 1992; 122: 879–886.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>879</start><end>886</end></extent></part><relatedItem type="host"><titleInfo><title>Scweiz Med Wschr</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><extent unit="pages"><start>879</start><end>886</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Cerebral malaria in children</title></titleInfo><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Steele</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Baffoe‐Bonnie</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Steele RW, Baffoe‐Bonnie B. Cerebral malaria in children. Pediatr Infect Dis J 1995; 14: 281–285.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>281</start><end>285</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Infect Dis J</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>281</start><end>285</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Efflux of chloroquine from Plasmodium falciparum: Mechanism of chloroquine resistance</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Krogstad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IY</namePart><namePart type="family">Gluzman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Oduola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PH</namePart><namePart type="family">Schlesinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, Milhous WK, Schlesinger PH. Efflux of chloroquine from Plasmodium falciparum: Mechanism of chloroquine resistance. Science 1987; 238: 1283–1285.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>238</number></detail><extent unit="pages"><start>1283</start><end>1285</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>238</number></detail><extent unit="pages"><start>1283</start><end>1285</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>Malaria chemotherapy: Resistance to quinoline containing drugs in Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bray PG, Ward SA. Malaria chemotherapy: Resistance to quinoline containing drugs in Plasmodium falciparum. FEMS Microbial Lett 1993; 13: 1–8.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1</start><end>8</end></extent></part><relatedItem type="host"><titleInfo><title>FEMS Microbial Lett</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>1</start><end>8</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Antimalarial drug development and new targets</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Macreadie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Ginsburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Sirawaraporn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Tilley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Macreadie I, Ginsburg H, Sirawaraporn W, Tilley L. Antimalarial drug development and new targets. Parasitol Today 2000; 16: 438–444.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>438</start><end>444</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>438</start><end>444</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Rapid chloroquine efflux phenotype in both chloroquine‐sensitive and chloroquine‐resistant P. falciparum. A correlation of chloroquine sensitivity with energy‐dependent drug accumulation</title></titleInfo><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bray PG. Rapid chloroquine efflux phenotype in both chloroquine‐sensitive and chloroquine‐resistant P. falciparum. A correlation of chloroquine sensitivity with energy‐dependent drug accumulation. Biochem Pharmacol 1992; 44: 1317–1324.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1317</start><end>1324</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1317</start><end>1324</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>Drug‐resistant Malaria: Laboratory and field investigations</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Warhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Warhurst DC. Drug‐resistant Malaria: Laboratory and field investigations. J Pharm Pharmacol 1997; 49: 3–7.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>3</start><end>7</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharm Pharmacol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>3</start><end>7</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Reversal of chloroquine‐resistance in P. falciparum by verapamil</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Odula</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Martin SK, Odula AM, Milhous WK. Reversal of chloroquine‐resistance in P. falciparum by verapamil. Science 1987; 235: 899–901.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>Prevalence of the dihydrofolate reductase Asn‐108 mutation as the basis for pyrimethamine‐resistant P. falciparum malaria in the Brazilian Amazon</title></titleInfo><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Santi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Povoa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VS</namePart><namePart type="family">Calvosa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VE</namePart><namePart type="family">Rosario</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Wellems</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peterson DS, Santi SM, Povoa M, Calvosa VS, Rosario VE, Wellems TE. Prevalence of the dihydrofolate reductase Asn‐108 mutation as the basis for pyrimethamine‐resistant P. falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 1991; 45: 492–497.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>492</start><end>497</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>492</start><end>497</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>Molecular basis of differential resistance to cycloguanil and pyrimethamine in P. falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Wellems</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peterson DS, Milhous WK, Wellems TE. Molecular basis of differential resistance to cycloguanil and pyrimethamine in P. falciparum malaria. Proc Natl Acad Sci USA 1990; 87: 3018–3022.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>3018</start><end>3022</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>3018</start><end>3022</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Evidence that a point mutation in dihydrofolate reductase‐thymidylate synthase confers resistance to pyrimethamine in falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Walliker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Wellems</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peterson DS, Walliker D, Wellems TE. Evidence that a point mutation in dihydrofolate reductase‐thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA 1988; 85: 9114–9118.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>9114</start><end>9118</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>9114</start><end>9118</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>Early clinical failures after pyrimethamine‐sulfadoxine treatment of uncomplicated falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Onyiorah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MB</namePart><namePart type="family">van Hensbrock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Jah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Greenwood</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Onyiorah E, van Hensbrock MB, Jah MS, Greenwood B. Early clinical failures after pyrimethamine‐sulfadoxine treatment of uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 1996; 90: 307–308.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>307</start><end>308</end></extent></part><relatedItem type="host"><titleInfo><title>Trans R Soc Trop Med Hyg</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>307</start><end>308</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Edwards</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Winstanley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Edwards G, Winstanley PA, Ward SA. Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations. Clin Pharmacokinet 1994; 27: 150–165.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>150</start><end>165</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Pharmacokinet</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>150</start><end>165</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>New antimalarials. A risk‐benefit analysis</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Nosten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RN</namePart><namePart type="family">Price</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nosten F, Price RN. New antimalarials. A risk‐benefit analysis. Drug Saf 1995; 12: 264–273.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>264</start><end>273</end></extent></part><relatedItem type="host"><titleInfo><title>Drug Saf</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>264</start><end>273</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>Halofantrine versus mefloquine in the treatment of multi‐drug resistant falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">FO</namePart><namePart type="family">Kuile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GFN</namePart><namePart type="family">Dolan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kuile FO, Dolan GFN. Halofantrine versus mefloquine in the treatment of multi‐drug resistant falciparum malaria. Lancet 1993; 341: 1044–1049.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>1044</start><end>1049</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>1044</start><end>1049</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro</title></titleInfo><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Canfield</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Pudney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WE</namePart><namePart type="family">Gutteridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Canfield CJ, Pudney M, Gutteridge WE. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp Parasitol 1995; 80: 373–381.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>373</start><end>381</end></extent></part><relatedItem type="host"><titleInfo><title>Exp Parasitol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>373</start><end>381</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Strategies for prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria</title></titleInfo><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">White NJ, Olliaro PL. Strategies for prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria. Parasitol Today 1996; 12: 399–401.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>399</start><end>401</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>399</start><end>401</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>Antimalarial drug resistance: The pace quickens</title></titleInfo><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">White NJ. Antimalarial drug resistance: The pace quickens. J Antimicrob Chemother 1992; 30: 571–585.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>571</start><end>585</end></extent></part><relatedItem type="host"><titleInfo><title>J Antimicrob Chemother</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>571</start><end>585</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Wernsdorfer WH,Trigg PI. InPrimaquine: Pharmacokinetics, metabolism, toxicity and activity. (Published on behalf of UNDP/World Bank/Who Special Programme for Research and Training in Tropical Diseases.)Chichester: Wiley;1986.</title></titleInfo><note type="citation/reference">Wernsdorfer WH, Trigg PI. In Primaquine: Pharmacokinetics, metabolism, toxicity and activity. (Published on behalf of UNDP/World Bank/Who Special Programme for Research and Training in Tropical Diseases.) Chichester: Wiley; 1986.</note><name type="personal"><namePart type="given">WH</namePart><namePart type="family">Wernsdorfer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PI</namePart><namePart type="family">Trigg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Wiley</publisher><place><placeTerm type="text">Chichester</placeTerm></place></originInfo><part><date>1986</date></part></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Lawson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Basham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Chillingworth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Churcher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Craig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Davies</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Devlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Feltwell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Gentles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">William</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Hamlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Harris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Holroyd</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Hornsby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Horrocks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Jagels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Jassal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kyes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mclean</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Moule</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Mungall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Oliver</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Quail</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Rajandream</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Rutter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Skelton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Squares</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Squares</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Sulston</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Whitehead</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Woodward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Newbold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BG</namePart><namePart type="family">Barrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bowman S, Lawson D, Basham D, Brown D, Chillingworth T, Churcher CM, Craig A, Davies RM, Devlin K, Feltwell T, Gentles S, William R, Hamlin N, Harris D, Holroyd S, Hornsby T, Horrocks P, Jagels K, Jassal B, Kyes S, Mclean J, Moule S, Mungall K, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutter S, Skelton J, Squares R, Squares S, Sulston JE, Whitehead S, Woodward JR, Newbold C, Barrell BG. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature 1999; 400: 532–539.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>400</number></detail><extent unit="pages"><start>532</start><end>539</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>400</number></detail><extent unit="pages"><start>532</start><end>539</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>Hurrah for genomic projects!</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ivens</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ivens A. Hurrah for genomic projects! Parasitol Today 2000; 16: 317–320.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>317</start><end>320</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>317</start><end>320</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>The genome of the malaria parasite</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Gardner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gardner JM. The genome of the malaria parasite. Curr Opin in Genetics Devel 1999; 9: 704–708.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>704</start><end>708</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin in Genetics Devel</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>704</start><end>708</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Genome sequence of human malaria parasite P. falciparum</title></titleInfo><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Gardner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Hall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Fung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Berriman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Hyman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Carlton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Pain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KE</namePart><namePart type="family">Nelson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IT</namePart><namePart type="family">Paulsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">James</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Eisen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Rutherford</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Salzberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Craig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kyes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M‐S</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Nene</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Shallom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Suh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Angiuoli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Pertea</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Allen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Selengut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Haft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MW</namePart><namePart type="family">Mather</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Vaidya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DMA</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AH</namePart><namePart type="family">Fairlamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Fraunholz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Roos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ralph</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GI</namePart><namePart type="family">McFadden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LM</namePart><namePart type="family">Cummings</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Subramanian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Mungall</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Venter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Carucci</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Hoffman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Newbold</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Barrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan M‐S, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AK, Martin DMA, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B. Genome sequence of human malaria parasite P. falciparum. Nature 2002; 419: 498–511.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>419</number></detail><extent unit="pages"><start>498</start><end>511</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>419</number></detail><extent unit="pages"><start>498</start><end>511</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Sequence, expression and modeled structure of aspartic proteinase from the human malaria parasite P. falciparum</title></titleInfo><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Dame</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GR</namePart><namePart type="family">Reddy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Yowell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BM</namePart><namePart type="family">Dunn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Berry</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C. Sequence, expression and modeled structure of aspartic proteinase from the human malaria parasite P. falciparum. Mol Biol Med 1994; 65: 177–190.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>177</start><end>190</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Biol Med</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>65</number></detail><extent unit="pages"><start>177</start><end>190</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Toward a high resolution P. falciparum linkage map: Polymorphic markers from hundreds of simple sequence repeat</title></titleInfo><name type="personal"><namePart type="given">XZ</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Wellems</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Su XZ, Wellems TE. Toward a high resolution P. falciparum linkage map: Polymorphic markers from hundreds of simple sequence repeat. Genomics 1996; 33: 430–444.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>430</start><end>444</end></extent></part><relatedItem type="host"><titleInfo><title>Genomics</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><extent unit="pages"><start>430</start><end>444</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>New targets for antimalarial drug discovery</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Olliaro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Wirth</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Olliaro P, Wirth D. New targets for antimalarial drug discovery. J Pharm Pharmacol 1997; 49: 29–33.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>29</start><end>33</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharm Pharmacol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>29</start><end>33</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Inhibitors of the non‐mevalonate pathway of isoprenoid biosynthesis as antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jomaa H. Inhibitors of the non‐mevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 1999; 285: 1573–1576.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>285</number></detail><extent unit="pages"><start>1573</start><end>1576</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>285</number></detail><extent unit="pages"><start>1573</start><end>1576</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>Validating targets for antiparasite chemotherapy</title></titleInfo><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wang CC. Validating targets for antiparasite chemotherapy. Parasitol 1997; 114: S31–S44.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>S31</start><end>S44</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>S31</start><end>S44</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Qinghaosu</title></titleInfo><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Hien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hien TT, White NJ. Qinghaosu. Lancet 1993; 341: 603–608.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>603</start><end>608</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>341</number></detail><extent unit="pages"><start>603</start><end>608</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>Update on antimalarial drug artemisinin</title></titleInfo><name type="corporate"><namePart>Anonymous</namePart></name><genre>journal-article</genre><note type="citation/reference">Anonymous. Update on antimalarial drug artemisinin. Curr RD Highlights 1997; 41–62.</note><part><date>1997</date><extent unit="pages"><start>41</start><end>62</end></extent></part><relatedItem type="host"><titleInfo><title>Curr RD Highlights</title></titleInfo><part><date>1997</date><extent unit="pages"><start>41</start><end>62</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit78"><titleInfo><title>Mechanism‐based design, short synthesis and in vitro antimalarial testing of new 4‐methylated trioxanes structurally related to artemisinin: The importance of a carbon‐centered radical for antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Oh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gerena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Asawamahasadka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Posner GH, Oh CH, Wang D, Gerena L, Milhous WK, Meshnick SR, Asawamahasadka W. Mechanism‐based design, short synthesis and in vitro antimalarial testing of new 4‐methylated trioxanes structurally related to artemisinin: The importance of a carbon‐centered radical for antimalarial activity. J Med Chem 1994; 37: 1256–1258.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>1256</start><end>1258</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>1256</start><end>1258</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit79"><titleInfo><title>Synthesis, structure and antimalarial activity of tricyclic 1,2,4‐trioxanes related to artemisinin</title></titleInfo><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Jefford</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jefford CW. Synthesis, structure and antimalarial activity of tricyclic 1,2,4‐trioxanes related to artemisinin. Helv Chim Acta 1993; 76: 2775–2788.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>2775</start><end>2788</end></extent></part><relatedItem type="host"><titleInfo><title>Helv Chim Acta</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>2775</start><end>2788</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit80"><titleInfo><title>Dispiro‐1,2,4,5‐tetraoxanes: A new class of antimalarial peroxides</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vennerstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vennerstrom J. Dispiro‐1,2,4,5‐tetraoxanes: A new class of antimalarial peroxides. J Med Chem 1992; 35: 3023–3027.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>3023</start><end>3027</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>3023</start><end>3027</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit81"><titleInfo><title>New antimalarial, tricyclic 1,2,4‐trioxanes: Evaluations in mice and monkeys</title></titleInfo><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Oh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HK</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Ager Jr.</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RN</namePart><namePart type="family">Rossan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Posner GH, Oh CH, Webster HK, Ager AL, Jr., Rossan RN. New antimalarial, tricyclic 1,2,4‐trioxanes: Evaluations in mice and monkeys. Am J Trop Med Hyg 1994; 50: 522–526.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>522</start><end>526</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>522</start><end>526</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit82"><titleInfo><title>Arteflene (Ro 42‐1611): A new effective antimalarial</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Bradley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bradley DJ. Arteflene (Ro 42‐1611): A new effective antimalarial. Trop Med Parasitol 1994; 45: 259–291.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>259</start><end>291</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Med Parasitol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>259</start><end>291</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit83"><titleInfo><title>Second‐generation antimalarial endoperoxides</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Jefford</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Avery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Peters</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meshnick SR, Jefford CW, Posner GH, Avery MA, Peters W. Second‐generation antimalarial endoperoxides. Parasitol Today 1996; 12: 70–82.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>70</start><end>82</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitol Today</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>70</start><end>82</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit84"><titleInfo><title>New potential antimalarials: Arteether α/β: A fast‐acting blood schizontocide</title></titleInfo><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Tripathi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OP</namePart><namePart type="family">Asthana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dutta GP, Tripathi R, Asthana OP, Gupta KC. New potential antimalarials: Arteether α/β: A fast‐acting blood schizontocide. Trop Dis 1994; 301–311.</note><part><date>1994</date><extent unit="pages"><start>301</start><end>311</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Dis</title></titleInfo><part><date>1994</date><extent unit="pages"><start>301</start><end>311</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit85"><titleInfo><title>Blood schizontocidal activity of artemisinin (Qinghaosu) and a new antimalarial arteether (α/β) against Plasmodium berghei</title></titleInfo><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Bajpai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Vishwakarma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dutta GP, Bajpai R, Vishwakarma RA. Blood schizontocidal activity of artemisinin (Qinghaosu) and a new antimalarial arteether (α/β) against Plasmodium berghei. Indian J Parasitol 1987; 11: 253–257.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>253</start><end>257</end></extent></part><relatedItem type="host"><titleInfo><title>Indian J Parasitol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>253</start><end>257</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit86"><titleInfo><title>Antimalarial efficacy of arteether against a multiple drug resistant strain of Plasmodium yoelii nigeriensis</title></titleInfo><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Bajpai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Vishwakarma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dutta GP, Bajpai R, Vishwakarma RA. Antimalarial efficacy of arteether against a multiple drug resistant strain of Plasmodium yoelii nigeriensis. Pharmacol Res 1989; 21: 415–418.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>415</start><end>418</end></extent></part><relatedItem type="host"><titleInfo><title>Pharmacol Res</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>415</start><end>418</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit87"><titleInfo><title>Blood schizontocidal activity of new antimalarial drugs, arteether (α/β) against Plasmodium knowlesi in rhesus monkeys</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Bajpai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Vishwakarma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bajpai R, Dutta GP, Vishwakarma RA. Blood schizontocidal activity of new antimalarial drugs, arteether (α/β) against Plasmodium knowlesi in rhesus monkeys. Trans R Soc Trop Med Hyg 1989; 83: 484.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>484</start></extent></part><relatedItem type="host"><titleInfo><title>Trans R Soc Trop Med Hyg</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>484</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit88"><titleInfo><title>Standardization of Plasmodium cynomolgi B rhesus monkey model for radical curative test and primaquine sensitivity of the relapse stages of the parasite from different cyclic passages</title></titleInfo><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dutta GP, Puri SK. Standardization of Plasmodium cynomolgi B rhesus monkey model for radical curative test and primaquine sensitivity of the relapse stages of the parasite from different cyclic passages. Ind J Parasitol 1983; 12: 109–115.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>109</start><end>115</end></extent></part><relatedItem type="host"><titleInfo><title>Ind J Parasitol</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>109</start><end>115</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit89"><titleInfo><title>In new future potential antimalarials XIIIth Intern</title></titleInfo><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dutta GP. In new future potential antimalarials XIIIth Intern. Congress Trop Med Malaria 1992; 2: 86.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>86</start></extent></part><relatedItem type="host"><titleInfo><title>Congress Trop Med Malaria</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>86</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit90"><titleInfo><title>Synthetic peroxides as antimalarials</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Tang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstorm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tang Y, Dong Y, Vennerstorm JL. Synthetic peroxides as antimalarials. Med Res Rev 2004; 24: 425–448.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>425</start><end>448</end></extent></part><relatedItem type="host"><titleInfo><title>Med Res Rev</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>425</start><end>448</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit91"><titleInfo><title>A medicinal chemistry perspective on artemisinin and related endoperoxides</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides. J Med Chem 2004; 47: 2945–2964.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2945</start><end>2964</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2945</start><end>2964</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit92"><titleInfo><title>Antimalarial and antitumor evaluation of novel C‐10 non‐acetal dimmers of 10β‐(2‐hydroxyethyl)deoxoartemisinin</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Jeyadevan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chadwick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Mercer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Byrne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DP</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Cosstick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Davies</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">Higson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Irving</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jeyadevan JP, Bray PG, Chadwick J, Mercer AE, Byrne A, Ward SA, Park BK, Williams DP, Cosstick R, Davies J, Higson AP, Irving E, Posner GH, O'Neill PM. Antimalarial and antitumor evaluation of novel C‐10 non‐acetal dimmers of 10β‐(2‐hydroxyethyl)deoxoartemisinin. J Med Chem 2004; 47: 1290–1298.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1290</start><end>1298</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1290</start><end>1298</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit93"><titleInfo><title>Anticancer and antimalarial efficacy and safety of artemisinin‐derived trioxane dimmers in rodents</title></titleInfo><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Posner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">McRiner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IH</namePart><namePart type="family">Paik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Borstnik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Xie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TA</namePart><namePart type="family">Shapiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Alsgbala</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Foster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alsgbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin‐derived trioxane dimmers in rodents. J Med Chem 2004; 47: 1299–1301.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1299</start><end>1301</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1299</start><end>1301</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit94"><titleInfo><title>Orally active antimalarials: Hydrolytically stable derivatives of 10‐trifluoromethyl anhydrodihydroartemisinin</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Grellepois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Chorki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ourevitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Charneau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">McIntosh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WN</namePart><namePart type="family">Charman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Pradines</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Croisse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Bonnet‐Delphon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J‐P</namePart><namePart type="family">Begue</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grellepois F, Chorki F, Ourevitch M, Charneau S, Grellier P, McIntosh KA, Charman WN, Pradines B, Croisse B, Bonnet‐Delphon D, Begue J‐P. Orally active antimalarials: Hydrolytically stable derivatives of 10‐trifluoromethyl anhydrodihydroartemisinin. J Med Chem 2004; 47: 1423–1433.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1423</start><end>1433</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1423</start><end>1433</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit95"><titleInfo><title>Flororartemisinin: Trifluoromethyl analogs of artemether and artesunate</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Magueur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Crousse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Charneau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J‐P</namePart><namePart type="family">Begue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Bonnet‐Delphon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Magueur G, Crousse B, Charneau S, Grellier P, Begue J‐P, Bonnet‐Delphon D. Flororartemisinin: Trifluoromethyl analogs of artemether and artesunate. J Med Chem 2004; 47: 2694–2699.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2694</start><end>2699</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2694</start><end>2699</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit96"><titleInfo><title>Novel endoperoxide antimalarials: Synthesis, heme binding, and antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">DK</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TD</namePart><namePart type="family">Avery</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BW</namePart><namePart type="family">Greatrex</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ERT</namePart><namePart type="family">Tiekink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IG</namePart><namePart type="family">Macreadie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PI</namePart><namePart type="family">Macreadie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Humphries</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kalkanidis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EN</namePart><namePart type="family">Fox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Klonis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Tilley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Taylor DK, Avery TD, Greatrex BW, Tiekink ERT, Macreadie IG, Macreadie PI, Humphries AD, Kalkanidis M, Fox EN, Klonis N, Tilley L. Novel endoperoxide antimalarials: Synthesis, heme binding, and antimalarial activity. J Med Chem 2004; 47: 1833–1839.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1833</start><end>1839</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1833</start><end>1839</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit97"><titleInfo><title>Identification of an antimalarial synthetic trioxolane drug development candidate</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Arbe‐Branes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Burn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Charman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FCK</namePart><namePart type="family">Chiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chollet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Hunziker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Matile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">McIntosh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Padmaniliayam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Tomas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Scheurer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Scorneaux</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Tang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Urwyler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wittlin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WN</namePart><namePart type="family">Charman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vennerstrom JL, Arbe‐Branes S, Burn R, Charman SA, Chiu FCK, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmaniliayam M, Tomas JS, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 2004; 430: 900–904.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>430</number></detail><extent unit="pages"><start>900</start><end>904</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>430</number></detail><extent unit="pages"><start>900</start><end>904</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit98"><titleInfo><title>Synthesis of new 6‐alkylvinyl/arylalkylvinyl substituted 1,2,4‐trioxanes active against multidrug‐resistant malaria in mice</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Singh C, Gupta N, Puri SK. Synthesis of new 6‐alkylvinyl/arylalkylvinyl substituted 1,2,4‐trioxanes active against multidrug‐resistant malaria in mice. Bioorg Med Chem 2004; 12: 5553–5562.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5553</start><end>5562</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5553</start><end>5562</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit99"><titleInfo><title>Synthesis and antimalarial activity of 6‐cycloalkylvinyl substituted 1,2,4‐trioxanes</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NC</namePart><namePart type="family">Srivastav</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Singh C, Srivastav NC, Puri SK. Synthesis and antimalarial activity of 6‐cycloalkylvinyl substituted 1,2,4‐trioxanes. Bioorg Med Chem 2004; 12: 5745–5752.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5745</start><end>5752</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5745</start><end>5752</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit100"><titleInfo><title>Structure‐activity relationship of anti‐malarial spongean peroxides having a 3‐methoxy‐1,2‐dioxane structure</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kawanishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Kotoku</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Itagaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Horii</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kawanishi M, Kotoku N, Itagaki S, Horii T, Kobayashi M. Structure‐activity relationship of anti‐malarial spongean peroxides having a 3‐methoxy‐1,2‐dioxane structure. Bioorg Med Chem 2004; 12: 5297–5307.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5297</start><end>5307</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>5297</start><end>5307</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit101"><titleInfo><title>Basco LK,Ruggeri C,Le Bras J.Molécules antipaludiques.Paris: Masson.1994;115–120.</title></titleInfo><note type="citation/reference">Basco LK, Ruggeri C, Le Bras J. Molécules antipaludiques. Paris: Masson. 1994; 115–120.</note><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Basco</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Ruggeri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Le Bras</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Masson</publisher><place><placeTerm type="text">Paris</placeTerm></place></originInfo><part><date>1994</date><extent unit="pages"><start>115</start><end>120</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit102"><titleInfo><title>Bisquinolines: 1. N,N‐Bis(7‐chloroquine‐4‐yl)alkanediamines with potential activity against chloroquine‐resistant malaria</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WY</namePart><namePart type="family">Ellis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Ager</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gerena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vennerstrom JL, Ellis WY, Ager LA, Anderson SL, Gerena L, Milhous WK. Bisquinolines: 1. N,N‐Bis(7‐chloroquine‐4‐yl)alkanediamines with potential activity against chloroquine‐resistant malaria. J Med Chem 1992; 35: 2129–2134.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2129</start><end>2134</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>2129</start><end>2134</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit103"><titleInfo><title>Antiplasmodial activity and cytotoxicity of bis‐, tris‐ and tetraquinolines with liner or cyclic amino linkers</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Girault</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Berecibar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Maes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Lemiere</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mouray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Elisabeth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Girault S, Grellier P, Berecibar A, Maes L, Lemiere P, Mouray E, Elisabeth DC, Sergheraert C. Antiplasmodial activity and cytotoxicity of bis‐, tris‐ and tetraquinolines with liner or cyclic amino linkers. J Med Chem 2001; 44: 1658–1665.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1658</start><end>1665</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>1658</start><end>1665</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit104"><titleInfo><title>Bisquinolines:2. Antimalarial N,N‐bis(7‐chloroquine‐4‐yl)heteroalkanediamines</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstorm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Ager</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gerena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vennerstorm JL, Ager LA, Dorn A, Anderson SL, Gerena L, Ridley RG, Milhous WK. Bisquinolines:2. Antimalarial N,N‐bis(7‐chloroquine‐4‐yl)heteroalkanediamines. J Med Chem 1998; 41: 4360–4364.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>4360</start><end>4364</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>4360</start><end>4364</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit105"><titleInfo><title>Synthesis and activity of some antimalarial bisquinolines</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Raynes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Galatis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AF</namePart><namePart type="family">Cowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Tilley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Deady</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Raynes K, Galatis D, Cowman AF, Tilley L, Deady L. Synthesis and activity of some antimalarial bisquinolines. J Med Chem 1995; 38: 204–206.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>204</start><end>206</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><extent unit="pages"><start>204</start><end>206</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit106"><titleInfo><title>Synthesis and activity of some antimalarial bisquinolinemethanols</title></titleInfo><name type="personal"><namePart type="given">AF</namePart><namePart type="family">Cowman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LW</namePart><namePart type="family">Deady</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Deharo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Desneves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Tilley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cowman AF, Deady LW, Deharo E, Desneves J, Tilley L. Synthesis and activity of some antimalarial bisquinolinemethanols. Aus J Chem 1997; 52: 551–559.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>551</start><end>559</end></extent></part><relatedItem type="host"><titleInfo><title>Aus J Chem</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>551</start><end>559</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit107"><titleInfo><title>Synthesis, antimalarial activity and inhibition of heme detoxification of novel bisquinolines</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Ayad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Tilley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LW</namePart><namePart type="family">Deady</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ayad F, Tilley L, Deady LW. Synthesis, antimalarial activity and inhibition of heme detoxification of novel bisquinolines. Bioorg Med Chem Lett 2001; 11: 2075–2077.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>2075</start><end>2077</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>2075</start><end>2077</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit108"><titleInfo><title>Amodiaquine remains effective for uncomplicated infections in West and Central Africa</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Brasseur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Guiguemide</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Diallo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Guiyedi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brasseur P, Guiguemide R, Diallo S, Guiyedi V. Amodiaquine remains effective for uncomplicated infections in West and Central Africa. Trans R Soc Trop Med Hyg 1999; 93: 645–650.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>645</start><end>650</end></extent></part><relatedItem type="host"><titleInfo><title>Trans R Soc Trop Med Hyg</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><extent unit="pages"><start>645</start><end>650</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit109"><titleInfo><title>Synthesis and in vitro and in vivo antimalarial activity of new 4‐anilinoquinolines</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Delarue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Girault</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Maes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DF</namePart><namePart type="family">Marie‐Ange</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Mehdi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Delarue S, Girault S, Maes L, Marie‐Ange DF, Mehdi L, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of new 4‐anilinoquinolines. J Med Chem 2001; 44: 2827–2833.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>2827</start><end>2833</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>2827</start><end>2833</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit110"><titleInfo><title>A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4‐anilinoquinoline</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Davioud‐Charvet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Delarue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Biot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Schwobel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Boehme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mussigbrodt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Mase</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RH</namePart><namePart type="family">Schirmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Becker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Davioud‐Charvet E, Delarue S, Biot C, Schwobel B, Boehme CC, Mussigbrodt A, Mase L, Sergheraert C, Grellier P, Schirmer RH, Becker K. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4‐anilinoquinoline. J Med Chem 2001; 44: 4268–4276.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>4268</start><end>4276</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>4268</start><end>4276</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit111"><titleInfo><title>Isoquine and related amodiaquine analogs: A new generation of improved 4‐aminoquinoline antimalariala</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mukhtar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Stocks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Randle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Hindley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Storr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Bickley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IA</namePart><namePart type="family">O'Neil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Maggs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RH</namePart><namePart type="family">Hughes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Winstanley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">O'Neill PM, Mukhtar A, Stocks PA, Randle PA, Hindley S, Ward SA, Storr RC, Bickley JF, O'Neil IA, Maggs JL, Hughes RH, Winstanley PA, Bray PG, Park BK. Isoquine and related amodiaquine analogs: A new generation of improved 4‐aminoquinoline antimalariala. J Med Chem 2003; 46: 4933–4945.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>4933</start><end>4945</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>4933</start><end>4945</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit112"><titleInfo><title>Hematin (haem) polymerization and its inhibition by chloroquine antimalarials</title></titleInfo><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Vippagunta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstorm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ridley RG, Dorn A, Vippagunta SR, Vennerstorm JL. Hematin (haem) polymerization and its inhibition by chloroquine antimalarials. Ann Trop Med Parasitol 1997; 91: 559–566.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>559</start><end>566</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Trop Med Parasitol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>559</start><end>566</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit113"><titleInfo><title>An iron‐carboxylate bond links the heme units of malaria pigment</title></titleInfo><name type="personal"><namePart type="given">AFG</namePart><namePart type="family">Slater</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WJ</namePart><namePart type="family">Swiggard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BR</namePart><namePart type="family">Orton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WD</namePart><namePart type="family">Flitter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Cerami</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GB</namePart><namePart type="family">Henderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Slater AFG, Swiggard WJ, Orton BR, Flitter WD, Goldberg DE, Cerami A, Henderson GB. An iron‐carboxylate bond links the heme units of malaria pigment. Proc Natl Acad Sci USA 1991; 88: 325–329.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>325</start><end>329</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>325</start><end>329</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit114"><titleInfo><title>Synthesis, antimalarial activity, and molecular modeling of tebuquine analogs</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Willock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Hawley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Storr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. Synthesis, antimalarial activity, and molecular modeling of tebuquine analogs. J Med Chem 1997; 40: 437–448.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>437</start><end>448</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>437</start><end>448</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit115"><titleInfo><title>Structural specificity of chloroquine‐hematin binding related to inhibition of hematin polymerization and parasite growth</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Vippagunta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dorn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Matile</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Bhattacharjee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Karle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WY</namePart><namePart type="family">Ellis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Ridley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Vennerstorm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vippagunta SR, Dorn A, Matile H, Bhattacharjee AK, Karle JM, Ellis WY, Ridley RG, Vennerstorm JL. Structural specificity of chloroquine‐hematin binding related to inhibition of hematin polymerization and parasite growth. J Med Chem 1999; 42: 4630–4639.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>4630</start><end>4639</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>4630</start><end>4639</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit116"><titleInfo><title>Parallel synthesis and antimalarial activity of a sulfonamide library</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ryckebusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Deprez‐Poulain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M‐A</namePart><namePart type="family">Debreu‐Fontaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Vandaele</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mouray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ryckebusch A, Deprez‐Poulain R, Debreu‐Fontaine M‐A, Vandaele R, Mouray E, Grellier P, Sergheraert C. Parallel synthesis and antimalarial activity of a sulfonamide library. Bioorg Med Chem Lett 2002; 12: 2595–2598.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2595</start><end>2598</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2595</start><end>2598</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit117"><titleInfo><title>Design, synthesis and antimalarial activity of novel, quinoline‐based, zinc metallo‐aminopeptidase inhibitors</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Flipo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Florent</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Deprez‐Poulain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Flipo M, Florent I, Grellier P, Sergheraert C, Deprez‐Poulain R. Design, synthesis and antimalarial activity of novel, quinoline‐based, zinc metallo‐aminopeptidase inhibitors. Bioorg Med Chem Lett 2003; 12: 2659–2662.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2659</start><end>2662</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2659</start><end>2662</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit118"><titleInfo><title>Synthesis and in vitro and in vivo antimalarial activity of N1‐(7‐chloro‐4‐quinolyl)‐1,4‐bis(3‐aminopropyl)piperazine derivatives</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ryckebusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Deprez‐Poulain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Maes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M‐A</namePart><namePart type="family">Debreu‐Fontaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mouray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ryckebusch A, Deprez‐Poulain R, Maes L, Debreu‐Fontaine M‐A, Mouray E, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of N1‐(7‐chloro‐4‐quinolyl)‐1,4‐bis(3‐aminopropyl)piperazine derivatives. J Med Chem 2003; 46: 542–557.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>542</start><end>557</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>542</start><end>557</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit119"><titleInfo><title>Synthesis and antimalarial evaluation of new N1‐(7‐chloro‐4‐quinolyl)‐1,4‐bis(3‐aminopropyl)piperazine derivatives</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ryckebusch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M‐A</namePart><namePart type="family">Debreu‐Fontaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mouray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Grellier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sergheraert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Melnyk</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ryckebusch A, Debreu‐Fontaine M‐A, Mouray E, Grellier P, Sergheraert C, Melnyk P. Synthesis and antimalarial evaluation of new N1‐(7‐chloro‐4‐quinolyl)‐1,4‐bis(3‐aminopropyl)piperazine derivatives. Bioorg Med Chem Lett 2005; 15: 297–302.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>297</start><end>302</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>297</start><end>302</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit120"><titleInfo><title>Novel short chain chloroquine analogs retain activity against chloroquine resistant K1 P. falciparum</title></titleInfo><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Stocks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Raynes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PG</namePart><namePart type="family">Bray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BK</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">O'Neill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Ward</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stocks PA, Raynes KJ, Bray PG, Park BK, O'Neill PM, Ward SA. Novel short chain chloroquine analogs retain activity against chloroquine resistant K1 P. falciparum. J Med Chem 2002; 45: 4975–4983.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>4975</start><end>4983</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>4975</start><end>4983</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit121"><titleInfo><title>Application of multi‐component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4‐aminoquinoline Ugi adduct</title></titleInfo><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Musonda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Taylor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Lehman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Chibale</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Application of multi‐component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4‐aminoquinoline Ugi adduct. Bioorg Med Chem Lett 2004; 14: 3901–3905.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>3901</start><end>3905</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>3901</start><end>3905</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit122"><titleInfo><title>Design and synthesis of new antimalarial agents from 4‐aminoquinoline</title></titleInfo><name type="personal"><namePart type="given">VR</namePart><namePart type="family">Solomon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Katti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Solomon VR, Puri SK, Srivastava K, Katti SB. Design and synthesis of new antimalarial agents from 4‐aminoquinoline. Bioorg Med Chem 2005; 15: 2157–2165.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>2157</start><end>2165</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>2157</start><end>2165</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit123"><titleInfo><title>Reversal of chloroquine resistance in Plasmodium falciparum by verapamil</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Oduola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Martin SK, Oduola AM, Milhous WK. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. Science 1987; 235: 899–901.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>235</number></detail><extent unit="pages"><start>899</start><end>901</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit124"><titleInfo><title>Reversal of chloroquine resistance in malaria parasite P. falciparum by desipramine</title></titleInfo><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Bitonti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Sjoerdsma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">McCann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AMJ</namePart><namePart type="family">Oduola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RN</namePart><namePart type="family">Rossan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Davidson Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">(a) Bitonti AJ, Sjoerdsma A, McCann PP, Kyle DE, Oduola AMJ, Rossan RN, Davidson DE, Jr. Reversal of chloroquine resistance in malaria parasite P. falciparum by desipramine. Science 1988; 242: 1301–1303.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>242</number></detail><extent unit="pages"><start>1301</start><end>1303</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>242</number></detail><extent unit="pages"><start>1301</start><end>1303</end></extent></part></relatedItem><titleInfo><title>Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant P. falciparum</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gerena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GE</namePart><namePart type="family">Bass</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AMJ</namePart><namePart type="family">Oduola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RK</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">(b) Gerena L, Bass GE, Kyle DE, Oduola AMJ, Milhous WK, Martin RK. Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant P. falciparum. Antimicrob Agents Chemother 1992; 36: 2761–2765.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>2761</start><end>2765</end></extent></part><relatedItem type="host"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>2761</start><end>2765</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit126"><titleInfo><title>Antihistaminic drugs that reverse chloroquine resistance in P. falciparum</title></titleInfo><name type="personal"><namePart type="given">W</namePart><namePart type="family">Peters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ekong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BL</namePart><namePart type="family">Robinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Warhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XQ</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peters W, Ekong R, Robinson BL, Warhurst DC, Pan XQ. Antihistaminic drugs that reverse chloroquine resistance in P. falciparum. Lancet 1989; 334–335.</note><part><date>1989</date><extent unit="pages"><start>334</start><end>335</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1989</date><extent unit="pages"><start>334</start><end>335</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit127"><titleInfo><title>Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Chandra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Ohnishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BN</namePart><namePart type="family">Dhawan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chandra S, Ohnishi ST, Dhawan BN. Reversal of chloroquine resistance in murine malaria parasites by prostaglandin derivatives. Am J Trop Med Hyg 1993; 48: 645–651.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>645</start><end>651</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>645</start><end>651</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit128"><titleInfo><title>Design, synthesis and evaluation of new chemosensitizers in multi‐drug‐resistant Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gerene</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guan J, Kyle DE, Gerene L, Zhang Q, Milhous WK, Lin AJ. Design, synthesis and evaluation of new chemosensitizers in multi‐drug‐resistant Plasmodium falciparum. J Med Chem 2002; 45: 2741–2748.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>2741</start><end>2748</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>2741</start><end>2748</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit129"><titleInfo><title>Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Alibert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Santelli‐Rouvier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Pradines</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Houdoin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Parzy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Karolak‐Wojciechowska</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Barbe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Alibert S, Santelli‐Rouvier C, Pradines B, Houdoin C, Parzy D, Karolak‐Wojciechowska J, Barbe J. Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives. J Med Chem 2002; 45: 3195–3209.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>3195</start><end>3209</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>3195</start><end>3209</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit130"><titleInfo><title>In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Pradines</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Alibert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Houdouin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mosnier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Santelli‐Rouvier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Papa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Rogier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Fusai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Barbe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Parzy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pradines B, Alibert S, Houdouin C, Mosnier J, Santelli‐Rouvier C, Papa V, Rogier C, Fusai T, Barbe J, Parzy D. In vitro reversal of chloroquine resistance in Plasmodium falciparum with dihydroethanoanthracene derivatives. Am J Trop Med Hyg 2002; 66: 661–666.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>661</start><end>666</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>661</start><end>666</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit131"><titleInfo><title>Evaluation of resistant‐reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Pandey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">Bhaduri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Srivastava P, Pandey VC, Bhaduri AP. Evaluation of resistant‐reversal, CDRI compound 87/209 and its possible mode of action in rodent experimental malaria. Trop Med Parasitol 1995; 46: 83–87.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>83</start><end>87</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Med Parasitol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>83</start><end>87</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit132"><titleInfo><title>A new class of potential chloroquine‐resistance reversal agents for plasmodia: Syntheses and biological evaluation of 1‐(3′‐diethylaminopropyl)‐3‐(substituted phenylmethylene)pyrrolidines</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Batra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Roy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Pandey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">Bhaduri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Batra S, Srivastava P, Roy K, Pandey VC, Bhaduri AP. A new class of potential chloroquine‐resistance reversal agents for plasmodia: Syntheses and biological evaluation of 1‐(3′‐diethylaminopropyl)‐3‐(substituted phenylmethylene)pyrrolidines. J Med Chem 2000; 43: 3428–3433.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>3428</start><end>3433</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>3428</start><end>3433</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit133"><titleInfo><title>Berl Klin Wochenschr</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Guttman P, Ehrilich P. Berl Klin Wochenschr 1891; 28: 953–956.</note><name type="personal"><namePart type="given">P</namePart><namePart type="family">Guttman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ehrilich</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1891</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>953</start><end>956</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit134"><titleInfo><title>Schulemann W,Mietzsch F,Wingler A.U S Patent 1,766,403, 5p. Chem Abst1930;24:2242.</title></titleInfo><genre>other</genre><part><date>1930</date></part></relatedItem><relatedItem type="references" displayLabel="cit135"><titleInfo><title>Antimalarial activity of 8‐aminoquinolines</title></titleInfo><name type="personal"><namePart type="given">EA</namePart><namePart type="family">Nodiff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Chatterjee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HA</namePart><namePart type="family">Musallam</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nodiff EA, Chatterjee S, Musallam HA. Antimalarial activity of 8‐aminoquinolines. Prog Med Chem 1991; 28: 1–40.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1</start><end>40</end></extent></part><relatedItem type="host"><titleInfo><title>Prog Med Chem</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1</start><end>40</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit136"><titleInfo><title>Peters W. InChemotherapy and drug resistance in malaria.London: Academic Press;1987. pp 581–589.</title></titleInfo><note type="citation/reference">Peters W. In Chemotherapy and drug resistance in malaria. London: Academic Press; 1987. pp 581–589.</note><name type="personal"><namePart type="given">W</namePart><namePart type="family">Peters</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Academic Press</publisher><place><placeTerm type="text">London</placeTerm></place></originInfo><part><date>1987</date><extent unit="pages"><start>581</start><end>589</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit137"><titleInfo><title>Excretion, distribution, and metabolism of primaquine in rats</title></titleInfo><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Baker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Clark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">McChesney</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Baker JK, Clark AM, McChesney JD. Excretion, distribution, and metabolism of primaquine in rats. J Pharm Sci 1984; 73: 502–506.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>502</start><end>506</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharm Sci</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>502</start><end>506</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit138"><titleInfo><title>In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin‐forming metabolite</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Strother</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Allahyari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Buchholz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IM;</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BE</namePart><namePart type="family">Tilton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Strother A, Allahyari R, Buchholz J, Fraser IM; Tilton BE. In vitro metabolism of the antimalarial agent primaquine by mouse liver enzymes and identification of a methemoglobin‐forming metabolite. Drug Metab Dispos 1984; 12: 35–44.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>35</start><end>44</end></extent></part><relatedItem type="host"><titleInfo><title>Drug Metab Dispos</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>35</start><end>44</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit139"><titleInfo><title>Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin‐producing and glutathione‐depleting activity in human erythrocytes</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Allahyari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Strother</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IM</namePart><namePart type="family">Fraser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Verbiscar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Allahyari R, Strother A, Fraser IM, Verbiscar AJ. Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin‐producing and glutathione‐depleting activity in human erythrocytes. J Med Chem 1984; 27: 407–410.</note><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>407</start><end>410</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>407</start><end>410</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit140"><titleInfo><title>Putative metabolites of 8‐aminoquinoline antimalarilas: Synthesis and tissue‐schizontocidal activity of 8‐substituted‐amino‐5,6‐dihydroxy/5‐hydroxy‐6‐methoxy‐4‐methylquinolines and 6‐alkoxy‐5,8‐quinolinequinones</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Anand</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jain R, Gupta RC, Anand N. Putative metabolites of 8‐aminoquinoline antimalarilas: Synthesis and tissue‐schizontocidal activity of 8‐substituted‐amino‐5,6‐dihydroxy/5‐hydroxy‐6‐methoxy‐4‐methylquinolines and 6‐alkoxy‐5,8‐quinolinequinones. Indian J Chem 1994; 33B: 792–794.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33B</number></detail><extent unit="pages"><start>792</start><end>794</end></extent></part><relatedItem type="host"><titleInfo><title>Indian J Chem</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33B</number></detail><extent unit="pages"><start>792</start><end>794</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit141"><titleInfo><title>WR 238605: A potential broad‐spectrum antimalarial, PID (CSIR)</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BG</namePart><namePart type="family">Schuster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Davidson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Puri SK, Dutta GP, Milhous WK, Schuster BG, Davidson DE. WR 238605: A potential broad‐spectrum antimalarial, PID (CSIR). In Proc Trop Dis Mol Biol and Contr Strat 1994; 276–285.</note><part><date>1994</date><extent unit="pages"><start>276</start><end>285</end></extent></part><relatedItem type="host"><titleInfo><title>In Proc Trop Dis Mol Biol and Contr Strat</title></titleInfo><part><date>1994</date><extent unit="pages"><start>276</start><end>285</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit142"><titleInfo><title>Studies on the cyclic transmission of P. cynomolgi B and standardization of 3‐day simian model for causal prophylactic activity</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Puri SK, Dutta GP. Studies on the cyclic transmission of P. cynomolgi B and standardization of 3‐day simian model for causal prophylactic activity. Indian J Parasitol 1988; 12: 99–107.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>99</start><end>107</end></extent></part><relatedItem type="host"><titleInfo><title>Indian J Parasitol</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>99</start><end>107</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit143"><titleInfo><title>Infectivity studies on Anopheles stephensi using P. cynomolgi B infection in rhesus monkeys</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KK</namePart><namePart type="family">Kamboj</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Puri SK, Kamboj KK, Dutta GP. Infectivity studies on Anopheles stephensi using P. cynomolgi B infection in rhesus monkeys. Trop Med Parasitol 1989; 40: 409–411.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>409</start><end>411</end></extent></part><relatedItem type="host"><titleInfo><title>Trop Med Parasitol</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>409</start><end>411</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit144"><titleInfo><title>Development of new derivatives of primaquine by association with lysosomotropic carriers</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Trouet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Pirson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RF</namePart><namePart type="family">Steiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Masquelier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Baurain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gillet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Trouet A, Pirson P, Steiger RF, Masquelier M, Baurain R, Gillet J. Development of new derivatives of primaquine by association with lysosomotropic carriers. Bull World Health Organ 1981; 59: 449–458.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>449</start><end>458</end></extent></part><relatedItem type="host"><titleInfo><title>Bull World Health Organ</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>449</start><end>458</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit145"><titleInfo><title>Primaquine liposomes in the chemotherapy of experimental murine malaria</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Pirson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RF</namePart><namePart type="family">Steiger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Trouet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gillet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Herman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pirson P, Steiger RF, Trouet A, Gillet J, Herman F. Primaquine liposomes in the chemotherapy of experimental murine malaria. Ann Trop Med Parasitol 1980; 74: 383–391.</note><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>383</start><end>391</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Trop Med Parasitol</title></titleInfo><part><date>1980</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>383</start><end>391</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit146"><titleInfo><title>Carrier‐linked primaquine in the chemotherapy of malaria</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hofsteenge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Capuano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Altszuler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Moore</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hofsteenge J, Capuano A, Altszuler R, Moore S. Carrier‐linked primaquine in the chemotherapy of malaria. J Med Chem 1986; 29: 1765–1769.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>1765</start><end>1769</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>1765</start><end>1769</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit147"><titleInfo><title>Peptide derivatives of primaquine as potential antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Philip</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Kepler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BH</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FI</namePart><namePart type="family">Carroll</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Philip A, Kepler JA, Johnson BH, Carroll FI. Peptide derivatives of primaquine as potential antimalarial agents. J Med Chem 1988; 31: 870–874.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>870</start><end>874</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>870</start><end>874</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit148"><titleInfo><title>Pharmacology of compound CDRI 80/53, a potential new anti‐relapse antimalarial drug</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GK</namePart><namePart type="family">Patnaik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kar K, Patnaik GK, Puri SK, Dutta GP. Pharmacology of compound CDRI 80/53, a potential new anti‐relapse antimalarial drug. Indian J Parasitol 1988; 12: 259–262.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>259</start><end>262</end></extent></part><relatedItem type="host"><titleInfo><title>Indian J Parasitol</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>259</start><end>262</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit149"><titleInfo><title>Methemoglobin toxicity and hematological studies on malaria anti‐relapse compound CDRI 80/53 in dogs</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VC</namePart><namePart type="family">Pandey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Sethi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Puri SK, Srivastava R, Pandey VC, Sethi N, Dutta GP. Methemoglobin toxicity and hematological studies on malaria anti‐relapse compound CDRI 80/53 in dogs. Am J Trop Med Hyg 1989; 41: 638–642.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>638</start><end>642</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>638</start><end>642</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit150"><titleInfo><title>Appraisals of compounds of diverse chemical classes for capacities to cure infections with sporozoites of P. cynomolgi</title></titleInfo><name type="personal"><namePart type="given">LH</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Schmidt LH. Appraisals of compounds of diverse chemical classes for capacities to cure infections with sporozoites of P. cynomolgi. Am J Trop Med Hyg 1983; 32: 231–257.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>231</start><end>257</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>231</start><end>257</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit151"><titleInfo><title>Synthesis of amino acid derivatives of 8‐[(4‐amino‐1‐methylbutyl)amino]‐6‐methoxy‐4‐substituted/4,5‐disustituted‐quinolines as potential antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Anand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">Dutta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jain R, Jain S, Gupta RC, Anand N, Dutta GP, Puri SK. Synthesis of amino acid derivatives of 8‐[(4‐amino‐1‐methylbutyl)amino]‐6‐methoxy‐4‐substituted/4,5‐disustituted‐quinolines as potential antimalarial agents. Indian J Chem 1994; 33B: 251–254.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33B</number></detail><extent unit="pages"><start>251</start><end>254</end></extent></part><relatedItem type="host"><titleInfo><title>Indian J Chem</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>33B</number></detail><extent unit="pages"><start>251</start><end>254</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit152"><titleInfo><title>8‐Quinolinamines and their pro prodrug conjugates as potent blood‐schizontocidal antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vangapandu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sachdeva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Kaul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vangapandu S, Sachdeva S, Jain M, Singh S, Singh PP, Kaul CL, Jain R. 8‐Quinolinamines and their pro prodrug conjugates as potent blood‐schizontocidal antimalarial agents. Bioorg Med Chem 2003; 11: 4557–4568.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>4557</start><end>4568</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>4557</start><end>4568</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit153"><titleInfo><title>8‐Quinolinamines conjugated with amino acids are exhibiting potent blood‐schizontocidal antimalarial activities</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vangapandu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sachdeva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Kaul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vangapandu S, Sachdeva S, Jain M, Singh S, Singh PP, Kaul CL, Jain R. 8‐Quinolinamines conjugated with amino acids are exhibiting potent blood‐schizontocidal antimalarial activities. Bioorg Med Chem 2004; 12: 239–247.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>239</start><end>247</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>239</start><end>247</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit154"><titleInfo><title>Plasmepsin II inhibition and antiplasmodial activity of primaquine‐statine double drugs</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Romeo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">dell'Agli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Parapini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Rizzi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Galli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Mondani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Spartore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Taramelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Bosisio</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Romeo S, dell'Agli M, Parapini S, Rizzi L, Galli G, Mondani M, Spartore A, Taramelli D, Bosisio E. Plasmepsin II inhibition and antiplasmodial activity of primaquine‐statine double drugs. Bioorg Med Chem Lett 2004; 14: 2931–2934.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>2931</start><end>2934</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>2931</start><end>2934</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit155"><titleInfo><title>Discovery of a bulky tert‐butyl group containing primaquine analog that exhibits potent blood‐schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vangapandu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sachdeva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GB</namePart><namePart type="family">Gena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Tikoo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ramarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Kaul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jain M, Vangapandu S, Sachdeva S, Singh S, Singh PP, Gena GB, Tikoo K, Ramarao P, Kaul CL, Jain R. Discovery of a bulky tert‐butyl group containing primaquine analog that exhibits potent blood‐schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. J Med Chem 2004; 47: 285–287.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>285</start><end>287</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>285</start><end>287</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit156"><titleInfo><title>Synthesis and blood‐schizontocidal antimalarial activities of 2‐substituted/2,5‐disubstituted‐8‐quinolinamines and some of their amino acid conjugates</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vangapandu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sachdeva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jain M, Vangapandu S, Sachdeva S, Jain R. Synthesis and blood‐schizontocidal antimalarial activities of 2‐substituted/2,5‐disubstituted‐8‐quinolinamines and some of their amino acid conjugates. Bioorg Med Chem 2004; 12: 1003–1010.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1003</start><end>1010</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1003</start><end>1010</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit157"><titleInfo><title>Synthesis, antimalarial, antileishmainal and antimicrobial activities of some 8‐quinolinamine analogs</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SI</namePart><namePart type="family">Khan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BL</namePart><namePart type="family">Tekwani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MR</namePart><namePart type="family">Jacob</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jain M, Khan SI, Tekwani BL, Jacob MR, Singh S, Singh PP, Jain R. Synthesis, antimalarial, antileishmainal and antimicrobial activities of some 8‐quinolinamine analogs. Bioorg Med Chem 2005; 13: 4458–4466.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>4458</start><end>4466</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>4458</start><end>4466</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit158"><titleInfo><title>Synthesis of imidazolidin‐4‐one and 1H‐imidazo[1,2‐a]isoindole‐2,5‐(3H,9bH)‐dione derivatives of primaquine: scope and limitations</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Gomes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Araujo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Rodrigues</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Vale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Azevedo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Iley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Chambel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Morais</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Moreira</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gomes P, Araujo MA, Rodrigues M, Vale N, Azevedo Z, Iley J, Chambel P, Morais J, Moreira R. Synthesis of imidazolidin‐4‐one and 1H‐imidazo[1,2‐a]isoindole‐2,5‐(3H,9bH)‐dione derivatives of primaquine: scope and limitations. Tetrahedron 2004; 60: 5551–5562.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>5551</start><end>5562</end></extent></part><relatedItem type="host"><titleInfo><title>Tetrahedron</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>5551</start><end>5562</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit159"><titleInfo><title>Imidazolidin‐4‐one derivatives of primaquine as novel transmission‐blocking antimalarials</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Araujo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Capela</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Casimiro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Chambel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Gomes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Iley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Lopes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Morais</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Moreira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">de Oliveira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">do Rosario</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Vale</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Araujo MA, Bom J, Capela R, Casimiro C, Chambel P, Gomes P, Iley J, Lopes F, Morais J, Moreira R, de Oliveira E, do Rosario V, Vale N. Imidazolidin‐4‐one derivatives of primaquine as novel transmission‐blocking antimalarials. J Med Chem 2005; 48: 888–892.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>888</start><end>892</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>888</start><end>892</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit160"><titleInfo><title>Antimalarial activity of 77 phospholipid polar head analogs: close correlation between inhibition of phospholipid metabolism and in vitro P. falciparum growth</title></titleInfo><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Ancelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Calas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bompart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Cordina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ben Bari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Jei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Druilhe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Vial</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ancelin ML, Calas M, Bompart J, Cordina G, Martin D, Ben Bari M, Jei T, Druilhe P, Vial H. Antimalarial activity of 77 phospholipid polar head analogs: close correlation between inhibition of phospholipid metabolism and in vitro P. falciparum growth. Blood 1998; 91: 1426–1437.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>1426</start><end>1437</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>91</number></detail><extent unit="pages"><start>1426</start><end>1437</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit161"><titleInfo><title>Antimalarial activity of molecules interfering with P. falciparum phospholipid metabolism. Structure‐activity relationship analysis</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Calas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Cordina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bompart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ben Bari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Jei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Ancelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Vial</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Calas M, Cordina G, Bompart J, Ben Bari M, Jei T, Ancelin ML, Vial H. Antimalarial activity of molecules interfering with P. falciparum phospholipid metabolism. Structure‐activity relationship analysis. J Med Chem 1997; 40: 3557–3566.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>3557</start><end>3566</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>3557</start><end>3566</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit162"><titleInfo><title>Antimalarial activity of compounds interfering with P. falciparum phospholipid metabolism: Comparison between mono‐ and bisquaternary ammonium salts</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Calas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Ancelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Coirdina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Portefaix</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Piquet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Vidal‐Sailhan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Vial</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Calas M, Ancelin ML, Coirdina G, Portefaix P, Piquet G, Vidal‐Sailhan V, Vial H. Antimalarial activity of compounds interfering with P. falciparum phospholipid metabolism: Comparison between mono‐ and bisquaternary ammonium salts. J Med Chem 2000; 43: 505–516.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>505</start><end>516</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>43</number></detail><extent unit="pages"><start>505</start><end>516</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit163"><titleInfo><title>A class of potent antimalarials and their specific accumulation in infected erythrocytes</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Wengelnik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Vidal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Ancelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Cathiard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Morgat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Kocken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Calas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Herrera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AW</namePart><namePart type="family">Thomas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Vial</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wengelnik K, Vidal V, Ancelin ML, Cathiard AM, Morgat JL, Kocken CH, Calas M, Herrera S, Thomas AW, Vial H. A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science 2002; 295: 1311–1314.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>295</number></detail><extent unit="pages"><start>1311</start><end>1314</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>295</number></detail><extent unit="pages"><start>1311</start><end>1314</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit164"><titleInfo><title>Mono‐ and Bis‐thiazolium salts have potent antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hamze</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Rubi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Arnal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Boisburn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Carcel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Salom‐Roig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Mayadier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Vial</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Calas</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hamze A, Rubi E, Arnal P, Boisburn M, Carcel C, Salom‐Roig X, Mayadier M, Wein S, Vial H, Calas M. Mono‐ and Bis‐thiazolium salts have potent antimalarial activity. J Med Chem 2005; 48: 3639–3643.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3639</start><end>3643</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3639</start><end>3643</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit165"><titleInfo><title>Discovery of a novel lead structure for anti‐malarials</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Wißner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐M</namePart><namePart type="family">Dahse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Wißner P, Dahse H‐M, Jomaa H, Schlitzer M. Discovery of a novel lead structure for anti‐malarials. Bioorg Med Chem 2001; 9: 785–792.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>785</start><end>792</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>785</start><end>792</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit166"><titleInfo><title>Structure‐activity relationships of novel antimalarial agents. Part 2: Cinnamic acid derivatives</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mitsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Wißner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Mitsch A, Wißner P, Jomaa H, Schlitzer M. Structure‐activity relationships of novel antimalarial agents. Part 2: Cinnamic acid derivatives. Bioorg Med Chem Lett 2001; 11: 423–424.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>423</start><end>424</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>423</start><end>424</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit167"><titleInfo><title>Structure‐activity relationships of novel antimalarial agents. Part 3: N‐(4‐Acylamino‐3‐benzoylphenyl)‐4‐propoxycinnamic acid amides</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kettler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Kettler K, Jomaa H, Schlitzer M. Structure‐activity relationships of novel antimalarial agents. Part 3: N‐(4‐Acylamino‐3‐benzoylphenyl)‐4‐propoxycinnamic acid amides. Bioorg Med Chem Lett 2002; 12: 543–545.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>543</start><end>545</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>543</start><end>545</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit168"><titleInfo><title>Structure–activity relationships of novel antimalarial agents. Part 4: N‐(3‐Benzoyl‐4‐tolylacetylamino‐phenyl)‐3‐(5‐aryl‐2‐furyl)acrylic acid amides</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mitsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Wißner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Kramer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Mitsch A, Wißner P, Kramer O, Jomaa H, Schlitzer M. Structure–activity relationships of novel antimalarial agents. Part 4: N‐(3‐Benzoyl‐4‐tolylacetylamino‐phenyl)‐3‐(5‐aryl‐2‐furyl)acrylic acid amides. Bioorg Med Chem Lett 2002; 12: 2681–2683.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2681</start><end>2683</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2681</start><end>2683</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit169"><titleInfo><title>Structure–activity relationships of novel antimalarial agents: Part 5. N‐(4‐Acylamino‐3‐benzoylphenyl)‐[5‐(4‐nitrophenyl)‐2‐furyl]acrylic acid amides</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kettler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Sakowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ortmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Kettler K, Sakowski J, Ortmann R, Jomaa H, Schlitzer M. Structure–activity relationships of novel antimalarial agents: Part 5. N‐(4‐Acylamino‐3‐benzoylphenyl)‐[5‐(4‐nitrophenyl)‐2‐furyl]acrylic acid amides. Bioorg Med Chem Lett 2003; 13: 361–363.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>361</start><end>363</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>361</start><end>363</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit170"><titleInfo><title>Structure–activity relationships of novel antimalarial agents. Part 7: N‐(3‐Benzoyl‐4‐tolylacetylaminophenyl)‐3‐(5‐aryl‐2‐furyl)acrylic acid amides with polar moieties</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mitsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Mitsch A, Jomaa H, Schlitzer M. Structure–activity relationships of novel antimalarial agents. Part 7: N‐(3‐Benzoyl‐4‐tolylacetylaminophenyl)‐3‐(5‐aryl‐2‐furyl)acrylic acid amides with polar moieties. Bioorg Med Chem Lett 2003; 13: 2159–2161.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2159</start><end>2161</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2159</start><end>2161</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit171"><titleInfo><title>Novel and potent antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">KM</namePart><namePart type="family">Brinner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Habashita</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IY</namePart><namePart type="family">Gluzman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Goldberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Ellman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brinner KM, Kim JM, Habashita H, Gluzman IY, Goldberg DE, Ellman JA. Novel and potent antimalarial agents. Bioorg Med Chem 2002; 10: 3649–3661.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>3649</start><end>3661</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>3649</start><end>3661</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit172"><titleInfo><title>Potent 4‐aminopiperidine based antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">KM</namePart><namePart type="family">Brinner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Powles</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Schmatz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Ellman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brinner KM, Powles MA, Schmatz DM, Ellman JA. Potent 4‐aminopiperidine based antimalarial agents. Bioorg Med Chem Lett 2005; 15: 345–348.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>345</start><end>348</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>345</start><end>348</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit173"><titleInfo><title>1,2,4‐Triazino‐[5,6‐b]indole derivatives: Effects of the trifluoromethyl group on in vitro antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Kgokong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PP</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Matsabisa</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kgokong JL, Smith PP, Matsabisa GM. 1,2,4‐Triazino‐[5,6‐b]indole derivatives: Effects of the trifluoromethyl group on in vitro antimalarial activity. Bioorg Med Chem 2005; 13: 2935–2942.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2935</start><end>2942</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2935</start><end>2942</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit174"><titleInfo><title>Design, synthesis and evaluation of 5‐substituted amino‐2,4‐diamino‐8‐chloropyrimido‐[4,5‐b]quinolones as novel antimalarials</title></titleInfo><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Joshi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Narkhede</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Viswanathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Joshi AA, Narkhede SS, Viswanathan CL. Design, synthesis and evaluation of 5‐substituted amino‐2,4‐diamino‐8‐chloropyrimido‐[4,5‐b]quinolones as novel antimalarials. Bioorg Med Chem Lett 2005; 15: 73–76.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>73</start><end>76</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>73</start><end>76</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit175"><titleInfo><title>Sulfonyl‐phenyl‐ureido benzamidines: A novel structural class of potent antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Leban</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Pegoraro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Dormeyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Lanzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Aschenbrenner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Kramer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Leban J, Pegoraro S, Dormeyer M, Lanzer M, Aschenbrenner A, Kramer B. Sulfonyl‐phenyl‐ureido benzamidines: A novel structural class of potent antimalarial agents. Bioorg Med Chem Lett 2004; 14: 1979–1982.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1979</start><end>1982</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1979</start><end>1982</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit176"><titleInfo><title>In vitro antiplasmodial activities of semisynthetic N,N′‐spacer‐linked oligomeric ergolines</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Jenett‐Siems</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Kohler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Kraft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Pertz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Kren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Fiserova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kuzma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ulrichova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Bienzled</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Eich</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jenett‐Siems K, Kohler I, Kraft C, Pertz HH, Kren V, Fiserova A, Kuzma M, Ulrichova J, Bienzled U, Eich E. In vitro antiplasmodial activities of semisynthetic N,N′‐spacer‐linked oligomeric ergolines. Bioorg Med Chem 2004; 12: 817–824.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>817</start><end>824</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>817</start><end>824</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit177"><titleInfo><title>Diamine derivatives with antiparasitic activities</title></titleInfo><name type="personal"><namePart type="given">GR</namePart><namePart type="family">Labadie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐R</namePart><namePart type="family">Choi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Avery</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Labadie GR, Choi S‐R, Avery MA. Diamine derivatives with antiparasitic activities. Bioorg Med Chem Lett 2004; 14: 615–619.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>615</start><end>619</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>615</start><end>619</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit178"><titleInfo><title>In vitro antimalarial activity of a series of cationic 2,2′‐bipyridyl‐ and 1,10‐phenanthrolineplatinum(II) benzoylthiourea complexes</title></titleInfo><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Egan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KR</namePart><namePart type="family">Koch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Swan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Clarkson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Van Schalkwyk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Egan TJ, Koch KR, Swan PL, Clarkson C, Van Schalkwyk DA, Smith PJ. In vitro antimalarial activity of a series of cationic 2,2′‐bipyridyl‐ and 1,10‐phenanthrolineplatinum(II) benzoylthiourea complexes. J Med Chem 2004; 47: 2926–2934.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2926</start><end>2934</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>2926</start><end>2934</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit179"><titleInfo><title>Synthesis of glycosylated β‐amino hydroxamates as new class of antimalarials</title></titleInfo><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Mishra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Tripathi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Katiyar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Tewari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RP</namePart><namePart type="family">Tripathi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mishra RC, Tripathi R, Katiyar D, Tewari N, Singh D, Tripathi RP. Synthesis of glycosylated β‐amino hydroxamates as new class of antimalarials. Bioorg Med Chem 2003; 11: 5363–5374.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>5363</start><end>5374</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>5363</start><end>5374</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit180"><titleInfo><title>The imidazo[2,1‐a]isoindole system. A new skeletal basis for antiplasmodial compounds</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">del Olmo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Garcia Armas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ybarra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Lopez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Oporto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Gimenez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Deharo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">San Feliciano</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">del Olmo E, Garcia Armas M, Ybarra M, Lopez JL, Oporto P, Gimenez A, Deharo E, San Feliciano A. The imidazo[2,1‐a]isoindole system. A new skeletal basis for antiplasmodial compounds. Bioorg Med Chem Lett 2003; 13: 2769–2772.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2769</start><end>2772</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>2769</start><end>2772</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit181"><titleInfo><title>New antimalarial compounds from database searching</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Griffith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Chanphen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SP</namePart><namePart type="family">Leachb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PA</namePart><namePart type="family">Keller</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Griffith R, Chanphen R, Leachb SP, Keller PA. New antimalarial compounds from database searching. Bioorg Med Chem Lett 2002; 12: 539–542.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>539</start><end>542</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>539</start><end>542</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit182"><titleInfo><title>Solid‐phase synthesis and bioevaluation of lupeol‐based libraries as antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Srinivasan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GK</namePart><namePart type="family">Srivastava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Pathak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Batra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Raj</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Puri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Kundu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Srinivasan T, Srivastava GK, Pathak A, Batra S, Raj K, Singh K, Puri SK, Kundu B. Solid‐phase synthesis and bioevaluation of lupeol‐based libraries as antimalarial agents. Bioorg Med Chem Lett 2002; 12: 2803–2806.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2803</start><end>2806</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2803</start><end>2806</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit183"><titleInfo><title>Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TH</namePart><namePart type="family">Hudson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DE</namePart><namePart type="family">Kyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zhu S, Hudson TH, Kyle DE, Lin AJ. Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents. J Med Chem 2002; 45: 3491–3496.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>3491</start><end>3496</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>3491</start><end>3496</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit184"><titleInfo><title>Antimalarial activity of N6‐substituted adenosine derivatives. Part 3</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Herforth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Heidler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sanderbrand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Van Calenbergh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Link</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Herforth C, Wiesner J, Heidler P, Sanderbrand S, Van Calenbergh S, Jomaa H, Link A. Antimalarial activity of N6‐substituted adenosine derivatives. Part 3. Bioorg Med Chem 2004; 12: 755–762.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>755</start><end>762</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>755</start><end>762</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit185"><titleInfo><title>Structure‐activity relationship study of antimalarial indolo [2,1‐b]quinazoline‐6,12‐diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates</title></titleInfo><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Bhattacharjee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MG</namePart><namePart type="family">Hartell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Nichols</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RP</namePart><namePart type="family">Hicks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Stanton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">van Hamont</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WK</namePart><namePart type="family">Milhous</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bhattacharjee AK, Hartell MG, Nichols DA, Hicks RP, Stanton B, van Hamont JE, Milhous WK. Structure‐activity relationship study of antimalarial indolo [2,1‐b]quinazoline‐6,12‐diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates. Eur J Med Chem 2004; 39: 59–67.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>59</start><end>67</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>59</start><end>67</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit186"><titleInfo><title>Stage‐dependent effect of desferrioxamine on growth of P. falciparum in vitro</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Whitehead</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TEA</namePart><namePart type="family">Peto</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Whitehead S, Peto TEA. Stage‐dependent effect of desferrioxamine on growth of P. falciparum in vitro. Blood 1990; 76: 1250–1255.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>1250</start><end>1255</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>1250</start><end>1255</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit187"><titleInfo><title>Reversed siderosphores act as antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Shanzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Libman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SD</namePart><namePart type="family">Lytton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Glickstien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZL</namePart><namePart type="family">Cabantchik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shanzer A, Libman J, Lytton SD, Glickstien H, Cabantchik ZL. Reversed siderosphores act as antimalarial agents. Proc Natl Acad Sci USA 1991; 88: 6585–6589.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>6585</start><end>6589</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>6585</start><end>6589</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit188"><titleInfo><title>Mode of action of iron(III) chelators as antimalarials: 1. Membrane permeation properties and cytotoxic activity</title></titleInfo><name type="personal"><namePart type="given">SD</namePart><namePart type="family">Lytton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Mester</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Dayan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Glickstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Libman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Shanzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZI</namePart><namePart type="family">Cabantchik</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lytton SD, Mester B, Dayan I, Glickstein H, Libman J, Shanzer A, Cabantchik ZI. Mode of action of iron(III) chelators as antimalarials: 1. Membrane permeation properties and cytotoxic activity. Blood 1993; 81: 214–221.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>214</start><end>221</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>214</start><end>221</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit189"><titleInfo><title>Antimalarial properties of orally active iron chelators</title></titleInfo><name type="personal"><namePart type="given">DG</namePart><namePart type="family">Heppner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Hallaway</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Kontoghiorghes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Eaton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Heppner DG, Hallaway PE, Kontoghiorghes GJ, Eaton JW. Antimalarial properties of orally active iron chelators. Blood 1988; 72: 358–361.</note><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>358</start><end>361</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>358</start><end>361</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit190"><titleInfo><title>Antimalarial effect of HBED and other phenolic and catecholic iron chelators</title></titleInfo><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Yinnan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EN</namePart><namePart type="family">Theancho</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Grady</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DT</namePart><namePart type="family">Spira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Hershko</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yinnan AM, Theancho EN, Grady RW, Spira DT, Hershko C. Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood 1989; 74: 2166–2171.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>2166</start><end>2171</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>2166</start><end>2171</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit191"><titleInfo><title>P. falciparum: Inhibition in vitro with lactoferrin, desferrithiocin and desferricrocin</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Fritsch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sawatzki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Treumer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Jung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DR</namePart><namePart type="family">Spira</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fritsch G, Sawatzki M, Treumer J, Jung A, Spira DR. P. falciparum: Inhibition in vitro with lactoferrin, desferrithiocin and desferricrocin. Exp Parasitol 1987; 63: 1–9.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>1</start><end>9</end></extent></part><relatedItem type="host"><titleInfo><title>Exp Parasitol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>1</start><end>9</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit192"><titleInfo><title>Daphnetin: A novel antimalarial agent with in vitro and in vivo activity</title></titleInfo><name type="personal"><namePart type="given">YZ</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ranz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HZ</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZN</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XB</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Meshnick</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang YZ, Ranz A, Pan HZ, Zhang ZN, Lin XB, Meshnick SR. Daphnetin: A novel antimalarial agent with in vitro and in vivo activity. Am J Trop Med Hyg 1989; 46: 15–20.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>15</start><end>20</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Trop Med Hyg</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>15</start><end>20</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit193"><titleInfo><title>Malaria pigment and extracellular iron. Possible target from iron chelating agents</title></titleInfo><name type="personal"><namePart type="given">RL</namePart><namePart type="family">Van Zyl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Havlik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hemplemann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">MacPhail</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">McNamara</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Van Zyl RL, Havlik I, Hemplemann E, MacPhail AP, McNamara L. Malaria pigment and extracellular iron. Possible target from iron chelating agents. Biochem Pharmacol 1993; 45: 1431–1436.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>1431</start><end>1436</end></extent></part><relatedItem type="host"><titleInfo><title>Biochem Pharmacol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>1431</start><end>1436</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit194"><titleInfo><title>The treatment of malaria with iron chelators</title></titleInfo><name type="personal"><namePart type="given">CR</namePart><namePart type="family">Hider</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hider CR, Liu Z. The treatment of malaria with iron chelators. J Pharm Pharmacol 1997; 49: 59–64.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>59</start><end>64</end></extent></part><relatedItem type="host"><titleInfo><title>J Pharm Pharmacol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>59</start><end>64</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit195"><titleInfo><title>The antimalarial effect of iron chelator studies in animal models and in humans with mild falciparum malaria</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Herhko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VR</namePart><namePart type="family">Gorduek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Tuma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EN</namePart><namePart type="family">Thenancho</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DT</namePart><namePart type="family">Spira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RC</namePart><namePart type="family">Hider</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TEA</namePart><namePart type="family">Peta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GM</namePart><namePart type="family">Brittenham</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Herhko C, Gorduek VR, Tuma PE, Thenancho EN, Spira DT, Hider RC, Peta TEA, Brittenham GM. The antimalarial effect of iron chelator studies in animal models and in humans with mild falciparum malaria. J Inorg Biochem 1992; 47: 267–277.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>267</start><end>277</end></extent></part><relatedItem type="host"><titleInfo><title>J Inorg Biochem</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>267</start><end>277</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit196"><titleInfo><title>Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Boss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Richard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Weller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Fischli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Meyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Binkert</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boss C, Richard S, Weller T, Fischli W, Meyer S, Binkert C. Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents. Curr Med Chem 2003; 10: 883–907.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>883</start><end>907</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>883</start><end>907</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit197"><titleInfo><title>Novel antiplasmodial agents</title></titleInfo><name type="personal"><namePart type="given">M‐L</namePart><namePart type="family">Lo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lo M‐L. Novel antiplasmodial agents. Med Res Rev 2003; 23: 456–487.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>456</start><end>487</end></extent></part><relatedItem type="host"><titleInfo><title>Med Res Rev</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>456</start><end>487</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit198"><titleInfo><title>Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum‐infected cultured human erythrocytes</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Noteberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hulten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Wahlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Vrang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Noteberg D, Hamelink E, Hulten J, Wahlgren M, Vrang L, Samuelsson B, Hallberg A. Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum‐infected cultured human erythrocytes. J Med Chem 2003; 46: 734–746.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>734</start><end>746</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>734</start><end>746</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit199"><titleInfo><title>New inhibitors of the malaria aspartyl proteases plasmepsin I and II</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dahlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Kvarnstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Vrang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Rosenquist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dahlgren A, Kvarnstrom I, Vrang L, Hamelink E, Hallberg A, Rosenquist A, Samuelsson B. New inhibitors of the malaria aspartyl proteases plasmepsin I and II. Bioorg Med Chem 2003; 11: 3423–3437.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>3423</start><end>3437</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>3423</start><end>3437</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit200"><titleInfo><title>High‐speed optimization of inhibitors of the malarial proteases plasmepsin I and II</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Noteberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Schaal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Vrang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Larhed</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Noteberg D, Schaal W, Hamelink E, Vrang L, Larhed M. High‐speed optimization of inhibitors of the malarial proteases plasmepsin I and II. J Comb Chem 2003; 5: 456–464.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>456</start><end>464</end></extent></part><relatedItem type="host"><titleInfo><title>J Comb Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>456</start><end>464</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit201"><titleInfo><title>C2‐Symmetric inhibitors of Plasmodium falciparum plasmepsin II: Synthesis and theoretical predictions</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Ersmark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Feierberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bjelic</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hulten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Åqvist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ersmark K, Feierberg I, Bjelic S, Hulten J, Samuelsson B, Åqvist J, Hallberg A. C2‐Symmetric inhibitors of Plasmodium falciparum plasmepsin II: Synthesis and theoretical predictions. Bioorg Med Chem 2003; 11: 3723–3733.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>3723</start><end>3733</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>3723</start><end>3733</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit202"><titleInfo><title>Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Ersmark</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Feierberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Bjelic</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Hackett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Blackman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hulten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Åqvist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ersmark K, Feierberg I, Bjelic S, Hamelink E, Hackett F, Blackman MJ, Hulten J, Samuelsson B, Åqvist J, Hallberg A. Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. J Med Chem 2004; 47: 110–122.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>110</start><end>122</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>110</start><end>122</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit203"><titleInfo><title>Solid‐phase library synthesis of reversed‐statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Dahlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Kvarnstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Vrang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Rosenquist</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dahlgren A, Kvarnstrom I, Vrang L, Hamelink E, Hallberg A, Rosenquist A, Samuelsson B. Solid‐phase library synthesis of reversed‐statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II. Bioorg Med Chem 2003; 11: 827–841.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>827</start><end>841</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>827</start><end>841</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit204"><titleInfo><title>New potent C2‐symmetric malaria plasmepsin I and II inhibitors</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Oscarsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Oscarson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Vrang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hamelink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hallberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samuelsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oscarsson K, Oscarson S, Vrang L, Hamelink E, Hallberg A, Samuelsson B. New potent C2‐symmetric malaria plasmepsin I and II inhibitors. Bioorg Med Chem 2003; 11: 1235–1246.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1235</start><end>1246</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>1235</start><end>1246</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit205"><titleInfo><title>Synthesis and structure‐activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Greenbaum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Mackey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hansell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Doyle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CR</namePart><namePart type="family">Caffrey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Lehrman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JH</namePart><namePart type="family">McKerrow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Chibale</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure‐activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem 2004; 47: 3212–3219.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>3212</start><end>3219</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>3212</start><end>3219</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit206"><titleInfo><title>Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ohkanda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Lockman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Yokoyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Gelb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Croft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kendrick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MI</namePart><namePart type="family">Harrell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Feagin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Blaskovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Sebti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Hamilton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorg Med Chem Lett 2001; 11: 761–764.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>761</start><end>764</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>761</start><end>764</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit207"><titleInfo><title>In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Carrico</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ohkanda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kendrick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Yokoyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Blaskovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CJ</namePart><namePart type="family">Bucher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FS</namePart><namePart type="family">Buckner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WC</namePart><namePart type="family">Van Voorhis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Chakrabarti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Croft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Gelb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Sebti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Hamilton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorg Med Chem 2004; 12: 6517–6526.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>6517</start><end>6526</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>6517</start><end>6526</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit208"><titleInfo><title>Design and synthesis of Pfmrk inhibitors as potential antimalarial agents</title></titleInfo><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Xiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NC</namePart><namePart type="family">Waters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Woodard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P‐K</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Xiao Z, Waters NC, Woodard CL, Li Z, Li P‐K. Design and synthesis of Pfmrk inhibitors as potential antimalarial agents. Bioorg Med Chem Lett 2001; 11: 2875–2878.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>2875</start><end>2878</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>2875</start><end>2878</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit209"><titleInfo><title>A three‐dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin‐dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors</title></titleInfo><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Bhattacharjee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Geyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Woodard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Kathcart</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Nichols</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ST</namePart><namePart type="family">Prigge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BT</namePart><namePart type="family">Mott</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NC</namePart><namePart type="family">Waters</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bhattacharjee AK, Geyer JA, Woodard CL, Kathcart AK, Nichols DA, Prigge ST, Li Z, Mott BT, Waters NC. A three‐dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin‐dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 2004; 47: 5418–5426.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>5418</start><end>5426</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>5418</start><end>5426</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit210"><titleInfo><title>New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6′R)‐6′‐C‐methylneplanocin A, a potent AdoHcy hydrolase inhibitor</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Shuto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Minakawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Niizuma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐S</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wataya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Matsuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shuto S, Minakawa N, Niizuma S, Kim H‐S, Wataya Y, Matsuda A. New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6′R)‐6′‐C‐methylneplanocin A, a potent AdoHcy hydrolase inhibitor. J Med Chem 2002; 45: 748–751.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>748</start><end>751</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>748</start><end>751</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit211"><titleInfo><title>Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: Towards antimalarials with a novel mechanism of action?</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Krungkrai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Scozzafava</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Reungprapavut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Krungkrai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Rattanajak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamchonwongpaisan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CT</namePart><namePart type="family">Supuran</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Krungkrai J, Scozzafava A, Reungprapavut S, Krungkrai SR, Rattanajak R, Kamchonwongpaisan S, Supuran CT. Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: Towards antimalarials with a novel mechanism of action? Bioorg Med Chem 2005; 13: 483–489.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>483</start><end>489</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>483</start><end>489</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit212"><titleInfo><title>Target guided synthesis of 5‐benzyl‐2,4‐diamonopyrimidines: Their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sirichaiwat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Intaraudom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamchonwongpaisan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vanichtanankul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Thebtaranonth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yuthavong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sirichaiwat C, Intaraudom C, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Target guided synthesis of 5‐benzyl‐2,4‐diamonopyrimidines: Their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 2004; 47: 345–354.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>345</start><end>354</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>345</start><end>354</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit213"><titleInfo><title>Development of 2,4‐diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine‐resistant Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Tarnchompoo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Sirichaiwat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Phupong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Intaraudom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Sirawaraporn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamchonwongpaisan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vanichtanankul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Thebtaranonth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yuthavong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tarnchompoo B, Sirichaiwat C, Phupong W, Intaraudom C, Sirawaraporn W, Kamchonwongpaisan S, Vanichtanankul J, Thebtaranonth Y, Yuthavong Y. Development of 2,4‐diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine‐resistant Plasmodium falciparum. J Med Chem 2002; 45: 1244–1252.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>1244</start><end>1252</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>45</number></detail><extent unit="pages"><start>1244</start><end>1252</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit214"><titleInfo><title>Synthesis of solution‐phase combinatorial library of 4,6‐diamino‐1,2‐dihydro‐1,3,5‐triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Vilaivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Saesaengseerung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Jarprung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kamchonwongpaisan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Sirawaraporn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yuthavong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vilaivan T, Saesaengseerung N, Jarprung D, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y. Synthesis of solution‐phase combinatorial library of 4,6‐diamino‐1,2‐dihydro‐1,3,5‐triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum. Bioorg Med Chem 2003; 11: 217–224.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>217</start><end>224</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>217</start><end>224</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit215"><titleInfo><title>New antimalarial drugs</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ortmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jomaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schlitzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiesner J, Ortmann R, Jomaa H, Schlitzer M. New antimalarial drugs. Angew Chem Int Ed 2003; 42: 5274–5293.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>5274</start><end>5293</end></extent></part><relatedItem type="host"><titleInfo><title>Angew Chem Int Ed</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>5274</start><end>5293</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit216"><titleInfo><title>Antimalarial drugs: Current status and new developments</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Rathore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TF</namePart><namePart type="family">McCutchan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kumar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rathore D, McCutchan TF, Sullivan M, Kumar S. Antimalarial drugs: Current status and new developments. Expert Opin Investig Drugs 2005; 14: 871–883.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>871</start><end>883</end></extent></part><relatedItem type="host"><titleInfo><title>Expert Opin Investig Drugs</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>871</start><end>883</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit217"><titleInfo><title>Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives</title></titleInfo><name type="personal"><namePart type="given">JN</namePart><namePart type="family">Domınguez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Leon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Rodrigues</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NG</namePart><namePart type="family">de Domınguez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Rosenthal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Domınguez JN, Leon C, Rodrigues J, de Domınguez NG, Gut J, Rosenthal PJ. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem 2005; 48: 3654–3658.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3654</start><end>3658</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>3654</start><end>3658</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit218"><titleInfo><title>Antimalarial activity of ferrocenyl chalcones</title></titleInfo><name type="personal"><namePart type="given">X</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Wilairat</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Go</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu X, Wilairat P, Go M. Antimalarial activity of ferrocenyl chalcones. Bioorg Med Chem Lett 2002; 12: 2299–2302.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2299</start><end>2302</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2299</start><end>2302</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit219"><titleInfo><title>3D QSAR studies on antimalarial alkoxylated and hydroxylated chalcones by CoMFA and CoMSIA</title></titleInfo><name type="personal"><namePart type="given">CX</namePart><namePart type="family">Xue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Cui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ZD</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BT</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Xue CX, Cui SY, Liu MC, Hu ZD, Fan BT. 3D QSAR studies on antimalarial alkoxylated and hydroxylated chalcones by CoMFA and CoMSIA. Eur J Med Chem 2004; 39: 745–753.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>745</start><end>753</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Med Chem</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>745</start><end>753</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit220"><titleInfo><title>Antimalarial agents from plant sources</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Saxena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Pant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Bhakuni</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Saxena S, Pant N, Jain DC, Bhakuni RS. Antimalarial agents from plant sources. Curr Sci 2003; 85: 1314–1329.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>1314</start><end>1329</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Sci</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>1314</start><end>1329</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit221"><titleInfo><title>π‐Delocalized β‐carbolinium cations as potential antimalarials</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Takasu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Shimogama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Saiin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐S</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wataya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ihara</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Takasu K, Shimogama T, Saiin C, Kim H‐S, Wataya Y, Ihara M. π‐Delocalized β‐carbolinium cations as potential antimalarials. Bioorg Med Chem Lett 2004; 14: 1689–1692.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1689</start><end>1692</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>1689</start><end>1692</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit222"><titleInfo><title>Antimalarial compounds from Parinari capensis</title></titleInfo><name type="personal"><namePart type="given">ACU</namePart><namePart type="family">Uys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Malan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">van Dyk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RL</namePart><namePart type="family">van Zyl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Uys ACU, Malan SF, van Dyk S, van Zyl RL. Antimalarial compounds from Parinari capensis. Bioorg Med Chem Lett 2002; 12: 2167–2169.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2167</start><end>2169</end></extent></part><relatedItem type="host"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>2167</start><end>2169</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit223"><titleInfo><title>A new antimalarial quassinoid from Simaba orinocensis</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Muhammad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Bedir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SI</namePart><namePart type="family">Khan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BL</namePart><namePart type="family">Tekwani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Khan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Takamatsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Pelletier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Walker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Muhammad I, Bedir E, Khan SI, Tekwani BL, Khan IA, Takamatsu S, Pelletier J, Walker LA. A new antimalarial quassinoid from Simaba orinocensis. J Nat Prod 2004; 67: 772–777.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>772</start><end>777</end></extent></part><relatedItem type="host"><titleInfo><title>J Nat Prod</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>772</start><end>777</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit224"><titleInfo><title>New semisynthetic quassinoids with in vivo antimalarial activity</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Murakami</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sugimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kawanishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐S</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Begum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wataya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim H‐S, Begum K, Wataya Y, Kobayashi M. New semisynthetic quassinoids with in vivo antimalarial activity. J Med Chem 2003; 46: 638–641.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>638</start><end>641</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>638</start><end>641</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit225"><titleInfo><title>Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Hirai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kikuchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H‐S</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Begum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wataya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Tasaka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Miyazawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Yamamoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Oshima</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hirai S, Kikuchi H, Kim H‐S, Begum K, Wataya Y, Tasaka H, Miyazawa Y, Yamamoto K, Oshima Y. Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite. J Med Chem 2003; 46: 4351–4359.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>4351</start><end>4359</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>4351</start><end>4359</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit226"><titleInfo><title>Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action</title></titleInfo><name type="personal"><namePart type="given">O</namePart><namePart type="family">Onyeibor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Croft</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HI</namePart><namePart type="family">Dodson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Feiz‐Haddad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kendrick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">Millington</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Parapini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Phillips</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Seville</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SD</namePart><namePart type="family">Shnyder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Taramelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Wright</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Onyeibor O, Croft SL, Dodson HI, Feiz‐Haddad M, Kendrick H, Millington NJ, Parapini S, Phillips RM, Seville S, Shnyder SD, Taramelli D, Wright CW. Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. J Med Chem 2005; 48: 2701–2709.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>2701</start><end>2709</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Chem</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>2701</start><end>2709</end></extent></part></relatedItem></relatedItem><identifier type="istex">6EB6B8455CDE3E9CE47A857C57BCF11CE5906A5C</identifier><identifier type="ark">ark:/67375/WNG-JQ6TG66S-J</identifier><identifier type="DOI">10.1002/med.20062</identifier><identifier type="ArticleID">MED20062</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-JQ6TG66S-J/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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