Serveur d'exploration Chloroquine

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.

Identifieur interne : 001033 ( Main/Exploration ); précédent : 001032; suivant : 001034

Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.

Auteurs : Xiahui Tan [États-Unis] ; Michael J. Sanderson

Source :

RBID : pubmed:24117140

Descripteurs français

English descriptors

Abstract

While selective, bitter tasting, TAS2R agonists can relax agonist-contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca²⁺ signalling and Ca²⁺ sensitivity. We have therefore investigated how the TAS2R10 agonists chloroquine, quinine and denotonium regulate contractile agonist-induced Ca²⁺ signalling and sensitivity.

DOI: 10.1111/bph.12460
PubMed: 24117140


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.</title>
<author>
<name sortKey="Tan, Xiahui" sort="Tan, Xiahui" uniqKey="Tan X" first="Xiahui" last="Tan">Xiahui Tan</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sanderson, Michael J" sort="Sanderson, Michael J" uniqKey="Sanderson M" first="Michael J" last="Sanderson">Michael J. Sanderson</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24117140</idno>
<idno type="pmid">24117140</idno>
<idno type="doi">10.1111/bph.12460</idno>
<idno type="wicri:Area/PubMed/Corpus">000323</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000323</idno>
<idno type="wicri:Area/PubMed/Curation">000323</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000323</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000303</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000303</idno>
<idno type="wicri:Area/Ncbi/Merge">000216</idno>
<idno type="wicri:Area/Ncbi/Curation">000216</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000216</idno>
<idno type="wicri:Area/Main/Merge">001034</idno>
<idno type="wicri:Area/Main/Curation">001033</idno>
<idno type="wicri:Area/Main/Exploration">001033</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.</title>
<author>
<name sortKey="Tan, Xiahui" sort="Tan, Xiahui" uniqKey="Tan X" first="Xiahui" last="Tan">Xiahui Tan</name>
<affiliation wicri:level="2">
<nlm:affiliation>Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sanderson, Michael J" sort="Sanderson, Michael J" uniqKey="Sanderson M" first="Michael J" last="Sanderson">Michael J. Sanderson</name>
</author>
</analytic>
<series>
<title level="j">British journal of pharmacology</title>
<idno type="eISSN">1476-5381</idno>
<imprint>
<date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Airway Resistance (drug effects)</term>
<term>Animals</term>
<term>Bronchodilator Agents (pharmacology)</term>
<term>Caffeine (antagonists & inhibitors)</term>
<term>Caffeine (pharmacology)</term>
<term>Calcium Channel Blockers (chemistry)</term>
<term>Calcium Channel Blockers (pharmacology)</term>
<term>Calcium Signaling (drug effects)</term>
<term>Chloroquine (pharmacology)</term>
<term>Drug Resistance (drug effects)</term>
<term>Female</term>
<term>In Vitro Techniques</term>
<term>Inositol 1,4,5-Trisphosphate (analogs & derivatives)</term>
<term>Inositol 1,4,5-Trisphosphate (metabolism)</term>
<term>Inositol 1,4,5-Trisphosphate Receptors (agonists)</term>
<term>Inositol 1,4,5-Trisphosphate Receptors (metabolism)</term>
<term>Lung (cytology)</term>
<term>Lung (drug effects)</term>
<term>Lung (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Muscle Relaxation (drug effects)</term>
<term>Muscle, Smooth (cytology)</term>
<term>Muscle, Smooth (drug effects)</term>
<term>Muscle, Smooth (metabolism)</term>
<term>Phosphodiesterase Inhibitors (chemistry)</term>
<term>Phosphodiesterase Inhibitors (pharmacology)</term>
<term>Quaternary Ammonium Compounds (pharmacology)</term>
<term>Quinine (pharmacology)</term>
<term>Receptors, G-Protein-Coupled (agonists)</term>
<term>Receptors, G-Protein-Coupled (metabolism)</term>
<term>Ryanodine (antagonists & inhibitors)</term>
<term>Ryanodine (pharmacology)</term>
<term>Taste</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Animaux</term>
<term>Bronchodilatateurs (pharmacologie)</term>
<term>Caféine (antagonistes et inhibiteurs)</term>
<term>Caféine (pharmacologie)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Composés d'ammonium quaternaire (pharmacologie)</term>
<term>Femelle</term>
<term>Goût</term>
<term>Inhibiteurs de la phosphodiestérase ()</term>
<term>Inhibiteurs de la phosphodiestérase (pharmacologie)</term>
<term>Inhibiteurs des canaux calciques ()</term>
<term>Inhibiteurs des canaux calciques (pharmacologie)</term>
<term>Inositol 1,4,5-trisphosphate (analogues et dérivés)</term>
<term>Inositol 1,4,5-trisphosphate (métabolisme)</term>
<term>Muscles lisses ()</term>
<term>Muscles lisses (cytologie)</term>
<term>Muscles lisses (métabolisme)</term>
<term>Poumon ()</term>
<term>Poumon (cytologie)</term>
<term>Poumon (métabolisme)</term>
<term>Quinine (pharmacologie)</term>
<term>Relâchement musculaire ()</term>
<term>Ryanodine (antagonistes et inhibiteurs)</term>
<term>Ryanodine (pharmacologie)</term>
<term>Récepteurs couplés aux protéines G (agonistes)</term>
<term>Récepteurs couplés aux protéines G (métabolisme)</term>
<term>Récepteurs à l'inositol 1,4,5-triphosphate (agonistes)</term>
<term>Récepteurs à l'inositol 1,4,5-triphosphate (métabolisme)</term>
<term>Résistance aux substances ()</term>
<term>Résistance des voies aériennes ()</term>
<term>Signalisation du calcium ()</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Techniques in vitro</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en">
<term>Inositol 1,4,5-Trisphosphate Receptors</term>
<term>Receptors, G-Protein-Coupled</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en">
<term>Inositol 1,4,5-Trisphosphate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en">
<term>Caffeine</term>
<term>Ryanodine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en">
<term>Calcium Channel Blockers</term>
<term>Phosphodiesterase Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Inositol 1,4,5-Trisphosphate</term>
<term>Inositol 1,4,5-Trisphosphate Receptors</term>
<term>Receptors, G-Protein-Coupled</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en">
<term>Bronchodilator Agents</term>
<term>Caffeine</term>
<term>Calcium Channel Blockers</term>
<term>Chloroquine</term>
<term>Phosphodiesterase Inhibitors</term>
<term>Quaternary Ammonium Compounds</term>
<term>Quinine</term>
<term>Ryanodine</term>
</keywords>
<keywords scheme="MESH" qualifier="agonistes" xml:lang="fr">
<term>Récepteurs couplés aux protéines G</term>
<term>Récepteurs à l'inositol 1,4,5-triphosphate</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr">
<term>Inositol 1,4,5-trisphosphate</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr">
<term>Caféine</term>
<term>Ryanodine</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr">
<term>Muscles lisses</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en">
<term>Lung</term>
<term>Muscle, Smooth</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Airway Resistance</term>
<term>Calcium Signaling</term>
<term>Drug Resistance</term>
<term>Lung</term>
<term>Muscle Relaxation</term>
<term>Muscle, Smooth</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Lung</term>
<term>Muscle, Smooth</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Inositol 1,4,5-trisphosphate</term>
<term>Muscles lisses</term>
<term>Poumon</term>
<term>Récepteurs couplés aux protéines G</term>
<term>Récepteurs à l'inositol 1,4,5-triphosphate</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr">
<term>Bronchodilatateurs</term>
<term>Caféine</term>
<term>Chloroquine</term>
<term>Composés d'ammonium quaternaire</term>
<term>Inhibiteurs de la phosphodiestérase</term>
<term>Inhibiteurs des canaux calciques</term>
<term>Quinine</term>
<term>Ryanodine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Female</term>
<term>In Vitro Techniques</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Taste</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Animaux</term>
<term>Femelle</term>
<term>Goût</term>
<term>Inhibiteurs de la phosphodiestérase</term>
<term>Inhibiteurs des canaux calciques</term>
<term>Muscles lisses</term>
<term>Poumon</term>
<term>Relâchement musculaire</term>
<term>Résistance aux substances</term>
<term>Résistance des voies aériennes</term>
<term>Signalisation du calcium</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Techniques in vitro</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">While selective, bitter tasting, TAS2R agonists can relax agonist-contracted airway smooth muscle (ASM), their mechanism of action is unclear. However, ASM contraction is regulated by Ca²⁺ signalling and Ca²⁺ sensitivity. We have therefore investigated how the TAS2R10 agonists chloroquine, quinine and denotonium regulate contractile agonist-induced Ca²⁺ signalling and sensitivity.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Massachusetts</li>
</region>
</list>
<tree>
<noCountry>
<name sortKey="Sanderson, Michael J" sort="Sanderson, Michael J" uniqKey="Sanderson M" first="Michael J" last="Sanderson">Michael J. Sanderson</name>
</noCountry>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Tan, Xiahui" sort="Tan, Xiahui" uniqKey="Tan X" first="Xiahui" last="Tan">Xiahui Tan</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001033 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001033 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:24117140
   |texte=   Bitter tasting compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24117140" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021