Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
Identifieur interne : 000206 ( Istex/Corpus ); précédent : 000205; suivant : 000207Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
Auteurs : Guo-Lin Wu ; Tian-Yi Li ; Yong-Sheng Fan ; Guo-You YuSource :
- Chinese Journal of Integrative Medicine [ 1672-0415 ] ; 2011-09-01.
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- KwdEn :
Abstract
Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.
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DOI: 10.1007/s11655-011-0850-8
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><author><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name><affiliation><mods:affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wuguolin28@yahoo.com.cn</mods:affiliation></affiliation></author><author><name sortKey="Li, Tian Yi" sort="Li, Tian Yi" uniqKey="Li T" first="Tian-Yi" last="Li">Tian-Yi Li</name><affiliation><mods:affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Fan, Yong Sheng" sort="Fan, Yong Sheng" uniqKey="Fan Y" first="Yong-Sheng" last="Fan">Yong-Sheng Fan</name><affiliation><mods:affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Yu, Guo You" sort="Yu, Guo You" uniqKey="Yu G" first="Guo-You" last="Yu">Guo-You Yu</name><affiliation><mods:affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D46751B994D4007952DB9C62D6D1F8FBDDFCD417</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s11655-011-0850-8</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000206</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000206</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><author><name sortKey="Wu, Guo Lin" sort="Wu, Guo Lin" uniqKey="Wu G" first="Guo-Lin" last="Wu">Guo-Lin Wu</name><affiliation><mods:affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wuguolin28@yahoo.com.cn</mods:affiliation></affiliation></author><author><name sortKey="Li, Tian Yi" sort="Li, Tian Yi" uniqKey="Li T" first="Tian-Yi" last="Li">Tian-Yi Li</name><affiliation><mods:affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Fan, Yong Sheng" sort="Fan, Yong Sheng" uniqKey="Fan Y" first="Yong-Sheng" last="Fan">Yong-Sheng Fan</name><affiliation><mods:affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Yu, Guo You" sort="Yu, Guo You" uniqKey="Yu G" first="Guo-You" last="Yu">Guo-You Yu</name><affiliation><mods:affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Chinese Journal of Integrative Medicine</title><title level="j" type="abbrev">Chin. J. Integr. Med.</title><idno type="ISSN">1672-0415</idno><idno type="eISSN">1993-0402</idno><imprint><publisher>Chinese Association of Traditional and Western Medicine</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2011-09-01">2011-09-01</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="710">710</biblScope><biblScope unit="page" to="714">714</biblScope></imprint><idno type="ISSN">1672-0415</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1672-0415</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chinese herbal medicine</term><term>nourishing yin</term><term>primary Sjogren's syndrome</term><term>quality of life</term><term>removing stasis</term><term>strengthening qi</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Guo-lin Wu</name><affiliations><json:string>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</json:string><json:string>E-mail: wuguolin28@yahoo.com.cn</json:string></affiliations></json:item><json:item><name>Tian-yi Li</name><affiliations><json:string>Zhejiang Chinese Medical University, 310053, Hangzhou, China</json:string></affiliations></json:item><json:item><name>Yong-sheng Fan</name><affiliations><json:string>Zhejiang Chinese Medical University, 310053, Hangzhou, China</json:string></affiliations></json:item><json:item><name>Guo-you Yu</name><affiliations><json:string>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>primary Sjogren's syndrome</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chinese herbal medicine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>strengthening qi</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nourishing yin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>removing stasis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item></subject><articleId><json:string>850</json:string><json:string>s11655-011-0850-8</json:string></articleId><arkIstex>ark:/67375/VQC-3ZQ304MC-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P>0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P>0.05) and higher in the treatment group than in the control group after treatment (P>0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P>0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>284</abstractWordCount><abstractCharCount>1805</abstractCharCount><keywordCount>6</keywordCount><score>7.726</score><pdfWordCount>2726</pdfWordCount><pdfCharCount>17696</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>612.284 x 824.882 pts</pdfPageSize></qualityIndicators><title>Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><genre><json:string>research-article</json:string></genre><host><title>Chinese Journal of Integrative Medicine</title><language><json:string>unknown</json:string></language><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><issn><json:string>1672-0415</json:string></issn><eissn><json:string>1993-0402</json:string></eissn><journalId><json:string>11655</json:string></journalId><volume>17</volume><issue>9</issue><pages><first>710</first><last>714</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Medicine/Public Health, general</value></json:item></subject></host><ark><json:string>ark:/67375/VQC-3ZQ304MC-2</json:string></ark><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1007/s11655-011-0850-8</json:string></doi><id>D46751B994D4007952DB9C62D6D1F8FBDDFCD417</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Chinese Association of Traditional and Western Medicine</publisher><pubPlace>Heidelberg</pubPlace><availability><licence><p>Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg, 2011</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>2010-05-10</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Clinical Experience</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Guo-lin</forename><surname>Wu</surname><surname type="transliteration">吴国琳</surname></persName><email>wuguolin28@yahoo.com.cn</email><affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tian-yi</forename><surname>Li</surname><surname type="transliteration">李天一</surname></persName><affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Yong-sheng</forename><surname>Fan</surname><surname type="transliteration">范永升</surname></persName><affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Guo-you</forename><surname>Yu</surname><surname type="transliteration">余国友</surname></persName><affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</affiliation></author><idno type="istex">D46751B994D4007952DB9C62D6D1F8FBDDFCD417</idno><idno type="ark">ark:/67375/VQC-3ZQ304MC-2</idno><idno type="DOI">10.1007/s11655-011-0850-8</idno><idno type="article-id">850</idno><idno type="article-id">s11655-011-0850-8</idno></analytic><monogr><title level="j">Chinese Journal of Integrative Medicine</title><title level="j" type="abbrev">Chin. J. Integr. Med.</title><idno type="pISSN">1672-0415</idno><idno type="eISSN">1993-0402</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">13</idno><idno type="volume-issue-count">12</idno><imprint><publisher>Chinese Association of Traditional and Western Medicine</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2011-09-01"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="710">710</biblScope><biblScope unit="page" to="714">714</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010-05-10</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>primary Sjogren's syndrome</term></item><item><term>Chinese herbal medicine</term></item><item><term>strengthening qi</term></item><item><term>nourishing yin</term></item><item><term>removing stasis</term></item><item><term>quality of life</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Medicine/Public Health, general</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-05-10">Created</change><change when="2011-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Chinese Association of Traditional and Western Medicine</PublisherName><PublisherLocation>Heidelberg</PublisherLocation></PublisherInfo><Journal OutputMedium="All"><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>11655</JournalID><JournalPrintISSN>1672-0415</JournalPrintISSN><JournalElectronicISSN>1993-0402</JournalElectronicISSN><JournalTitle>Chinese Journal of Integrative Medicine</JournalTitle><JournalAbbreviatedTitle>Chin. 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Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control.</Para></AbstractSection><AbstractSection ID="ASec3"><Heading>Results</Heading><Para TextBreak="No">Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (<Emphasis Type="Italic">P</Emphasis><0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (<Emphasis Type="Italic">P</Emphasis><0.05) and higher in the treatment group than in the control group after treatment (<Emphasis Type="Italic">P</Emphasis><0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (<Emphasis Type="Italic">P</Emphasis><0.05).</Para></AbstractSection><AbstractSection ID="ASec4"><Heading>Conclusions</Heading><Para TextBreak="No">Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</Para></AbstractSection></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>primary Sjogren's syndrome</Keyword><Keyword>Chinese herbal medicine</Keyword><Keyword>strengthening qi</Keyword><Keyword>nourishing yin</Keyword><Keyword>removing stasis</Keyword><Keyword>quality of life</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Guo-lin</namePart><namePart type="family" transliteration="吴国琳">Wu</namePart><affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</affiliation><affiliation>E-mail: wuguolin28@yahoo.com.cn</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tian-yi</namePart><namePart type="family" transliteration="李天一">Li</namePart><affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yong-sheng</namePart><namePart type="family" transliteration="范永升">Fan</namePart><affiliation>Zhejiang Chinese Medical University, 310053, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guo-you</namePart><namePart type="family" transliteration="余国友">Yu</namePart><affiliation>The First Affiliated Hospital of Medical School of Zhejiang University, 310003, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Chinese Association of Traditional and Western Medicine</publisher><place><placeTerm type="text">Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2010-05-10</dateCreated><dateIssued encoding="w3cdtf">2011-09-01</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Objective: To observe the therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Methods: Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment, immunoglobulin G (IgG) level, erythrocyte sedimentation rate (ESR), and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Results: Before treatment, levels of IgG, ESR, and OPN in patients were higher than those in the normal control. After 3 months of treatment, those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore, there was a positive correlation between the levels of OPN and the levels of IgG and ESR, and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Conclusions: Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis could alleviate pSS disease and improve the QOL. In addition, the OPN level might be used as an evaluating index for pSS disease.</abstract><note>Clinical Experience</note><subject lang="en"><genre>Keywords</genre><topic>primary Sjogren's syndrome</topic><topic>Chinese herbal medicine</topic><topic>strengthening qi</topic><topic>nourishing yin</topic><topic>removing stasis</topic><topic>quality of life</topic></subject><relatedItem type="host"><titleInfo><title>Chinese Journal of Integrative Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Chin. J. Integr. Med.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2011-09-11</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Medicine/Public Health, general</topic></subject><identifier type="ISSN">1672-0415</identifier><identifier type="eISSN">1993-0402</identifier><identifier type="JournalID">11655</identifier><identifier type="IssueArticleCount">13</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2011</date><detail type="volume"><number>17</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="pages"><start>710</start><end>714</end></extent></part><recordInfo><recordOrigin>Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg, 2011</recordOrigin></recordInfo></relatedItem><identifier type="istex">D46751B994D4007952DB9C62D6D1F8FBDDFCD417</identifier><identifier type="ark">ark:/67375/VQC-3ZQ304MC-2</identifier><identifier type="DOI">10.1007/s11655-011-0850-8</identifier><identifier type="ArticleID">850</identifier><identifier type="ArticleID">s11655-011-0850-8</identifier><accessCondition type="use and reproduction" contentType="copyright">Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg, 2011</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg, 2011</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-3ZQ304MC-2/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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