Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
Identifieur interne : 001496 ( Main/Exploration ); précédent : 001495; suivant : 001497Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
Auteurs : Guo-Lin Wu [République populaire de Chine] ; Tian-Yi Li [République populaire de Chine] ; Yong-Sheng Fan [République populaire de Chine] ; Guo-You Yu [République populaire de Chine]Source :
- Chinese Journal of Integrative Medicine [ 1672-0415 ] ; 2011-09-01.
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Abstract
Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.
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DOI: 10.1007/s11655-011-0850-8
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><author><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name></author><author><name sortKey="Li, Tian Yi" sort="Li, Tian Yi" uniqKey="Li T" first="Tian-Yi" last="Li">Tian-Yi Li</name></author><author><name sortKey="Fan, Yong Sheng" sort="Fan, Yong Sheng" uniqKey="Fan Y" first="Yong-Sheng" last="Fan">Yong-Sheng Fan</name></author><author><name sortKey="Yu, Guo You" sort="Yu, Guo You" uniqKey="Yu G" first="Guo-You" last="Yu">Guo-You Yu</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D46751B994D4007952DB9C62D6D1F8FBDDFCD417</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s11655-011-0850-8</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000206</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000206</idno><idno type="wicri:Area/Istex/Curation">000206</idno><idno type="wicri:Area/Istex/Checkpoint">000472</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000472</idno><idno type="wicri:doubleKey">1672-0415:2011:Wu G:therapeutic:effect:of</idno><idno type="wicri:Area/Main/Merge">001498</idno><idno type="wicri:Area/Main/Curation">001496</idno><idno type="wicri:Area/Main/Exploration">001496</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><author><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author><author><name sortKey="Li, Tian Yi" sort="Li, Tian Yi" uniqKey="Li T" first="Tian-Yi" last="Li">Tian-Yi Li</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Chinese Medical University, 310053, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Fan, Yong Sheng" sort="Fan, Yong Sheng" uniqKey="Fan Y" first="Yong-Sheng" last="Fan">Yong-Sheng Fan</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Chinese Medical University, 310053, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Yu, Guo You" sort="Yu, Guo You" uniqKey="Yu G" first="Guo-You" last="Yu">Guo-You Yu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Chinese Journal of Integrative Medicine</title><title level="j" type="abbrev">Chin. J. Integr. Med.</title><idno type="ISSN">1672-0415</idno><idno type="eISSN">1993-0402</idno><imprint><publisher>Chinese Association of Traditional and Western Medicine</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2011-09-01">2011-09-01</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="710">710</biblScope><biblScope unit="page" to="714">714</biblScope></imprint><idno type="ISSN">1672-0415</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1672-0415</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chinese herbal medicine</term><term>nourishing yin</term><term>primary Sjogren's syndrome</term><term>quality of life</term><term>removing stasis</term><term>strengthening qi</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement></list><tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name></region><name sortKey="Fan, Yong Sheng" sort="Fan, Yong Sheng" uniqKey="Fan Y" first="Yong-Sheng" last="Fan">Yong-Sheng Fan</name><name sortKey="Li, Tian Yi" sort="Li, Tian Yi" uniqKey="Li T" first="Tian-Yi" last="Li">Tian-Yi Li</name><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name><name sortKey="Yu, Guo You" sort="Yu, Guo You" uniqKey="Yu G" first="Guo-You" last="Yu">Guo-You Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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