ChloroquineV1, Main, Exploration, bibRecord, 001303

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Identifieur interne : 001303 ( Main/Exploration ); précédent : 001302; suivant : 001304

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Auteurs : I-Lun Hsin [Taïwan] ; Gwo-Tarng Sheu ; Ming-Shiou Jan ; Hai-Lun Sun ; Tzu-Chin Wu ; Ling-Yen Chiu ; Ko-Huang Lue ; Jiunn-Liang Ko

Source :

British journal of pharmacology [ 1476-5381 ] ; 2012.

RBID : pubmed:22708544

Descripteurs français

KwdFr :
- Autophagie (), Chloroquine (pharmacologie), Extinction de l'expression des gènes, Facteurs immunologiques (pharmacologie), Ganoderma, Humains, Lignée cellulaire tumorale, Lysosomes (), Macrolides (pharmacologie), Phagosomes (), Protéines fongiques (pharmacologie), Protéines proto-oncogènes c-akt (métabolisme), Sérine-thréonine kinases TOR (métabolisme), Vacuolar Proton-Translocating ATPases (génétique).
MESH :
- génétique : Vacuolar Proton-Translocating ATPases.
- métabolisme : Protéines proto-oncogènes c-akt, Sérine-thréonine kinases TOR.
- pharmacologie : Chloroquine, Facteurs immunologiques, Macrolides, Protéines fongiques.
- Autophagie, Extinction de l'expression des gènes, Ganoderma, Humains, Lignée cellulaire tumorale, Lysosomes, Phagosomes.

English descriptors

KwdEn :
- Autophagy (drug effects), Cell Line, Tumor, Chloroquine (pharmacology), Fungal Proteins (pharmacology), Ganoderma, Gene Silencing, Humans, Immunologic Factors (pharmacology), Lysosomes (drug effects), Macrolides (pharmacology), Phagosomes (drug effects), Proto-Oncogene Proteins c-akt (metabolism), TOR Serine-Threonine Kinases (metabolism), Vacuolar Proton-Translocating ATPases (genetics).
MESH :
- chemical , genetics : Vacuolar Proton-Translocating ATPases.
- chemical , metabolism : Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases.
- chemical , pharmacology : Chloroquine, Fungal Proteins, Immunologic Factors, Macrolides.
- drug effects : Autophagy, Lysosomes, Phagosomes.
- Cell Line, Tumor, Ganoderma, Gene Silencing, Humans.

Abstract

Autophagic cell death is considered a self-destructive process that results from large amounts of autophagic flux. In our previous study, GMI, a recombinant fungal immunomodulatory protein cloned from Ganoderma microsporum, induced autophagic cell death in lung cancer cells. The aim of this study was to examine the role of autophagosome accumulation in GMI-mediated cell death.

DOI: 10.1111/j.1476-5381.2012.02073.x
PubMed: 22708544

Affiliations:

Taïwan

Le document en format XML

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<term>Ganoderma</term>
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<front><div type="abstract" xml:lang="en">Autophagic cell death is considered a self-destructive process that results from large amounts of autophagic flux. In our previous study, GMI, a recombinant fungal immunomodulatory protein cloned from Ganoderma microsporum, induced autophagic cell death in lung cancer cells. The aim of this study was to examine the role of autophagosome accumulation in GMI-mediated cell death.</div>
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Serveur d'exploration Chloroquine

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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