Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.
Identifieur interne : 001033 ( Main/Exploration ); précédent : 001032; suivant : 001034Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.
Auteurs : Xiahui Tan [États-Unis] ; Michael J. SandersonSource :
- British journal of pharmacology [ 1476-5381 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Bronchodilatateurs (pharmacologie), Caféine (antagonistes et inhibiteurs), Caféine (pharmacologie), Chloroquine (pharmacologie), Composés d'ammonium quaternaire (pharmacologie), Femelle, Goût, Inhibiteurs de la phosphodiestérase (), Inhibiteurs de la phosphodiestérase (pharmacologie), Inhibiteurs des canaux calciques (), Inhibiteurs des canaux calciques (pharmacologie), Inositol 1,4,5-trisphosphate (analogues et dérivés), Inositol 1,4,5-trisphosphate (métabolisme), Muscles lisses (), Muscles lisses (cytologie), Muscles lisses (métabolisme), Poumon (), Poumon (cytologie), Poumon (métabolisme), Quinine (pharmacologie), Relâchement musculaire (), Ryanodine (antagonistes et inhibiteurs), Ryanodine (pharmacologie), Récepteurs couplés aux protéines G (agonistes), Récepteurs couplés aux protéines G (métabolisme), Récepteurs à l'inositol 1,4,5-triphosphate (agonistes), Récepteurs à l'inositol 1,4,5-triphosphate (métabolisme), Résistance aux substances (), Résistance des voies aériennes (), Signalisation du calcium (), Souris, Souris de lignée BALB C, Techniques in vitro.
- MESH :
- agonistes : Récepteurs couplés aux protéines G, Récepteurs à l'inositol 1,4,5-triphosphate.
- analogues et dérivés : Inositol 1,4,5-trisphosphate.
- antagonistes et inhibiteurs : Caféine, Ryanodine.
- cytologie : Muscles lisses, Poumon.
- métabolisme : Inositol 1,4,5-trisphosphate, Muscles lisses, Poumon, Récepteurs couplés aux protéines G, Récepteurs à l'inositol 1,4,5-triphosphate.
- pharmacologie : Bronchodilatateurs, Caféine, Chloroquine, Composés d'ammonium quaternaire, Inhibiteurs de la phosphodiestérase, Inhibiteurs des canaux calciques, Quinine, Ryanodine.
- Animaux, Femelle, Goût, Inhibiteurs de la phosphodiestérase, Inhibiteurs des canaux calciques, Muscles lisses, Poumon, Relâchement musculaire, Résistance aux substances, Résistance des voies aériennes, Signalisation du calcium, Souris, Souris de lignée BALB C, Techniques in vitro.
English descriptors
- KwdEn :
- Airway Resistance (drug effects), Animals, Bronchodilator Agents (pharmacology), Caffeine (antagonists & inhibitors), Caffeine (pharmacology), Calcium Channel Blockers (chemistry), Calcium Channel Blockers (pharmacology), Calcium Signaling (drug effects), Chloroquine (pharmacology), Drug Resistance (drug effects), Female, In Vitro Techniques, Inositol 1,4,5-Trisphosphate (analogs & derivatives), Inositol 1,4,5-Trisphosphate (metabolism), Inositol 1,4,5-Trisphosphate Receptors (agonists), Inositol 1,4,5-Trisphosphate Receptors (metabolism), Lung (cytology), Lung (drug effects), Lung (metabolism), Mice, Mice, Inbred BALB C, Muscle Relaxation (drug effects), Muscle, Smooth (cytology), Muscle, Smooth (drug effects), Muscle, Smooth (metabolism), Phosphodiesterase Inhibitors (chemistry), Phosphodiesterase Inhibitors (pharmacology), Quaternary Ammonium Compounds (pharmacology), Quinine (pharmacology), Receptors, G-Protein-Coupled (agonists), Receptors, G-Protein-Coupled (metabolism), Ryanodine (antagonists & inhibitors), Ryanodine (pharmacology), Taste.
- MESH :
- chemical , agonists : Inositol 1,4,5-Trisphosphate Receptors, Receptors, G-Protein-Coupled.
- chemical , analogs & derivatives : Inositol 1,4,5-Trisphosphate.
- chemical , antagonists & inhibitors : Caffeine, Ryanodine.
- chemical , chemistry : Calcium Channel Blockers, Phosphodiesterase Inhibitors.
- chemical , metabolism : Inositol 1,4,5-Trisphosphate, Inositol 1,4,5-Trisphosphate Receptors, Receptors, G-Protein-Coupled.
- chemical , pharmacology : Bronchodilator Agents, Caffeine, Calcium Channel Blockers, Chloroquine, Phosphodiesterase Inhibitors, Quaternary Ammonium Compounds, Quinine, Ryanodine.
- cytology : Lung, Muscle, Smooth.
- drug effects : Airway Resistance, Calcium Signaling, Drug Resistance, Lung, Muscle Relaxation, Muscle, Smooth.
- metabolism : Lung, Muscle, Smooth.
- Animals, Female, In Vitro Techniques, Mice, Mice, Inbred BALB C, Taste.
Abstract
While selective, bitter tasting, TAS2R agonists can relax agonist-contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca²⁺ signalling and Ca²⁺ sensitivity. We have therefore investigated how the TAS2R10 agonists chloroquine, quinine and denotonium regulate contractile agonist-induced Ca²⁺ signalling and sensitivity.
DOI: 10.1111/bph.12460
PubMed: 24117140
Affiliations:
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Le document en format XML
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<series><title level="j">British journal of pharmacology</title>
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<term>Caffeine (pharmacology)</term>
<term>Calcium Channel Blockers (chemistry)</term>
<term>Calcium Channel Blockers (pharmacology)</term>
<term>Calcium Signaling (drug effects)</term>
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<term>Drug Resistance (drug effects)</term>
<term>Female</term>
<term>In Vitro Techniques</term>
<term>Inositol 1,4,5-Trisphosphate (analogs & derivatives)</term>
<term>Inositol 1,4,5-Trisphosphate (metabolism)</term>
<term>Inositol 1,4,5-Trisphosphate Receptors (agonists)</term>
<term>Inositol 1,4,5-Trisphosphate Receptors (metabolism)</term>
<term>Lung (cytology)</term>
<term>Lung (drug effects)</term>
<term>Lung (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Muscle Relaxation (drug effects)</term>
<term>Muscle, Smooth (cytology)</term>
<term>Muscle, Smooth (drug effects)</term>
<term>Muscle, Smooth (metabolism)</term>
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<term>Ryanodine (antagonists & inhibitors)</term>
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<term>Taste</term>
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<term>Chloroquine (pharmacologie)</term>
<term>Composés d'ammonium quaternaire (pharmacologie)</term>
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<term>Muscles lisses (cytologie)</term>
<term>Muscles lisses (métabolisme)</term>
<term>Poumon ()</term>
<term>Poumon (cytologie)</term>
<term>Poumon (métabolisme)</term>
<term>Quinine (pharmacologie)</term>
<term>Relâchement musculaire ()</term>
<term>Ryanodine (antagonistes et inhibiteurs)</term>
<term>Ryanodine (pharmacologie)</term>
<term>Récepteurs couplés aux protéines G (agonistes)</term>
<term>Récepteurs couplés aux protéines G (métabolisme)</term>
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<term>Récepteurs à l'inositol 1,4,5-triphosphate (métabolisme)</term>
<term>Résistance aux substances ()</term>
<term>Résistance des voies aériennes ()</term>
<term>Signalisation du calcium ()</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Techniques in vitro</term>
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<term>Phosphodiesterase Inhibitors</term>
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<term>Inositol 1,4,5-Trisphosphate Receptors</term>
<term>Receptors, G-Protein-Coupled</term>
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<term>Calcium Channel Blockers</term>
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<term>Phosphodiesterase Inhibitors</term>
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<term>Quinine</term>
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<term>Récepteurs à l'inositol 1,4,5-triphosphate</term>
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<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Inositol 1,4,5-trisphosphate</term>
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<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Caféine</term>
<term>Ryanodine</term>
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<term>Inhibiteurs des canaux calciques</term>
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<term>Female</term>
<term>In Vitro Techniques</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Taste</term>
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<term>Inhibiteurs des canaux calciques</term>
<term>Muscles lisses</term>
<term>Poumon</term>
<term>Relâchement musculaire</term>
<term>Résistance aux substances</term>
<term>Résistance des voies aériennes</term>
<term>Signalisation du calcium</term>
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<front><div type="abstract" xml:lang="en">While selective, bitter tasting, TAS2R agonists can relax agonist-contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca²⁺ signalling and Ca²⁺ sensitivity. We have therefore investigated how the TAS2R10 agonists chloroquine, quinine and denotonium regulate contractile agonist-induced Ca²⁺ signalling and sensitivity.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
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<tree><noCountry><name sortKey="Sanderson, Michael J" sort="Sanderson, Michael J" uniqKey="Sanderson M" first="Michael J" last="Sanderson">Michael J. Sanderson</name>
</noCountry>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Tan, Xiahui" sort="Tan, Xiahui" uniqKey="Tan X" first="Xiahui" last="Tan">Xiahui Tan</name>
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